| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Camber Capital Management LP | 200,000 | 1,500,000 | +1,300,000 | 0.18 | 1.00 | +0.82 | buy |
| RTW INVESTMENTS, LP | 6,654,033 | 7,557,835 | +903,802 | 2.69 | 3.29 | +0.59 | buy |
| LOOMIS SAYLES & CO L P | 1,882,936 | 2,302,905 | +419,969 | 0.07 | 0.08 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 48,918 | 416,968 | +368,050 | 0.41 | 3.01 | +2.60 | buy |
| FIRST TRUST ADVISORS LP | 1,781,135 | 1,493,651 | +287,484 | 0.05 | 0.04 | 0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 3,240,967 | 3,450,707 | +209,740 | 0.06 | 0.06 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 1,000,000 | 1,100,000 | +100,000 | 4.34 | 4.94 | +0.60 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 136,697 | 45,925 | +90,772 | 0.02 | 0.01 | 0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 405,659 | 328,520 | +77,139 | 0.03 | 0.02 | 0.00 | sell |
| Fisher Asset Management, LLC | 260,785 | 331,359 | +70,574 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 265,990 | 197,631 | +68,359 | 0.01 | 0.01 | 0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 5,421,031 | 5,478,728 | +57,697 | 0.25 | 0.26 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,873,927 | 3,818,649 | +55,278 | 0.01 | 0.01 | 0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 12,690 | 66,862 | +54,172 | 0.08 | 0.35 | +0.27 | buy |
| Artisan Partners Limited Partnership | 1,938,326 | 1,988,796 | +50,470 | 0.08 | 0.09 | +0.01 | buy |
| EFG Asset Management (North America) Corp. | 81,761 | 129,662 | +47,901 | 0.38 | 0.51 | +0.13 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 49,961 | 9,710 | +40,251 | 0.11 | 0.02 | 0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 90,994 | 57,359 | +33,635 | 0.02 | 0.01 | 0.00 | sell |
| Atle Fund Management AB | 236,610 | 266,499 | +29,889 | 3.11 | 3.64 | +0.52 | buy |
| Robeco Institutional Asset Management B.V. | 95,509 | 122,489 | +26,980 | 0.01 | 0.01 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 576,129 | 601,129 | +25,000 | 0.65 | 0.72 | +0.07 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 877,943 | 899,764 | +21,821 | 0.01 | 0.01 | 0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 831,250 | 811,541 | +19,709 | 0.03 | 0.03 | 0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 52,273 | 68,151 | +15,878 | 0.02 | 0.02 | +0.00 | buy |
| ProShare Advisors LLC | 43,937 | 56,211 | +12,274 | 0.00 | 0.00 | 0.00 | buy |
| Legal & General Group Plc | 563,666 | 574,248 | +10,582 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 56,916 | 47,344 | +9,572 | 0.06 | 0.05 | 0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 286,300 | 295,600 | +9,300 | 0.01 | 0.01 | 0.00 | buy |
| Corebridge Financial, Inc. | 94,102 | 85,767 | +8,335 | 0.01 | 0.01 | 0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 152,295 | 146,628 | +5,667 | 0.01 | 0.01 | -0.00 | sell |
| AdvisorShares Investments LLC | 8,290 | 13,171 | +4,881 | 0.04 | 0.07 | +0.03 | buy |
| ALPS ADVISORS INC | 126,222 | 130,838 | +4,616 | 0.02 | 0.02 | +0.00 | buy |
| Diversified Trust Co | 38,131 | 42,509 | +4,378 | 0.03 | 0.03 | +0.00 | buy |
| CHOREO, LLC | 19,985 | 23,722 | +3,737 | 0.01 | 0.01 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 95,999 | 93,146 | +2,853 | 0.00 | 0.00 | 0.00 | sell |
| Vise Technologies, Inc. | 17,046 | 19,801 | +2,755 | 0.06 | 0.05 | -0.01 | buy |
| Vident Advisory, LLC | 68,884 | 66,131 | +2,753 | 0.05 | 0.03 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 31,671 | 34,308 | +2,637 | 0.10 | 0.09 | -0.01 | buy |
| YOUSIF CAPITAL MANAGEMENT, LLC | 65,031 | 62,641 | +2,390 | 0.02 | 0.02 | 0.00 | sell |
| State of Alaska, Department of Revenue | 93,969 | 91,956 | +2,013 | 0.03 | 0.03 | 0.00 | sell |
| RHUMBLINE ADVISERS | 463,031 | 464,714 | +1,683 | 0.01 | 0.01 | 0.00 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 110,454 | 111,909 | +1,455 | 0.05 | 0.06 | +0.00 | buy |
| EVERGREEN CAPITAL MANAGEMENT LLC | 9,009 | 10,181 | +1,172 | 0.01 | 0.01 | 0.00 | buy |
