| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 6,410,603 | 8,091,351 | +1,680,748 | 1.78 | 1.75 | -0.03 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 103,278 | 1,208,944 | +1,105,666 | 0.00 | 0.02 | +0.02 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 901,333 | +901,333 | 0.00 | 0.18 | +0.18 | buy |
| AMERICAN CENTURY COMPANIES INC | 3,657,223 | 4,397,471 | +740,248 | 0.06 | 0.07 | +0.01 | buy |
| Sio Capital Management, LLC | 0 | 674,840 | +674,840 | 0.00 | 5.12 | +5.12 | buy |
| CITADEL ADVISORS LLC | 37,423 | 704,834 | +667,411 | 0.00 | 0.02 | +0.02 | buy |
| Commodore Capital LP | 2,450,000 | 3,096,754 | +646,754 | 4.95 | 4.54 | -0.41 | buy |
| Pictet Asset Management Holding SA | 269,170 | 893,046 | +623,876 | 0.01 | 0.03 | +0.02 | buy |
| Man Group plc | 275,822 | 897,274 | +621,452 | 0.02 | 0.05 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 3,096,637 | 3,697,996 | +601,359 | 0.02 | 0.02 | +0.00 | buy |
| Artisan Partners Limited Partnership | 1,541,807 | 2,109,772 | +567,965 | 0.07 | 0.09 | +0.03 | buy |
| Allianz Asset Management GmbH | 13,093 | 524,795 | +511,702 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 5,810,160 | 6,292,528 | +482,368 | 0.22 | 0.25 | +0.03 | buy |
| Opaleye Management Inc. | 0 | 450,000 | +450,000 | 0.00 | 1.91 | +1.91 | buy |
| Squarepoint Ops LLC | 49,267 | 445,306 | +396,039 | 0.00 | 0.03 | +0.03 | buy |
| Paradigm Biocapital Advisors LP | 1,375,569 | 1,719,334 | +343,765 | 1.68 | 1.53 | -0.15 | buy |
| STATE STREET CORP | 8,208,256 | 8,540,351 | +332,095 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 325,903 | 656,499 | +330,596 | 0.02 | 0.03 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,667,697 | 1,994,945 | +327,248 | 0.01 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 1,000,000 | 1,250,000 | +250,000 | 4.23 | 3.49 | -0.74 | buy |
| TWO SIGMA ADVISERS, LP | 7,800 | 205,200 | +197,400 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,041,900 | 10,238,357 | +196,457 | 0.03 | 0.03 | +0.00 | buy |
| ROYAL BANK OF CANADA | 226,442 | 419,290 | +192,848 | 0.00 | 0.00 | +0.00 | buy |
| Edgestream Partners, L.P. | 73,898 | 259,411 | +185,513 | 0.06 | 0.23 | +0.17 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 180,513 | +180,513 | 0.00 | 0.78 | +0.78 | buy |
| MACKENZIE FINANCIAL CORP | 290,327 | 442,350 | +152,023 | 0.01 | 0.02 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 204,595 | 344,490 | +139,895 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 131,431 | 264,446 | +133,015 | 0.01 | 0.03 | +0.01 | buy |
| Nuveen, LLC | 2,048,073 | 2,173,476 | +125,403 | 0.02 | 0.02 | +0.00 | buy |
| BlackRock, Inc. | 27,856,163 | 27,972,078 | +115,915 | 0.02 | 0.01 | -0.00 | buy |
| Rock Springs Capital Management LP | 0 | 106,537 | +106,537 | 0.00 | 0.19 | +0.19 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 240,453 | 344,202 | +103,749 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 94,011 | 184,346 | +90,335 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 161,386 | 249,727 | +88,341 | 0.06 | 0.10 | +0.05 | buy |
| Eagle Health Investments LP | 0 | 81,800 | +81,800 | 0.00 | 0.64 | +0.64 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 39,929 | 120,959 | +81,030 | 0.01 | 0.04 | +0.02 | buy |
| TFG Asset Management GP Ltd | 15,632 | 89,612 | +73,980 | 0.08 | 0.39 | +0.31 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 636,913 | 710,700 | +73,787 | 0.08 | 0.08 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 72,079 | +72,079 | 0.00 | 1.51 | +1.51 | buy |
| MILLENNIUM MANAGEMENT LLC | 77,939 | 147,460 | +69,521 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 56,383 | +56,383 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 39,000 | 94,000 | +55,000 | 0.14 | 0.31 | +0.17 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 141,084 | 195,999 | +54,915 | 0.01 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 656,648 | 707,196 | +50,548 | 0.11 | 0.10 | -0.01 | buy |
| GLOBEFLEX CAPITAL L P | 15,793 | 66,218 | +50,425 | 0.04 | 0.31 | +0.27 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,092,049 | 2,140,373 | +48,324 | 0.01 | 0.01 | -0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 370,900 | 415,800 | +44,900 | 0.01 | 0.01 | -0.00 | buy |
| XTX Topco Ltd | 0 | 44,628 | +44,628 | 0.00 | 0.07 | +0.07 | buy |
