| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 28,272,412 | 28,314,410 | +41,998 | 0.01 | 0.02 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 10,012,267 | 10,012,267 | 0 | 1.64 | 2.03 | +0.39 | hold |
| STATE STREET CORP | 9,472,858 | 9,465,286 | -7,572 | 0.01 | 0.01 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 6,668,028 | 6,160,428 | -507,600 | 0.29 | 0.34 | +0.05 | sell |
| AMERICAN CENTURY COMPANIES INC | 5,956,824 | 6,072,103 | +115,279 | 0.08 | 0.11 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,998,963 | 4,664,576 | -4,334,387 | 0.03 | 0.02 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 4,412,783 | 4,522,378 | +109,595 | 0.03 | 0.03 | +0.01 | buy |
| Commodore Capital LP | 3,550,000 | 4,200,000 | +650,000 | 6.61 | 8.59 | +1.98 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,080,776 | 4,182,267 | +101,491 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 5,184,547 | 4,101,789 | -1,082,758 | 0.01 | 0.01 | -0.00 | sell |
| Deep Track Capital, LP | 2,000,000 | 3,590,323 | +1,590,323 | 1.28 | 2.62 | +1.34 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,020,442 | 2,970,166 | -50,276 | 0.01 | 0.02 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 1,454,002 | 2,968,785 | +1,514,783 | 0.03 | 0.08 | +0.05 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 2,564,300 | 2,539,990 | -24,310 | 0.05 | 0.07 | +0.02 | sell |
| Nuveen, LLC | 2,427,028 | 2,460,569 | +33,541 | 0.02 | 0.02 | +0.01 | buy |
| Holocene Advisors, LP | 0 | 2,317,326 | +2,317,326 | 0.00 | 0.20 | +0.20 | buy |
| CITADEL ADVISORS LLC | 1,198,268 | 2,241,584 | +1,043,316 | 0.02 | 0.06 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,152,756 | 2,236,756 | +84,000 | 0.01 | 0.01 | +0.00 | buy |
| BVF INC/IL | 0 | 2,000,000 | +2,000,000 | 0.00 | 2.25 | +2.25 | buy |
| Soleus Capital Management, L.P. | 1,322,364 | 1,970,864 | +648,500 | 1.57 | 2.82 | +1.25 | buy |
| GOLDMAN SACHS GROUP INC | 2,267,588 | 1,882,178 | -385,410 | 0.01 | 0.01 | -0.00 | sell |
| LOOMIS SAYLES & CO L P | 1,902,522 | 1,784,581 | -117,941 | 0.06 | 0.08 | +0.02 | sell |
| MORGAN STANLEY | 1,888,487 | 1,736,091 | -152,396 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 1,653,475 | 1,697,082 | +43,607 | 0.01 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 1,672,356 | 1,672,356 | 0 | 0.47 | 0.59 | +0.12 | hold |
| Affinity Asset Advisors, LLC | 1,000,000 | 1,350,000 | +350,000 | 2.01 | 2.80 | +0.79 | buy |
| FMR LLC | 1,355,253 | 1,323,747 | -31,506 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,333,105 | 1,210,851 | -122,254 | 0.00 | 0.00 | +0.00 | sell |
| Avoro Capital Advisors LLC | 1,400,000 | 1,200,000 | -200,000 | 0.39 | 0.42 | +0.03 | sell |
| Artisan Partners Limited Partnership | 1,349,122 | 1,111,741 | -237,381 | 0.06 | 0.06 | +0.01 | sell |
| Bank of New York Mellon Corp | 1,074,087 | 1,036,460 | -37,627 | 0.01 | 0.01 | +0.00 | sell |
| MARSHALL WACE, LLP | 129,899 | 999,322 | +869,423 | 0.00 | 0.04 | +0.03 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 947,623 | 958,016 | +10,393 | 0.01 | 0.02 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,477,214 | 942,184 | -535,030 | 0.04 | 0.03 | -0.01 | sell |
| PANAGORA ASSET MANAGEMENT INC | 928,964 | 932,942 | +3,978 | 0.09 | 0.12 | +0.03 | buy |
| T. Rowe Price Investment Management, Inc. | 2,099 | 894,276 | +892,177 | 0.00 | 0.02 | +0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 796,968 | 791,963 | -5,005 | 0.15 | 0.21 | +0.05 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,213,397 | 780,683 | -432,714 | 0.05 | 0.02 | -0.03 | sell |
| AMERIPRISE FINANCIAL INC | 531,362 | 741,141 | +209,779 | 0.00 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 911,272 | 710,297 | -200,975 | 0.02 | 0.02 | +0.00 | sell |
| Frazier Life Sciences Management, L.P. | 700,647 | 700,647 | 0 | 0.53 | 0.64 | +0.11 | hold |
| Pacer Advisors, Inc. | 674,874 | 688,563 | +13,689 | 0.03 | 0.00 | -0.03 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 671,170 | 677,405 | +6,235 | 0.06 | 0.07 | +0.01 | buy |
| Man Group plc | 312,512 | 625,046 | +312,534 | 0.02 | 0.05 | +0.03 | buy |
| Bain Capital Life Sciences Investors, LLC | 0 | 610,000 | +610,000 | 0.00 | 1.95 | +1.95 | buy |
| SEGALL BRYANT & HAMILL, LLC | 615,292 | 606,751 | -8,541 | 0.23 | 0.17 | -0.06 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 679,633 | 586,775 | -92,858 | 0.04 | 0.04 | +0.01 | sell |
| SEGALL BRYANT & HAMILL, LLC | 615,292 | 585,769 | -29,523 | 0.23 | 0.21 | -0.02 | sell |
