| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 4,483,285 | 6,410,603 | +1,927,318 | 1.64 | 1.78 | +0.14 | buy |
| Holocene Advisors, LP | 2,174,602 | 2,853,768 | +679,166 | 0.21 | 0.20 | -0.01 | buy |
| Commodore Capital LP | 1,950,000 | 2,450,000 | +500,000 | 4.74 | 4.95 | +0.20 | buy |
| Avoro Capital Advisors LLC | 2,450,000 | 2,900,000 | +450,000 | 1.26 | 1.45 | +0.19 | buy |
| Frazier Life Sciences Management, L.P. | 601,129 | 1,000,647 | +399,518 | 0.91 | 1.14 | +0.24 | buy |
| TWO SIGMA INVESTMENTS, LP | 557,940 | 325,903 | +232,037 | 0.04 | 0.02 | 0.00 | sell |
| FIRST TRUST ADVISORS LP | 1,621,046 | 1,397,281 | +223,765 | 0.05 | 0.03 | 0.00 | sell |
| MPM BioImpact LLC | 337,603 | 549,262 | +211,659 | 1.92 | 2.72 | +0.81 | buy |
| AMERICAN CENTURY COMPANIES INC | 3,465,674 | 3,657,223 | +191,549 | 0.07 | 0.06 | -0.01 | buy |
| STEMPOINT CAPITAL LP | 192,352 | 351,124 | +158,772 | 2.03 | 3.23 | +1.20 | buy |
| Y-Intercept (Hong Kong) Ltd | 25,339 | 138,433 | +113,094 | 0.06 | 0.10 | 0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,939,694 | 4,023,552 | +83,858 | 0.01 | 0.01 | 0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 532,265 | 452,522 | +79,743 | 0.02 | 0.01 | 0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 5,738,828 | 5,810,160 | +71,332 | 0.32 | 0.24 | -0.07 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 305,500 | 370,900 | +65,400 | 0.01 | 0.01 | 0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 528,821 | 593,938 | +65,117 | 0.27 | 0.24 | -0.03 | buy |
| ALGERT GLOBAL LLC | 176,859 | 115,270 | +61,589 | 0.15 | 0.07 | 0.00 | sell |
| RITHOLTZ WEALTH MANAGEMENT | 10,532 | 68,634 | +58,102 | 0.01 | 0.04 | +0.03 | buy |
| Gotham Asset Management, LLC | 79,668 | 133,472 | +53,804 | 0.02 | 0.02 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 93,094 | 135,251 | +42,157 | 0.08 | 0.09 | +0.02 | buy |
| Robeco Institutional Asset Management B.V. | 76,853 | 113,320 | +36,467 | 0.00 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 792,831 | 826,811 | +33,980 | 0.25 | 0.19 | -0.06 | buy |
| JANUS HENDERSON GROUP PLC | 232,944 | 204,595 | +28,349 | 0.00 | 0.00 | 0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 47,738 | 75,339 | +27,601 | 0.01 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 115,732 | 88,909 | +26,823 | 0.02 | 0.01 | 0.00 | sell |
| Aberdeen Group plc | 156,867 | 178,719 | +21,852 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 455,197 | 472,857 | +17,660 | 0.01 | 0.01 | 0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 928,865 | 914,795 | +14,070 | 0.02 | 0.01 | 0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 39,790 | 53,200 | +13,410 | 0.01 | 0.01 | 0.00 | buy |
| TEXAS PERMANENT SCHOOL FUND CORP | 77,536 | 90,738 | +13,202 | 0.02 | 0.03 | 0.00 | buy |
| Atle Fund Management AB | 214,778 | 227,224 | +12,446 | 3.13 | 2.78 | -0.35 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 117,516 | 128,462 | +10,946 | 0.08 | 0.07 | -0.01 | buy |
