| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| 5AM Venture Management, LLC | 0 | 10,179,505 | +10,179,505 | 0.00 | 18.24 | +18.24 | buy |
| Altium Capital Management LLC | 0 | 1,350,093 | +1,350,093 | 0.00 | 4.47 | +4.47 | buy |
| Logos Global Management LP | 0 | 1,301,518 | +1,301,518 | 0.00 | 1.20 | +1.20 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 1,298,312 | +1,298,312 | 0.00 | 1.69 | +1.69 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 905,650 | +905,650 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 0 | 833,620 | +833,620 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 650,758 | +650,758 | 0.00 | 0.05 | +0.05 | buy |
| Point72 Asset Management, L.P. | 0 | 560,000 | +560,000 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 500,000 | +500,000 | 0.00 | 0.10 | +0.10 | buy |
| BAKER BROS. ADVISORS LP | 0 | 500,000 | +500,000 | 0.00 | 0.05 | +0.05 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 431,355 | +431,355 | 0.00 | 0.03 | +0.03 | buy |
| Velan Capital Investment Management LP | 0 | 422,142 | +422,142 | 0.00 | 1.94 | +1.94 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 370,179 | +370,179 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 331,004 | +331,004 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 300,000 | +300,000 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 265,587 | +265,587 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 58,778 | +58,778 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 51,656 | +51,656 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 42,469 | +42,469 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 42,338 | +42,338 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 31,647 | +31,647 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 27,768 | +27,768 | 0.00 | 0.05 | +0.05 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 27,713 | +27,713 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 0 | 26,000 | +26,000 | 0.00 | 0.04 | +0.04 | buy |
| RHUMBLINE ADVISERS | 0 | 19,754 | +19,754 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 16,807 | +16,807 | 0.00 | 0.02 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 13,800 | +13,800 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 8,781 | +8,781 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 7,272 | +7,272 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 6,000 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 4,796 | +4,796 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 3,848 | +3,848 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 3,762 | +3,762 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 3,200 | +3,200 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,687 | +1,687 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 1,486 | +1,486 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 1,248 | +1,248 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 596 | +596 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 51 | +51 | 0.00 | 0.00 | +0.00 | buy |
| Dunhill Financial, LLC | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Newbridge Financial Services Group, Inc. | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Asset Dedication, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Beacon Capital Management, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Plante Moran Financial Advisors, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Versant Venture Management, LLC | 2,007,702 | 2,007,704 | +2 | 30.45 | 20.81 | -9.64 | buy |
| TD Waterhouse Canada Inc. | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| PFS Partners, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |