| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 28,314,410 | 29,235,739 | +921,329 | 0.02 | 0.02 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 10,012,267 | 10,012,267 | 0 | 2.03 | 2.63 | +0.60 | hold |
| STATE STREET CORP | 9,465,286 | 9,160,575 | -304,711 | 0.01 | 0.01 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,664,576 | 6,737,328 | +2,072,752 | 0.02 | 0.04 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 6,160,428 | 6,460,928 | +300,500 | 0.34 | 0.47 | +0.13 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,182,267 | 4,477,876 | +295,609 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 4,522,378 | 4,194,873 | -327,505 | 0.03 | 0.04 | +0.01 | sell |
| Deep Track Capital, LP | 3,590,323 | 4,000,000 | +409,677 | 2.62 | 3.09 | +0.47 | buy |
| AMERICAN CENTURY COMPANIES INC | 6,072,103 | 3,954,239 | -2,117,864 | 0.11 | 0.09 | -0.02 | sell |
| Holocene Advisors, LP | 2,317,326 | 3,601,472 | +1,284,146 | 0.20 | 0.43 | +0.23 | buy |
| Commodore Capital LP | 4,200,000 | 3,000,000 | -1,200,000 | 8.59 | 9.36 | +0.77 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 2,970,166 | 2,814,804 | -155,362 | 0.02 | 0.03 | +0.01 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 2,539,990 | 2,528,680 | -11,310 | 0.07 | 0.08 | +0.01 | sell |
| FIRST TRUST ADVISORS LP | 2,968,785 | 2,421,016 | -547,769 | 0.08 | 0.07 | -0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 2,335,117 | +2,335,117 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,236,756 | 2,335,117 | +98,361 | 0.01 | 0.02 | +0.00 | buy |
| Nuveen, LLC | 2,460,569 | 2,324,197 | -136,372 | 0.02 | 0.03 | +0.01 | sell |
| NORGES BANK | 0 | 2,156,814 | +2,156,814 | 0.00 | 0.01 | +0.01 | buy |
| BVF INC/IL | 2,000,000 | 2,154,704 | +154,704 | 2.25 | 2.89 | +0.63 | buy |
| GOLDMAN SACHS GROUP INC | 1,882,178 | 2,023,984 | +141,806 | 0.01 | 0.01 | +0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 610,000 | 1,937,938 | +1,327,938 | 1.95 | 6.04 | +4.09 | buy |
| NORTHERN TRUST CORP | 1,697,082 | 1,831,619 | +134,537 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 1,736,091 | 1,751,882 | +15,791 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 1,672,356 | 1,672,356 | 0 | 0.59 | 0.75 | +0.16 | hold |
| CITADEL ADVISORS LLC | 2,241,584 | 1,645,101 | -596,483 | 0.06 | 0.05 | -0.01 | sell |
| LOOMIS SAYLES & CO L P | 1,784,581 | 1,585,518 | -199,063 | 0.08 | 0.10 | +0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,368,000 | +1,368,000 | 0.00 | 0.10 | +0.10 | buy |
| D. E. Shaw & Co., Inc. | 710,297 | 1,312,031 | +601,734 | 0.02 | 0.04 | +0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 791,963 | 1,238,809 | +446,846 | 0.21 | 0.38 | +0.17 | buy |
| FRANKLIN RESOURCES INC | 182,535 | 1,170,242 | +987,707 | 0.00 | 0.01 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 239,671 | 1,159,216 | +919,545 | 0.01 | 0.06 | +0.05 | buy |
| FMR LLC | 1,323,747 | 1,134,410 | -189,337 | 0.00 | 0.00 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 1,350,000 | 1,125,000 | -225,000 | 2.80 | 2.88 | +0.08 | sell |
| Bank of New York Mellon Corp | 1,036,460 | 1,097,282 | +60,822 | 0.01 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 894,276 | 1,090,947 | +196,671 | 0.02 | 0.04 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 780,683 | 1,038,311 | +257,628 | 0.02 | 0.04 | +0.02 | buy |
| Soleus Capital Management, L.P. | 1,970,864 | 1,029,252 | -941,612 | 2.82 | 1.86 | -0.96 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 958,016 | 983,822 | +25,806 | 0.02 | 0.03 | +0.01 | buy |
| MARSHALL WACE, LLP | 999,322 | 969,954 | -29,368 | 0.04 | 0.04 | +0.01 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 950,234 | +950,234 | 0.00 | 1.29 | +1.29 | buy |
| BANK OF AMERICA CORP /DE/ | 1,210,851 | 918,303 | -292,548 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 308,929 | 916,709 | +607,780 | 0.01 | 0.03 | +0.02 | buy |
| Pictet Asset Management Holding SA | 942,184 | 838,026 | -104,158 | 0.03 | 0.04 | +0.01 | sell |
| Artisan Partners Limited Partnership | 1,111,741 | 831,006 | -280,735 | 0.06 | 0.07 | +0.01 | sell |
| PANAGORA ASSET MANAGEMENT INC | 932,942 | 765,543 | -167,399 | 0.12 | 0.12 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 700,647 | 700,647 | 0 | 0.64 | 0.80 | +0.16 | hold |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 677,405 | 677,405 | 0 | 0.07 | 0.09 | +0.02 | hold |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 659,562 | +659,562 | 0.00 | 0.32 | +0.32 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 527,967 | 655,140 | +127,173 | 0.01 | 0.02 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 741,141 | 630,325 | -110,816 | 0.01 | 0.01 | +0.00 | sell |
