| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 0 | 4,181,751 | +4,181,751 | 0.00 | 1.29 | +1.29 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,326,256 | 11,012,312 | +2,686,056 | 0.03 | 0.03 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 672,218 | 2,699,179 | +2,026,961 | 0.48 | 1.70 | +1.22 | buy |
| Commodore Capital LP | 0 | 1,375,000 | +1,375,000 | 0.00 | 2.26 | +2.26 | buy |
| Pacer Advisors, Inc. | 4,278,563 | 5,640,642 | +1,362,079 | 0.27 | 0.31 | +0.05 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,177,551 | 2,203,456 | +1,025,905 | 0.02 | 0.03 | +0.01 | buy |
| RTW INVESTMENTS, LP | 6,054,280 | 7,056,988 | +1,002,708 | 2.42 | 2.63 | +0.21 | buy |
| Affinity Asset Advisors, LLC | 75,000 | 650,000 | +575,000 | 0.33 | 2.47 | +2.14 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 570,749 | +570,749 | 0.00 | 0.02 | +0.02 | buy |
| MPM BioImpact LLC | 0 | 557,556 | +557,556 | 0.00 | 2.09 | +2.09 | buy |
| FMR LLC | 104,637 | 609,841 | +505,204 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 424,264 | 803,504 | +379,240 | 0.02 | 0.03 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,512,973 | 2,884,012 | +371,039 | 0.02 | 0.02 | -0.00 | buy |
| CITADEL ADVISORS LLC | 54,283 | 322,214 | +267,931 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 248,391 | +248,391 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 9,003,913 | 9,215,058 | +211,145 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,742,771 | 3,933,964 | +191,193 | 0.01 | 0.01 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 170,649 | +170,649 | 0.00 | 0.05 | +0.05 | buy |
| Qube Research & Technologies Ltd | 74,880 | 245,334 | +170,454 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 1,953,447 | 2,115,592 | +162,145 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 306,329 | 454,896 | +148,567 | 0.01 | 0.01 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 1,082,466 | 1,220,935 | +138,469 | 0.55 | 0.52 | -0.03 | buy |
| Aberdeen Group plc | 274,767 | 408,980 | +134,213 | 0.01 | 0.02 | +0.00 | buy |
| JANE STREET GROUP, LLC | 74,758 | 207,394 | +132,636 | 0.00 | 0.01 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 120,700 | +120,700 | 0.00 | 0.69 | +0.69 | buy |
| LSV ASSET MANAGEMENT | 212,400 | 327,700 | +115,300 | 0.01 | 0.02 | +0.01 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 144,297 | 257,957 | +113,660 | 0.05 | 0.07 | +0.02 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 0 | 110,464 | +110,464 | 0.00 | 0.05 | +0.05 | buy |
| PANAGORA ASSET MANAGEMENT INC | 762,846 | 860,767 | +97,921 | 0.11 | 0.10 | -0.00 | buy |
| Invesco Ltd. | 600,303 | 696,240 | +95,937 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 91,738 | +91,738 | 0.00 | 0.12 | +0.12 | buy |
| Allspring Global Investments Holdings, LLC | 120,701 | 209,535 | +88,834 | 0.01 | 0.01 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 77,000 | +77,000 | 0.00 | 0.05 | +0.05 | buy |
| VAN ECK ASSOCIATES CORP | 0 | 74,988 | +74,988 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 469,503 | 541,345 | +71,842 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 2,060,014 | 2,128,943 | +68,929 | 0.01 | 0.01 | -0.00 | buy |
| Atle Fund Management AB | 0 | 68,800 | +68,800 | 0.00 | 1.01 | +1.01 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 400,809 | 467,759 | +66,950 | 0.62 | 0.68 | +0.06 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 195,442 | 260,876 | +65,434 | 0.00 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 1,472,868 | 1,538,112 | +65,244 | 0.04 | 0.04 | -0.00 | buy |
| Trexquant Investment LP | 74,388 | 136,794 | +62,406 | 0.04 | 0.05 | +0.01 | buy |
| Prosight Management, LP | 215,000 | 275,000 | +60,000 | 1.62 | 1.98 | +0.36 | buy |
| UBS Group AG | 412,665 | 466,786 | +54,121 | 0.00 | 0.00 | -0.00 | buy |
| DekaBank Deutsche Girozentrale | 0 | 53,517 | +53,517 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 348,992 | 397,592 | +48,600 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,336,905 | 2,382,567 | +45,662 | 0.01 | 0.01 | -0.00 | buy |
| Handelsbanken Fonder AB | 175,200 | 219,900 | +44,700 | 0.02 | 0.02 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 110,000 | 150,000 | +40,000 | 0.28 | 0.35 | +0.06 | buy |
| ADAR1 Capital Management, LLC | 156,600 | 196,577 | +39,977 | 1.16 | 0.95 | -0.20 | buy |
