| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 10,132,728 | 10,263,815 | +131,087 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 6,425,263 | 6,631,554 | +206,291 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 3,692,487 | 4,303,046 | +610,559 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 4,011,429 | 3,974,030 | -37,399 | 0.01 | 0.01 | -0.00 | sell |
| SANDS CAPITAL MANAGEMENT, LLC | 3,769,853 | 3,485,724 | -284,129 | 0.31 | 0.24 | -0.07 | sell |
| RTW INVESTMENTS, LP | 3,258,266 | 3,000,139 | -258,127 | 1.21 | 0.69 | -0.52 | sell |
| BAKER BROS. ADVISORS LP | 2,772,692 | 2,772,692 | 0 | 0.60 | 0.37 | -0.23 | hold |
| FMR LLC | 7,283,296 | 2,666,249 | -4,617,047 | 0.01 | 0.00 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,945,129 | 2,461,910 | +516,781 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 330,953 | 2,326,125 | +1,995,172 | 0.01 | 0.04 | +0.03 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,019,000 | 2,019,000 | 0 | 1.84 | 1.16 | -0.68 | hold |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,069,098 | 1,965,084 | +895,986 | 0.29 | 0.48 | +0.19 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,545,279 | 1,899,661 | +354,382 | 0.12 | 0.05 | -0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,580,507 | 1,838,208 | +257,701 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 910,183 | 1,826,295 | +916,112 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2,167,729 | 1,749,268 | -418,461 | 0.26 | 0.16 | -0.10 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,310,174 | 1,554,366 | -755,808 | 0.01 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 973,656 | 1,469,951 | +496,295 | 0.05 | 0.05 | +0.01 | buy |
| GW&K Investment Management, LLC | 1,150,169 | 1,375,407 | +225,238 | 0.31 | 0.27 | -0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 746,182 | 1,360,497 | +614,315 | 0.01 | 0.02 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,246,341 | 1,267,241 | +20,900 | 2.19 | 1.50 | -0.70 | buy |
| NORGES BANK | 0 | 1,261,026 | +1,261,026 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,458,187 | 1,231,331 | -226,856 | 0.04 | 0.03 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 655,021 | 1,213,928 | +558,907 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 354,168 | 1,021,499 | +667,331 | 0.01 | 0.03 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 573,019 | 903,050 | +330,031 | 0.01 | 0.01 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 99,213 | 880,644 | +781,431 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 840,451 | 840,820 | +369 | 0.03 | 0.02 | -0.01 | buy |
| Nuveen, LLC | 682,144 | 801,473 | +119,329 | 0.01 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 754,714 | 799,384 | +44,670 | 0.12 | 0.09 | -0.03 | buy |
| Schonfeld Strategic Advisors LLC | 1,144,589 | 741,618 | -402,971 | 0.24 | 0.09 | -0.15 | sell |
| UBS Group AG | 547,025 | 668,811 | +121,786 | 0.00 | 0.00 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 482,582 | 643,356 | +160,774 | 0.05 | 0.05 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,546,101 | 599,473 | -946,628 | 0.02 | 0.00 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 600,160 | 598,924 | -1,236 | 0.00 | 0.00 | -0.00 | sell |
| Polar Capital Holdings Plc | 583,710 | 556,628 | -27,082 | 0.08 | 0.06 | -0.03 | sell |
| NORTHERN TRUST CORP | 499,232 | 526,686 | +27,454 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 520,054 | +520,054 | 0.00 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 0 | 501,679 | +501,679 | 0.00 | 0.04 | +0.04 | buy |
| TWO SIGMA ADVISERS, LP | 517,700 | 481,600 | -36,100 | 0.03 | 0.02 | -0.01 | sell |
| Jefferies Financial Group Inc. | 0 | 477,092 | +477,092 | 0.00 | 0.09 | +0.09 | buy |
| Palo Alto Investors LP | 369,531 | 461,294 | +91,763 | 2.06 | 1.48 | -0.58 | buy |
| TWO SIGMA INVESTMENTS, LP | 326,180 | 424,049 | +97,869 | 0.02 | 0.01 | -0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 448,717 | 411,863 | -36,854 | 0.05 | 0.04 | -0.02 | sell |
| Legal & General Group Plc | 402,815 | 411,273 | +8,458 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 476,938 | 400,358 | -76,580 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 133,772 | 390,599 | +256,827 | 0.01 | 0.02 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 21,900 | 366,100 | +344,200 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 425,351 | 359,148 | -66,203 | 0.00 | 0.00 | -0.00 | sell |
| Privium Fund Management B.V. | 289,804 | 357,502 | +67,698 | 1.57 | 1.51 | -0.05 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 20,848 | 348,350 | +327,502 | 0.00 | 0.03 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 237,640 | 344,763 | +107,123 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 344,923 | 331,169 | -13,754 | 0.01 | 0.01 | -0.00 | sell |
| Eversept Partners, LP | 0 | 317,182 | +317,182 | 0.00 | 0.41 | +0.41 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 501,163 | 310,108 | -191,055 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 677,184 | 309,062 | -368,122 | 0.01 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 352,558 | 300,623 | -51,935 | 2.52 | 1.44 | -1.07 | sell |
| GREAT POINT PARTNERS LLC | 0 | 300,000 | +300,000 | 0.00 | 2.24 | +2.24 | buy |
| Bank of New York Mellon Corp | 324,845 | 298,706 | -26,139 | 0.00 | 0.00 | -0.00 | sell |
| Motley Fool Wealth Management, LLC | 355,540 | 297,486 | -58,054 | 0.73 | 0.53 | -0.19 | sell |
| Newtyn Management, LLC | 0 | 295,915 | +295,915 | 0.00 | 0.72 | +0.72 | buy |
| Verition Fund Management LLC | 23,520 | 282,376 | +258,856 | 0.00 | 0.04 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 430,000 | 280,000 | -150,000 | 0.02 | 0.01 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 138,684 | 276,927 | +138,243 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 78,922 | 263,869 | +184,947 | 0.01 | 0.02 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 177,421 | 250,571 | +73,150 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 794,849 | 230,271 | -564,578 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 106,000 | 222,395 | +116,395 | 0.29 | 0.43 | +0.14 | buy |
| Caption Management, LLC | 164,501 | 219,500 | +54,999 | 0.29 | 0.22 | -0.07 | buy |
| ALGERT GLOBAL LLC | 321,633 | 219,232 | -102,401 | 0.16 | 0.08 | -0.08 | sell |
| Blue Owl Capital Holdings LP | 422,438 | 212,638 | -209,800 | 3.94 | 1.51 | -2.44 | sell |
| EMERALD ADVISERS, LLC | 418,566 | 212,358 | -206,208 | 0.40 | 0.15 | -0.25 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 207,042 | 204,107 | -2,935 | 0.00 | 0.00 | -0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 270,000 | 200,000 | -70,000 | 0.16 | 0.09 | -0.07 | sell |
| Assenagon Asset Management S.A. | 252,669 | 199,720 | -52,949 | 0.01 | 0.01 | -0.00 | sell |
| Fisher Asset Management, LLC | 168,084 | 198,696 | +30,612 | 0.00 | 0.00 | -0.00 | buy |
| PDT Partners, LLC | 156,693 | 176,813 | +20,120 | 0.30 | 0.26 | -0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 150,571 | 175,635 | +25,064 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 273,251 | 171,805 | -101,446 | 0.04 | 0.02 | -0.02 | sell |
| Swiss National Bank | 164,952 | 171,052 | +6,100 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 155,388 | 165,017 | +9,629 | 0.05 | 0.03 | -0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 288,109 | 163,272 | -124,837 | 0.02 | 0.01 | -0.01 | sell |
| ROYAL BANK OF CANADA | 236,289 | 163,227 | -73,062 | 0.00 | 0.00 | -0.00 | sell |
| Catalio Capital Management, LP | 291,262 | 162,550 | -128,712 | 1.62 | 0.66 | -0.96 | sell |
| Rafferty Asset Management, LLC | 156,484 | 157,061 | +577 | 0.02 | 0.01 | -0.00 | buy |
| SEI INVESTMENTS CO | 190,462 | 153,726 | -36,736 | 0.01 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 234,126 | 152,316 | -81,810 | 0.01 | 0.00 | -0.01 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 177,061 | 150,201 | -26,860 | 0.05 | 0.03 | -0.02 | sell |
| Krensavage Asset Management, LLC | 0 | 149,634 | +149,634 | 0.00 | 1.22 | +1.22 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 0 | 137,753 | +137,753 | 0.00 | 0.45 | +0.45 | buy |
| ExodusPoint Capital Management, LP | 106,575 | 137,392 | +30,817 | 0.04 | 0.04 | -0.01 | buy |
| B Group, Inc. | 135,000 | 135,000 | 0 | 3.88 | 2.30 | -1.58 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 194,982 | 134,467 | -60,515 | 0.02 | 0.02 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 11 | 122,854 | +122,843 | 0.00 | 0.69 | +0.69 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 242,802 | 120,505 | -122,297 | 0.38 | 0.14 | -0.24 | sell |
| XTX Topco Ltd | 14,374 | 119,996 | +105,622 | 0.02 | 0.07 | +0.05 | buy |
| COMERICA BANK | 83,711 | 118,422 | +34,711 | 0.01 | 0.01 | +0.00 | buy |
| Jump Financial, LLC | 57,468 | 115,928 | +58,460 | 0.03 | 0.03 | +0.01 | buy |
| PINNACLE ASSOCIATES LTD | 114,845 | 111,560 | -3,285 | 0.05 | 0.03 | -0.01 | sell |
| Brevan Howard Capital Management LP | 67,035 | 107,903 | +40,868 | 0.03 | 0.05 | +0.02 | buy |