| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARMISTICE CAPITAL, LLC | 4,592,000 | 7,024,000 | +2,432,000 | 0.43 | 0.33 | -0.10 | buy |
| BAKER BROS. ADVISORS LP | 584,757 | 2,499,338 | +1,914,581 | 0.02 | 0.05 | +0.03 | buy |
| Rosalind Advisors, Inc. | 2,138,475 | 3,986,509 | +1,848,034 | 4.55 | 5.66 | +1.10 | buy |
| Hennion & Walsh Asset Management, Inc. | 221,323 | 569,195 | +347,872 | 0.04 | 0.06 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 343,678 | 632,632 | +288,954 | 0.29 | 0.32 | +0.03 | buy |
| Alyeska Investment Group, L.P. | 2,050,000 | 2,289,625 | +239,625 | 0.03 | 0.02 | -0.01 | buy |
| RTW INVESTMENTS, LP | 6,576,306 | 6,635,793 | +59,487 | 0.35 | 0.22 | -0.13 | buy |
| Stonepine Capital Management, LLC | 3,302,300 | 3,349,627 | +47,327 | 7.01 | 5.99 | -1.02 | buy |
| Aries Wealth Management | 26,249 | 30,833 | +4,584 | 0.03 | 0.02 | -0.01 | buy |
| CANTOR FITZGERALD, L. P. | 363,132 | 140,000 | -223,132 | 0.03 | 0.01 | -0.02 | sell |
| J. Goldman & Co LP | 1,680,752 | 650,074 | -1,030,678 | 0.26 | 0.06 | -0.19 | sell |