| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 4,483,285 | 6,410,603 | +1,927,318 | 1.64 | 1.78 | +0.14 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,375,569 | +1,375,569 | 0.00 | 1.68 | +1.68 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 127,990 | 1,135,478 | +1,007,488 | 0.00 | 0.03 | +0.02 | buy |
| Holocene Advisors, LP | 2,174,602 | 2,853,768 | +679,166 | 0.21 | 0.20 | -0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 1,507,182 | 2,155,087 | +647,905 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 500,000 | +500,000 | 0.00 | 0.85 | +0.85 | buy |
| Commodore Capital LP | 1,950,000 | 2,450,000 | +500,000 | 4.74 | 4.95 | +0.20 | buy |
| Avoro Capital Advisors LLC | 2,450,000 | 2,900,000 | +450,000 | 1.26 | 1.45 | +0.19 | buy |
| BlackRock, Inc. | 27,406,368 | 27,856,163 | +449,795 | 0.02 | 0.02 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 601,129 | 1,000,647 | +399,518 | 0.91 | 1.14 | +0.24 | buy |
| D. E. Shaw & Co., Inc. | 468,481 | 820,096 | +351,615 | 0.02 | 0.02 | +0.00 | buy |
| VANGUARD GROUP INC | 18,212,674 | 18,503,074 | +290,400 | 0.01 | 0.01 | -0.00 | buy |
| BARCLAYS PLC | 419,951 | 694,122 | +274,171 | 0.01 | 0.01 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 264,620 | +264,620 | 0.00 | 0.23 | +0.23 | buy |
| MPM BioImpact LLC | 337,603 | 549,262 | +211,659 | 1.92 | 2.72 | +0.81 | buy |
| MARSHALL WACE, LLP | 0 | 207,511 | +207,511 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,472,051 | 1,667,697 | +195,646 | 0.01 | 0.01 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 3,465,674 | 3,657,223 | +191,549 | 0.07 | 0.06 | -0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 482,332 | 671,429 | +189,097 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 8,022,670 | 8,208,256 | +185,586 | 0.01 | 0.01 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 530,772 | 706,007 | +175,235 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 192,352 | 351,124 | +158,772 | 2.03 | 3.23 | +1.20 | buy |
| Man Group plc | 135,828 | 275,822 | +139,994 | 0.01 | 0.02 | +0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 126,000 | +126,000 | 0.00 | 0.82 | +0.82 | buy |
| Magnetar Financial LLC | 0 | 123,678 | +123,678 | 0.00 | 0.02 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 120,997 | 240,453 | +119,456 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 25,339 | 138,433 | +113,094 | 0.06 | 0.10 | +0.04 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,991,005 | 3,096,637 | +105,632 | 0.02 | 0.02 | -0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 103,278 | +103,278 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 217,000 | 318,400 | +101,400 | 0.03 | 0.03 | +0.00 | buy |
| MetLife Investment Management, LLC | 567,621 | 656,648 | +89,027 | 0.10 | 0.11 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,939,694 | 4,023,552 | +83,858 | 0.01 | 0.01 | -0.00 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 27,935 | 108,735 | +80,800 | 0.01 | 0.02 | +0.01 | buy |
| MACQUARIE GROUP LTD | 300,000 | 374,324 | +74,324 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 5,738,828 | 5,810,160 | +71,332 | 0.29 | 0.22 | -0.07 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 305,500 | 370,900 | +65,400 | 0.01 | 0.01 | -0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 528,821 | 593,938 | +65,117 | 0.27 | 0.24 | -0.03 | buy |
| Verition Fund Management LLC | 57,491 | 119,686 | +62,195 | 0.01 | 0.02 | +0.01 | buy |
| RITHOLTZ WEALTH MANAGEMENT | 10,532 | 68,634 | +58,102 | 0.01 | 0.04 | +0.03 | buy |
| Gotham Asset Management, LLC | 79,668 | 133,472 | +53,804 | 0.02 | 0.02 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 237,004 | 290,327 | +53,323 | 0.01 | 0.01 | -0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 585,262 | 636,913 | +51,651 | 0.08 | 0.08 | -0.01 | buy |
| Knott David M Jr | 0 | 49,000 | +49,000 | 0.00 | 0.64 | +0.64 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 48,506 | +48,506 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 13,988 | 60,842 | +46,854 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 0 | 45,000 | +45,000 | 0.00 | 0.21 | +0.21 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,047,403 | 2,092,049 | +44,646 | 0.01 | 0.01 | -0.00 | buy |
| Oliver Luxxe Assets LLC | 0 | 44,551 | +44,551 | 0.00 | 0.23 | +0.23 | buy |
