| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 83,114 | 625,942 | +542,828 | 0.00 | 0.01 | +0.01 | buy |
| Checkpoint Capital L.P. | 0 | 168,739 | +168,739 | 0.00 | 1.33 | +1.33 | buy |
| GOLDMAN SACHS GROUP INC | 21,799 | 173,736 | +151,937 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 1,425,634 | 1,540,634 | +115,000 | 1.29 | 1.60 | +0.31 | buy |
| Qube Research & Technologies Ltd | 2,367 | 80,626 | +78,259 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 72,265 | +72,265 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 162,312 | 233,283 | +70,971 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 65,206 | +65,206 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,300,000 | 1,350,000 | +50,000 | 0.02 | 0.03 | +0.01 | buy |
| Marathon Trading Investment Management LLC | 0 | 33,700 | +33,700 | 0.00 | 0.16 | +0.16 | buy |
| JPMORGAN CHASE & CO | 0 | 31,723 | +31,723 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 30,496 | +30,496 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,061 | 31,061 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 24,980 | +24,980 | 0.00 | 0.08 | +0.08 | buy |
| Brevan Howard Capital Management LP | 0 | 24,102 | +24,102 | 0.00 | 0.03 | +0.03 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 19,394 | +19,394 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 18,824 | +18,824 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 232,128 | 248,952 | +16,824 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 15,741 | +15,741 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 14,229 | +14,229 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 13,200 | +13,200 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 11,159 | +11,159 | 0.00 | 0.00 | +0.00 | buy |
| Cannon Global Investment Management, LLC | 0 | 11,100 | +11,100 | 0.00 | 0.35 | +0.35 | buy |
| VANGUARD GROUP INC | 1,150,253 | 1,160,931 | +10,678 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 39,423 | 43,653 | +4,230 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 83,587 | 87,487 | +3,900 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 73,908 | 77,220 | +3,312 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,573 | +1,573 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 5,435 | 7,004 | +1,569 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 1,089 | +1,089 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,538,461 | 1,538,461 | 0 | 0.23 | 0.32 | +0.08 | hold |
| ORBIMED ADVISORS LLC | 1,529,115 | 1,529,115 | 0 | 0.25 | 0.33 | +0.08 | hold |
| BVF INC/IL | 1,685,219 | 1,685,219 | 0 | 0.34 | 0.55 | +0.20 | hold |
| CORNERCAP INVESTMENT COUNSEL INC | 25,274 | 25,274 | 0 | 0.03 | 0.05 | +0.01 | hold |
| VIKING GLOBAL INVESTORS LP | 2,456,292 | 2,456,292 | 0 | 0.07 | 0.11 | +0.03 | hold |
| RHUMBLINE ADVISERS | 674 | 674 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Opaleye Management Inc. | 211,400 | 211,400 | 0 | 0.46 | 0.54 | +0.09 | hold |
| Vivo Capital, LLC | 1,538,461 | 1,538,461 | 0 | 1.03 | 1.43 | +0.40 | hold |
| Aries Wealth Management | 13,081 | 13,081 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Global Retirement Partners, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PSI Advisors, LLC | 27 | 27 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NewEdge Wealth, LLC | 25,885 | 25,885 | 0 | 0.01 | 0.01 | +0.00 | hold |
| NORTHERN TRUST CORP | 44,924 | 44,924 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 16 | 16 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 14 | 14 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 10,103 | 10,103 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 92 | 92 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 2,949 | 2,949 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIRST MANHATTAN CO. LLC. | 81 | 61 | -20 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 1,386 | 1,345 | -41 | 0.00 | 0.00 | +0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 166 | 0 | -166 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 17,570 | 17,303 | -267 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 1,292 | 289 | -1,003 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 54,661 | 53,383 | -1,278 | 0.00 | 0.00 | +0.00 | sell |
| Advisory Services Network, LLC | 3,094 | 0 | -3,094 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 31,365 | 25,065 | -6,300 | 0.00 | 0.00 | +0.00 | sell |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 9,158 | 0 | -9,158 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 22,612 | 12,082 | -10,530 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 11,499 | 0 | -11,499 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 61,803 | 46,232 | -15,571 | 0.02 | 0.02 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 232,249 | 207,095 | -25,154 | 1.06 | 1.59 | +0.52 | sell |
| Jefferies Financial Group Inc. | 159,541 | 130,141 | -29,400 | 0.02 | 0.03 | +0.01 | sell |
| ExodusPoint Capital Management, LP | 51,379 | 14,752 | -36,627 | 0.01 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 203,327 | 74,200 | -129,127 | 0.71 | 0.34 | -0.37 | sell |
| MORGAN STANLEY | 143,600 | 0 | -143,600 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 741,514 | 541,514 | -200,000 | 0.56 | 0.67 | +0.11 | sell |
| Vontobel Holding Ltd. | 203,327 | 0 | -203,327 | 0.01 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 576,231 | 39,808 | -536,423 | 0.00 | 0.00 | -0.00 | sell |