| Rafferty Asset Management, LLC | 150,448 | 161,285 | +10,837 | 0.02 | 0.02 | -0.01 | buy |
| TD ASSET MANAGEMENT INC | 205,642 | 216,442 | +10,800 | 0.01 | 0.01 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 151,396 | 161,386 | +9,990 | 0.07 | 0.06 | 0.00 | buy |
| DAFNA Capital Management LLC | 94,200 | 103,748 | +9,548 | 0.88 | 0.82 | -0.06 | buy |
| State of Alaska, Department of Revenue | 90,103 | 98,173 | +8,070 | 0.04 | 0.03 | 0.00 | buy |
| E Fund Management Co., Ltd. | 14,060 | 18,003 | +3,943 | 0.02 | 0.02 | +0.00 | buy |
| STRS OHIO | 42,500 | 46,100 | +3,600 | 0.01 | 0.00 | -0.00 | buy |
| CHOREO, LLC | 20,812 | 24,314 | +3,502 | 0.01 | 0.01 | -0.00 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 38,915 | 42,337 | +3,422 | 0.01 | 0.01 | -0.00 | buy |
| ProShare Advisors LLC | 45,286 | 42,422 | +2,864 | 0.00 | 0.00 | 0.00 | sell |
| Vident Advisory, LLC | 56,817 | 59,576 | +2,759 | 0.03 | 0.02 | 0.00 | buy |
| PROFUND ADVISORS LLC | 37,228 | 39,869 | +2,641 | 0.05 | 0.04 | -0.01 | buy |
| ROYCE & ASSOCIATES LP | 47,187 | 49,732 | +2,545 | 0.02 | 0.01 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 178,641 | 176,301 | +2,340 | 0.01 | 0.01 | 0.00 | sell |
| AVIVA PLC | 17,425 | 19,494 | +2,069 | 0.00 | 0.00 | -0.00 | buy |
| Bayforest Capital Ltd | 9,270 | 11,242 | +1,972 | 0.13 | 0.14 | +0.01 | buy |
| YOUSIF CAPITAL MANAGEMENT, LLC | 61,347 | 62,951 | +1,604 | 0.02 | 0.02 | 0.00 | buy |
| DnB Asset Management AS | 9,928 | 11,446 | +1,518 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 297,800 | 299,300 | +1,500 | 0.01 | 0.01 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 85,564 | 84,709 | +855 | 0.03 | 0.02 | -0.01 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 42,430 | 42,961 | +531 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 32,618 | 33,120 | +502 | 0.10 | 0.09 | -0.01 | buy |
| Diversified Trust Co | 43,860 | 44,232 | +372 | 0.04 | 0.03 | -0.01 | buy |
| EVERGREEN CAPITAL MANAGEMENT LLC | 10,770 | 10,445 | +325 | 0.01 | 0.01 | 0.00 | sell |
| New Age Alpha Advisors, LLC | 13,702 | 13,911 | +209 | 0.02 | 0.02 | -0.00 | buy |
| OREGON PUBLIC EMPLOYEES RETIREMENT FUND | 37,260 | 37,460 | +200 | 0.02 | 0.02 | 0.00 | buy |
| Advisors Asset Management, Inc. | 17,460 | 17,384 | +76 | 0.01 | 0.01 | 0.00 | sell |
| AMG National Trust Bank | 59,735 | 59,787 | +52 | 0.06 | 0.04 | -0.01 | buy |
| Bell Investment Advisors, Inc | 179 | 214 | +35 | 0.00 | 0.00 | 0.00 | buy |
| Vermillion & White Wealth Management Group, LLC | 129 | 151 | +22 | 0.00 | 0.00 | -0.00 | buy |
| SouthState Corp | 172 | 134 | -38 | 0.00 | 0.00 | -0.00 | sell |
| WealthCollab, LLC | 604 | 544 | -60 | 0.01 | 0.01 | -0.00 | sell |
| AUXIER ASSET MANAGEMENT | 11,816 | 11,641 | -175 | 0.06 | 0.05 | -0.01 | sell |