| Woodline Partners LP | 558,567 | 560,282 | +1,715 | 0.07 | 0.09 | +0.02 | buy |
| MetLife Investment Management, LLC | 88,852 | 512,924 | +424,072 | 0.02 | 0.12 | +0.11 | buy |
| SEGALL BRYANT & HAMILL, LLC | 606,751 | 498,222 | -108,529 | 0.17 | 0.31 | +0.14 | sell |
| Artia Global Partners LP | 0 | 448,964 | +448,964 | 0.00 | 4.47 | +4.47 | buy |
| Invesco Ltd. | 524,275 | 443,107 | -81,168 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 317,434 | 422,761 | +105,327 | 0.00 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 390,479 | 419,102 | +28,623 | 0.00 | 0.01 | +0.00 | buy |
| GENDELL JEFFREY L | 263,604 | 395,882 | +132,278 | 0.13 | 0.19 | +0.06 | buy |
| Prosight Management, LP | 513,632 | 394,389 | -119,243 | 2.98 | 3.56 | +0.58 | sell |
| Legal & General Group Plc | 380,722 | 393,524 | +12,802 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 390,344 | 390,866 | +522 | 0.77 | 1.00 | +0.23 | buy |
| RHUMBLINE ADVISERS | 449,531 | 387,999 | -61,532 | 0.01 | 0.02 | +0.00 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 328,202 | 347,246 | +19,044 | 0.01 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 9,316 | 335,208 | +325,892 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 319,595 | +319,595 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 310,300 | 316,900 | +6,600 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 495,023 | 300,350 | -194,673 | 0.00 | 0.00 | -0.00 | sell |
| Eagle Health Investments LP | 238,673 | 297,302 | +58,629 | 1.77 | 2.58 | +0.81 | buy |
| GW&K Investment Management, LLC | 0 | 292,387 | +292,387 | 0.00 | 0.12 | +0.12 | buy |
| Senator Investment Group LP | 235,000 | 275,000 | +40,000 | 0.38 | 0.53 | +0.14 | buy |
| JPMORGAN CHASE & CO | 4,101,789 | 262,721 | -3,839,068 | 0.01 | 0.00 | -0.01 | sell |
| Neuberger Berman Group LLC | 197,220 | 260,208 | +62,988 | 0.01 | 0.01 | +0.00 | buy |
| C WorldWide Group Holding A/S | 250,000 | 250,000 | 0 | 0.19 | 0.32 | +0.13 | hold |
| STEMPOINT CAPITAL LP | 80,492 | 248,015 | +167,523 | 0.55 | 2.25 | +1.70 | buy |
| S&CO INC | 244,760 | 244,760 | 0 | 0.54 | 0.74 | +0.20 | hold |
| Palo Alto Investors LP | 242,560 | 242,560 | 0 | 1.31 | 1.76 | +0.44 | hold |
| PEREGRINE CAPITAL MANAGEMENT LLC | 244,007 | 232,255 | -11,752 | 0.32 | 0.40 | +0.08 | sell |
| Russell Investments Group, Ltd. | 98,718 | 221,810 | +123,092 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 29,459 | 221,589 | +192,130 | 0.00 | 0.02 | +0.01 | buy |
| BARCLAYS PLC | 174,983 | 219,935 | +44,952 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 260,935 | 217,917 | -43,018 | 0.00 | 0.00 | +0.00 | sell |
| Amundi | 64,710 | 217,739 | +153,029 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 242,473 | 213,329 | -29,144 | 2.66 | 3.01 | +0.35 | sell |
| AQR CAPITAL MANAGEMENT LLC | 383,977 | 212,968 | -171,009 | 0.01 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 183,986 | 199,811 | +15,825 | 0.38 | 0.51 | +0.13 | buy |
| WELLS FARGO & COMPANY/MN | 117,926 | 199,433 | +81,507 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 183,795 | 197,412 | +13,617 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 16,584 | 195,174 | +178,590 | 0.00 | 0.05 | +0.05 | buy |
| Aberdeen Group plc | 0 | 193,805 | +193,805 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 149,734 | 191,316 | +41,582 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 159,791 | 189,979 | +30,188 | 1.11 | 1.62 | +0.51 | buy |
| Rhenman & Partners Asset Management AB | 133,250 | 185,250 | +52,000 | 0.58 | 0.92 | +0.33 | buy |
| CITIGROUP INC | 47,450 | 184,901 | +137,451 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 73,189 | 179,256 | +106,067 | 0.71 | 2.14 | +1.43 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 194,766 | 170,004 | -24,762 | 0.17 | 0.21 | +0.04 | sell |
| SG Americas Securities, LLC | 178,993 | 164,236 | -14,757 | 0.01 | 0.00 | -0.00 | sell |
| BESSEMER GROUP INC | 158,397 | 157,097 | -1,300 | 0.01 | 0.01 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 586,775 | 142,366 | -444,409 | 0.04 | 0.01 | -0.03 | sell |
| SEI INVESTMENTS CO | 153,817 | 141,362 | -12,455 | 0.01 | 0.01 | +0.00 | sell |
| Cinctive Capital Management LP | 0 | 138,603 | +138,603 | 0.00 | 0.29 | +0.29 | buy |