| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| 5AM Venture Management, LLC | 9,913,168 | 9,913,168 | 0 | 8.01 | 6.69 | -1.31 | hold |
| Versant Venture Management, LLC | 2,007,704 | 2,007,704 | 0 | 12.35 | 6.55 | -5.80 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 1,563,522 | 1,564,628 | +1,106 | 1.00 | 0.82 | -0.18 | buy |
| BAKER BROS. ADVISORS LP | 1,434,634 | 1,450,638 | +16,004 | 0.06 | 0.04 | -0.01 | buy |
| Schonfeld Strategic Advisors LLC | 959,097 | 1,422,741 | +463,644 | 0.03 | 0.03 | -0.01 | buy |
| BlackRock, Inc. | 1,193,515 | 1,220,186 | +26,671 | 0.00 | 0.00 | -0.00 | buy |
| Altium Capital Management LLC | 1,315,146 | 1,139,000 | -176,146 | 1.53 | 1.00 | -0.53 | sell |
| VANGUARD GROUP INC | 844,173 | 860,827 | +16,654 | 0.00 | 0.00 | -0.00 | buy |
| BRAIDWELL LP | 0 | 825,732 | +825,732 | 0.00 | 0.07 | +0.07 | buy |
| Ensign Peak Advisors, Inc | 900,000 | 767,287 | -132,713 | 0.01 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 650,758 | 650,758 | 0 | 0.02 | 0.02 | -0.01 | hold |
| Alyeska Investment Group, L.P. | 554,177 | 456,163 | -98,014 | 0.01 | 0.00 | -0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 485,199 | 434,046 | -51,153 | 0.09 | 0.07 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 385,793 | 405,694 | +19,901 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 354,205 | 374,504 | +20,299 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 344,454 | 326,241 | -18,213 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 250,013 | 250,014 | +1 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 140,882 | 135,712 | -5,170 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 110,927 | 110,927 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AdvisorShares Investments LLC | 115,000 | 88,391 | -26,609 | 0.09 | 0.05 | -0.04 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 57,000 | 72,000 | +15,000 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 47,800 | 71,079 | +23,279 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 57,889 | 69,620 | +11,731 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 51,656 | 62,363 | +10,707 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 44,907 | 44,908 | +1 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 8,781 | 40,835 | +32,054 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 47,417 | 31,637 | -15,780 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 0 | 21,653 | +21,653 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 21,560 | +21,560 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 16,841 | 17,505 | +664 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 12,524 | 15,262 | +2,738 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,800 | 13,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Squarepoint Ops LLC | 0 | 13,546 | +13,546 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 11,200 | +11,200 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 10,142 | +10,142 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 9,208 | 9,786 | +578 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,674 | 3,231 | +557 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 294 | 2,151 | +1,857 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,687 | 1,687 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Financial Gravity Companies, Inc. | 1,600 | 1,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,486 | 1,486 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,248 | 1,248 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 39 | 847 | +808 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 596 | 596 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 50 | 492 | +442 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 51 | 51 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MAI Capital Management | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 2 | 25 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Newbridge Financial Services Group, Inc. | 18 | 18 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 0 | 17 | +17 | 0.00 | 0.00 | 0.00 | buy |
| Beacon Capital Management, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 7 | 7 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Coppell Advisory Solutions LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Plante Moran Financial Advisors, LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 0 | 3 | +3 | 0.00 | 0.00 | 0.00 | buy |
| IFP Advisors, Inc | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| PFS Partners, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 394,386 | 0 | -394,386 | 0.00 | 0.00 | -0.00 | sell |
| Jaffetilchin Investment Partners, LLC | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| AWM Investment Company, Inc. | 400,000 | 0 | -400,000 | 0.19 | 0.00 | -0.19 | sell |
| Cubist Systematic Strategies, LLC | 6,421 | 0 | -6,421 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 416,424 | 0 | -416,424 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 27,768 | 0 | -27,768 | 0.02 | 0.00 | -0.02 | sell |
| ExodusPoint Capital Management, LP | 24,552 | 0 | -24,552 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 100,000 | 0 | -100,000 | 0.04 | 0.00 | -0.04 | sell |
| Briaud Financial Planning, Inc | 1 | 0 | -1 | 0.00 | 0.00 | 0.00 | sell |
| Velan Capital Investment Management LP | 211,071 | 0 | -211,071 | 0.90 | 0.00 | -0.90 | sell |
| NEOS Investment Management LLC | 54,871 | 0 | -54,871 | 0.01 | 0.00 | -0.01 | sell |
| Point72 (DIFC) Ltd | 7,865 | 0 | -7,865 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 3,200 | 0 | -3,200 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 15 | 0 | -15 | 0.00 | 0.00 | -0.00 | sell |