| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 20,161,180 | 19,999,872 | -161,308 | 0.01 | 0.01 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 14,892,360 | 14,354,752 | -537,608 | 0.07 | 0.06 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,326,256 | 11,012,312 | +2,686,056 | 0.03 | 0.03 | +0.00 | buy |
| STATE STREET CORP | 9,003,913 | 9,215,058 | +211,145 | 0.01 | 0.01 | -0.00 | buy |
| RTW INVESTMENTS, LP | 6,054,280 | 7,056,988 | +1,002,708 | 2.42 | 2.63 | +0.21 | buy |
| Pacer Advisors, Inc. | 4,278,563 | 5,640,642 | +1,362,079 | 0.27 | 0.31 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 5,887,151 | 5,483,831 | -403,320 | 0.25 | 0.22 | -0.03 | sell |
| BAKER BROS. ADVISORS LP | 0 | 4,181,751 | +4,181,751 | 0.00 | 1.29 | +1.29 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,742,771 | 3,933,964 | +191,193 | 0.01 | 0.01 | -0.00 | buy |
| Deep Track Capital, LP | 3,500,000 | 3,500,000 | 0 | 2.72 | 2.52 | -0.20 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 3,473,190 | 3,385,795 | -87,395 | 0.07 | 0.06 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 2,512,973 | 2,884,012 | +371,039 | 0.02 | 0.02 | -0.00 | buy |
| ARMISTICE CAPITAL, LLC | 672,218 | 2,699,179 | +2,026,961 | 0.48 | 1.70 | +1.22 | buy |
| Bank of New York Mellon Corp | 2,882,411 | 2,422,134 | -460,277 | 0.01 | 0.01 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,336,905 | 2,382,567 | +45,662 | 0.01 | 0.01 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,177,551 | 2,203,456 | +1,025,905 | 0.02 | 0.03 | +0.01 | buy |
| NORGES BANK | 2,060,014 | 2,128,943 | +68,929 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 1,953,447 | 2,115,592 | +162,145 | 0.00 | 0.00 | -0.00 | buy |
| Artisan Partners Limited Partnership | 2,066,020 | 2,022,489 | -43,531 | 0.08 | 0.07 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 1,957,100 | 1,961,175 | +4,075 | 0.01 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 1,796,918 | 1,772,751 | -24,167 | 0.01 | 0.01 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 1,472,868 | 1,538,112 | +65,244 | 0.04 | 0.04 | -0.00 | buy |
| Commodore Capital LP | 0 | 1,375,000 | +1,375,000 | 0.00 | 2.26 | +2.26 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,282,741 | 1,316,605 | +33,864 | 0.18 | 0.16 | -0.03 | buy |
| GOLDMAN SACHS GROUP INC | 1,385,347 | 1,238,176 | -147,171 | 0.01 | 0.01 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 1,082,466 | 1,220,935 | +138,469 | 0.55 | 0.52 | -0.03 | buy |
| Woodline Partners LP | 1,069,840 | 1,071,071 | +1,231 | 0.27 | 0.25 | -0.02 | buy |
| Pictet Asset Management Holding SA | 2,729,131 | 1,026,058 | -1,703,073 | 0.08 | 0.03 | -0.05 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 978,551 | 947,316 | -31,235 | 0.02 | 0.01 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 762,846 | 860,767 | +97,921 | 0.11 | 0.10 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 424,264 | 803,504 | +379,240 | 0.02 | 0.03 | +0.01 | buy |
| Invesco Ltd. | 600,303 | 696,240 | +95,937 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 75,000 | 650,000 | +575,000 | 0.33 | 2.47 | +2.14 | buy |
| FMR LLC | 104,637 | 609,841 | +505,204 | 0.00 | 0.00 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 570,749 | +570,749 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 583,306 | 559,913 | -23,393 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 0 | 557,556 | +557,556 | 0.00 | 2.09 | +2.09 | buy |
| AMERIPRISE FINANCIAL INC | 601,971 | 550,146 | -51,825 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 469,503 | 541,345 | +71,842 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 873,633 | 516,831 | -356,802 | 0.06 | 0.03 | -0.03 | sell |
| RHUMBLINE ADVISERS | 489,591 | 497,313 | +7,722 | 0.01 | 0.01 | -0.00 | buy |
| Palo Alto Investors LP | 495,592 | 495,592 | 0 | 1.51 | 1.38 | -0.13 | hold |
| FEDERATED HERMES, INC. | 490,472 | 490,326 | -146 | 0.03 | 0.03 | -0.00 | sell |
| AXA S.A. | 481,092 | 481,257 | +165 | 0.04 | 0.03 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 400,809 | 467,759 | +66,950 | 0.62 | 0.68 | +0.06 | buy |
| UBS Group AG | 412,665 | 466,786 | +54,121 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 306,329 | 454,896 | +148,567 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 274,767 | 408,980 | +134,213 | 0.01 | 0.02 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 767,077 | 404,514 | -362,563 | 0.03 | 0.01 | -0.02 | sell |