| AMG National Trust Bank | 0 | 35,445 | +35,445 | 0.00 | 0.02 | +0.02 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,282,741 | 1,316,605 | +33,864 | 0.18 | 0.16 | -0.03 | buy |
| TODD ASSET MANAGEMENT LLC | 130,039 | 160,588 | +30,549 | 0.07 | 0.08 | +0.01 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 342,060 | 372,317 | +30,257 | 0.07 | 0.06 | -0.01 | buy |
| Hudson Bay Capital Management LP | 0 | 30,000 | +30,000 | 0.00 | 0.01 | +0.01 | buy |
| Fisher Asset Management, LLC | 213,437 | 242,638 | +29,201 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 28,105 | +28,105 | 0.00 | 0.04 | +0.04 | buy |
| Amundi | 308,672 | 336,685 | +28,013 | 0.00 | 0.00 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 21,700 | 47,812 | +26,112 | 0.08 | 0.09 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 89,214 | 115,061 | +25,847 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 22,594 | 47,756 | +25,162 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 24,800 | +24,800 | 0.00 | 0.06 | +0.06 | buy |
| Tower Research Capital LLC (TRC) | 375 | 24,444 | +24,069 | 0.00 | 0.01 | +0.01 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 221,257 | 244,857 | +23,600 | 0.05 | 0.05 | -0.00 | buy |
| INCEPTIONR LLC | 0 | 22,516 | +22,516 | 0.00 | 0.15 | +0.15 | buy |
| OMERS ADMINISTRATION Corp | 35,400 | 57,900 | +22,500 | 0.01 | 0.01 | +0.00 | buy |
| AGF MANAGEMENT LTD | 75,826 | 98,230 | +22,404 | 0.01 | 0.01 | +0.00 | buy |
| Allianz Asset Management GmbH | 22,047 | 41,947 | +19,900 | 0.00 | 0.00 | +0.00 | buy |
| CHOREO, LLC | 0 | 18,071 | +18,071 | 0.00 | 0.01 | +0.01 | buy |
| Corient Private Wealth LLC | 22,766 | 40,435 | +17,669 | 0.00 | 0.00 | +0.00 | buy |
| Vise Technologies, Inc. | 0 | 17,525 | +17,525 | 0.00 | 0.07 | +0.07 | buy |
| Assenagon Asset Management S.A. | 70,256 | 86,451 | +16,195 | 0.01 | 0.01 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 16,194 | +16,194 | 0.00 | 0.07 | +0.07 | buy |
| ALGERT GLOBAL LLC | 0 | 16,191 | +16,191 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 117,846 | 131,992 | +14,146 | 0.02 | 0.02 | -0.00 | buy |
| ROYCE & ASSOCIATES LP | 31,846 | 45,272 | +13,426 | 0.01 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 17,645 | 29,455 | +11,810 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 95,515 | 107,255 | +11,740 | 0.02 | 0.02 | +0.00 | buy |
| Savant Capital, LLC | 10,001 | 21,625 | +11,624 | 0.00 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 85,701 | 97,201 | +11,500 | 0.02 | 0.01 | -0.00 | buy |
| Kestra Advisory Services, LLC | 0 | 11,033 | +11,033 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 193,077 | 203,441 | +10,364 | 0.02 | 0.02 | -0.00 | buy |
| Robeco Institutional Asset Management B.V. | 39,917 | 49,652 | +9,735 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 45,371 | 54,488 | +9,117 | 0.00 | 0.00 | +0.00 | buy |
| Dana Investment Advisors, Inc. | 19,028 | 27,968 | +8,940 | 0.02 | 0.02 | +0.01 | buy |
| Triumph Capital Management | 0 | 8,889 | +8,889 | 0.00 | 0.08 | +0.08 | buy |
| Aquatic Capital Management LLC | 0 | 8,300 | +8,300 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 315,761 | 323,548 | +7,787 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 489,591 | 497,313 | +7,722 | 0.01 | 0.01 | -0.00 | buy |
| Creative Planning | 26,069 | 33,365 | +7,296 | 0.00 | 0.00 | +0.00 | buy |
| Summit Global Investments | 39,895 | 46,808 | +6,913 | 0.08 | 0.08 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 77,102 | 83,711 | +6,609 | 0.00 | 0.00 | -0.00 | buy |
| Neuberger Berman Group LLC | 8,691 | 14,177 | +5,486 | 0.00 | 0.00 | +0.00 | buy |
| Edgestream Partners, L.P. | 79,609 | 85,023 | +5,414 | 0.11 | 0.10 | -0.01 | buy |
| CWM, LLC | 2,732 | 7,932 | +5,200 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 59,451 | 64,277 | +4,826 | 0.02 | 0.02 | +0.00 | buy |
| Ashton Thomas Private Wealth, LLC | 0 | 4,812 | +4,812 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF NOVA SCOTIA | 12,857 | 17,405 | +4,548 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 8,500 | 13,000 | +4,500 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 20,119 | 24,574 | +4,455 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 311,800 | 316,200 | +4,400 | 0.01 | 0.01 | -0.00 | buy |