| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Qube Research & Technologies Ltd | 0 | 43,082 | +43,082 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 20,142 | 56,327 | +36,185 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 26,976 | +26,976 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 233,095 | 233,095 | 0 | 0.04 | 0.04 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,575,243 | 1,575,243 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 52 | 52 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Plante Moran Financial Advisors, LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 678,928 | 678,928 | 0 | 0.07 | 0.07 | -0.00 | hold |
| Versant Venture Management, LLC | 2,007,704 | 2,007,704 | 0 | 0.87 | 0.86 | -0.02 | hold |
| Engineers Gate Manager LP | 20,194 | 20,194 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 39 | 39 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 9,681,763 | 9,681,763 | 0 | 1.65 | 2.33 | +0.68 | hold |
| Optiver Holding B.V. | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Newbridge Financial Services Group, Inc. | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CoreCap Advisors, LLC | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PFS Partners, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 51 | 51 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| TD Waterhouse Canada Inc. | 79 | 52 | -27 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 1,158 | 0 | -1,158 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 75,326 | 73,830 | -1,496 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 7,205 | 4,589 | -2,616 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 18,089 | 655 | -17,434 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 40,919 | 20,993 | -19,926 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 25,684 | 0 | -25,684 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 286,131 | 232,874 | -53,257 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 277,256 | 218,055 | -59,201 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 258,200 | 198,524 | -59,676 | 0.00 | 0.00 | -0.00 | sell |