| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SPHERA FUNDS MANAGEMENT LTD. | 478,928 | 678,928 | +200,000 | 0.08 | 0.07 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,450,638 | 1,575,243 | +124,605 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 210,151 | 277,256 | +67,105 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 281,841 | 286,131 | +4,290 | 0.00 | 0.00 | -0.00 | buy |
| TD Waterhouse Canada Inc. | 25 | 79 | +54 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 1 | 2 | +1 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 1,158 | 1,158 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 233,095 | 233,095 | 0 | 0.04 | 0.04 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 52 | 52 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Plante Moran Financial Advisors, LLC | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Versant Venture Management, LLC | 2,007,704 | 2,007,704 | 0 | 1.00 | 0.87 | -0.12 | hold |
| Rockefeller Capital Management L.P. | 39 | 39 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 9,681,763 | 9,681,763 | 0 | 2.28 | 1.65 | -0.63 | hold |
| Optiver Holding B.V. | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CoreCap Advisors, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFS Partners, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 51 | 51 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 20,142 | 20,142 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 75,326 | 75,326 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Dynamic Wealth Strategies, LLC | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| Newbridge Financial Services Group, Inc. | 18 | 1 | -17 | 0.00 | 0.00 | -0.00 | sell |
| Fortitude Family Office, LLC | 385 | 0 | -385 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 510 | 0 | -510 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 23,138 | 20,194 | -2,944 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 21,251 | 18,089 | -3,162 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 6,331 | 0 | -6,331 | 0.00 | 0.00 | -0.00 | sell |
| CAPITAL ADVISORS INC/OK | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 17,697 | 7,205 | -10,492 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 53,040 | 40,919 | -12,121 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 14,782 | 0 | -14,782 | 0.01 | 0.00 | -0.01 | sell |
| GSA CAPITAL PARTNERS LLP | 22,877 | 0 | -22,877 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 51,706 | 25,684 | -26,022 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 27,348 | 0 | -27,348 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 40,982 | 0 | -40,982 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 93,407 | 0 | -93,407 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 380,478 | 258,200 | -122,278 | 0.00 | 0.00 | -0.00 | sell |