| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 10,213,422 | 10,132,728 | -80,694 | 0.01 | 0.00 | -0.00 | sell |
| FMR LLC | 2,604,588 | 7,283,296 | +4,678,708 | 0.01 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 6,256,145 | 6,425,263 | +169,118 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 3,260,868 | 4,011,429 | +750,561 | 0.01 | 0.01 | -0.00 | buy |
| SANDS CAPITAL MANAGEMENT, LLC | 3,943,485 | 3,769,853 | -173,632 | 0.41 | 0.31 | -0.10 | sell |
| STATE STREET CORP | 2,572,240 | 3,692,487 | +1,120,247 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 1,707,402 | 3,258,266 | +1,550,864 | 0.88 | 1.21 | +0.32 | buy |
| BAKER BROS. ADVISORS LP | 2,772,692 | 2,772,692 | 0 | 0.98 | 0.60 | -0.38 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,886,268 | 2,310,174 | -576,094 | 0.01 | 0.01 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 303,565 | 2,167,729 | +1,864,164 | 0.04 | 0.26 | +0.22 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,278,000 | 2,019,000 | -259,000 | 3.12 | 1.84 | -1.28 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,871,820 | 1,945,129 | +73,309 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,712,931 | 1,580,507 | -132,424 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 1,665,852 | 1,546,101 | -119,751 | 0.02 | 0.02 | -0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,452,130 | 1,545,279 | +93,149 | 0.13 | 0.12 | -0.01 | buy |
| Pictet Asset Management Holding SA | 1,699,944 | 1,458,187 | -241,757 | 0.06 | 0.04 | -0.02 | sell |
| Rock Springs Capital Management LP | 1,391,072 | 1,246,341 | -144,731 | 3.15 | 2.19 | -0.96 | sell |
| GW&K Investment Management, LLC | 481,288 | 1,150,169 | +668,881 | 0.16 | 0.31 | +0.15 | buy |
| Schonfeld Strategic Advisors LLC | 567,175 | 1,144,589 | +577,414 | 0.16 | 0.24 | +0.08 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 525,464 | 1,069,098 | +543,634 | 0.18 | 0.29 | +0.11 | buy |
| Frazier Life Sciences Management, L.P. | 983,715 | 983,715 | 0 | 1.43 | 0.89 | -0.54 | hold |
| Aberdeen Group plc | 501,056 | 973,656 | +472,600 | 0.03 | 0.05 | +0.02 | buy |
| MORGAN STANLEY | 638,879 | 910,183 | +271,304 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 120,195 | 840,451 | +720,256 | 0.01 | 0.03 | +0.02 | buy |
| Invesco Ltd. | 724,115 | 794,849 | +70,734 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 526,267 | 754,714 | +228,447 | 0.11 | 0.12 | +0.01 | buy |
| Vestal Point Capital, LP | 0 | 750,000 | +750,000 | 0.00 | 1.02 | +1.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 252,333 | 746,182 | +493,849 | 0.01 | 0.01 | +0.01 | buy |
| Eagle Health Investments LP | 627,600 | 697,000 | +69,400 | 5.63 | 5.50 | -0.13 | buy |
| Nuveen, LLC | 505,152 | 682,144 | +176,992 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 475,156 | 677,184 | +202,028 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 637,690 | 655,021 | +17,331 | 0.00 | 0.00 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 606,407 | 603,397 | -3,010 | 0.18 | 0.13 | -0.05 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 615,969 | 600,160 | -15,809 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 0 | 588,700 | +588,700 | 0.00 | 0.53 | +0.53 | buy |
| Polar Capital Holdings Plc | 551,383 | 583,710 | +32,327 | 0.11 | 0.08 | -0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 225,826 | 573,019 | +347,193 | 0.01 | 0.01 | +0.01 | buy |
| UBS Group AG | 440,432 | 547,025 | +106,593 | 0.00 | 0.00 | -0.00 | buy |
| Alyeska Investment Group, L.P. | 1,429,437 | 531,996 | -897,441 | 0.18 | 0.05 | -0.14 | sell |
| TWO SIGMA ADVISERS, LP | 860,400 | 517,700 | -342,700 | 0.06 | 0.03 | -0.03 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 486,632 | 501,163 | +14,531 | 0.01 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 493,470 | 499,232 | +5,762 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 2,049,501 | 496,060 | -1,553,441 | 0.14 | 0.03 | -0.11 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 482,582 | +482,582 | 0.00 | 0.05 | +0.05 | buy |
| GOLDMAN SACHS GROUP INC | 425,994 | 476,938 | +50,944 | 0.00 | 0.00 | -0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 430,339 | 448,717 | +18,378 | 0.07 | 0.05 | -0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,529,474 | 430,000 | -1,099,474 | 0.09 | 0.02 | -0.07 | sell |
| BARCLAYS PLC | 178,611 | 425,351 | +246,740 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 255,238 | 422,438 | +167,200 | 3.00 | 3.94 | +0.95 | buy |
| EMERALD ADVISERS, LLC | 461,402 | 418,566 | -42,836 | 0.61 | 0.40 | -0.21 | sell |