| Woodline Partners LP | 558,567 | 558,567 | 0 | 0.06 | 0.07 | +0.01 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 430,330 | 527,967 | +97,637 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 538,716 | 524,275 | -14,441 | 0.00 | 0.00 | +0.00 | sell |
| Prosight Management, LP | 0 | 513,632 | +513,632 | 0.00 | 2.98 | +2.98 | buy |
| UBS Group AG | 2,544,895 | 495,023 | -2,049,872 | 0.01 | 0.00 | -0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 460,314 | +460,314 | 0.00 | 1.92 | +1.92 | buy |
| RHUMBLINE ADVISERS | 439,195 | 449,531 | +10,336 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 394,853 | 403,153 | +8,300 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 390,493 | 390,479 | -14 | 0.00 | 0.00 | +0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 379,458 | 390,344 | +10,886 | 0.58 | 0.77 | +0.18 | buy |
| AQR CAPITAL MANAGEMENT LLC | 514,324 | 383,977 | -130,347 | 0.01 | 0.01 | -0.00 | sell |
| Legal & General Group Plc | 429,497 | 380,722 | -48,775 | 0.00 | 0.00 | +0.00 | sell |
| Logos Global Management LP | 0 | 350,000 | +350,000 | 0.00 | 0.64 | +0.64 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 324,578 | 328,202 | +3,624 | 0.01 | 0.01 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 328,205 | 317,434 | -10,771 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 309,200 | 310,300 | +1,100 | 0.01 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 402,578 | 308,929 | -93,649 | 0.01 | 0.01 | +0.00 | sell |
| ROYAL BANK OF CANADA | 325,496 | 304,337 | -21,159 | 0.00 | 0.00 | +0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 976,483 | 300,383 | -676,100 | 0.16 | 0.08 | -0.08 | sell |
| Squarepoint Ops LLC | 1,095,846 | 277,619 | -818,227 | 0.06 | 0.02 | -0.04 | sell |
| GENDELL JEFFREY L | 0 | 263,604 | +263,604 | 0.00 | 0.13 | +0.13 | buy |
| ALLIANCEBERNSTEIN L.P. | 215,854 | 260,935 | +45,081 | 0.00 | 0.00 | +0.00 | buy |
| C WorldWide Group Holding A/S | 250,000 | 250,000 | 0 | 0.12 | 0.19 | +0.07 | hold |
| MACKENZIE FINANCIAL CORP | 95,447 | 249,182 | +153,735 | 0.00 | 0.01 | +0.01 | buy |
| S&CO INC | 201,760 | 244,760 | +43,000 | 0.35 | 0.54 | +0.19 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 254,333 | 244,007 | -10,326 | 0.22 | 0.32 | +0.10 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 150,775 | 243,043 | +92,268 | 0.04 | 0.08 | +0.04 | buy |
| Palo Alto Investors LP | 242,560 | 242,560 | 0 | 0.94 | 1.31 | +0.37 | hold |
| Atle Fund Management AB | 242,473 | 242,473 | 0 | 2.16 | 2.66 | +0.49 | hold |
| BNP Paribas Asset Management Holding S.A. | 241,133 | 239,671 | -1,462 | 0.01 | 0.01 | +0.00 | sell |
| Eagle Health Investments LP | 81,800 | 238,673 | +156,873 | 0.50 | 1.77 | +1.27 | buy |
| Senator Investment Group LP | 0 | 235,000 | +235,000 | 0.00 | 0.38 | +0.38 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 522,097 | 227,939 | -294,158 | 0.02 | 0.01 | -0.01 | sell |
| Robeco Institutional Asset Management B.V. | 285,670 | 220,521 | -65,149 | 0.01 | 0.01 | -0.00 | sell |
| Engineers Gate Manager LP | 47,731 | 208,497 | +160,766 | 0.02 | 0.09 | +0.08 | buy |
| ExodusPoint Capital Management, LP | 0 | 204,324 | +204,324 | 0.00 | 0.07 | +0.07 | buy |
| Neuberger Berman Group LLC | 152,772 | 197,220 | +44,448 | 0.00 | 0.01 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 170,267 | 194,766 | +24,499 | 0.12 | 0.17 | +0.05 | buy |
| Rock Springs Capital Management LP | 139,228 | 183,986 | +44,758 | 0.20 | 0.38 | +0.18 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 148,793 | 183,795 | +35,002 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 192,807 | 182,535 | -10,272 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 35,872 | 178,993 | +143,121 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 194,530 | 178,455 | -16,075 | 0.01 | 0.01 | +0.00 | sell |
| BARCLAYS PLC | 565,033 | 174,983 | -390,050 | 0.01 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 0 | 173,626 | +173,626 | 0.00 | 0.04 | +0.04 | buy |
| Rafferty Asset Management, LLC | 203,264 | 162,424 | -40,840 | 0.02 | 0.02 | +0.00 | sell |
| TFG Asset Management GP Ltd | 141,172 | 159,791 | +18,619 | 0.83 | 1.11 | +0.28 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 158,499 | +158,499 | 0.00 | 0.20 | +0.20 | buy |
| BESSEMER GROUP INC | 157,640 | 158,397 | +757 | 0.01 | 0.01 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 156,259 | +156,259 | 0.00 | 0.18 | +0.18 | buy |
| JANUS HENDERSON GROUP PLC | 145,804 | 154,016 | +8,212 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 190,717 | 153,817 | -36,900 | 0.01 | 0.01 | -0.00 | sell |