| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 27,972,078 | 28,272,412 | +300,334 | 0.01 | 0.01 | -0.00 | buy |
| VANGUARD GROUP INC | 18,179,511 | 18,007,364 | -172,147 | 0.01 | 0.01 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 8,091,351 | 10,012,267 | +1,920,916 | 1.75 | 1.64 | -0.11 | buy |
| STATE STREET CORP | 8,540,351 | 9,472,858 | +932,507 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,238,357 | 8,998,963 | -1,239,394 | 0.03 | 0.03 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 6,292,528 | 6,668,028 | +375,500 | 0.25 | 0.29 | +0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 4,397,471 | 5,956,824 | +1,559,353 | 0.07 | 0.08 | +0.02 | buy |
| JPMORGAN CHASE & CO | 3,928,170 | 5,184,547 | +1,256,377 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 3,697,996 | 4,412,783 | +714,787 | 0.02 | 0.03 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,061,394 | 4,080,776 | +19,382 | 0.01 | 0.01 | -0.00 | buy |
| Commodore Capital LP | 3,096,754 | 3,550,000 | +453,246 | 4.54 | 6.61 | +2.08 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 375,190 | 3,020,442 | +2,645,252 | 0.00 | 0.01 | +0.01 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 2,759,080 | 2,564,300 | -194,780 | 0.06 | 0.05 | -0.01 | sell |
| UBS Group AG | 754,166 | 2,544,895 | +1,790,729 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 2,173,476 | 2,427,028 | +253,552 | 0.02 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,994,945 | 2,267,588 | +272,643 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,140,373 | 2,152,756 | +12,383 | 0.01 | 0.01 | -0.00 | buy |
| Deep Track Capital, LP | 0 | 2,000,000 | +2,000,000 | 0.00 | 1.28 | +1.28 | buy |
| NORGES BANK | 0 | 1,945,734 | +1,945,734 | 0.00 | 0.01 | +0.01 | buy |
| LOOMIS SAYLES & CO L P | 2,048,851 | 1,902,522 | -146,329 | 0.07 | 0.06 | -0.01 | sell |
| MORGAN STANLEY | 1,551,499 | 1,888,487 | +336,988 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 1,672,356 | 1,672,356 | 0 | 0.62 | 0.47 | -0.15 | hold |
| NORTHERN TRUST CORP | 1,766,180 | 1,653,475 | -112,705 | 0.01 | 0.01 | -0.00 | sell |
| Pictet Asset Management Holding SA | 893,046 | 1,477,214 | +584,168 | 0.03 | 0.04 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 1,398,021 | 1,454,002 | +55,981 | 0.03 | 0.03 | -0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,208,944 | 1,450,841 | +241,897 | 0.02 | 0.02 | +0.00 | buy |
| Avoro Capital Advisors LLC | 2,240,000 | 1,400,000 | -840,000 | 0.87 | 0.39 | -0.48 | sell |
| FMR LLC | 1,295,493 | 1,355,253 | +59,760 | 0.00 | 0.00 | -0.00 | buy |
| Artisan Partners Limited Partnership | 2,109,772 | 1,349,122 | -760,650 | 0.09 | 0.06 | -0.03 | sell |
| BANK OF AMERICA CORP /DE/ | 1,096,455 | 1,333,105 | +236,650 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 1,322,364 | +1,322,364 | 0.00 | 1.57 | +1.57 | buy |
| TWO SIGMA INVESTMENTS, LP | 656,499 | 1,213,397 | +556,898 | 0.03 | 0.05 | +0.02 | buy |
| CITADEL ADVISORS LLC | 704,834 | 1,198,268 | +493,434 | 0.02 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 445,306 | 1,095,846 | +650,540 | 0.03 | 0.06 | +0.03 | buy |
| Bank of New York Mellon Corp | 1,424,466 | 1,074,087 | -350,379 | 0.01 | 0.01 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 1,250,000 | 1,000,000 | -250,000 | 3.49 | 2.01 | -1.48 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 901,333 | 976,483 | +75,150 | 0.18 | 0.16 | -0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 900,330 | 947,623 | +47,293 | 0.01 | 0.01 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 887,197 | 928,964 | +41,767 | 0.11 | 0.09 | -0.02 | buy |
| D. E. Shaw & Co., Inc. | 528,749 | 911,272 | +382,523 | 0.01 | 0.02 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 827,473 | 796,968 | -30,505 | 0.18 | 0.15 | -0.03 | sell |
| Frazier Life Sciences Management, L.P. | 700,647 | 700,647 | 0 | 0.63 | 0.53 | -0.10 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 679,633 | +679,633 | 0.00 | 0.04 | +0.04 | buy |
| Pacer Advisors, Inc. | 808,132 | 674,874 | -133,258 | 0.06 | 0.03 | -0.03 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 710,700 | 671,170 | -39,530 | 0.08 | 0.06 | -0.02 | sell |
| SEGALL BRYANT & HAMILL, LLC | 596,479 | 615,292 | +18,813 | 0.24 | 0.23 | -0.01 | buy |
| BARCLAYS PLC | 556,651 | 565,033 | +8,382 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 205,200 | 562,587 | +357,387 | 0.01 | 0.03 | +0.02 | buy |
| Woodline Partners LP | 558,567 | 558,567 | 0 | 0.08 | 0.06 | -0.02 | hold |
