| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SANDS CAPITAL MANAGEMENT, LLC | 2,577,217 | 4,118,008 | +1,540,791 | 0.31 | 0.60 | +0.29 | buy |
| RTW INVESTMENTS, LP | 5,405,089 | 6,887,086 | +1,481,997 | 4.07 | 5.14 | +1.08 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 679,459 | 2,126,306 | +1,446,847 | 1.31 | 4.65 | +3.34 | buy |
| VANGUARD GROUP INC | 7,233,168 | 8,673,432 | +1,440,264 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 90,000 | 1,025,000 | +935,000 | 0.01 | 0.10 | +0.09 | buy |
| Camber Capital Management LP | 0 | 900,000 | +900,000 | 0.00 | 1.50 | +1.50 | buy |
| STATE STREET CORP | 2,567,858 | 3,252,502 | +684,644 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 940,763 | 1,489,486 | +548,723 | 0.07 | 0.14 | +0.06 | buy |
| Bank of New York Mellon Corp | 621,706 | 1,010,830 | +389,124 | 0.00 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 342,812 | +342,812 | 0.00 | 0.13 | +0.13 | buy |
| Avidity Partners Management LP | 544,000 | 844,500 | +300,500 | 0.78 | 1.54 | +0.76 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 1,943,815 | 2,241,832 | +298,017 | 0.44 | 0.70 | +0.26 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,160,160 | 3,448,698 | +288,538 | 0.02 | 0.02 | +0.01 | buy |
| Rock Springs Capital Management LP | 1,476,441 | 1,754,038 | +277,597 | 1.41 | 2.07 | +0.66 | buy |
| Blue Owl Capital Holdings LP | 0 | 263,238 | +263,238 | 0.00 | 3.01 | +3.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 250,052 | +250,052 | 0.00 | 0.02 | +0.02 | buy |
| FEDERATED HERMES, INC. | 2,196,500 | 2,446,500 | +250,000 | 0.21 | 0.29 | +0.08 | buy |
| DEUTSCHE BANK AG\ | 947,732 | 1,172,866 | +225,134 | 0.02 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,083,287 | 1,283,622 | +200,335 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 200,054 | +200,054 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 205,483 | 400,124 | +194,641 | 0.09 | 0.21 | +0.12 | buy |
| NORGES BANK | 598,088 | 770,506 | +172,418 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 170,689 | +170,689 | 0.00 | 0.02 | +0.02 | buy |
| Pictet Asset Management Holding SA | 869,388 | 1,023,136 | +153,748 | 0.04 | 0.05 | +0.02 | buy |
| Aberdeen Group plc | 0 | 141,117 | +141,117 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 221,246 | 359,166 | +137,920 | 0.10 | 0.21 | +0.10 | buy |
| MORGAN STANLEY | 495,489 | 597,549 | +102,060 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,366,547 | 1,466,547 | +100,000 | 0.28 | 0.80 | +0.52 | buy |
| Candriam S.C.A. | 49,480 | 148,480 | +99,000 | 0.01 | 0.05 | +0.04 | buy |
| Cinctive Capital Management LP | 0 | 98,051 | +98,051 | 0.00 | 0.33 | +0.33 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 75,398 | 168,684 | +93,286 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 29,650 | 120,715 | +91,065 | 0.00 | 0.01 | +0.01 | buy |
| Clearbridge Investments, LLC | 2,293,570 | 2,383,492 | +89,922 | 0.08 | 0.10 | +0.02 | buy |
| Man Group plc | 0 | 87,811 | +87,811 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 39,200 | 126,610 | +87,410 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 82,933 | +82,933 | 0.00 | 0.01 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 82,619 | +82,619 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 396,725 | 471,825 | +75,100 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 322,571 | 374,661 | +52,090 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 115,241 | 166,506 | +51,265 | 1.22 | 2.23 | +1.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,532,505 | 1,578,603 | +46,098 | 0.02 | 0.03 | +0.01 | buy |
| BARCLAYS PLC | 120,693 | 166,742 | +46,049 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 385,441 | 430,018 | +44,577 | 0.00 | 0.00 | +0.00 | buy |
| NFJ INVESTMENT GROUP, LLC | 0 | 44,084 | +44,084 | 0.00 | 0.06 | +0.06 | buy |
| Rafferty Asset Management, LLC | 183,051 | 221,910 | +38,859 | 0.04 | 0.04 | +0.01 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 150,000 | 185,000 | +35,000 | 0.14 | 0.21 | +0.07 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 240,857 | 272,339 | +31,482 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 189,594 | 214,738 | +25,144 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 29,548 | 53,500 | +23,952 | 0.03 | 0.06 | +0.03 | buy |