| Woodline Partners LP | 741,680 | 742,716 | +1,036 | 0.18 | 0.14 | -0.03 | buy |
| Moors & Cabot, Inc. | 7,969 | 8,997 | +1,028 | 0.01 | 0.01 | +0.00 | buy |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 22,066 | 23,033 | +967 | 0.01 | 0.01 | -0.00 | buy |
| OREGON PUBLIC EMPLOYEES RETIREMENT FUND | 38,818 | 38,018 | +800 | 0.02 | 0.02 | 0.00 | sell |
| HOHIMER WEALTH MANAGEMENT, LLC | 11,243 | 11,912 | +669 | 0.07 | 0.06 | -0.00 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 35,197 | 34,542 | +655 | 0.01 | 0.01 | -0.00 | sell |
| CIBC Asset Management Inc | 8,771 | 9,155 | +384 | 0.00 | 0.00 | 0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 99,721 | 100,032 | +311 | 0.01 | 0.01 | -0.00 | buy |
| AMG National Trust Bank | 59,645 | 59,870 | +225 | 0.04 | 0.05 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 16,721 | 16,847 | +126 | 0.02 | 0.02 | +0.00 | buy |
| PDT Partners, LLC | 103,958 | 103,947 | -11 | 0.26 | 0.26 | +0.01 | sell |
| Dana Investment Advisors, Inc. | 28,592 | 28,570 | -22 | 0.03 | 0.03 | +0.00 | sell |
| AUXIER ASSET MANAGEMENT | 11,891 | 11,816 | -75 | 0.05 | 0.05 | +0.00 | sell |
| CENTAURUS FINANCIAL, INC. | 42,752 | 42,673 | -79 | 0.08 | 0.07 | -0.00 | sell |
| Nicollet Investment Management, Inc. | 43,845 | 43,737 | -108 | 0.42 | 0.43 | +0.01 | sell |
| S&CO INC | 214,715 | 214,465 | -250 | 0.39 | 0.42 | +0.03 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 93,273 | 92,854 | -419 | 0.06 | 0.06 | +0.01 | sell |
| Catalyst Funds Management Pty Ltd | 8,800 | 8,000 | -800 | 0.05 | 0.06 | +0.00 | sell |
| E Fund Management Co., Ltd. | 16,413 | 14,895 | -1,518 | 0.02 | 0.02 | -0.00 | sell |
| DnB Asset Management AS | 14,829 | 13,176 | -1,653 | 0.00 | 0.00 | -0.00 | sell |
| AVIVA PLC | 23,194 | 20,914 | -2,280 | 0.00 | 0.00 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 84,907 | 82,473 | -2,434 | 0.43 | 0.44 | +0.01 | sell |
| Hudson Portfolio Management LLC | 54,490 | 50,575 | -3,915 | 1.50 | 1.43 | -0.07 | sell |
| BURNEY CO/ | 19,332 | 15,185 | -4,147 | 0.02 | 0.02 | -0.00 | sell |
| PRAXIS INVESTMENT MANAGEMENT INC | 18,380 | 9,540 | -8,840 | 0.03 | 0.02 | -0.01 | sell |
| Advantage Alpha Capital Partners LP | 23,318 | 13,947 | -9,371 | 0.15 | 0.09 | -0.05 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 53,521 | 43,398 | -10,123 | 0.00 | 0.00 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 67,628 | 54,431 | -13,197 | 0.02 | 0.01 | -0.00 | sell |
| Krensavage Asset Management, LLC | 251,495 | 238,136 | -13,359 | 3.94 | 4.05 | +0.11 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 451,657 | 429,927 | -21,730 | 0.68 | 0.68 | -0.01 | sell |
| TODD ASSET MANAGEMENT LLC | 164,517 | 133,560 | -30,957 | 0.11 | 0.09 | -0.02 | sell |
| Rafferty Asset Management, LLC | 255,457 | 209,580 | -45,877 | 0.02 | 0.02 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 133,000 | 77,999 | -55,001 | 0.30 | 0.23 | -0.07 | sell |
| ADAR1 Capital Management, LLC | 74,431 | 10,188 | -64,243 | 0.35 | 0.06 | -0.29 | sell |
| Gotham Asset Management, LLC | 114,920 | 30,937 | -83,983 | 0.03 | 0.01 | -0.03 | sell |
| Palo Alto Investors LP | 384,656 | 289,308 | -95,348 | 1.40 | 1.29 | -0.11 | sell |
| PFM Health Sciences, LP | 205,073 | 80,719 | -124,354 | 0.33 | 0.14 | -0.18 | sell |
| Aberdeen Group plc | 392,542 | 244,319 | -148,223 | 0.02 | 0.01 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 404,230 | 221,730 | -182,500 | 0.01 | 0.01 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 3,297,115 | 3,095,510 | -201,605 | 0.07 | 0.07 | +0.00 | sell |
| Edgestream Partners, L.P. | 270,671 | 54,106 | -216,565 | 0.33 | 0.07 | -0.27 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 568,075 | 213,928 | -354,147 | 0.02 | 0.01 | -0.01 | sell |
| Commodore Capital LP | 2,900,000 | 2,300,000 | -600,000 | 5.07 | 4.85 | -0.22 | sell |
| SEGALL BRYANT & HAMILL, LLC | 1,183,100 | 569,620 | -613,480 | 0.45 | 0.23 | -0.23 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,998,606 | 12,256,447 | -742,159 | 0.04 | 0.04 | -0.00 | sell |