| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 750,000 | 1,500,000 | +750,000 | 3.29 | 3.74 | +0.45 | buy |
| BlackRock, Inc. | 5,828,848 | 6,536,517 | +707,669 | 0.01 | 0.01 | -0.00 | buy |
| Deep Track Capital, LP | 0 | 653,513 | +653,513 | 0.00 | 1.03 | +1.03 | buy |
| Pictet Asset Management Holding SA | 520,550 | 1,173,638 | +653,088 | 0.03 | 0.05 | +0.02 | buy |
| Point72 Asset Management, L.P. | 653,660 | 1,182,877 | +529,217 | 0.13 | 0.14 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 17,022 | 544,202 | +527,180 | 0.00 | 0.02 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 400,833 | 747,429 | +346,596 | 0.18 | 0.20 | +0.02 | buy |
| Alyeska Investment Group, L.P. | 1,170,007 | 1,439,740 | +269,733 | 0.33 | 0.23 | -0.10 | buy |
| Fisher Asset Management, LLC | 0 | 265,189 | +265,189 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 47,953 | 286,179 | +238,226 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 35,937 | 272,940 | +237,003 | 0.00 | 0.02 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 724,182 | 958,077 | +233,895 | 0.10 | 0.10 | +0.00 | buy |
| UBS Group AG | 93,069 | 325,651 | +232,582 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 822,012 | 1,051,573 | +229,561 | 0.06 | 0.06 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 218,903 | 427,359 | +208,456 | 0.00 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 77,306 | 285,041 | +207,735 | 0.03 | 0.06 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 182,865 | 376,161 | +193,296 | 0.01 | 0.02 | +0.01 | buy |
| Hudson Bay Capital Management LP | 195,000 | 377,500 | +182,500 | 0.07 | 0.10 | +0.02 | buy |
| MORGAN STANLEY | 467,836 | 598,189 | +130,353 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 79,546 | 206,108 | +126,562 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 124,388 | +124,388 | 0.00 | 1.17 | +1.17 | buy |
| Cutter Capital Management, LP | 286,803 | 406,803 | +120,000 | 4.70 | 7.01 | +2.31 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 28,831 | 142,628 | +113,797 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 109,900 | +109,900 | 0.00 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 8,600 | 117,571 | +108,971 | 0.05 | 0.20 | +0.15 | buy |
| STEMPOINT CAPITAL LP | 0 | 101,809 | +101,809 | 0.00 | 1.07 | +1.07 | buy |
| VANGUARD GROUP INC | 9,945,473 | 10,034,862 | +89,389 | 0.01 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 87,989 | +87,989 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 24,991 | 112,816 | +87,825 | 0.03 | 0.10 | +0.07 | buy |
| ExodusPoint Capital Management, LP | 0 | 87,017 | +87,017 | 0.00 | 0.04 | +0.04 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,546,265 | 1,627,932 | +81,667 | 0.03 | 0.02 | -0.01 | buy |
| Aquatic Capital Management LLC | 24,000 | 102,571 | +78,571 | 0.03 | 0.12 | +0.08 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 182,100 | 254,700 | +72,600 | 0.02 | 0.02 | +0.00 | buy |
| Eagle Health Investments LP | 561,700 | 627,600 | +65,900 | 6.01 | 6.47 | +0.46 | buy |
| Aberdeen Group plc | 253,304 | 317,125 | +63,821 | 0.03 | 0.03 | -0.00 | buy |
| MPM BioImpact LLC | 329,733 | 391,018 | +61,285 | 2.75 | 2.34 | -0.41 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 120,337 | 180,425 | +60,088 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 2,664,077 | 2,722,624 | +58,547 | 0.01 | 0.00 | -0.00 | buy |
| KBC Group NV | 2,568 | 61,010 | +58,442 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 473,324 | 528,965 | +55,641 | 0.00 | 0.00 | -0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 294,723 | 346,597 | +51,874 | 0.02 | 0.02 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 506,510 | 553,670 | +47,160 | 0.01 | 0.00 | -0.00 | buy |
| Cinctive Capital Management LP | 15,902 | 62,960 | +47,058 | 0.05 | 0.14 | +0.09 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 783,944 | 829,465 | +45,521 | 0.37 | 0.29 | -0.09 | buy |
| GW&K Investment Management, LLC | 466,569 | 509,545 | +42,976 | 0.22 | 0.18 | -0.04 | buy |
| F/m Investments LLC | 0 | 42,004 | +42,004 | 0.00 | 0.07 | +0.07 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 39,694 | +39,694 | 0.00 | 0.13 | +0.13 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 195,349 | 228,776 | +33,427 | 1.78 | 1.78 | +0.00 | buy |