| Invesco Ltd. | 584,293 | 538,716 | -45,577 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 557,866 | 531,362 | -26,504 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 707,196 | 530,379 | -176,817 | 0.10 | 0.07 | -0.03 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 568,675 | 522,097 | -46,578 | 0.03 | 0.02 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 372,422 | 514,324 | +141,902 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 533,650 | 501,807 | -31,843 | 0.02 | 0.01 | -0.00 | sell |
| Opaleye Management Inc. | 450,000 | 490,000 | +40,000 | 1.91 | 1.81 | -0.10 | buy |
| RHUMBLINE ADVISERS | 473,837 | 439,195 | -34,642 | 0.01 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 761,203 | 430,330 | -330,873 | 0.02 | 0.01 | -0.01 | sell |
| Legal & General Group Plc | 499,623 | 429,497 | -70,126 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 344,202 | 402,578 | +58,376 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 392,427 | 394,853 | +2,426 | 0.00 | 0.00 | -0.00 | buy |
| Fisher Asset Management, LLC | 322,748 | 390,493 | +67,745 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 385,342 | 379,458 | -5,884 | 0.63 | 0.58 | -0.05 | sell |
| Allianz Asset Management GmbH | 524,795 | 347,308 | -177,487 | 0.02 | 0.01 | -0.01 | sell |
| Bridgewater Associates, LP | 0 | 344,452 | +344,452 | 0.00 | 0.04 | +0.04 | buy |
| RAYMOND JAMES FINANCIAL INC | 446,925 | 328,205 | -118,720 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 419,290 | 325,496 | -93,794 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 320,879 | 324,578 | +3,699 | 0.01 | 0.01 | -0.00 | buy |
| Man Group plc | 897,274 | 312,512 | -584,762 | 0.05 | 0.02 | -0.04 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 415,800 | 310,600 | -105,200 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 303,600 | 309,200 | +5,600 | 0.01 | 0.01 | -0.00 | buy |
| Edgestream Partners, L.P. | 259,411 | 291,299 | +31,888 | 0.23 | 0.23 | +0.00 | buy |
| Robeco Institutional Asset Management B.V. | 134,387 | 285,670 | +151,283 | 0.01 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 276,558 | +276,558 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 264,446 | 273,158 | +8,712 | 0.03 | 0.03 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 257,795 | 254,333 | -3,462 | 0.23 | 0.22 | -0.01 | sell |
| C WorldWide Group Holding A/S | 250,000 | 250,000 | 0 | 0.12 | 0.12 | +0.01 | hold |
| Palo Alto Investors LP | 183,938 | 242,560 | +58,622 | 1.02 | 0.94 | -0.08 | buy |
| Atle Fund Management AB | 252,875 | 242,473 | -10,402 | 2.99 | 2.16 | -0.82 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,777 | 241,133 | +239,356 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 132,619 | 232,987 | +100,368 | 0.00 | 0.00 | +0.00 | buy |
| Abacus FCF Advisors LLC | 0 | 219,495 | +219,495 | 0.00 | 0.80 | +0.80 | buy |
| ALLIANCEBERNSTEIN L.P. | 238,539 | 215,854 | -22,685 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 179,902 | 203,264 | +23,362 | 0.02 | 0.02 | +0.00 | buy |
| S&CO INC | 201,210 | 201,760 | +550 | 0.37 | 0.35 | -0.02 | buy |
| HRT FINANCIAL LP | 18,277 | 200,224 | +181,947 | 0.00 | 0.02 | +0.02 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 139,166 | 194,530 | +55,364 | 0.01 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 209,826 | 194,505 | -15,321 | 0.01 | 0.01 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 184,346 | 192,807 | +8,461 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 225,807 | 190,717 | -35,090 | 0.01 | 0.01 | -0.00 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 141,090 | 172,250 | +31,160 | 0.07 | 0.09 | +0.01 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 165,110 | 170,267 | +5,157 | 0.12 | 0.12 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 74,037 | 159,581 | +85,544 | 0.02 | 0.04 | +0.02 | buy |
| BESSEMER GROUP INC | 2,222 | 157,640 | +155,418 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 179,465 | 157,359 | -22,106 | 0.01 | 0.00 | -0.00 | sell |
| Neuberger Berman Group LLC | 152,721 | 152,772 | +51 | 0.00 | 0.00 | -0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 120,959 | 150,775 | +29,816 | 0.04 | 0.04 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 195,999 | 149,284 | -46,715 | 0.01 | 0.01 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 148,909 | 148,793 | -116 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 344,490 | 145,804 | -198,686 | 0.00 | 0.00 | -0.00 | sell |