| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 610,000 | 1,937,938 | +1,327,938 | 1.95 | 6.04 | +4.09 | buy |
| Holocene Advisors, LP | 2,317,326 | 3,601,472 | +1,284,146 | 0.20 | 0.43 | +0.23 | buy |
| BVF INC/IL | 2,000,000 | 2,154,704 | +154,704 | 2.25 | 2.89 | +0.63 | buy |
| GENDELL JEFFREY L | 263,604 | 395,882 | +132,278 | 0.13 | 0.18 | +0.06 | buy |
| Bellevue Group AG | 8,870 | 120,243 | +111,373 | 0.01 | 0.13 | +0.13 | buy |
| HighVista Strategies LLC | 73,189 | 179,256 | +106,067 | 0.71 | 2.14 | +1.43 | buy |
| Rhenman & Partners Asset Management AB | 133,250 | 185,250 | +52,000 | 0.58 | 0.92 | +0.33 | buy |
| Senator Investment Group LP | 235,000 | 275,000 | +40,000 | 0.38 | 0.53 | +0.14 | buy |
| TFG Asset Management GP Ltd | 159,791 | 189,979 | +30,188 | 1.10 | 1.57 | +0.47 | buy |
| Rock Springs Capital Management LP | 183,986 | 199,811 | +15,825 | 0.38 | 0.51 | +0.13 | buy |
| AdvisorShares Investments LLC | 26,369 | 36,438 | +10,069 | 0.17 | 0.23 | +0.06 | buy |
| VIRTUS ADVISERS, LLC | 47,468 | 49,354 | +1,886 | 0.78 | 0.99 | +0.21 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 390,344 | 390,866 | +522 | 0.77 | 1.00 | +0.23 | buy |
| Moors & Cabot, Inc. | 7,117 | 7,544 | +427 | 0.01 | 0.02 | +0.00 | buy |
| GREENLEAF TRUST | 5,792 | 5,845 | +53 | 0.00 | 0.00 | +0.00 | buy |
| Lumbard & Kellner, LLC | 52,593 | 52,592 | -1 | 0.64 | 0.84 | +0.19 | sell |
| GW HENSSLER & ASSOCIATES LTD | 6,370 | 6,358 | -12 | 0.01 | 0.01 | +0.00 | sell |
| INVESTORS ASSET MANAGEMENT OF GEORGIA INC /GA/ /ADV | 8,600 | 8,200 | -400 | 0.12 | 0.15 | +0.02 | sell |
| AUXIER ASSET MANAGEMENT | 7,652 | 6,883 | -769 | 0.04 | 0.05 | +0.01 | sell |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 21,099 | 20,132 | -967 | 0.01 | 0.01 | +0.00 | sell |
| Dana Investment Advisors, Inc. | 40,368 | 38,992 | -1,376 | 0.04 | 0.05 | +0.01 | sell |
| China Universal Asset Management Co., Ltd. | 29,573 | 26,527 | -3,046 | 0.08 | 0.08 | +0.00 | sell |
| Summit Global Investments | 11,691 | 6,001 | -5,690 | 0.02 | 0.02 | -0.01 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 2,539,990 | 2,528,680 | -11,310 | 0.07 | 0.08 | +0.01 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 244,007 | 232,255 | -11,752 | 0.32 | 0.40 | +0.08 | sell |
| SummitTX Capital, L.P. | 156,259 | 134,194 | -22,065 | 0.17 | 0.18 | +0.01 | sell |
| Atle Fund Management AB | 242,473 | 213,329 | -29,144 | 2.66 | 3.01 | +0.35 | sell |
| DAFNA Capital Management LLC | 139,482 | 101,266 | -38,216 | 1.12 | 1.01 | -0.11 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 158,499 | 76,540 | -81,959 | 0.11 | 0.06 | -0.05 | sell |
| SEGALL BRYANT & HAMILL, LLC | 585,769 | 498,222 | -87,547 | 0.30 | 0.31 | +0.01 | sell |
| Prosight Management, LP | 513,632 | 394,389 | -119,243 | 2.98 | 3.56 | +0.58 | sell |
| Robeco Institutional Asset Management B.V. | 220,521 | 92,592 | -127,929 | 0.01 | 0.01 | -0.01 | sell |
| Artisan Partners Limited Partnership | 1,111,741 | 831,006 | -280,735 | 0.06 | 0.07 | +0.01 | sell |