| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 0 | 2,450,000 | +2,450,000 | 0.00 | 1.00 | +1.00 | buy |
| Camber Capital Management LP | 200,000 | 1,500,000 | +1,300,000 | 0.22 | 1.69 | +1.47 | buy |
| RTW INVESTMENTS, LP | 6,654,033 | 7,557,835 | +903,802 | 2.69 | 3.29 | +0.59 | buy |
| Sofinnova Investments, Inc. | 0 | 894,266 | +894,266 | 0.00 | 1.89 | +1.89 | buy |
| JPMORGAN CHASE & CO | 359,510 | 889,472 | +529,962 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 500,000 | +500,000 | 0.00 | 1.68 | +1.68 | buy |
| LOOMIS SAYLES & CO L P | 1,882,936 | 2,302,905 | +419,969 | 0.07 | 0.08 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 48,918 | 416,968 | +368,050 | 0.41 | 3.01 | +2.60 | buy |
| Holocene Advisors, LP | 0 | 257,903 | +257,903 | 0.00 | 0.02 | +0.02 | buy |
| C WorldWide Group Holding A/S | 0 | 250,000 | +250,000 | 0.00 | 0.09 | +0.09 | buy |
| AMERICAN CENTURY COMPANIES INC | 3,240,967 | 3,450,707 | +209,740 | 0.05 | 0.06 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 186,885 | +186,885 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,744,680 | 1,912,132 | +167,452 | 0.01 | 0.01 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,890,807 | 3,019,508 | +128,701 | 0.02 | 0.02 | +0.00 | buy |
| CITIGROUP INC | 224,858 | 331,668 | +106,810 | 0.01 | 0.01 | +0.00 | buy |
| PHILADELPHIA TRUST CO | 0 | 100,000 | +100,000 | 0.00 | 0.21 | +0.21 | buy |
| Affinity Asset Advisors, LLC | 1,000,000 | 1,100,000 | +100,000 | 4.34 | 4.94 | +0.60 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 86,899 | +86,899 | 0.00 | 0.04 | +0.04 | buy |
| ROYAL BANK OF CANADA | 48,414 | 126,830 | +78,416 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 260,785 | 331,359 | +70,574 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 149,493 | 217,980 | +68,487 | 0.00 | 0.00 | +0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 67,200 | +67,200 | 0.00 | 0.57 | +0.57 | buy |
| JANE STREET GROUP, LLC | 261,628 | 327,841 | +66,213 | 0.01 | 0.02 | +0.00 | buy |
| Quantedge Capital Pte Ltd | 0 | 57,900 | +57,900 | 0.00 | 0.61 | +0.61 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 5,421,031 | 5,478,728 | +57,697 | 0.23 | 0.23 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 405,382 | 462,241 | +56,859 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 54,446 | +54,446 | 0.00 | 0.58 | +0.58 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 12,690 | 66,862 | +54,172 | 0.08 | 0.35 | +0.27 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 349,417 | 403,103 | +53,686 | 0.05 | 0.05 | -0.00 | buy |
| Artisan Partners Limited Partnership | 1,938,326 | 1,988,796 | +50,470 | 0.08 | 0.09 | +0.01 | buy |
| EFG Asset Management (North America) Corp. | 81,761 | 129,662 | +47,901 | 0.38 | 0.51 | +0.13 | buy |
| IEQ CAPITAL, LLC | 0 | 36,763 | +36,763 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 189,650 | 223,069 | +33,419 | 0.02 | 0.02 | -0.00 | buy |
| Proficio Capital Partners LLC | 0 | 32,700 | +32,700 | 0.00 | 0.00 | +0.00 | buy |
| VAN ECK ASSOCIATES CORP | 104,986 | 137,567 | +32,581 | 0.00 | 0.01 | +0.00 | buy |
| Atle Fund Management AB | 236,610 | 266,499 | +29,889 | 3.11 | 3.64 | +0.52 | buy |
| MACKENZIE FINANCIAL CORP | 305,022 | 332,626 | +27,604 | 0.01 | 0.01 | -0.01 | buy |
| MACKENZIE FINANCIAL CORP | 305,022 | 332,626 | +27,604 | 0.01 | 0.01 | -0.01 | buy |
| Robeco Institutional Asset Management B.V. | 95,509 | 122,489 | +26,980 | 0.01 | 0.01 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 576,129 | 601,129 | +25,000 | 0.65 | 0.72 | +0.07 | buy |
| WELLS FARGO & COMPANY/MN | 69,041 | 94,020 | +24,979 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 877,943 | 899,764 | +21,821 | 0.01 | 0.01 | +0.00 | buy |
| Virtu Financial LLC | 0 | 21,783 | +21,783 | 0.00 | 0.03 | +0.03 | buy |
| Creative Planning | 50,629 | 71,452 | +20,823 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 17,574 | +17,574 | 0.00 | 0.14 | +0.14 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 17,120 | +17,120 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 13,129 | 29,663 | +16,534 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,190 | 20,674 | +16,484 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 18,870 | 34,966 | +16,096 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 52,273 | 68,151 | +15,878 | 0.02 | 0.02 | +0.00 | buy |