| HSBC HOLDINGS PLC | 16,100 | 47,516 | +31,416 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 425,390 | 456,588 | +31,198 | 0.07 | 0.06 | -0.01 | buy |
| EFG Asset Management (North America) Corp. | 109,388 | 139,443 | +30,055 | 1.02 | 0.80 | -0.22 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 134,204 | 163,888 | +29,684 | 0.23 | 0.20 | -0.02 | buy |
| PINNACLE ASSOCIATES LTD | 119,360 | 148,493 | +29,133 | 0.10 | 0.08 | -0.01 | buy |
| TWINBEECH CAPITAL LP | 5,360 | 33,857 | +28,497 | 0.01 | 0.02 | +0.02 | buy |
| Crestline Management, LP | 0 | 27,949 | +27,949 | 0.00 | 0.04 | +0.04 | buy |
| Invesco Ltd. | 1,674,269 | 1,699,756 | +25,487 | 0.02 | 0.01 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 633,715 | 658,715 | +25,000 | 1.41 | 1.15 | -0.26 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 177,756 | 202,376 | +24,620 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 261,594 | 286,079 | +24,485 | 0.02 | 0.01 | -0.01 | buy |
| Engineers Gate Manager LP | 11,575 | 35,254 | +23,679 | 0.01 | 0.03 | +0.01 | buy |
| CITIGROUP INC | 43,493 | 66,921 | +23,428 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 23,077 | +23,077 | 0.00 | 0.44 | +0.44 | buy |
| NORGES BANK | 940,626 | 961,794 | +21,168 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 594,521 | 613,633 | +19,112 | 0.01 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 16,241 | 35,201 | +18,960 | 0.04 | 0.04 | -0.01 | buy |
| Point72 Hong Kong Ltd | 10,020 | 27,399 | +17,379 | 0.04 | 0.07 | +0.03 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 114,119 | 131,344 | +17,225 | 0.00 | 0.00 | -0.00 | buy |
| Simplify Asset Management Inc. | 0 | 16,810 | +16,810 | 0.00 | 0.05 | +0.05 | buy |
| Graham Capital Management, L.P. | 43,001 | 59,129 | +16,128 | 0.08 | 0.08 | -0.00 | buy |
| Birchview Capital, LP | 0 | 16,000 | +16,000 | 0.00 | 0.55 | +0.55 | buy |
| Tower Research Capital LLC (TRC) | 853 | 16,827 | +15,974 | 0.00 | 0.01 | +0.01 | buy |
| Privium Fund Management B.V. | 242,512 | 258,380 | +15,868 | 3.35 | 2.46 | -0.89 | buy |
| MACKENZIE FINANCIAL CORP | 4,290 | 16,115 | +11,825 | 0.00 | 0.00 | -0.00 | buy |
| MACKENZIE FINANCIAL CORP | 4,290 | 16,115 | +11,825 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 34,769 | 46,514 | +11,745 | 0.01 | 0.01 | -0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 10,916 | +10,916 | 0.00 | 0.07 | +0.07 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 10,387 | +10,387 | 0.00 | 0.14 | +0.14 | buy |
| ALGERT GLOBAL LLC | 73,902 | 82,793 | +8,891 | 0.11 | 0.08 | -0.03 | buy |
| First Light Asset Management, LLC | 755,102 | 763,607 | +8,505 | 3.49 | 3.07 | -0.42 | buy |
| ADAR1 Capital Management, LLC | 0 | 8,000 | +8,000 | 0.00 | 0.07 | +0.07 | buy |
| Y-Intercept (Hong Kong) Ltd | 19,151 | 26,695 | +7,544 | 0.07 | 0.07 | +0.01 | buy |
| SYON CAPITAL LLC | 0 | 7,362 | +7,362 | 0.00 | 0.03 | +0.03 | buy |
| MACQUARIE GROUP LTD | 275,927 | 282,963 | +7,036 | 0.02 | 0.01 | -0.00 | buy |
| EntryPoint Capital, LLC | 0 | 6,939 | +6,939 | 0.00 | 0.12 | +0.12 | buy |
| Magnetar Financial LLC | 0 | 6,779 | +6,779 | 0.00 | 0.01 | +0.01 | buy |
| AlphaQuest LLC | 2,145 | 8,167 | +6,022 | 0.01 | 0.05 | +0.04 | buy |
| Legal & General Group Plc | 92,836 | 98,732 | +5,896 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 17,770 | 22,874 | +5,104 | 0.00 | 0.00 | -0.00 | buy |
| Quantinno Capital Management LP | 0 | 5,013 | +5,013 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 23,675 | 28,500 | +4,825 | 0.01 | 0.01 | -0.00 | buy |
| Nebula Research & Development LLC | 4,221 | 8,876 | +4,655 | 0.03 | 0.04 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 1,688,971 | 1,693,108 | +4,137 | 0.04 | 0.03 | -0.01 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 20,444 | 24,574 | +4,130 | 0.01 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 14,517 | 18,620 | +4,103 | 0.06 | 0.07 | +0.01 | buy |
| Swiss National Bank | 159,152 | 163,152 | +4,000 | 0.01 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 89,569 | 93,439 | +3,870 | 0.01 | 0.01 | -0.00 | buy |
| ROYAL BANK OF CANADA | 66,130 | 69,742 | +3,612 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 86,440 | 89,955 | +3,515 | 0.00 | 0.00 | -0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 36,427 | 39,673 | +3,246 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 65,266 | 68,345 | +3,079 | 0.01 | 0.01 | -0.00 | buy |