| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 27,406,368 | 27,856,163 | +449,795 | 0.02 | 0.02 | -0.00 | buy |
| VANGUARD GROUP INC | 18,212,674 | 18,503,074 | +290,400 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,788,245 | 10,041,900 | -1,746,345 | 0.05 | 0.03 | -0.02 | sell |
| STATE STREET CORP | 8,022,670 | 8,208,256 | +185,586 | 0.01 | 0.01 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 4,483,285 | 6,410,603 | +1,927,318 | 1.64 | 1.78 | +0.14 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 5,738,828 | 5,810,160 | +71,332 | 0.29 | 0.22 | -0.07 | buy |
| JPMORGAN CHASE & CO | 5,234,995 | 4,836,294 | -398,701 | 0.01 | 0.01 | -0.00 | sell |
| RTW INVESTMENTS, LP | 6,884,698 | 4,682,289 | -2,202,409 | 3.48 | 1.91 | -1.57 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,939,694 | 4,023,552 | +83,858 | 0.01 | 0.01 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 3,465,674 | 3,657,223 | +191,549 | 0.07 | 0.06 | -0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,991,005 | 3,096,637 | +105,632 | 0.02 | 0.02 | -0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 3,004,095 | 2,902,510 | -101,585 | 0.08 | 0.07 | -0.02 | sell |
| Avoro Capital Advisors LLC | 2,450,000 | 2,900,000 | +450,000 | 1.26 | 1.45 | +0.19 | buy |
| Holocene Advisors, LP | 2,174,602 | 2,853,768 | +679,166 | 0.21 | 0.20 | -0.01 | buy |
| Commodore Capital LP | 1,950,000 | 2,450,000 | +500,000 | 4.74 | 4.95 | +0.20 | buy |
| BANK OF AMERICA CORP /DE/ | 1,507,182 | 2,155,087 | +647,905 | 0.00 | 0.00 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 2,440,283 | 2,109,894 | -330,389 | 0.12 | 0.08 | -0.04 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,047,403 | 2,092,049 | +44,646 | 0.01 | 0.01 | -0.00 | buy |
| Nuveen, LLC | 2,019,668 | 2,048,073 | +28,405 | 0.02 | 0.02 | -0.00 | buy |
| NORGES BANK | 1,916,546 | 1,863,895 | -52,651 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 1,876,890 | 1,813,609 | -63,281 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 2,163,599 | 1,802,052 | -361,547 | 0.01 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 3,096,879 | 1,700,103 | -1,396,776 | 0.02 | 0.01 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 1,472,051 | 1,667,697 | +195,646 | 0.01 | 0.01 | -0.00 | buy |
| Artisan Partners Limited Partnership | 1,636,269 | 1,541,807 | -94,462 | 0.09 | 0.07 | -0.02 | sell |
| Bank of New York Mellon Corp | 1,690,195 | 1,535,886 | -154,309 | 0.01 | 0.01 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 1,621,046 | 1,397,281 | -223,765 | 0.05 | 0.03 | -0.02 | sell |
| Paradigm Biocapital Advisors LP | 0 | 1,375,569 | +1,375,569 | 0.00 | 1.68 | +1.68 | buy |
| UBS Group AG | 3,043,209 | 1,342,402 | -1,700,807 | 0.02 | 0.01 | -0.01 | sell |
| FMR LLC | 1,543,058 | 1,278,006 | -265,052 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 127,990 | 1,135,478 | +1,007,488 | 0.00 | 0.03 | +0.02 | buy |
| Frazier Life Sciences Management, L.P. | 601,129 | 1,000,647 | +399,518 | 0.91 | 1.14 | +0.24 | buy |
| Affinity Asset Advisors, LLC | 1,000,000 | 1,000,000 | 0 | 5.17 | 4.23 | -0.94 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 928,865 | 914,795 | -14,070 | 0.02 | 0.01 | -0.00 | sell |
| Pacer Advisors, Inc. | 890,144 | 906,957 | +16,813 | 0.07 | 0.07 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 859,982 | 877,174 | +17,192 | 0.14 | 0.11 | -0.03 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 792,831 | 826,811 | +33,980 | 0.25 | 0.19 | -0.06 | buy |
| D. E. Shaw & Co., Inc. | 468,481 | 820,096 | +351,615 | 0.02 | 0.02 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 530,772 | 706,007 | +175,235 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 419,951 | 694,122 | +274,171 | 0.01 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 1,389,800 | 691,663 | -698,137 | 0.25 | 0.09 | -0.16 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 881,827 | 687,252 | -194,575 | 0.08 | 0.04 | -0.04 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 482,332 | 671,429 | +189,097 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 567,621 | 656,648 | +89,027 | 0.10 | 0.11 | +0.01 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 585,262 | 636,913 | +51,651 | 0.08 | 0.08 | -0.01 | buy |
| Invesco Ltd. | 735,496 | 613,023 | -122,473 | 0.00 | 0.00 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 528,821 | 593,938 | +65,117 | 0.27 | 0.24 | -0.03 | buy |
| Woodline Partners LP | 744,000 | 558,465 | -185,535 | 0.16 | 0.08 | -0.08 | sell |
| MPM BioImpact LLC | 337,603 | 549,262 | +211,659 | 1.92 | 2.72 | +0.81 | buy |
