| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Holocene Advisors, LP | 0 | 2,317,326 | +2,317,326 | 0.00 | 0.20 | +0.20 | buy |
| BVF INC/IL | 0 | 2,000,000 | +2,000,000 | 0.00 | 2.25 | +2.25 | buy |
| Deep Track Capital, LP | 2,000,000 | 3,590,323 | +1,590,323 | 1.28 | 2.62 | +1.34 | buy |
| FIRST TRUST ADVISORS LP | 1,454,002 | 2,968,785 | +1,514,783 | 0.03 | 0.08 | +0.05 | buy |
| CITADEL ADVISORS LLC | 1,198,268 | 2,241,584 | +1,043,316 | 0.02 | 0.06 | +0.03 | buy |
| T. Rowe Price Investment Management, Inc. | 2,099 | 894,276 | +892,177 | 0.00 | 0.02 | +0.02 | buy |
| MARSHALL WACE, LLP | 129,899 | 999,322 | +869,423 | 0.00 | 0.04 | +0.03 | buy |
| Commodore Capital LP | 3,550,000 | 4,200,000 | +650,000 | 6.61 | 8.59 | +1.98 | buy |
| Soleus Capital Management, L.P. | 1,322,364 | 1,970,864 | +648,500 | 1.57 | 2.82 | +1.25 | buy |
| Bain Capital Life Sciences Investors, LLC | 0 | 610,000 | +610,000 | 0.00 | 1.95 | +1.95 | buy |
| Prosight Management, LP | 0 | 513,632 | +513,632 | 0.00 | 2.98 | +2.98 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 460,314 | +460,314 | 0.00 | 1.92 | +1.92 | buy |
| Affinity Asset Advisors, LLC | 1,000,000 | 1,350,000 | +350,000 | 2.01 | 2.80 | +0.79 | buy |
| Logos Global Management LP | 0 | 350,000 | +350,000 | 0.00 | 0.64 | +0.64 | buy |
| Man Group plc | 312,512 | 625,046 | +312,534 | 0.02 | 0.05 | +0.03 | buy |
| GENDELL JEFFREY L | 0 | 263,604 | +263,604 | 0.00 | 0.13 | +0.13 | buy |
| Senator Investment Group LP | 0 | 235,000 | +235,000 | 0.00 | 0.38 | +0.38 | buy |
| AMERIPRISE FINANCIAL INC | 531,362 | 741,141 | +209,779 | 0.00 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 204,324 | +204,324 | 0.00 | 0.07 | +0.07 | buy |
| Hudson Bay Capital Management LP | 0 | 173,626 | +173,626 | 0.00 | 0.04 | +0.04 | buy |
| Engineers Gate Manager LP | 47,731 | 208,497 | +160,766 | 0.02 | 0.09 | +0.08 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 158,499 | +158,499 | 0.00 | 0.20 | +0.20 | buy |
| Eagle Health Investments LP | 81,800 | 238,673 | +156,873 | 0.50 | 1.77 | +1.27 | buy |
| SummitTX Capital, L.P. | 0 | 156,259 | +156,259 | 0.00 | 0.18 | +0.18 | buy |
| MACKENZIE FINANCIAL CORP | 95,447 | 249,182 | +153,735 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 35,872 | 178,993 | +143,121 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 5,956,824 | 6,072,103 | +115,279 | 0.08 | 0.11 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 4,412,783 | 4,522,378 | +109,595 | 0.03 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,080,776 | 4,182,267 | +101,491 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 430,330 | 527,967 | +97,637 | 0.01 | 0.01 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 150,775 | 243,043 | +92,268 | 0.04 | 0.08 | +0.04 | buy |
| GENDELL JEFFREY L | 0 | 87,869 | +87,869 | 0.00 | 0.04 | +0.04 | buy |
| Exome Asset Management LLC | 0 | 84,103 | +84,103 | 0.00 | 1.75 | +1.75 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,152,756 | 2,236,756 | +84,000 | 0.01 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 80,492 | +80,492 | 0.00 | 0.55 | +0.55 | buy |
| Lumbard & Kellner, LLC | 0 | 52,593 | +52,593 | 0.00 | 0.64 | +0.64 | buy |
| GREAT POINT PARTNERS LLC | 0 | 50,000 | +50,000 | 0.00 | 0.43 | +0.43 | buy |
| DIADEMA PARTNERS LP | 0 | 50,000 | +50,000 | 0.00 | 0.73 | +0.73 | buy |
| HighVista Strategies LLC | 26,401 | 73,189 | +46,788 | 0.19 | 0.71 | +0.52 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 93,233 | 139,333 | +46,100 | 0.01 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 215,854 | 260,935 | +45,081 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 139,228 | 183,986 | +44,758 | 0.20 | 0.38 | +0.18 | buy |
| Neuberger Berman Group LLC | 152,772 | 197,220 | +44,448 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,653,475 | 1,697,082 | +43,607 | 0.01 | 0.01 | +0.00 | buy |
| S&CO INC | 201,760 | 244,760 | +43,000 | 0.35 | 0.54 | +0.19 | buy |
| BlackRock, Inc. | 28,272,412 | 28,314,410 | +41,998 | 0.01 | 0.02 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,873 | 56,795 | +41,922 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 0 | 38,625 | +38,625 | 0.00 | 0.07 | +0.07 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 148,793 | 183,795 | +35,002 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 2,427,028 | 2,460,569 | +33,541 | 0.02 | 0.02 | +0.01 | buy |
