| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RENAISSANCE TECHNOLOGIES LLC | 5,166,413 | 6,116,013 | +949,600 | 0.26 | 0.32 | +0.06 | buy |
| Deep Track Capital, LP | 3,000,000 | 3,800,000 | +800,000 | 4.39 | 4.13 | -0.26 | buy |
| GREAT POINT PARTNERS LLC | 411,453 | 875,044 | +463,591 | 2.58 | 4.61 | +2.03 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 569,800 | 976,200 | +406,400 | 0.17 | 0.27 | +0.10 | buy |
| LOOMIS SAYLES & CO L P | 368,007 | 685,927 | +317,920 | 0.02 | 0.03 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 681,619 | 964,594 | +282,975 | 0.04 | 0.05 | 0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 944,719 | 1,189,189 | +244,470 | 0.08 | 0.10 | 0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 756,401 | 995,227 | +238,826 | 0.03 | 0.03 | 0.00 | buy |
| FIRST TRUST ADVISORS LP | 1,723,569 | 1,487,789 | +235,780 | 0.06 | 0.05 | 0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,659,031 | 1,447,501 | +211,530 | 0.07 | 0.05 | 0.00 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 76,000 | 271,100 | +195,100 | 0.01 | 0.03 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 275,916 | 434,342 | +158,426 | 0.02 | 0.03 | 0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,336,443 | 3,475,694 | +139,251 | 0.01 | 0.01 | 0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,327,889 | 1,461,246 | +133,357 | 0.24 | 0.24 | +0.00 | buy |
| BURNEY CO/ | 48,590 | 177,378 | +128,788 | 0.07 | 0.23 | +0.16 | buy |
| TODD ASSET MANAGEMENT LLC | 12,166 | 111,166 | +99,000 | 0.01 | 0.07 | +0.06 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 44,689 | 126,500 | +81,811 | 0.95 | 2.58 | +1.63 | buy |
| ALGERT GLOBAL LLC | 205,869 | 268,543 | +62,674 | 0.28 | 0.35 | 0.00 | buy |
| PDT Partners, LLC | 10,235 | 72,742 | +62,507 | 0.04 | 0.26 | +0.21 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 632,929 | 586,592 | +46,337 | 0.10 | 0.09 | -0.01 | sell |
| Rafferty Asset Management, LLC | 266,792 | 308,545 | +41,753 | 0.05 | 0.05 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 11,485 | 46,893 | +35,408 | 0.04 | 0.13 | +0.09 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 379,733 | 412,822 | +33,089 | 0.07 | 0.07 | -0.00 | buy |
| Pearl River Capital, LLC | 19,608 | 47,382 | +27,774 | 0.10 | 0.21 | +0.11 | buy |
| Edgestream Partners, L.P. | 13,680 | 33,760 | +20,080 | 0.04 | 0.08 | +0.04 | buy |
| Rhenman & Partners Asset Management AB | 350,000 | 370,000 | +20,000 | 1.15 | 1.12 | -0.04 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 185,384 | 168,825 | +16,559 | 0.01 | 0.01 | -0.00 | sell |
| Strategic Investment Solutions, Inc. /IL | 250 | 15,750 | +15,500 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,509,446 | 1,520,485 | +11,039 | 0.01 | 0.01 | -0.00 | buy |
| PFM Health Sciences, LP | 1,151,384 | 1,162,030 | +10,646 | 1.45 | 1.56 | +0.11 | buy |
| GUGGENHEIM CAPITAL LLC | 65,996 | 76,422 | +10,426 | 0.02 | 0.02 | 0.00 | buy |
| Diversified Trust Co | 31,432 | 40,844 | +9,412 | 0.04 | 0.04 | +0.01 | buy |
| SEGALL BRYANT & HAMILL, LLC | 982,617 | 991,169 | +8,552 | 0.32 | 0.32 | -0.00 | buy |
| GLOBEFLEX CAPITAL L P | 9,930 | 17,966 | +8,036 | 0.03 | 0.06 | +0.02 | buy |
| Swiss National Bank | 322,100 | 328,700 | +6,600 | 0.01 | 0.01 | +0.00 | buy |
| AdvisorShares Investments LLC | 9,797 | 14,461 | +4,664 | 0.09 | 0.11 | +0.02 | buy |
| PROFUND ADVISORS LLC | 50,687 | 54,170 | +3,483 | 0.09 | 0.08 | -0.00 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 12,315 | 15,118 | +2,803 | 0.03 | 0.03 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 13,702 | 16,486 | +2,784 | 0.02 | 0.02 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 27,347 | 30,041 | +2,694 | 0.11 | 0.08 | -0.02 | buy |
