| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 500,000 | 1,434,634 | +934,634 | 0.05 | 0.06 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 0 | 900,000 | +900,000 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 431,355 | 959,097 | +527,742 | 0.03 | 0.03 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 485,199 | +485,199 | 0.00 | 0.09 | +0.09 | buy |
| AWM Investment Company, Inc. | 0 | 400,000 | +400,000 | 0.00 | 0.19 | +0.19 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 394,386 | +394,386 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 344,454 | +344,454 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,298,312 | 1,563,522 | +265,210 | 1.69 | 1.00 | -0.69 | buy |
| Alyeska Investment Group, L.P. | 300,000 | 554,177 | +254,177 | 0.01 | 0.01 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 110,927 | +110,927 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 42,469 | 140,882 | +98,413 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 26,000 | 115,000 | +89,000 | 0.04 | 0.09 | +0.05 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 57,000 | +57,000 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 47,800 | +47,800 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 24,552 | +24,552 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 31,647 | 54,871 | +23,224 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 331,004 | 354,205 | +23,201 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 27,713 | 47,417 | +19,704 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 370,179 | 385,793 | +15,614 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 42,338 | 57,889 | +15,551 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 833,620 | 844,173 | +10,553 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 3,848 | 12,524 | +8,676 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,674 | +2,674 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 3,762 | 6,421 | +2,659 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 6,000 | 7,865 | +1,865 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 0 | 294 | +294 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 39 | +39 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Jaffetilchin Investment Partners, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Briaud Financial Planning, Inc | 0 | 1 | +1 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,687 | 1,687 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,248 | 1,248 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Plante Moran Financial Advisors, LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Versant Venture Management, LLC | 2,007,704 | 2,007,704 | 0 | 20.81 | 12.35 | -8.46 | hold |
| IFP Advisors, Inc | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Point72 Asia (Singapore) Pte. Ltd. | 27,768 | 27,768 | 0 | 0.05 | 0.02 | -0.03 | hold |
| Newbridge Financial Services Group, Inc. | 18 | 18 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Beacon Capital Management, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD Waterhouse Canada Inc. | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFS Partners, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 51 | 51 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,486 | 1,486 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 7 | 7 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,800 | 13,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 3,200 | 3,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 51,656 | 51,656 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 596 | 596 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 650,758 | 650,758 | 0 | 0.05 | 0.02 | -0.03 | hold |
| DEUTSCHE BANK AG\ | 8,781 | 8,781 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CoreCap Advisors, LLC | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| Asset Dedication, LLC | 16 | 0 | -16 | 0.00 | 0.00 | -0.00 | sell |
| Dunhill Financial, LLC | 50 | 0 | -50 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 9,264 | 9,208 | -56 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 19,754 | 16,841 | -2,913 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 4,796 | 0 | -4,796 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 7,272 | 0 | -7,272 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 58,778 | 44,907 | -13,871 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 265,587 | 250,013 | -15,574 | 0.00 | 0.00 | -0.00 | sell |
| Alpine Global Management, LLC | 16,807 | 0 | -16,807 | 0.02 | 0.00 | -0.02 | sell |
| Altium Capital Management LLC | 1,350,093 | 1,315,146 | -34,947 | 4.47 | 1.53 | -2.93 | sell |
| Point72 Asset Management, L.P. | 560,000 | 416,424 | -143,576 | 0.01 | 0.01 | -0.01 | sell |
| Velan Capital Investment Management LP | 422,142 | 211,071 | -211,071 | 1.94 | 0.90 | -1.04 | sell |
| 5AM Venture Management, LLC | 10,179,505 | 9,913,168 | -266,337 | 18.24 | 8.01 | -10.23 | sell |
| PERCEPTIVE ADVISORS LLC | 500,000 | 0 | -500,000 | 0.10 | 0.00 | -0.10 | sell |
| JANUS HENDERSON GROUP PLC | 905,650 | 0 | -905,650 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 1,301,518 | 100,000 | -1,201,518 | 1.20 | 0.04 | -1.16 | sell |