| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 8,091,351 | 10,012,267 | +1,920,916 | 1.75 | 1.64 | -0.11 | buy |
| AMERICAN CENTURY COMPANIES INC | 4,397,471 | 5,956,824 | +1,559,353 | 0.07 | 0.09 | +0.02 | buy |
| Commodore Capital LP | 3,096,754 | 3,550,000 | +453,246 | 4.54 | 6.61 | +2.08 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 6,292,528 | 6,668,028 | +375,500 | 0.27 | 0.31 | +0.04 | buy |
| Allianz Asset Management GmbH | 524,795 | 347,308 | +177,487 | 0.02 | 0.01 | -0.01 | sell |
| Robeco Institutional Asset Management B.V. | 134,387 | 285,670 | +151,283 | 0.01 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 74,037 | 159,581 | +85,544 | 0.02 | 0.04 | +0.02 | buy |
| Knott David M Jr | 19,300 | 95,000 | +75,700 | 0.24 | 1.23 | +0.99 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 901,333 | 976,483 | +75,150 | 0.18 | 0.16 | -0.01 | buy |
| Palo Alto Investors LP | 183,938 | 242,560 | +58,622 | 1.02 | 0.94 | -0.08 | buy |
| ALPS ADVISORS INC | 77,832 | 135,379 | +57,547 | 0.01 | 0.02 | 0.00 | buy |
| TFG Asset Management GP Ltd | 89,612 | 141,172 | +51,560 | 0.36 | 0.83 | +0.47 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 900,330 | 947,623 | +47,293 | 0.01 | 0.01 | 0.00 | buy |
| Entropy Technologies, LP | 23,291 | 63,724 | +40,433 | 0.05 | 0.10 | +0.04 | buy |
| Opaleye Management Inc. | 450,000 | 490,000 | +40,000 | 1.91 | 1.81 | -0.10 | buy |
| Rhenman & Partners Asset Management AB | 94,000 | 133,250 | +39,250 | 0.31 | 0.35 | +0.04 | buy |
| PROFUND ADVISORS LLC | 44,557 | 80,624 | +36,067 | 0.04 | 0.07 | 0.00 | buy |
| Rock Springs Capital Management LP | 106,537 | 139,228 | +32,691 | 0.19 | 0.20 | +0.01 | buy |
| Edgestream Partners, L.P. | 259,411 | 291,299 | +31,888 | 0.23 | 0.23 | +0.00 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 141,090 | 172,250 | +31,160 | 0.07 | 0.09 | +0.01 | buy |
| Marex Group plc | 14,100 | 44,851 | +30,751 | 0.01 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 53,067 | 79,336 | +26,269 | 0.04 | 0.05 | 0.00 | buy |
| Rafferty Asset Management, LLC | 179,902 | 203,264 | +23,362 | 0.02 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,061,394 | 4,080,776 | +19,382 | 0.01 | 0.01 | 0.00 | buy |
| GC Wealth Management RIA, LLC | 18,041 | 37,418 | +19,377 | 0.02 | 0.04 | +0.02 | buy |
| SEGALL BRYANT & HAMILL, LLC | 596,479 | 615,292 | +18,813 | 11.57 | 0.23 | -11.34 | buy |
| DnB Asset Management AS | 13,230 | 30,762 | +17,532 | 0.00 | 0.00 | +0.00 | buy |
| Vinva Investment Management Ltd | 9,259 | 26,520 | +17,261 | 0.01 | 0.01 | +0.01 | buy |
| LSV ASSET MANAGEMENT | 14,800 | 30,500 | +15,700 | 0.00 | 0.00 | +0.00 | buy |
| Dana Investment Advisors, Inc. | 27,334 | 39,456 | +12,122 | 0.02 | 0.03 | +0.01 | buy |
| Oliver Luxxe Assets LLC | 45,884 | 56,031 | +10,147 | 0.22 | 0.24 | +0.02 | buy |
| Summit Global Investments | 19,938 | 29,662 | +9,724 | 0.03 | 0.05 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 56,200 | 63,700 | +7,500 | 0.17 | 0.13 | -0.03 | buy |
| YOUSIF CAPITAL MANAGEMENT, LLC | 52,663 | 46,011 | +6,652 | 0.02 | 0.02 | 0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 165,110 | 170,267 | +5,157 | 0.12 | 0.12 | -0.00 | buy |
| AdvisorShares Investments LLC | 25,649 | 30,580 | +4,931 | 0.13 | 0.14 | +0.02 | buy |
| TODD ASSET MANAGEMENT LLC | 12,347 | 16,845 | +4,498 | 0.01 | 0.01 | +0.00 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 21,081 | 24,814 | +3,733 | 0.01 | 0.01 | -0.00 | buy |
| Moran Wealth Management, LLC | 17,850 | 20,651 | +2,801 | 0.02 | 0.02 | +0.00 | buy |
| Bleakley Financial Group, LLC | 12,318 | 14,732 | +2,414 | 0.01 | 0.01 | -0.00 | buy |
