| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 750,000 | 1,500,000 | +750,000 | 3.29 | 3.74 | +0.45 | buy |
| Alyeska Investment Group, L.P. | 1,170,007 | 1,439,740 | +269,733 | 0.33 | 0.23 | -0.10 | buy |
| BNP Paribas Asset Management Holding S.A. | 724,182 | 958,077 | +233,895 | 0.10 | 0.10 | +0.00 | buy |
| Hudson Bay Capital Management LP | 195,000 | 377,500 | +182,500 | 0.04 | 0.06 | +0.01 | buy |
| Cutter Capital Management, LP | 286,803 | 406,803 | +120,000 | 4.70 | 7.01 | +2.31 | buy |
| Eagle Health Investments LP | 561,700 | 627,600 | +65,900 | 6.01 | 6.47 | +0.46 | buy |
| Aberdeen Group plc | 253,304 | 317,125 | +63,821 | 0.03 | 0.03 | -0.00 | buy |
| MPM BioImpact LLC | 329,733 | 391,018 | +61,285 | 2.75 | 2.34 | -0.41 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 294,723 | 346,597 | +51,874 | 0.02 | 0.01 | -0.00 | buy |
| Cinctive Capital Management LP | 15,902 | 62,960 | +47,058 | 0.05 | 0.13 | +0.09 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 783,944 | 829,465 | +45,521 | 0.37 | 0.29 | -0.09 | buy |
| GW&K Investment Management, LLC | 466,569 | 509,545 | +42,976 | 0.22 | 0.18 | -0.04 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 195,349 | 228,776 | +33,427 | 1.73 | 1.74 | +0.01 | buy |
| EFG Asset Management (North America) Corp. | 109,388 | 139,443 | +30,055 | 1.02 | 0.80 | -0.22 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 134,204 | 163,888 | +29,684 | 0.23 | 0.20 | -0.02 | buy |
| PINNACLE ASSOCIATES LTD | 119,360 | 148,493 | +29,133 | 0.10 | 0.08 | -0.01 | buy |
| TWINBEECH CAPITAL LP | 5,360 | 33,857 | +28,497 | 0.01 | 0.02 | +0.02 | buy |
| Frazier Life Sciences Management, L.P. | 633,715 | 658,715 | +25,000 | 1.41 | 1.15 | -0.26 | buy |
| Brevan Howard Capital Management LP | 16,241 | 35,201 | +18,960 | 0.01 | 0.01 | +0.00 | buy |
| Point72 Hong Kong Ltd | 10,020 | 27,399 | +17,379 | 0.04 | 0.07 | +0.03 | buy |
| Privium Fund Management B.V. | 242,512 | 258,380 | +15,868 | 3.35 | 2.46 | -0.89 | buy |
| First Light Asset Management, LLC | 755,102 | 763,607 | +8,505 | 3.49 | 3.07 | -0.42 | buy |
| Nebula Research & Development LLC | 4,221 | 8,876 | +4,655 | 0.03 | 0.04 | +0.02 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 36,427 | 39,673 | +3,246 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 267,555 | 269,556 | +2,001 | 0.13 | 0.08 | -0.05 | buy |
| DnB Asset Management AS | 10,243 | 12,132 | +1,889 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,726 | 19,580 | +1,854 | 0.11 | 0.08 | -0.03 | buy |
| Crestwood Advisors Group, LLC | 100,280 | 101,730 | +1,450 | 0.11 | 0.08 | -0.03 | buy |
| Teza Capital Management LLC | 4,864 | 5,857 | +993 | 0.03 | 0.04 | +0.01 | buy |
| E Fund Management Co., Ltd. | 6,323 | 7,200 | +877 | 0.02 | 0.02 | -0.00 | buy |
| Ikarian Capital, LLC | 179,000 | 178,989 | -11 | 1.39 | 1.02 | -0.36 | sell |
| STEPH & CO | 2,797 | 2,617 | -180 | 0.05 | 0.04 | -0.01 | sell |
| VIRTUS ADVISERS, LLC | 7,638 | 7,457 | -181 | 0.20 | 0.13 | -0.07 | sell |
