| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SANDS CAPITAL MANAGEMENT, LLC | 2,577,217 | 4,118,008 | +1,540,791 | 0.31 | 0.60 | +0.29 | buy |
| RTW INVESTMENTS, LP | 5,405,089 | 6,887,086 | +1,481,997 | 4.07 | 5.14 | +1.08 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 679,459 | 2,126,306 | +1,446,847 | 1.31 | 4.60 | +3.29 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 90,000 | 1,025,000 | +935,000 | 0.01 | 0.10 | +0.09 | buy |
| Avidity Partners Management LP | 544,000 | 844,500 | +300,500 | 0.78 | 1.47 | +0.69 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 1,943,815 | 2,241,832 | +298,017 | 0.12 | 0.24 | +0.12 | buy |
| Rock Springs Capital Management LP | 1,476,441 | 1,754,038 | +277,597 | 1.41 | 2.06 | +0.65 | buy |
| Woodline Partners LP | 205,483 | 400,124 | +194,641 | 0.09 | 0.21 | +0.12 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 221,246 | 359,166 | +137,920 | 0.10 | 0.21 | +0.10 | buy |
| BAKER BROS. ADVISORS LP | 1,366,547 | 1,466,547 | +100,000 | 0.28 | 0.80 | +0.52 | buy |
| Candriam S.C.A. | 49,480 | 148,480 | +99,000 | 0.01 | 0.05 | +0.04 | buy |
| Clearbridge Investments, LLC | 2,293,570 | 2,383,492 | +89,922 | 0.08 | 0.10 | +0.02 | buy |
| Privium Fund Management B.V. | 115,241 | 166,506 | +51,265 | 1.22 | 2.23 | +1.01 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 150,000 | 185,000 | +35,000 | 0.10 | 0.15 | +0.05 | buy |
| Hennion & Walsh Asset Management, Inc. | 19,751 | 35,378 | +15,627 | 0.04 | 0.10 | +0.05 | buy |
| PDT Partners, LLC | 33,229 | 47,501 | +14,272 | 0.15 | 0.25 | +0.10 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 107,765 | 120,985 | +13,220 | 0.01 | 0.02 | +0.00 | buy |
| DUALITY ADVISERS, LP | 27,038 | 39,371 | +12,333 | 0.12 | 0.20 | +0.08 | buy |
| EFG Asset Management (North America) Corp. | 57,921 | 68,468 | +10,547 | 0.49 | 0.62 | +0.13 | buy |
| GILDER GAGNON HOWE & CO LLC | 9,592 | 17,600 | +8,008 | 0.01 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 1,831 | 9,501 | +7,670 | 0.02 | 0.09 | +0.07 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 9,580 | 15,690 | +6,110 | 0.09 | 0.19 | +0.10 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 31,882 | 34,930 | +3,048 | 0.24 | 0.32 | +0.08 | buy |
| B. Metzler seel. Sohn & Co. AG | 21,080 | 23,817 | +2,737 | 0.01 | 0.01 | +0.00 | buy |
| E Fund Management Co., Ltd. | 9,404 | 11,871 | +2,467 | 0.03 | 0.04 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 6,072 | 7,105 | +1,033 | 0.13 | 0.22 | +0.08 | buy |
| PINNACLE ASSOCIATES LTD | 119,355 | 119,360 | +5 | 0.08 | 0.10 | +0.02 | buy |
| Itau Unibanco Holding S.A. | 330 | 271 | -59 | 0.00 | 0.00 | -0.00 | sell |
| Bridgewater Associates, LP | 11,389 | 10,635 | -754 | 0.00 | 0.00 | +0.00 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 46,386 | 45,465 | -921 | 0.00 | 0.00 | +0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 387,323 | 385,340 | -1,983 | 0.83 | 0.98 | +0.14 | sell |
| GW&K Investment Management, LLC | 310,915 | 307,529 | -3,386 | 0.11 | 0.14 | +0.03 | sell |
| Motley Fool Wealth Management, LLC | 168,259 | 164,235 | -4,024 | 0.35 | 0.41 | +0.07 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 9,580 | 4,900 | -4,680 | 0.09 | 0.06 | -0.03 | sell |
| Motley Fool Asset Management LLC | 156,104 | 149,443 | -6,661 | 0.45 | 0.53 | +0.09 | sell |
| EMERALD ADVISERS, LLC | 491,689 | 482,138 | -9,551 | 0.85 | 0.99 | +0.14 | sell |
| SECTOR GAMMA AS | 115,166 | 102,490 | -12,676 | 1.05 | 1.19 | +0.14 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 139,870 | 119,300 | -20,570 | 0.15 | 0.17 | +0.02 | sell |
| GREAT LAKES ADVISORS, LLC | 55,447 | 27,773 | -27,674 | 0.02 | 0.01 | -0.01 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 748,278 | 718,978 | -29,300 | 0.16 | 0.17 | +0.02 | sell |
| FRED ALGER MANAGEMENT, LLC | 638,866 | 603,976 | -34,890 | 0.13 | 0.16 | +0.02 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 259,135 | 201,044 | -58,091 | 1.68 | 1.55 | -0.14 | sell |
| GREAT POINT PARTNERS LLC | 727,426 | 648,000 | -79,426 | 4.72 | 5.28 | +0.56 | sell |
| Hudson Bay Capital Management LP | 734,272 | 490,000 | -244,272 | 0.21 | 0.15 | -0.06 | sell |
| First Light Asset Management, LLC | 1,125,032 | 744,665 | -380,367 | 3.81 | 2.86 | -0.94 | sell |
| Avoro Capital Advisors LLC | 1,500,000 | 350,000 | -1,150,000 | 0.83 | 0.23 | -0.60 | sell |