| ProShare Advisors LLC | 36,497 | 38,874 | +2,377 | 0.00 | 0.00 | 0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 57,639 | 55,523 | +2,116 | 0.00 | 0.00 | -0.00 | sell |
| State of Alaska, Department of Revenue | 91,717 | 93,027 | +1,310 | 0.03 | 0.03 | 0.00 | buy |
| Round Rock Advisors, LLC | 16,590 | 17,656 | +1,066 | 0.08 | 0.07 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 85,535 | 86,368 | +833 | 0.01 | 0.01 | 0.00 | buy |
| Salomon & Ludwin, LLC | 577 | 1,244 | +667 | 0.00 | 0.00 | 0.00 | buy |
| S&CO INC | 201,210 | 201,760 | +550 | 0.37 | 0.35 | -0.02 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 20,367 | 20,368 | +1 | 0.00 | 0.00 | -0.00 | buy |
| AUXIER ASSET MANAGEMENT | 7,837 | 7,652 | -185 | 0.03 | 0.03 | -0.00 | sell |
| AVIVA PLC | 17,145 | 16,946 | -199 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 3,552 | 3,244 | -308 | 0.00 | 0.00 | -0.00 | sell |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 90,932 | 90,574 | -358 | 0.02 | 0.01 | -0.00 | sell |
| EMC Capital Management | 2,428 | 2,064 | -364 | 0.03 | 0.03 | -0.01 | sell |
| Ameritas Investment Partners, Inc. | 13,556 | 13,171 | -385 | 0.01 | 0.01 | -0.00 | sell |
| Nicollet Investment Management, Inc. | 44,979 | 44,479 | -500 | 0.44 | 0.39 | -0.05 | sell |
| AXS Investments LLC | 20,150 | 19,500 | -650 | 0.19 | 0.19 | -0.00 | sell |
| Avanza Fonder AB | 8,220 | 7,327 | -893 | 0.01 | 0.01 | -0.00 | sell |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 23,033 | 22,066 | -967 | 0.01 | 0.01 | -0.00 | sell |
| CHOREO, LLC | 26,946 | 25,403 | -1,543 | 0.01 | 0.01 | -0.00 | sell |
| HOHIMER WEALTH MANAGEMENT, LLC | 10,755 | 9,050 | -1,705 | 0.05 | 0.03 | -0.01 | sell |
| ROYCE & ASSOCIATES LP | 49,769 | 48,010 | -1,759 | 0.01 | 0.01 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 28,936 | 26,906 | -2,030 | 0.07 | 0.06 | -0.01 | sell |
| Hudson Portfolio Management LLC | 36,455 | 33,505 | -2,950 | 0.97 | 0.81 | -0.16 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 257,795 | 254,333 | -3,462 | 0.23 | 0.22 | -0.01 | sell |
| DAFNA Capital Management LLC | 134,748 | 130,248 | -4,500 | 1.00 | 0.85 | -0.15 | sell |
| New Age Alpha Advisors, LLC | 13,633 | 8,016 | -5,617 | 0.02 | 0.01 | -0.01 | sell |
| GLOBEFLEX CAPITAL L P | 66,218 | 60,560 | -5,658 | 0.31 | 0.26 | -0.05 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 385,342 | 379,458 | -5,884 | 0.63 | 0.58 | -0.05 | sell |
| CIBC WORLD MARKETS CORP | 19,992 | 10,734 | -9,258 | 0.00 | 0.00 | -0.00 | sell |
| Atle Fund Management AB | 252,875 | 242,473 | -10,402 | 2.99 | 2.16 | -0.82 | sell |
| HighVista Strategies LLC | 44,081 | 26,401 | -17,680 | 0.32 | 0.19 | -0.13 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 126,000 | 105,000 | -21,000 | 0.82 | 0.71 | -0.11 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 827,473 | 796,968 | -30,505 | 0.18 | 0.15 | -0.03 | sell |
| Krensavage Asset Management, LLC | 207,822 | 107,822 | -100,000 | 2.66 | 1.07 | -1.59 | sell |
| LOOMIS SAYLES & CO L P | 2,048,851 | 1,902,522 | -146,329 | 0.07 | 0.06 | -0.01 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 2,759,080 | 2,564,300 | -194,780 | 0.06 | 0.05 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 1,250,000 | 1,000,000 | -250,000 | 3.49 | 2.01 | -1.48 | sell |
| Sio Capital Management, LLC | 674,840 | 95,353 | -579,487 | 5.12 | 0.42 | -4.70 | sell |
| Artisan Partners Limited Partnership | 2,109,772 | 1,349,122 | -760,650 | 0.09 | 0.06 | -0.03 | sell |
| Avoro Capital Advisors LLC | 2,240,000 | 1,400,000 | -840,000 | 0.87 | 0.39 | -0.48 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,238,357 | 8,998,963 | -1,239,394 | 0.03 | 0.03 | -0.01 | sell |