| Russell Investments Group, Ltd. | 140,723 | 179,465 | +38,742 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,023,552 | 4,061,394 | +37,842 | 0.01 | 0.01 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 202,180 | 238,539 | +36,359 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 47,594 | 83,157 | +35,563 | 0.02 | 0.03 | +0.01 | buy |
| JANE STREET GROUP, LLC | 357,097 | 392,181 | +35,084 | 0.02 | 0.01 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 97,350 | 131,696 | +34,346 | 0.00 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 176,301 | 209,826 | +33,525 | 0.01 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 53,200 | 85,535 | +32,335 | 0.01 | 0.01 | +0.00 | buy |
| DAFNA Capital Management LLC | 103,748 | 134,748 | +31,000 | 0.82 | 1.00 | +0.18 | buy |
| Fisher Asset Management, LLC | 291,947 | 322,748 | +30,801 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 503,585 | 533,650 | +30,065 | 0.01 | 0.02 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 135,251 | 165,110 | +29,859 | 0.09 | 0.12 | +0.03 | buy |
| OMERS ADMINISTRATION Corp | 0 | 29,500 | +29,500 | 0.00 | 0.01 | +0.01 | buy |
| Atle Fund Management AB | 227,224 | 252,875 | +25,651 | 2.78 | 2.99 | +0.20 | buy |
| Entropy Technologies, LP | 0 | 23,291 | +23,291 | 0.00 | 0.05 | +0.05 | buy |
| Assenagon Asset Management S.A. | 84,017 | 106,561 | +22,544 | 0.00 | 0.00 | +0.00 | buy |
| Vident Advisory, LLC | 59,576 | 81,430 | +21,854 | 0.02 | 0.02 | +0.00 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 0 | 21,081 | +21,081 | 0.00 | 0.01 | +0.01 | buy |
| Robeco Institutional Asset Management B.V. | 113,320 | 134,387 | +21,067 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 115,270 | 135,970 | +20,700 | 0.07 | 0.07 | -0.00 | buy |
| Summit Global Investments | 0 | 19,938 | +19,938 | 0.00 | 0.03 | +0.03 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 25,789 | 44,759 | +18,970 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 161,285 | 179,902 | +18,617 | 0.02 | 0.02 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 18,277 | +18,277 | 0.00 | 0.00 | +0.00 | buy |
| GC Wealth Management RIA, LLC | 0 | 18,041 | +18,041 | 0.00 | 0.02 | +0.02 | buy |
| FMR LLC | 1,278,006 | 1,295,493 | +17,487 | 0.00 | 0.00 | -0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 3,342 | 20,367 | +17,025 | 0.00 | 0.00 | +0.00 | buy |
| Round Rock Advisors, LLC | 0 | 16,590 | +16,590 | 0.00 | 0.08 | +0.08 | buy |
| Persistent Asset Partners Ltd | 0 | 16,541 | +16,541 | 0.00 | 0.36 | +0.36 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 123,665 | 139,166 | +15,501 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 191,448 | 206,422 | +14,974 | 0.00 | 0.00 | +0.00 | buy |
| LSV ASSET MANAGEMENT | 0 | 14,800 | +14,800 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 14,667 | +14,667 | 0.00 | 0.01 | +0.01 | buy |
| Marex Group plc | 0 | 14,100 | +14,100 | 0.00 | 0.01 | +0.01 | buy |
| Handelsbanken Fonder AB | 318,400 | 332,100 | +13,700 | 0.03 | 0.03 | -0.00 | buy |
| Neo Ivy Capital Management | 16,150 | 29,756 | +13,606 | 0.15 | 0.22 | +0.07 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 128,462 | 141,090 | +12,628 | 0.07 | 0.07 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 308,542 | 320,879 | +12,337 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 45,000 | 56,200 | +11,200 | 0.21 | 0.17 | -0.04 | buy |
| State of New Jersey Common Pension Fund D | 62,677 | 73,196 | +10,519 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 122,258 | 132,619 | +10,361 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 33,663 | 43,845 | +10,182 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 877,174 | 887,197 | +10,023 | 0.11 | 0.11 | -0.01 | buy |
| Cetera Investment Advisers | 13,907 | 23,504 | +9,597 | 0.00 | 0.00 | +0.00 | buy |
| Vinva Investment Management Ltd | 0 | 9,259 | +9,259 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 48,506 | 57,639 | +9,133 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 16,675 | 25,649 | +8,974 | 0.09 | 0.13 | +0.04 | buy |
| SEI INVESTMENTS CO | 216,906 | 225,807 | +8,901 | 0.01 | 0.01 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 36,833 | 45,302 | +8,469 | 0.01 | 0.01 | +0.00 | buy |
| Financiere des Professionnels - Fonds d,investissement inc. | 7,438 | 15,607 | +8,169 | 0.01 | 0.03 | +0.01 | buy |
| Bayesian Capital Management, LP | 0 | 8,074 | +8,074 | 0.00 | 0.05 | +0.05 | buy |
| Sequoia Financial Advisors, LLC | 0 | 7,793 | +7,793 | 0.00 | 0.00 | +0.00 | buy |