| Amundi | 32,383 | 64,710 | +32,327 | 0.00 | 0.00 | +0.00 | buy |
| Perbak Capital Partners LLP | 0 | 31,185 | +31,185 | 0.00 | 0.27 | +0.27 | buy |
| ALLSTATE CORP | 0 | 29,154 | +29,154 | 0.00 | 0.01 | +0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 28,649 | +28,649 | 0.00 | 0.01 | +0.01 | buy |
| Persistent Asset Partners Ltd | 0 | 25,563 | +25,563 | 0.00 | 0.35 | +0.35 | buy |
| Quantinno Capital Management LP | 19,440 | 44,932 | +25,492 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 95,000 | 120,000 | +25,000 | 1.23 | 2.53 | +1.29 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 170,267 | 194,766 | +24,499 | 0.12 | 0.17 | +0.05 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 21,290 | +21,290 | 0.00 | 0.14 | +0.14 | buy |
| DRW Securities, LLC | 0 | 20,180 | +20,180 | 0.00 | 0.04 | +0.04 | buy |
| TFG Asset Management GP Ltd | 141,172 | 159,791 | +18,619 | 0.83 | 1.11 | +0.28 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 48,976 | 66,815 | +17,839 | 0.00 | 0.01 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 20,368 | 37,964 | +17,596 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 16,928 | +16,928 | 0.00 | 0.05 | +0.05 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 16,584 | +16,584 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 134,461 | 149,734 | +15,273 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 60,780 | 75,023 | +14,243 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 674,874 | 688,563 | +13,689 | 0.03 | 0.00 | -0.03 | buy |
| Tower Research Capital LLC (TRC) | 2,584 | 16,120 | +13,536 | 0.00 | 0.01 | +0.01 | buy |
| Jackson Creek Investment Advisors LLC | 0 | 13,201 | +13,201 | 0.00 | 0.14 | +0.14 | buy |
| SIMPLEX TRADING, LLC | 0 | 13,138 | +13,138 | 0.00 | 0.01 | +0.01 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 65,763 | 77,928 | +12,165 | 0.01 | 0.02 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 55,523 | 67,458 | +11,935 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 110,282 | 122,127 | +11,845 | 0.00 | 0.01 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 379,458 | 390,344 | +10,886 | 0.58 | 0.77 | +0.18 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 947,623 | 958,016 | +10,393 | 0.01 | 0.02 | +0.00 | buy |
| RHUMBLINE ADVISERS | 439,195 | 449,531 | +10,336 | 0.01 | 0.01 | +0.00 | buy |
| Lombard Odier Asset Management (USA) Corp | 0 | 10,232 | +10,232 | 0.00 | 0.19 | +0.19 | buy |
| JONES FINANCIAL COMPANIES LLLP | 426 | 10,225 | +9,799 | 0.00 | 0.00 | +0.00 | buy |
| Ashton Thomas Private Wealth, LLC | 0 | 9,439 | +9,439 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 130,248 | 139,482 | +9,234 | 0.85 | 1.12 | +0.28 | buy |
| Jump Financial, LLC | 32,629 | 41,446 | +8,817 | 0.01 | 0.02 | +0.01 | buy |
| INVESTORS ASSET MANAGEMENT OF GEORGIA INC /GA/ /ADV | 0 | 8,600 | +8,600 | 0.00 | 0.12 | +0.12 | buy |
| GTS SECURITIES LLC | 0 | 8,485 | +8,485 | 0.00 | 0.01 | +0.01 | buy |
| Vestcor Inc | 21,766 | 30,230 | +8,464 | 0.02 | 0.03 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 394,853 | 403,153 | +8,300 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 145,804 | 154,016 | +8,212 | 0.00 | 0.00 | +0.00 | buy |
| Gallacher Capital Management LLC | 0 | 7,677 | +7,677 | 0.00 | 0.10 | +0.10 | buy |
| ROYCE & ASSOCIATES LP | 48,010 | 55,683 | +7,673 | 0.01 | 0.02 | +0.01 | buy |
| Moors & Cabot, Inc. | 0 | 7,117 | +7,117 | 0.00 | 0.01 | +0.01 | buy |
| Orion Porfolio Solutions, LLC | 0 | 7,104 | +7,104 | 0.00 | 0.00 | +0.00 | buy |
| IMC-Chicago, LLC | 0 | 6,879 | +6,879 | 0.00 | 0.00 | +0.00 | buy |
| GW HENSSLER & ASSOCIATES LTD | 0 | 6,370 | +6,370 | 0.00 | 0.01 | +0.01 | buy |
| Brooklyn Investment Group | 0 | 6,261 | +6,261 | 0.00 | 0.01 | +0.01 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 671,170 | 677,405 | +6,235 | 0.06 | 0.07 | +0.01 | buy |
| Federation des caisses Desjardins du Quebec | 60,006 | 66,144 | +6,138 | 0.01 | 0.01 | +0.00 | buy |
| FourThought Financial Partners, LLC | 0 | 6,068 | +6,068 | 0.00 | 0.02 | +0.02 | buy |
| Vontobel Holding Ltd. | 26,047 | 32,101 | +6,054 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 49,058 | 54,913 | +5,855 | 0.03 | 0.04 | +0.01 | buy |
| M&T BANK CORP | 0 | 5,850 | +5,850 | 0.00 | 0.00 | +0.00 | buy |