| CITIGROUP INC | 90,580 | 110,510 | +19,930 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 53,193 | 72,866 | +19,673 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 18,299 | +18,299 | 0.00 | 0.01 | +0.01 | buy |
| DekaBank Deutsche Girozentrale | 40,000 | 57,000 | +17,000 | 0.00 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 183,887 | 200,615 | +16,728 | 0.01 | 0.02 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 205,360 | 221,360 | +16,000 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 15,841 | +15,841 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 19,751 | 35,378 | +15,627 | 0.04 | 0.10 | +0.05 | buy |
| PDT Partners, LLC | 33,229 | 47,501 | +14,272 | 0.15 | 0.25 | +0.10 | buy |
| Graham Capital Management, L.P. | 0 | 13,860 | +13,860 | 0.00 | 0.02 | +0.02 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 107,765 | 120,985 | +13,220 | 0.01 | 0.02 | +0.00 | buy |
| DUALITY ADVISERS, LP | 27,038 | 39,371 | +12,333 | 0.12 | 0.20 | +0.08 | buy |
| Allianz Asset Management GmbH | 8,500 | 20,200 | +11,700 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 46,392 | 57,821 | +11,429 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 10,797 | +10,797 | 0.00 | 0.05 | +0.05 | buy |
| EFG Asset Management (North America) Corp. | 57,921 | 68,468 | +10,547 | 0.49 | 0.62 | +0.13 | buy |
| Ghisallo Capital Management LLC | 0 | 10,000 | +10,000 | 0.00 | 0.05 | +0.05 | buy |
| SEI INVESTMENTS CO | 55,552 | 65,380 | +9,828 | 0.00 | 0.01 | +0.00 | buy |
| CERTUITY, LLC | 0 | 9,145 | +9,145 | 0.00 | 0.04 | +0.04 | buy |
| PITCAIRN CO | 0 | 8,636 | +8,636 | 0.00 | 0.03 | +0.03 | buy |
| WOODSTOCK CORP | 0 | 8,060 | +8,060 | 0.00 | 0.04 | +0.04 | buy |
| RHUMBLINE ADVISERS | 92,615 | 100,665 | +8,050 | 0.00 | 0.01 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 9,592 | 17,600 | +8,008 | 0.01 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 1,831 | 9,501 | +7,670 | 0.02 | 0.09 | +0.07 | buy |
| Gotham Asset Management, LLC | 0 | 7,478 | +7,478 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 7,070 | +7,070 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 217,236 | 224,236 | +7,000 | 0.01 | 0.01 | +0.00 | buy |
| M&T BANK CORP | 0 | 6,486 | +6,486 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 6,176 | +6,176 | 0.00 | 0.00 | +0.00 | buy |
| Maryland State Retirement & Pension System | 0 | 6,111 | +6,111 | 0.00 | 0.01 | +0.01 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 9,580 | 15,690 | +6,110 | 0.09 | 0.19 | +0.10 | buy |
| ProShare Advisors LLC | 0 | 5,588 | +5,588 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 27,551 | 32,910 | +5,359 | 0.00 | 0.01 | +0.00 | buy |
| EFG Asset Management (Americas) Corp. | 0 | 5,274 | +5,274 | 0.00 | 0.05 | +0.05 | buy |
| Treasurer of the State of North Carolina | 29,703 | 34,853 | +5,150 | 0.01 | 0.01 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 0 | 5,146 | +5,146 | 0.00 | 0.04 | +0.04 | buy |
| PROFUND ADVISORS LLC | 30,061 | 35,015 | +4,954 | 0.06 | 0.07 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 4,900 | +4,900 | 0.00 | 0.02 | +0.02 | buy |
| Vident Advisory, LLC | 0 | 4,487 | +4,487 | 0.00 | 0.01 | +0.01 | buy |
| Angeles Investment Advisors, LLC | 0 | 4,447 | +4,447 | 0.00 | 0.01 | +0.01 | buy |
| Utah Retirement Systems | 0 | 4,300 | +4,300 | 0.00 | 0.00 | +0.00 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 4,280 | +4,280 | 0.00 | 0.03 | +0.03 | buy |
| Legal & General Group Plc | 68,933 | 72,832 | +3,899 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 114,521 | 118,206 | +3,685 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 7,306 | 10,565 | +3,259 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 31,882 | 34,930 | +3,048 | 0.24 | 0.32 | +0.08 | buy |
| B. Metzler seel. Sohn & Co. AG | 21,080 | 23,817 | +2,737 | 0.01 | 0.01 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 9,840 | 12,494 | +2,654 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 9,404 | 11,871 | +2,467 | 0.03 | 0.04 | +0.01 | buy |
| ALGERT GLOBAL LLC | 22,140 | 24,570 | +2,430 | 0.04 | 0.05 | +0.01 | buy |
| JPMORGAN CHASE & CO | 275,591 | 277,942 | +2,351 | 0.00 | 0.00 | +0.00 | buy |