| Jump Financial, LLC | 0 | 15,739 | +15,739 | 0.00 | 0.01 | +0.01 | buy |
| SYON CAPITAL LLC | 0 | 15,443 | +15,443 | 0.00 | 0.04 | +0.04 | buy |
| CIBC WORLD MARKETS CORP | 0 | 15,070 | +15,070 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 14,373 | +14,373 | 0.00 | 0.03 | +0.03 | buy |
| Pathstone Holdings, LLC | 71,324 | 84,992 | +13,668 | 0.01 | 0.01 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 36,490 | 49,922 | +13,432 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 43,937 | 56,211 | +12,274 | 0.00 | 0.00 | +0.00 | buy |
| INCEPTIONR LLC | 0 | 11,022 | +11,022 | 0.00 | 0.07 | +0.07 | buy |
| Legal & General Group Plc | 563,666 | 574,248 | +10,582 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 286,300 | 295,600 | +9,300 | 0.01 | 0.01 | +0.00 | buy |
| TOWNSQUARE CAPITAL LLC | 0 | 9,123 | +9,123 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 8,582 | +8,582 | 0.00 | 0.00 | +0.00 | buy |
| Gallacher Capital Management LLC | 0 | 7,568 | +7,568 | 0.00 | 0.11 | +0.11 | buy |
| Sequoia Financial Advisors, LLC | 0 | 7,474 | +7,474 | 0.00 | 0.00 | +0.00 | buy |
| Cornerstone Investment Partners, LLC | 0 | 7,058 | +7,058 | 0.00 | 0.01 | +0.01 | buy |
| State of New Jersey Common Pension Fund D | 69,575 | 76,389 | +6,814 | 0.01 | 0.01 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 10,034 | 16,107 | +6,073 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 40,320 | 46,338 | +6,018 | 0.01 | 0.00 | -0.00 | buy |
| New Age Alpha Advisors, LLC | 0 | 5,937 | +5,937 | 0.00 | 0.01 | +0.01 | buy |
| CWM, LLC | 14,547 | 20,364 | +5,817 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 8,290 | 13,171 | +4,881 | 0.04 | 0.07 | +0.03 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 137,681 | 142,480 | +4,799 | 0.01 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 126,222 | 130,838 | +4,616 | 0.02 | 0.02 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 33,892 | 38,336 | +4,444 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 38,131 | 42,509 | +4,378 | 0.03 | 0.03 | +0.00 | buy |
| Bleakley Financial Group, LLC | 11,514 | 15,849 | +4,335 | 0.01 | 0.01 | +0.00 | buy |
| HighTower Advisors, LLC | 12,274 | 16,543 | +4,269 | 0.00 | 0.00 | +0.00 | buy |
| Advisors Asset Management, Inc. | 10,158 | 14,144 | +3,986 | 0.01 | 0.01 | +0.00 | buy |
| Vestcor Inc | 9,539 | 13,377 | +3,838 | 0.01 | 0.01 | +0.00 | buy |
| CHOREO, LLC | 19,985 | 23,722 | +3,737 | 0.01 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 93,203 | 96,695 | +3,492 | 0.01 | 0.02 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 44,415 | 47,594 | +3,179 | 0.00 | 0.00 | +0.00 | buy |
| Vise Technologies, Inc. | 17,046 | 19,801 | +2,755 | 0.06 | 0.05 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 31,671 | 34,308 | +2,637 | 0.10 | 0.09 | -0.01 | buy |
| Smartleaf Asset Management LLC | 448 | 2,950 | +2,502 | 0.00 | 0.01 | +0.01 | buy |
| NISA INVESTMENT ADVISORS, LLC | 91,159 | 93,532 | +2,373 | 0.02 | 0.01 | -0.00 | buy |
| KBC Group NV | 4,890 | 7,176 | +2,286 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 15,696 | 17,930 | +2,234 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 423,931 | 425,777 | +1,846 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 463,031 | 464,714 | +1,683 | 0.01 | 0.01 | +0.00 | buy |
| Blue Trust, Inc. | 73 | 1,702 | +1,629 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 16,743 | 18,362 | +1,619 | 0.00 | 0.00 | +0.00 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 110,454 | 111,909 | +1,455 | 0.05 | 0.06 | +0.00 | buy |
| EVERGREEN CAPITAL MANAGEMENT LLC | 9,009 | 10,181 | +1,172 | 0.01 | 0.01 | +0.00 | buy |
| Savant Capital, LLC | 9,923 | 11,075 | +1,152 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 9,444 | 10,577 | +1,133 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 195,743 | 196,831 | +1,088 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 741,680 | 742,716 | +1,036 | 0.18 | 0.14 | -0.03 | buy |
| Moors & Cabot, Inc. | 7,969 | 8,997 | +1,028 | 0.01 | 0.01 | +0.00 | buy |
| Cetera Investment Advisers | 9,646 | 10,645 | +999 | 0.00 | 0.00 | +0.00 | buy |