| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 27,856,163 | 27,972,078 | +115,915 | 0.02 | 0.01 | -0.00 | buy |
| VANGUARD GROUP INC | 18,503,074 | 18,179,511 | -323,563 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,041,900 | 10,238,357 | +196,457 | 0.03 | 0.03 | +0.00 | buy |
| STATE STREET CORP | 8,208,256 | 8,540,351 | +332,095 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 6,410,603 | 8,091,351 | +1,680,748 | 1.78 | 1.75 | -0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 5,810,160 | 6,292,528 | +482,368 | 0.22 | 0.25 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 3,657,223 | 4,397,471 | +740,248 | 0.06 | 0.07 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,023,552 | 4,061,394 | +37,842 | 0.01 | 0.01 | -0.00 | buy |
| JPMORGAN CHASE & CO | 4,836,294 | 3,928,170 | -908,124 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 3,096,637 | 3,697,996 | +601,359 | 0.02 | 0.02 | +0.00 | buy |
| Commodore Capital LP | 2,450,000 | 3,096,754 | +646,754 | 4.95 | 4.54 | -0.41 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 2,902,510 | 2,759,080 | -143,430 | 0.07 | 0.06 | -0.00 | sell |
| Holocene Advisors, LP | 2,853,768 | 2,469,030 | -384,738 | 0.20 | 0.17 | -0.03 | sell |
| Avoro Capital Advisors LLC | 2,900,000 | 2,240,000 | -660,000 | 1.45 | 0.87 | -0.58 | sell |
| Nuveen, LLC | 2,048,073 | 2,173,476 | +125,403 | 0.02 | 0.02 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,092,049 | 2,140,373 | +48,324 | 0.01 | 0.01 | -0.00 | buy |
| Artisan Partners Limited Partnership | 1,541,807 | 2,109,772 | +567,965 | 0.07 | 0.09 | +0.03 | buy |
| LOOMIS SAYLES & CO L P | 2,109,894 | 2,048,851 | -61,043 | 0.08 | 0.07 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,667,697 | 1,994,945 | +327,248 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,813,609 | 1,766,180 | -47,429 | 0.01 | 0.01 | -0.00 | sell |
| Paradigm Biocapital Advisors LP | 1,375,569 | 1,719,334 | +343,765 | 1.68 | 1.53 | -0.15 | buy |
| RTW INVESTMENTS, LP | 4,682,289 | 1,672,356 | -3,009,933 | 1.91 | 0.62 | -1.29 | sell |
| MORGAN STANLEY | 1,802,052 | 1,551,499 | -250,553 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 1,535,886 | 1,424,466 | -111,420 | 0.01 | 0.01 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 1,397,281 | 1,398,021 | +740 | 0.03 | 0.03 | -0.00 | buy |
| FMR LLC | 1,278,006 | 1,295,493 | +17,487 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 1,000,000 | 1,250,000 | +250,000 | 4.23 | 3.49 | -0.74 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 103,278 | 1,208,944 | +1,105,666 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 2,155,087 | 1,096,455 | -1,058,632 | 0.00 | 0.00 | -0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 901,333 | +901,333 | 0.00 | 0.18 | +0.18 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 914,795 | 900,330 | -14,465 | 0.01 | 0.01 | -0.00 | sell |
| Man Group plc | 275,822 | 897,274 | +621,452 | 0.02 | 0.05 | +0.03 | buy |
| Pictet Asset Management Holding SA | 269,170 | 893,046 | +623,876 | 0.01 | 0.03 | +0.02 | buy |
| PANAGORA ASSET MANAGEMENT INC | 877,174 | 887,197 | +10,023 | 0.11 | 0.11 | -0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 826,811 | 827,473 | +662 | 0.19 | 0.18 | -0.01 | buy |
| Pacer Advisors, Inc. | 906,957 | 808,132 | -98,825 | 0.07 | 0.06 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,135,478 | 761,203 | -374,275 | 0.03 | 0.02 | -0.01 | sell |
| UBS Group AG | 1,342,402 | 754,166 | -588,236 | 0.01 | 0.00 | -0.00 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 636,913 | 710,700 | +73,787 | 0.08 | 0.08 | +0.00 | buy |
| MetLife Investment Management, LLC | 656,648 | 707,196 | +50,548 | 0.11 | 0.10 | -0.01 | buy |
| CITADEL ADVISORS LLC | 37,423 | 704,834 | +667,411 | 0.00 | 0.02 | +0.02 | buy |
| Frazier Life Sciences Management, L.P. | 1,000,647 | 700,647 | -300,000 | 1.14 | 0.63 | -0.51 | sell |
| Sio Capital Management, LLC | 0 | 674,840 | +674,840 | 0.00 | 5.12 | +5.12 | buy |
| TWO SIGMA INVESTMENTS, LP | 325,903 | 656,499 | +330,596 | 0.02 | 0.03 | +0.01 | buy |
| SEGALL BRYANT & HAMILL, LLC | 593,938 | 596,479 | +2,541 | 0.24 | 0.24 | -0.00 | buy |
| Invesco Ltd. | 613,023 | 584,293 | -28,730 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 687,252 | 568,675 | -118,577 | 0.04 | 0.03 | -0.01 | sell |
| Woodline Partners LP | 558,465 | 558,567 | +102 | 0.08 | 0.08 | -0.01 | buy |
| AMERIPRISE FINANCIAL INC | 706,007 | 557,866 | -148,141 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 694,122 | 556,651 | -137,471 | 0.01 | 0.01 | -0.00 | sell |