| NFJ INVESTMENT GROUP, LLC | 38,131 | 37,667 | -464 | 0.06 | 0.05 | -0.01 | sell |
| NewEdge Wealth, LLC | 5,945 | 5,463 | -482 | 0.01 | 0.00 | -0.00 | sell |
| Vestmark Advisory Solutions, Inc. | 5,945 | 5,277 | -668 | 0.01 | 0.01 | -0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 18,622 | 17,362 | -1,260 | 0.09 | 0.06 | -0.03 | sell |
| PITCAIRN CO | 10,584 | 8,342 | -2,242 | 0.03 | 0.02 | -0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 19,589 | 16,928 | -2,661 | 0.01 | 0.01 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 25,100 | 21,000 | -4,100 | 1.13 | 0.89 | -0.24 | sell |
| Bayesian Capital Management, LP | 13,836 | 8,268 | -5,568 | 0.09 | 0.04 | -0.05 | sell |
| INCEPTIONR LLC | 14,643 | 8,227 | -6,416 | 0.20 | 0.08 | -0.12 | sell |
| BAMCO INC /NY/ | 48,000 | 40,000 | -8,000 | 0.01 | 0.00 | -0.00 | sell |
| GREAT LAKES ADVISORS, LLC | 199,253 | 191,129 | -8,124 | 0.09 | 0.07 | -0.02 | sell |
| B. Metzler seel. Sohn & Co. AG | 23,817 | 15,457 | -8,360 | 0.01 | 0.01 | -0.01 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 22,540 | 14,090 | -8,450 | 0.28 | 0.12 | -0.16 | sell |
| Parkman Healthcare Partners LLC | 109,468 | 100,159 | -9,309 | 0.78 | 0.56 | -0.22 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 145,349 | 135,609 | -9,740 | 0.02 | 0.01 | -0.00 | sell |
| Motley Fool Wealth Management, LLC | 168,015 | 153,835 | -14,180 | 0.47 | 0.33 | -0.14 | sell |
| Granite Investment Partners, LLC | 175,026 | 160,415 | -14,611 | 0.42 | 0.29 | -0.12 | sell |
| Candriam S.C.A. | 688,942 | 674,257 | -14,685 | 0.17 | 0.16 | -0.01 | sell |
| Hennion & Walsh Asset Management, Inc. | 78,095 | 63,220 | -14,875 | 0.20 | 0.12 | -0.08 | sell |
| PDT Partners, LLC | 66,193 | 48,859 | -17,334 | 0.33 | 0.18 | -0.14 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 542,373 | 500,717 | -41,656 | 0.01 | 0.01 | -0.00 | sell |
| Blue Owl Capital Holdings LP | 163,238 | 118,238 | -45,000 | 1.76 | 1.15 | -0.61 | sell |
| EMERALD ADVISERS, LLC | 569,798 | 518,328 | -51,470 | 1.22 | 0.84 | -0.38 | sell |
| FRED ALGER MANAGEMENT, LLC | 536,298 | 466,265 | -70,033 | 0.14 | 0.09 | -0.05 | sell |
| Motley Fool Asset Management LLC | 141,649 | 48,448 | -93,201 | 0.47 | 0.11 | -0.37 | sell |
| Clearbridge Investments, LLC | 2,426,977 | 2,322,205 | -104,772 | 0.11 | 0.08 | -0.03 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 429,302 | 324,437 | -104,865 | 1.24 | 0.83 | -0.41 | sell |
| Rock Springs Capital Management LP | 1,978,272 | 1,739,813 | -238,459 | 3.58 | 2.79 | -0.79 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,525,741 | 1,183,081 | -342,660 | 0.15 | 0.09 | -0.06 | sell |
| Avidity Partners Management LP | 752,000 | 352,000 | -400,000 | 2.13 | 1.45 | -0.68 | sell |
| SANDS CAPITAL MANAGEMENT, LLC | 5,118,255 | 4,298,003 | -820,252 | 0.86 | 0.54 | -0.33 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 3,011,716 | 1,686,716 | -1,325,000 | 0.29 | 0.14 | -0.14 | sell |