| TD ASSET MANAGEMENT INC | 348,992 | 397,592 | +48,600 | 0.01 | 0.01 | +0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 342,060 | 372,317 | +30,257 | 0.07 | 0.06 | -0.01 | buy |
| JPMORGAN CHASE & CO | 567,692 | 365,991 | -201,701 | 0.00 | 0.00 | -0.00 | sell |
| Amundi | 308,672 | 336,685 | +28,013 | 0.00 | 0.00 | -0.00 | buy |
| LSV ASSET MANAGEMENT | 212,400 | 327,700 | +115,300 | 0.01 | 0.02 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 315,761 | 323,548 | +7,787 | 0.01 | 0.01 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 341,841 | 323,141 | -18,700 | 0.01 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 54,283 | 322,214 | +267,931 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 311,800 | 316,200 | +4,400 | 0.01 | 0.01 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 376,892 | 307,548 | -69,344 | 0.01 | 0.01 | -0.00 | sell |
| MACQUARIE GROUP LTD | 300,000 | 300,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Rafferty Asset Management, LLC | 313,523 | 288,473 | -25,050 | 0.03 | 0.03 | -0.01 | sell |
| Prosight Management, LP | 215,000 | 275,000 | +60,000 | 1.62 | 1.98 | +0.36 | buy |
| MACKENZIE FINANCIAL CORP | 267,712 | 261,404 | -6,308 | 0.01 | 0.01 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 195,442 | 260,876 | +65,434 | 0.00 | 0.00 | -0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 144,297 | 257,957 | +113,660 | 0.05 | 0.07 | +0.02 | buy |
| Krensavage Asset Management, LLC | 257,554 | 257,554 | 0 | 3.09 | 2.85 | -0.24 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 248,391 | +248,391 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 74,880 | 245,334 | +170,454 | 0.00 | 0.01 | +0.01 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 221,257 | 244,857 | +23,600 | 0.05 | 0.05 | -0.00 | buy |
| Fisher Asset Management, LLC | 213,437 | 242,638 | +29,201 | 0.00 | 0.00 | -0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 252,600 | 227,000 | -25,600 | 0.01 | 0.01 | -0.00 | sell |
| Handelsbanken Fonder AB | 175,200 | 219,900 | +44,700 | 0.02 | 0.02 | +0.00 | buy |
| Squarepoint Ops LLC | 563,519 | 217,151 | -346,368 | 0.06 | 0.02 | -0.04 | sell |
| S&CO INC | 210,715 | 214,715 | +4,000 | 0.40 | 0.36 | -0.04 | buy |
| Allspring Global Investments Holdings, LLC | 120,701 | 209,535 | +88,834 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 74,758 | 207,394 | +132,636 | 0.00 | 0.01 | +0.00 | buy |
| PFM Health Sciences, LP | 429,573 | 205,073 | -224,500 | 0.58 | 0.27 | -0.31 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 193,077 | 203,441 | +10,364 | 0.02 | 0.02 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 215,536 | 203,289 | -12,247 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 234,760 | 203,038 | -31,722 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 209,182 | 201,591 | -7,591 | 0.01 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 156,600 | 196,577 | +39,977 | 1.16 | 0.95 | -0.20 | buy |
| SECTOR GAMMA AS | 252,319 | 194,000 | -58,319 | 1.93 | 1.75 | -0.18 | sell |
| ExodusPoint Capital Management, LP | 0 | 170,649 | +170,649 | 0.00 | 0.05 | +0.05 | buy |
| TODD ASSET MANAGEMENT LLC | 130,039 | 160,588 | +30,549 | 0.07 | 0.08 | +0.01 | buy |
| CITIGROUP INC | 405,405 | 159,322 | -246,083 | 0.01 | 0.00 | -0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 160,080 | 157,863 | -2,217 | 0.01 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 157,254 | 155,052 | -2,202 | 0.01 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 110,000 | 150,000 | +40,000 | 0.28 | 0.35 | +0.06 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 210,876 | 140,478 | -70,398 | 0.01 | 0.01 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 146,381 | 137,302 | -9,079 | 0.01 | 0.01 | -0.00 | sell |
| Trexquant Investment LP | 74,388 | 136,794 | +62,406 | 0.04 | 0.05 | +0.01 | buy |
| ALPS ADVISORS INC | 117,846 | 131,992 | +14,146 | 0.02 | 0.02 | -0.00 | buy |
| TEXAS PERMANENT SCHOOL FUND CORP | 146,052 | 124,906 | -21,146 | 0.03 | 0.03 | -0.01 | sell |
| DAFNA Capital Management LLC | 0 | 120,700 | +120,700 | 0.00 | 0.69 | +0.69 | buy |
| FRANKLIN RESOURCES INC | 226,592 | 117,103 | -109,489 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 124,145 | 115,230 | -8,915 | 0.01 | 0.01 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 89,214 | 115,061 | +25,847 | 0.00 | 0.00 | +0.00 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 0 | 110,464 | +110,464 | 0.00 | 0.05 | +0.05 | buy |
| GUGGENHEIM CAPITAL LLC | 95,515 | 107,255 | +11,740 | 0.02 | 0.02 | +0.00 | buy |