| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sixth Street Partners Management Company, L.P. | 0 | 2,335,117 | +2,335,117 | 0.00 | 0.02 | +0.02 | buy |
| NORGES BANK | 0 | 2,156,814 | +2,156,814 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,664,576 | 6,737,328 | +2,072,752 | 0.02 | 0.04 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,368,000 | +1,368,000 | 0.00 | 0.10 | +0.10 | buy |
| Bain Capital Life Sciences Investors, LLC | 610,000 | 1,937,938 | +1,327,938 | 1.95 | 6.04 | +4.09 | buy |
| Holocene Advisors, LP | 2,317,326 | 3,601,472 | +1,284,146 | 0.20 | 0.43 | +0.23 | buy |
| FRANKLIN RESOURCES INC | 182,535 | 1,170,242 | +987,707 | 0.00 | 0.01 | +0.01 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 950,234 | +950,234 | 0.00 | 1.29 | +1.29 | buy |
| BlackRock, Inc. | 28,314,410 | 29,235,739 | +921,329 | 0.02 | 0.02 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 239,671 | 1,159,216 | +919,545 | 0.01 | 0.06 | +0.05 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 659,562 | +659,562 | 0.00 | 0.32 | +0.32 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 308,929 | 916,709 | +607,780 | 0.01 | 0.03 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 710,297 | 1,312,031 | +601,734 | 0.02 | 0.04 | +0.02 | buy |
| Artia Global Partners LP | 0 | 448,964 | +448,964 | 0.00 | 4.47 | +4.47 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 791,963 | 1,238,809 | +446,846 | 0.21 | 0.38 | +0.17 | buy |
| MetLife Investment Management, LLC | 88,852 | 512,924 | +424,072 | 0.02 | 0.12 | +0.11 | buy |
| Deep Track Capital, LP | 3,590,323 | 4,000,000 | +409,677 | 2.62 | 3.09 | +0.47 | buy |
| Ensign Peak Advisors, Inc | 9,316 | 335,208 | +325,892 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 319,595 | +319,595 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 6,160,428 | 6,460,928 | +300,500 | 0.34 | 0.47 | +0.13 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,182,267 | 4,477,876 | +295,609 | 0.01 | 0.01 | +0.00 | buy |
| GW&K Investment Management, LLC | 0 | 292,387 | +292,387 | 0.00 | 0.12 | +0.12 | buy |
| TWO SIGMA INVESTMENTS, LP | 780,683 | 1,038,311 | +257,628 | 0.02 | 0.04 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 894,276 | 1,090,947 | +196,671 | 0.02 | 0.04 | +0.02 | buy |
| Aberdeen Group plc | 0 | 193,805 | +193,805 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 29,459 | 221,589 | +192,130 | 0.00 | 0.02 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 16,584 | 195,174 | +178,590 | 0.00 | 0.05 | +0.05 | buy |
| STEMPOINT CAPITAL LP | 80,492 | 248,015 | +167,523 | 0.55 | 2.25 | +1.70 | buy |
| BVF INC/IL | 2,000,000 | 2,154,704 | +154,704 | 2.25 | 2.89 | +0.63 | buy |
| Amundi | 64,710 | 217,739 | +153,029 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,882,178 | 2,023,984 | +141,806 | 0.01 | 0.01 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 138,603 | +138,603 | 0.00 | 0.29 | +0.29 | buy |
| CITIGROUP INC | 47,450 | 184,901 | +137,451 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,697,082 | 1,831,619 | +134,537 | 0.01 | 0.01 | +0.00 | buy |
| GENDELL JEFFREY L | 263,604 | 395,882 | +132,278 | 0.13 | 0.19 | +0.06 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 527,967 | 655,140 | +127,173 | 0.01 | 0.02 | +0.01 | buy |
| Russell Investments Group, Ltd. | 98,718 | 221,810 | +123,092 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 0 | 118,432 | +118,432 | 0.00 | 0.01 | +0.01 | buy |
| Bellevue Group AG | 8,870 | 120,243 | +111,373 | 0.01 | 0.13 | +0.13 | buy |
| Informed Momentum Co LLC | 0 | 110,869 | +110,869 | 0.00 | 0.52 | +0.52 | buy |
| HighVista Strategies LLC | 73,189 | 179,256 | +106,067 | 0.71 | 2.14 | +1.43 | buy |
| RAYMOND JAMES FINANCIAL INC | 317,434 | 422,761 | +105,327 | 0.00 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.21 | +0.21 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,236,756 | 2,335,117 | +98,361 | 0.01 | 0.02 | +0.00 | buy |
| Neo Ivy Capital Management | 0 | 95,741 | +95,741 | 0.00 | 1.16 | +1.16 | buy |
| Carrera Capital Advisors | 0 | 90,034 | +90,034 | 0.00 | 0.70 | +0.70 | buy |
| WELLS FARGO & COMPANY/MN | 117,926 | 199,433 | +81,507 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 66,877 | +66,877 | 0.00 | 0.12 | +0.12 | buy |