| Horizon Investments, LLC | 0 | 42,615 | +42,615 | 0.00 | 0.02 | +0.02 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 93,094 | 135,251 | +42,157 | 0.08 | 0.09 | +0.02 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 39,929 | +39,929 | 0.00 | 0.01 | +0.01 | buy |
| Robeco Institutional Asset Management B.V. | 76,853 | 113,320 | +36,467 | 0.00 | 0.01 | +0.00 | buy |
| Vestcor Inc | 26,645 | 61,192 | +34,547 | 0.03 | 0.05 | +0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 792,831 | 826,811 | +33,980 | 0.25 | 0.19 | -0.06 | buy |
| JENNISON ASSOCIATES LLC | 0 | 31,761 | +31,761 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 99,957 | 131,431 | +31,474 | 0.01 | 0.01 | +0.00 | buy |
| HSBC HOLDINGS PLC | 81,056 | 110,816 | +29,760 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 2,019,668 | 2,048,073 | +28,405 | 0.02 | 0.02 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 47,738 | 75,339 | +27,601 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 477,183 | 503,585 | +26,402 | 0.02 | 0.01 | -0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 6,565 | 32,321 | +25,756 | 0.10 | 0.30 | +0.20 | buy |
| RAYMOND JAMES FINANCIAL INC | 429,482 | 454,417 | +24,935 | 0.01 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 99,997 | 122,258 | +22,261 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 156,867 | 178,719 | +21,852 | 0.01 | 0.01 | -0.00 | buy |
| CenterBook Partners LP | 0 | 21,349 | +21,349 | 0.00 | 0.03 | +0.03 | buy |
| Squarepoint Ops LLC | 29,764 | 49,267 | +19,503 | 0.00 | 0.00 | +0.00 | buy |
| Resona Asset Management Co.,Ltd. | 0 | 18,025 | +18,025 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 455,197 | 472,857 | +17,660 | 0.01 | 0.01 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 859,982 | 877,174 | +17,192 | 0.14 | 0.11 | -0.03 | buy |
| Pacer Advisors, Inc. | 890,144 | 906,957 | +16,813 | 0.07 | 0.07 | -0.00 | buy |
| Neo Ivy Capital Management | 0 | 16,150 | +16,150 | 0.00 | 0.15 | +0.15 | buy |
| Assenagon Asset Management S.A. | 68,049 | 84,017 | +15,968 | 0.00 | 0.00 | -0.00 | buy |
| Moran Wealth Management, LLC | 0 | 15,833 | +15,833 | 0.00 | 0.01 | +0.01 | buy |
| TFG Asset Management GP Ltd | 0 | 15,632 | +15,632 | 0.00 | 0.08 | +0.08 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 293,190 | 308,542 | +15,352 | 0.01 | 0.01 | -0.00 | buy |
| Engineers Gate Manager LP | 32,983 | 47,594 | +14,611 | 0.02 | 0.02 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 39,790 | 53,200 | +13,410 | 0.01 | 0.01 | -0.00 | buy |
| TEXAS PERMANENT SCHOOL FUND CORP | 77,536 | 90,738 | +13,202 | 0.02 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 194,992 | 208,088 | +13,096 | 0.01 | 0.01 | -0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 19,462 | 32,019 | +12,557 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 214,778 | 227,224 | +12,446 | 3.13 | 2.78 | -0.35 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 117,516 | 128,462 | +10,946 | 0.08 | 0.07 | -0.01 | buy |
| Rafferty Asset Management, LLC | 150,448 | 161,285 | +10,837 | 0.02 | 0.02 | -0.01 | buy |
| TD ASSET MANAGEMENT INC | 205,642 | 216,442 | +10,800 | 0.01 | 0.01 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 151,396 | 161,386 | +9,990 | 0.07 | 0.06 | -0.01 | buy |
| DAFNA Capital Management LLC | 94,200 | 103,748 | +9,548 | 0.88 | 0.82 | -0.06 | buy |
| MQS Management LLC | 0 | 9,370 | +9,370 | 0.00 | 0.15 | +0.15 | buy |
| DRW Securities, LLC | 0 | 9,219 | +9,219 | 0.00 | 0.02 | +0.02 | buy |
| IEQ CAPITAL, LLC | 35,268 | 44,293 | +9,025 | 0.01 | 0.01 | -0.00 | buy |
| State of New Jersey Common Pension Fund D | 54,463 | 62,677 | +8,214 | 0.01 | 0.01 | -0.00 | buy |
| State of Alaska, Department of Revenue | 90,103 | 98,173 | +8,070 | 0.03 | 0.03 | -0.00 | buy |
| State of Wyoming | 11,114 | 18,677 | +7,563 | 0.05 | 0.07 | +0.02 | buy |
| PZENA INVESTMENT MANAGEMENT LLC | 0 | 7,439 | +7,439 | 0.00 | 0.00 | +0.00 | buy |
| Financiere des Professionnels - Fonds d,investissement inc. | 0 | 7,438 | +7,438 | 0.00 | 0.01 | +0.01 | buy |
| Vontobel Holding Ltd. | 39,673 | 47,020 | +7,347 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 27,151 | 33,663 | +6,512 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 7,273 | 13,710 | +6,437 | 0.01 | 0.01 | +0.00 | buy |
| Quantbot Technologies LP | 1,091 | 6,976 | +5,885 | 0.00 | 0.01 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 0 | 5,614 | +5,614 | 0.00 | 0.00 | +0.00 | buy |