| China Universal Asset Management Co., Ltd. | 2,177 | 4,271 | +2,094 | 0.02 | 0.03 | +0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 242,173 | 244,260 | +2,087 | 1.26 | 1.33 | +0.07 | buy |
| INCEPTIONR LLC | 9,961 | 12,022 | +2,061 | 0.17 | 0.19 | +0.02 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 14,633 | 12,630 | +2,003 | 0.00 | 0.00 | 0.00 | sell |
| Paradiem, LLC | 47,684 | 49,628 | +1,944 | 0.43 | 0.42 | -0.01 | buy |
| West Tower Group, LLC | 193 | 1,827 | +1,634 | 0.00 | 0.03 | +0.02 | buy |
| E Fund Management Co., Ltd. | 14,348 | 15,850 | +1,502 | 0.04 | 0.03 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 40,000 | 41,455 | +1,455 | 0.42 | 0.43 | +0.01 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 35,215 | 36,453 | +1,238 | 0.15 | 0.17 | +0.01 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 10,561 | 11,585 | +1,024 | 0.05 | 0.06 | +0.01 | buy |
| Nicollet Investment Management, Inc. | 26,471 | 27,095 | +624 | 0.37 | 0.34 | -0.03 | buy |
| ZACKS INVESTMENT MANAGEMENT | 53,437 | 53,970 | +533 | 0.02 | 0.02 | -0.00 | buy |
| ALPS ADVISORS INC | 122,387 | 122,916 | +529 | 0.03 | 0.03 | -0.00 | buy |
| Advisors Asset Management, Inc. | 25,781 | 25,339 | +442 | 0.02 | 0.02 | 0.00 | sell |
| ProShare Advisors LLC | 32,329 | 32,446 | +117 | 0.00 | 0.00 | 0.00 | buy |
| Raleigh Capital Management Inc. | 309 | 342 | +33 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 84,745 | 84,748 | +3 | 0.05 | 0.05 | -0.00 | buy |
| PERSONAL CFO SOLUTIONS, LLC | 16,006 | 16,000 | -6 | 0.10 | 0.09 | -0.01 | sell |
| Jackson Creek Investment Advisors LLC | 34,863 | 34,845 | -18 | 0.44 | 0.41 | -0.02 | sell |
| Hillsdale Investment Management Inc. | 170,810 | 170,600 | -210 | 0.49 | 0.44 | -0.05 | sell |
| AUXIER ASSET MANAGEMENT | 13,491 | 13,191 | -300 | 0.07 | 0.06 | -0.01 | sell |
| Artisan Partners Limited Partnership | 1,878,411 | 1,877,731 | -680 | 0.09 | 0.09 | -0.01 | sell |
| Bridgewater Associates, LP | 34,268 | 32,901 | -1,367 | 0.01 | 0.01 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 56,869 | 54,771 | -2,098 | 0.00 | 0.00 | -0.00 | sell |
| Aristides Capital LLC | 10,200 | 7,200 | -3,000 | 0.19 | 0.13 | -0.05 | sell |
| Bleakley Financial Group, LLC | 16,115 | 13,060 | -3,055 | 0.02 | 0.01 | -0.00 | sell |
| EFG Asset Management (North America) Corp. | 61,242 | 55,904 | -5,338 | 0.41 | 0.37 | -0.04 | sell |
| AGF MANAGEMENT LTD | 117,408 | 111,503 | -5,905 | 0.03 | 0.02 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 17,839 | 11,496 | -6,343 | 0.11 | 0.07 | -0.04 | sell |
| Integral Health Asset Management, LLC | 284,000 | 275,000 | -9,000 | 1.17 | 1.09 | -0.07 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 25,675 | 11,293 | -14,382 | 0.23 | 0.09 | -0.13 | sell |
| Knott David M Jr | 67,000 | 22,491 | -44,509 | 0.83 | 0.24 | -0.59 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 721,138 | 658,361 | -62,777 | 0.16 | 0.13 | -0.03 | sell |
| Prosight Management, LP | 147,554 | 65,000 | -82,554 | 1.35 | 0.58 | -0.78 | sell |
| ARMISTICE CAPITAL, LLC | 2,000,000 | 1,896,775 | -103,225 | 1.57 | 1.58 | +0.01 | sell |
| Soleus Capital Management, L.P. | 194,400 | 54,400 | -140,000 | 0.68 | 0.15 | -0.52 | sell |
| Hardman Johnston Global Advisors LLC | 5,762,556 | 5,608,064 | -154,492 | 5.85 | 5.27 | -0.58 | sell |
| Krensavage Asset Management, LLC | 1,103,451 | 906,060 | -197,391 | 10.94 | 9.34 | -1.60 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 4,126,240 | 3,882,230 | -244,010 | 0.11 | 0.09 | -0.02 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 2,315,310 | 1,669,613 | -645,697 | 0.46 | 0.32 | -0.14 | sell |
| Polar Capital Holdings Plc | 2,888,016 | 1,388,016 | -1,500,000 | 0.62 | 0.29 | -0.33 | sell |
| Sarissa Capital Management LP | 14,040,000 | 7,042,200 | -6,997,800 | 43.75 | 26.57 | -17.18 | sell |