| Neuberger Berman Group LLC | 197,220 | 260,208 | +62,988 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 1,036,460 | 1,097,282 | +60,822 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 75,023 | 135,159 | +60,136 | 0.00 | 0.00 | +0.00 | buy |
| Eagle Health Investments LP | 238,673 | 297,302 | +58,629 | 1.77 | 2.58 | +0.81 | buy |
| Atika Capital Management LLC | 0 | 55,571 | +55,571 | 0.00 | 0.29 | +0.29 | buy |
| Baird Financial Group, Inc. | 0 | 53,267 | +53,267 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 133,250 | 185,250 | +52,000 | 0.58 | 0.92 | +0.33 | buy |
| XTX Topco Ltd | 0 | 50,788 | +50,788 | 0.00 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 71,415 | 120,562 | +49,147 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 47,317 | +47,317 | 0.00 | 0.07 | +0.07 | buy |
| BARCLAYS PLC | 174,983 | 219,935 | +44,952 | 0.00 | 0.00 | +0.00 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 0 | 42,920 | +42,920 | 0.00 | 0.05 | +0.05 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 42,000 | +42,000 | 0.00 | 0.51 | +0.51 | buy |
| DEUTSCHE BANK AG\ | 149,734 | 191,316 | +41,582 | 0.00 | 0.00 | +0.00 | buy |
| Senator Investment Group LP | 235,000 | 275,000 | +40,000 | 0.38 | 0.53 | +0.14 | buy |
| Blackstone Inc. | 0 | 31,682 | +31,682 | 0.00 | 0.01 | +0.01 | buy |
| TFG Asset Management GP Ltd | 159,791 | 189,979 | +30,188 | 1.11 | 1.62 | +0.51 | buy |
| Fisher Asset Management, LLC | 390,479 | 419,102 | +28,623 | 0.00 | 0.01 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 15,793 | 42,278 | +26,485 | 0.00 | 0.00 | +0.00 | buy |
| Massar Capital Management, LP | 0 | 26,010 | +26,010 | 0.00 | 0.47 | +0.47 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 25,889 | +25,889 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 93,130 | 118,998 | +25,868 | 0.00 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 958,016 | 983,822 | +25,806 | 0.02 | 0.03 | +0.01 | buy |
| Bridgefront Capital, LLC | 7,291 | 31,649 | +24,358 | 0.06 | 0.44 | +0.37 | buy |
| SIMPLEX TRADING, LLC | 13,138 | 36,189 | +23,051 | 0.01 | 0.05 | +0.04 | buy |
| Cetera Investment Advisers | 14,758 | 35,490 | +20,732 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 884 | 20,588 | +19,704 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 0 | 19,123 | +19,123 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 328,202 | 347,246 | +19,044 | 0.01 | 0.01 | +0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 0 | 15,829 | +15,829 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 183,986 | 199,811 | +15,825 | 0.38 | 0.51 | +0.13 | buy |
| MORGAN STANLEY | 1,736,091 | 1,751,882 | +15,791 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 14,313 | +14,313 | 0.00 | 0.08 | +0.08 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 13,694 | +13,694 | 0.00 | 0.06 | +0.06 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 183,795 | 197,412 | +13,617 | 0.01 | 0.01 | +0.00 | buy |
| IMC-Chicago, LLC | 6,879 | 20,383 | +13,504 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 380,722 | 393,524 | +12,802 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 80,360 | 91,708 | +11,348 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 26,369 | 36,438 | +10,069 | 0.17 | 0.23 | +0.06 | buy |
| Caption Management, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 0 | 9,990 | +9,990 | 0.00 | 0.00 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 9,970 | +9,970 | 0.00 | 0.01 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 42,416 | 52,193 | +9,777 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 9,050 | +9,050 | 0.00 | 0.01 | +0.01 | buy |
| Yorktown Management & Research Co Inc | 0 | 8,900 | +8,900 | 0.00 | 0.29 | +0.29 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 0 | 8,618 | +8,618 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 0 | 8,340 | +8,340 | 0.00 | 0.08 | +0.08 | buy |
| STIFEL FINANCIAL CORP | 0 | 8,034 | +8,034 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 6,829 | +6,829 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 310,300 | 316,900 | +6,600 | 0.01 | 0.01 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 5,840 | +5,840 | 0.00 | 0.00 | +0.00 | buy |
| PRAXIS INVESTMENT MANAGEMENT INC | 0 | 5,798 | +5,798 | 0.00 | 0.02 | +0.02 | buy |