| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 0 | 4,245,476 | +4,245,476 | 0.00 | 0.39 | +0.39 | buy |
| Rosalind Advisors, Inc. | 900,000 | 2,644,517 | +1,744,517 | 2.51 | 7.77 | +5.26 | buy |
| Octagon Capital Advisors LP | 0 | 1,720,000 | +1,720,000 | 0.00 | 1.42 | +1.42 | buy |
| MARSHALL WACE, LLP | 793,641 | 2,225,594 | +1,431,953 | 0.01 | 0.02 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,945,927 | 4,787,975 | +842,048 | 0.05 | 0.07 | +0.02 | buy |
| Octagon Capital Advisors LP | 0 | 625,000 | +625,000 | 0.00 | 1.07 | +1.07 | buy |
| Casdin Capital, LLC | 0 | 600,000 | +600,000 | 0.00 | 0.30 | +0.30 | buy |
| GOLDMAN SACHS GROUP INC | 224,529 | 756,402 | +531,873 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 500,000 | +500,000 | 0.00 | 0.33 | +0.33 | buy |
| MORGAN STANLEY | 811,990 | 1,154,790 | +342,800 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 270,520 | +270,520 | 0.00 | 0.03 | +0.03 | buy |
| NOMURA HOLDINGS INC | 0 | 208,105 | +208,105 | 0.00 | 0.01 | +0.01 | buy |
| J. Goldman & Co LP | 0 | 177,237 | +177,237 | 0.00 | 0.04 | +0.04 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 176,000 | +176,000 | 0.00 | 1.23 | +1.23 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 162,064 | +162,064 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 37,818 | 184,835 | +147,017 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 209,889 | 336,363 | +126,474 | 0.95 | 2.42 | +1.47 | buy |
| VANGUARD GROUP INC | 2,311,514 | 2,430,110 | +118,596 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 2,441,511 | 2,534,008 | +92,497 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 63,411 | 141,831 | +78,420 | 0.01 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 741,684 | 812,150 | +70,466 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 49,800 | +49,800 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 35,126 | 62,603 | +27,477 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 14,680 | 37,184 | +22,504 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 81,458 | 102,544 | +21,086 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 24,138 | 39,079 | +14,941 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 37,629 | 49,959 | +12,330 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 11,565 | +11,565 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 948,790 | 960,264 | +11,474 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 11,402 | +11,402 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 63,423 | 71,257 | +7,834 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 17,545 | 25,271 | +7,726 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 5,706 | +5,706 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 113,601 | 117,784 | +4,183 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 16,601 | 20,481 | +3,880 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,390 | 18,052 | +2,662 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 932 | 3,131 | +2,199 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 39,593 | 41,661 | +2,068 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 8,310 | 9,552 | +1,242 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,234 | 23,254 | +1,020 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 367 | 1,257 | +890 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 615 | +615 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 546 | +546 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 879 | 1,339 | +460 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 9 | 462 | +453 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,315 | 14,748 | +433 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 814 | 980 | +166 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 106 | +106 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 95 | +95 | 0.00 | 0.00 | +0.00 | buy |
| Accent Capital Management, LLC | 0 | 52 | +52 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 29 | 47 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Grove Bank & Trust | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 20,571 | 20,579 | +8 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 41 | 45 | +4 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 2,862,448 | 2,862,448 | 0 | 0.31 | 0.41 | +0.11 | hold |
| Ameritas Investment Partners, Inc. | 2,489 | 2,489 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 2,100,468 | 2,100,468 | 0 | 0.37 | 0.52 | +0.15 | hold |
| EVERMAY WEALTH MANAGEMENT LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,915 | 2,915 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 13,880 | 13,880 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 270,000 | 270,000 | 0 | 0.09 | 0.09 | -0.00 | hold |
| IFP Advisors, Inc | 41 | 41 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vivo Capital, LLC | 1,538,461 | 1,538,461 | 0 | 0.89 | 1.23 | +0.34 | hold |
| Russell Investments Group, Ltd. | 506 | 506 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Aries Wealth Management | 26,415 | 26,415 | 0 | 0.04 | 0.04 | +0.01 | hold |
| Police & Firemen's Retirement System of New Jersey | 9,273 | 9,273 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACORN CAPITAL ADVISORS, LLC | 779,498 | 779,498 | 0 | 0.42 | 3.13 | +2.72 | hold |
| HARBOUR INVESTMENTS, INC. | 14 | 14 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,200 | 5,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearstead Advisors, LLC | 416 | 416 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 5,949 | 5,949 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 16 | 0 | -16 | 0.00 | 0.00 | -0.00 | sell |
| NewEdge Wealth, LLC | 25,912 | 25,885 | -27 | 0.00 | 0.00 | +0.00 | sell |
| SBI Securities Co., Ltd. | 50 | 2 | -48 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 19,286 | 19,004 | -282 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 4,587 | 4,216 | -371 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 88,424 | 87,899 | -525 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 339,264 | 338,700 | -564 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 11,402 | 10,578 | -824 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 4,997 | 2,317 | -2,680 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 31,051 | 27,605 | -3,446 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 25,656 | 22,025 | -3,631 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 17,865 | 11,357 | -6,508 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 10,925 | 0 | -10,925 | 0.00 | 0.00 | -0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 11,741 | 0 | -11,741 | 0.02 | 0.00 | -0.02 | sell |
| TWO SIGMA ADVISERS, LP | 60,017 | 47,217 | -12,800 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 13,334 | 0 | -13,334 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 13,597 | 0 | -13,597 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 77,165 | 63,349 | -13,816 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 61,445 | 42,148 | -19,297 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 36,515 | 13,260 | -23,255 | 0.00 | 0.00 | -0.00 | sell |
| DRW Securities, LLC | 30,966 | 0 | -30,966 | 0.01 | 0.00 | -0.01 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 63,050 | 27,224 | -35,826 | 0.01 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 36,180 | 0 | -36,180 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 54,960 | 0 | -54,960 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 74,904 | 10,346 | -64,558 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 608,524 | 521,960 | -86,564 | 0.08 | 0.07 | -0.00 | sell |
| UBS Group AG | 322,806 | 203,504 | -119,302 | 0.00 | 0.00 | -0.00 | sell |