| Legal & General Group Plc | 552,569 | 535,342 | -17,227 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 477,183 | 503,585 | +26,402 | 0.02 | 0.01 | -0.00 | buy |
| EcoR1 Capital, LLC | 0 | 500,000 | +500,000 | 0.00 | 0.85 | +0.85 | buy |
| RHUMBLINE ADVISERS | 455,197 | 472,857 | +17,660 | 0.01 | 0.01 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 429,482 | 454,417 | +24,935 | 0.01 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 532,265 | 452,522 | -79,743 | 0.02 | 0.01 | -0.01 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 426,585 | 421,885 | -4,700 | 0.83 | 0.65 | -0.18 | sell |
| MACQUARIE GROUP LTD | 300,000 | 374,324 | +74,324 | 0.01 | 0.01 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 305,500 | 370,900 | +65,400 | 0.01 | 0.01 | -0.00 | buy |
| JANE STREET GROUP, LLC | 524,687 | 357,097 | -167,590 | 0.03 | 0.02 | -0.01 | sell |
| STEMPOINT CAPITAL LP | 192,352 | 351,124 | +158,772 | 2.03 | 3.23 | +1.20 | buy |
| TWO SIGMA INVESTMENTS, LP | 557,940 | 325,903 | -232,037 | 0.04 | 0.02 | -0.02 | sell |
| Handelsbanken Fonder AB | 217,000 | 318,400 | +101,400 | 0.03 | 0.03 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 293,190 | 308,542 | +15,352 | 0.01 | 0.01 | -0.00 | buy |
| Swiss National Bank | 297,800 | 299,300 | +1,500 | 0.01 | 0.01 | -0.00 | buy |
| Fisher Asset Management, LLC | 321,681 | 291,947 | -29,734 | 0.00 | 0.00 | -0.00 | sell |
| MACKENZIE FINANCIAL CORP | 237,004 | 290,327 | +53,323 | 0.01 | 0.01 | -0.00 | buy |
| Man Group plc | 135,828 | 275,822 | +139,994 | 0.01 | 0.02 | +0.00 | buy |
| Pictet Asset Management Holding SA | 411,321 | 269,170 | -142,151 | 0.02 | 0.01 | -0.01 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 264,620 | +264,620 | 0.00 | 0.23 | +0.23 | buy |
| C WorldWide Group Holding A/S | 250,000 | 250,000 | 0 | 0.10 | 0.10 | -0.01 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 120,997 | 240,453 | +119,456 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 235,809 | 236,189 | +380 | 0.03 | 0.02 | -0.01 | buy |
| Atle Fund Management AB | 214,778 | 227,224 | +12,446 | 3.13 | 2.78 | -0.35 | buy |
| ROYAL BANK OF CANADA | 275,526 | 226,442 | -49,084 | 0.00 | 0.00 | -0.00 | sell |
| Palo Alto Investors LP | 221,513 | 221,021 | -492 | 1.39 | 1.35 | -0.05 | sell |
| S&CO INC | 221,960 | 220,585 | -1,375 | 0.49 | 0.40 | -0.09 | sell |
| SEI INVESTMENTS CO | 211,997 | 216,906 | +4,909 | 0.01 | 0.01 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 205,642 | 216,442 | +10,800 | 0.01 | 0.01 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 194,992 | 208,088 | +13,096 | 0.01 | 0.01 | -0.00 | buy |
| Krensavage Asset Management, LLC | 207,822 | 207,822 | 0 | 3.79 | 3.15 | -0.65 | hold |
| MARSHALL WACE, LLP | 0 | 207,511 | +207,511 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 232,944 | 204,595 | -28,349 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 232,025 | 204,389 | -27,636 | 0.01 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 228,596 | 202,180 | -26,416 | 0.00 | 0.00 | -0.00 | sell |
| Neuberger Berman Group LLC | 199,977 | 196,331 | -3,646 | 0.01 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 206,835 | 191,448 | -15,387 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 362,385 | 187,846 | -174,539 | 0.01 | 0.00 | -0.01 | sell |
| Aberdeen Group plc | 156,867 | 178,719 | +21,852 | 0.01 | 0.01 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 178,641 | 176,301 | -2,340 | 0.01 | 0.01 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 151,396 | 161,386 | +9,990 | 0.07 | 0.06 | -0.01 | buy |
| Rafferty Asset Management, LLC | 150,448 | 161,285 | +10,837 | 0.02 | 0.02 | -0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 144,931 | 144,931 | 0 | 0.01 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 141,084 | 141,084 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Russell Investments Group, Ltd. | 152,859 | 140,723 | -12,136 | 0.01 | 0.01 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 25,339 | 138,433 | +113,094 | 0.06 | 0.10 | +0.04 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 93,094 | 135,251 | +42,157 | 0.08 | 0.09 | +0.02 | buy |
| Gotham Asset Management, LLC | 79,668 | 133,472 | +53,804 | 0.02 | 0.02 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 99,957 | 131,431 | +31,474 | 0.01 | 0.01 | +0.00 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 117,516 | 128,462 | +10,946 | 0.08 | 0.07 | -0.01 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 126,000 | +126,000 | 0.00 | 0.82 | +0.82 | buy |