| Legal & General Group Plc | 313,804 | 402,815 | +89,011 | 0.00 | 0.00 | -0.00 | buy |
| MPM BioImpact LLC | 395,700 | 395,700 | 0 | 2.49 | 1.95 | -0.54 | hold |
| Palo Alto Investors LP | 48,750 | 369,531 | +320,781 | 0.38 | 2.06 | +1.68 | buy |
| Motley Fool Wealth Management, LLC | 275,082 | 355,540 | +80,458 | 0.60 | 0.73 | +0.12 | buy |
| JANE STREET GROUP, LLC | 111,726 | 354,168 | +242,442 | 0.01 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 100,085 | 352,558 | +252,473 | 0.95 | 2.52 | +1.56 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 390,389 | 344,923 | -45,466 | 0.01 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 37,627 | 330,953 | +293,326 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 576,901 | 326,180 | -250,721 | 0.04 | 0.02 | -0.02 | sell |
| Bank of New York Mellon Corp | 473,887 | 324,845 | -149,042 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 116,347 | 321,633 | +205,286 | 0.09 | 0.16 | +0.07 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 415,733 | 298,891 | -116,842 | 0.01 | 0.01 | -0.00 | sell |
| Catalio Capital Management, LP | 213,402 | 291,262 | +77,860 | 1.63 | 1.62 | -0.01 | buy |
| Privium Fund Management B.V. | 253,304 | 289,804 | +36,500 | 1.98 | 1.57 | -0.41 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 210,469 | 288,109 | +77,640 | 0.02 | 0.02 | +0.00 | buy |
| First Light Asset Management, LLC | 547,905 | 285,699 | -262,206 | 2.58 | 0.81 | -1.77 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 311,101 | 280,466 | -30,635 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 273,251 | 273,251 | 0 | 0.05 | 0.04 | -0.01 | hold |
| MOORE CAPITAL MANAGEMENT, LP | 290,000 | 270,000 | -20,000 | 0.21 | 0.16 | -0.05 | sell |
| Hudson Bay Capital Management LP | 258,681 | 265,000 | +6,319 | 0.06 | 0.05 | -0.01 | buy |
| Assenagon Asset Management S.A. | 1,163,755 | 252,669 | -911,086 | 0.07 | 0.01 | -0.06 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 295,317 | 242,802 | -52,515 | 0.65 | 0.38 | -0.28 | sell |
| D. E. Shaw & Co., Inc. | 540,801 | 237,640 | -303,161 | 0.02 | 0.01 | -0.01 | sell |
| ROYAL BANK OF CANADA | 10,043 | 236,289 | +226,246 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 80,223 | 234,126 | +153,903 | 0.00 | 0.01 | +0.01 | buy |
| Yiheng Capital Management, L.P. | 0 | 225,758 | +225,758 | 0.00 | 2.25 | +2.25 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 300,962 | 207,042 | -93,920 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 235,097 | 200,717 | -34,380 | 0.01 | 0.01 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 194,982 | +194,982 | 0.00 | 0.02 | +0.02 | buy |
| Aquatic Capital Management LLC | 106,899 | 191,458 | +84,559 | 0.08 | 0.11 | +0.03 | buy |
| SEI INVESTMENTS CO | 90,192 | 190,462 | +100,270 | 0.00 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 36,071 | 177,421 | +141,350 | 0.00 | 0.01 | +0.01 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 91,987 | 177,061 | +85,074 | 0.04 | 0.05 | +0.02 | buy |
| Cubist Systematic Strategies, LLC | 85,282 | 172,674 | +87,392 | 0.03 | 0.07 | +0.04 | buy |
| Fisher Asset Management, LLC | 185,756 | 168,084 | -17,672 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 161,052 | 164,952 | +3,900 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 237,500 | 164,501 | -72,999 | 0.79 | 0.29 | -0.50 | sell |
| PDT Partners, LLC | 156,693 | 156,693 | 0 | 0.32 | 0.30 | -0.03 | hold |
| Rafferty Asset Management, LLC | 81,096 | 156,484 | +75,388 | 0.01 | 0.02 | +0.01 | buy |
| Clearbridge Investments, LLC | 2,140,577 | 155,752 | -1,984,825 | 0.06 | 0.00 | -0.06 | sell |
| Trexquant Investment LP | 234,912 | 155,388 | -79,524 | 0.10 | 0.05 | -0.05 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 336,173 | 150,571 | -185,602 | 0.01 | 0.00 | -0.01 | sell |
| MARSHALL WACE, LLP | 65,871 | 146,094 | +80,223 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 109,237 | 138,684 | +29,447 | 0.00 | 0.00 | -0.00 | buy |
| B Group, Inc. | 110,000 | 135,000 | +25,000 | 3.45 | 3.88 | +0.43 | buy |
| Squarepoint Ops LLC | 21,683 | 133,772 | +112,089 | 0.00 | 0.01 | +0.01 | buy |
| EFG Asset Management (North America) Corp. | 135,850 | 127,985 | -7,865 | 0.70 | 0.50 | -0.20 | sell |
| SG Americas Securities, LLC | 0 | 125,429 | +125,429 | 0.00 | 0.01 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 123,127 | 121,941 | -1,186 | 0.05 | 0.04 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 93,100 | 119,400 | +26,300 | 0.43 | 0.40 | -0.03 | buy |