| MPM BioImpact LLC | 549,262 | 549,262 | 0 | 2.72 | 2.70 | -0.03 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 503,585 | 533,650 | +30,065 | 0.01 | 0.02 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 820,096 | 528,749 | -291,347 | 0.02 | 0.01 | -0.01 | sell |
| Allianz Asset Management GmbH | 13,093 | 524,795 | +511,702 | 0.00 | 0.02 | +0.02 | buy |
| EcoR1 Capital, LLC | 500,000 | 500,000 | 0 | 0.85 | 0.72 | -0.13 | hold |
| Legal & General Group Plc | 535,342 | 499,623 | -35,719 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 472,857 | 473,837 | +980 | 0.01 | 0.01 | -0.00 | buy |
| Glenmede Investment Management, LP | 483,363 | 455,641 | -27,722 | 0.07 | 0.07 | -0.00 | sell |
| Opaleye Management Inc. | 0 | 450,000 | +450,000 | 0.00 | 1.91 | +1.91 | buy |
| RAYMOND JAMES FINANCIAL INC | 454,417 | 446,925 | -7,492 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 49,267 | 445,306 | +396,039 | 0.00 | 0.03 | +0.03 | buy |
| MACKENZIE FINANCIAL CORP | 290,327 | 442,350 | +152,023 | 0.01 | 0.02 | +0.01 | buy |
| ROYAL BANK OF CANADA | 226,442 | 419,290 | +192,848 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 370,900 | 415,800 | +44,900 | 0.01 | 0.01 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 671,429 | 392,427 | -279,002 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 357,097 | 392,181 | +35,084 | 0.02 | 0.01 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 421,885 | 385,342 | -36,543 | 0.65 | 0.63 | -0.02 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,700,103 | 375,190 | -1,324,913 | 0.01 | 0.00 | -0.01 | sell |
| MACQUARIE GROUP LTD | 374,324 | 372,890 | -1,434 | 0.01 | 0.01 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 452,522 | 372,422 | -80,100 | 0.01 | 0.01 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 204,595 | 344,490 | +139,895 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 240,453 | 344,202 | +103,749 | 0.00 | 0.01 | +0.00 | buy |
| Handelsbanken Fonder AB | 318,400 | 332,100 | +13,700 | 0.03 | 0.03 | -0.00 | buy |
| Fisher Asset Management, LLC | 291,947 | 322,748 | +30,801 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 308,542 | 320,879 | +12,337 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 299,300 | 303,600 | +4,300 | 0.01 | 0.01 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 131,431 | 264,446 | +133,015 | 0.01 | 0.03 | +0.01 | buy |
| Edgestream Partners, L.P. | 73,898 | 259,411 | +185,513 | 0.06 | 0.23 | +0.17 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 264,620 | 257,795 | -6,825 | 0.23 | 0.23 | +0.00 | sell |
| Atle Fund Management AB | 227,224 | 252,875 | +25,651 | 2.78 | 2.99 | +0.20 | buy |
| C WorldWide Group Holding A/S | 250,000 | 250,000 | 0 | 0.10 | 0.12 | +0.02 | hold |
| ExodusPoint Capital Management, LP | 161,386 | 249,727 | +88,341 | 0.06 | 0.10 | +0.05 | buy |
| STEMPOINT CAPITAL LP | 351,124 | 241,637 | -109,487 | 3.23 | 1.46 | -1.77 | sell |
| ALLIANCEBERNSTEIN L.P. | 202,180 | 238,539 | +36,359 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 216,906 | 225,807 | +8,901 | 0.01 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 176,301 | 209,826 | +33,525 | 0.01 | 0.01 | +0.00 | buy |
| Krensavage Asset Management, LLC | 207,822 | 207,822 | 0 | 3.15 | 2.66 | -0.49 | hold |
| DEUTSCHE BANK AG\ | 191,448 | 206,422 | +14,974 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 7,800 | 205,200 | +197,400 | 0.00 | 0.01 | +0.01 | buy |
| S&CO INC | 220,585 | 201,210 | -19,375 | 0.40 | 0.37 | -0.04 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 141,084 | 195,999 | +54,915 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 94,011 | 184,346 | +90,335 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 221,021 | 183,938 | -37,083 | 1.35 | 1.02 | -0.32 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 180,513 | +180,513 | 0.00 | 0.78 | +0.78 | buy |
| Rafferty Asset Management, LLC | 161,285 | 179,902 | +18,617 | 0.02 | 0.02 | +0.00 | buy |
| Russell Investments Group, Ltd. | 140,723 | 179,465 | +38,742 | 0.01 | 0.01 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 135,251 | 165,110 | +29,859 | 0.09 | 0.12 | +0.03 | buy |
| Neuberger Berman Group LLC | 196,331 | 152,721 | -43,610 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 144,931 | 148,909 | +3,978 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 77,939 | 147,460 | +69,521 | 0.00 | 0.00 | +0.00 | buy |