| Dana Investment Advisors, Inc. | 23,276 | 22,969 | -307 | 0.03 | 0.02 | -0.01 | sell |
| Palo Alto Investors LP | 221,513 | 221,021 | -492 | 1.39 | 1.35 | -0.05 | sell |
| Nicollet Investment Management, Inc. | 47,175 | 46,223 | -952 | 0.55 | 0.44 | -0.10 | sell |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 23,033 | 22,066 | -967 | 0.01 | 0.01 | -0.00 | sell |
| S&CO INC | 221,960 | 220,585 | -1,375 | 0.49 | 0.40 | -0.09 | sell |
| Bleakley Financial Group, LLC | 15,744 | 14,061 | -1,683 | 0.02 | 0.01 | -0.01 | sell |
| Hudson Portfolio Management LLC | 40,215 | 37,775 | -2,440 | 1.28 | 1.01 | -0.26 | sell |
| HOHIMER WEALTH MANAGEMENT, LLC | 12,362 | 9,319 | -3,043 | 0.08 | 0.05 | -0.03 | sell |
| AdvisorShares Investments LLC | 19,975 | 16,675 | -3,300 | 0.13 | 0.09 | -0.04 | sell |
| Advantage Alpha Capital Partners LP | 21,357 | 17,322 | -4,035 | 0.17 | 0.13 | -0.04 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 426,585 | 421,885 | -4,700 | 0.83 | 0.65 | -0.18 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 102,885 | 96,813 | -6,072 | 0.01 | 0.01 | -0.00 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 13,170 | 3,342 | -9,828 | 0.00 | 0.00 | -0.00 | sell |
| AXS Investments LLC | 31,200 | 20,800 | -10,400 | 0.28 | 0.24 | -0.04 | sell |
| MOODY ALDRICH PARTNERS LLC | 81,234 | 66,919 | -14,315 | 0.56 | 0.37 | -0.19 | sell |
| FRED ALGER MANAGEMENT, LLC | 37,511 | 22,648 | -14,863 | 0.01 | 0.00 | -0.00 | sell |
| CIBC WORLD MARKETS CORP | 35,733 | 19,992 | -15,741 | 0.01 | 0.00 | -0.01 | sell |
| Legal & General Group Plc | 552,569 | 535,342 | -17,227 | 0.01 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 70,762 | 52,944 | -17,818 | 0.90 | 0.56 | -0.34 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 33,728 | 14,521 | -19,207 | 0.17 | 0.07 | -0.10 | sell |
| Fisher Asset Management, LLC | 321,681 | 291,947 | -29,734 | 0.00 | 0.00 | -0.00 | sell |
| Edgestream Partners, L.P. | 110,244 | 73,898 | -36,346 | 0.12 | 0.06 | -0.06 | sell |
| PDT Partners, LLC | 131,383 | 91,610 | -39,773 | 0.31 | 0.15 | -0.16 | sell |
| Integral Health Asset Management, LLC | 150,000 | 100,000 | -50,000 | 0.55 | 0.27 | -0.28 | sell |
| J. Goldman & Co LP | 110,051 | 21,425 | -88,626 | 0.09 | 0.01 | -0.08 | sell |
| Artisan Partners Limited Partnership | 1,636,269 | 1,541,807 | -94,462 | 0.09 | 0.06 | -0.02 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 3,004,095 | 2,902,510 | -101,585 | 0.08 | 0.07 | -0.02 | sell |
| TODD ASSET MANAGEMENT LLC | 129,613 | 13,015 | -116,598 | 0.10 | 0.01 | -0.09 | sell |
| Woodline Partners LP | 744,000 | 558,465 | -185,535 | 0.16 | 0.08 | -0.08 | sell |
| LOOMIS SAYLES & CO L P | 2,440,283 | 2,109,894 | -330,389 | 0.12 | 0.08 | -0.04 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,788,245 | 10,041,900 | -1,746,345 | 0.05 | 0.03 | -0.02 | sell |
| RTW INVESTMENTS, LP | 6,884,698 | 4,682,289 | -2,202,409 | 3.48 | 1.91 | -1.57 | sell |