| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 6,576,306 | 6,576,306 | 0 | 0.51 | 0.35 | -0.16 | hold |
| BlackRock, Inc. | 4,752,842 | 6,194,925 | +1,442,083 | 0.00 | 0.00 | -0.00 | buy |
| Deep Track Capital, LP | 5,740,850 | 5,740,850 | 0 | 1.01 | 0.63 | -0.38 | hold |
| ARMISTICE CAPITAL, LLC | 3,536,000 | 4,592,000 | +1,056,000 | 0.67 | 0.80 | +0.14 | buy |
| Nantahala Capital Management, LLC | 462,140 | 3,584,820 | +3,122,680 | 0.21 | 1.19 | +0.97 | buy |
| STATE STREET CORP | 3,219,295 | 3,516,651 | +297,356 | 0.00 | 0.00 | -0.00 | buy |
| Stonepine Capital Management, LLC | 2,732,079 | 3,302,300 | +570,221 | 16.68 | 15.39 | -1.29 | buy |
| Foresite Capital Management VI LLC | 3,135,120 | 3,146,631 | +11,511 | 7.32 | 3.62 | -3.69 | buy |
| MILLENNIUM MANAGEMENT LLC | 555,129 | 2,411,965 | +1,856,836 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 2,353,465 | 2,308,669 | -44,796 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 1,871,562 | 2,247,273 | +375,711 | 0.00 | 0.00 | -0.00 | buy |
| Rosalind Advisors, Inc. | 1,788,475 | 2,138,475 | +350,000 | 5.03 | 4.64 | -0.39 | buy |
| Alyeska Investment Group, L.P. | 0 | 2,050,000 | +2,050,000 | 0.00 | 0.03 | +0.03 | buy |
| AIGH Capital Management LLC | 0 | 2,000,000 | +2,000,000 | 0.00 | 2.17 | +2.17 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,392,822 | 1,717,557 | +324,735 | 0.00 | 0.00 | -0.00 | buy |
| J. Goldman & Co LP | 947,303 | 1,680,752 | +733,449 | 0.28 | 0.41 | +0.13 | buy |
| GOLDMAN SACHS GROUP INC | 1,495,424 | 1,484,003 | -11,421 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 254,900 | 1,476,028 | +1,221,128 | 0.00 | 0.01 | +0.01 | buy |
| ACORN CAPITAL ADVISORS, LLC | 1,469,153 | 1,469,153 | 0 | 3.84 | 2.21 | -1.63 | hold |
| FRANKLIN RESOURCES INC | 926,011 | 1,105,885 | +179,874 | 0.00 | 0.00 | -0.00 | buy |
| Logos Global Management LP | 1,700,000 | 1,000,000 | -700,000 | 0.87 | 0.27 | -0.60 | sell |
| Longaeva Partners L.P. | 0 | 807,755 | +807,755 | 0.00 | 0.21 | +0.21 | buy |
| TWO SIGMA INVESTMENTS, LP | 476,892 | 667,010 | +190,118 | 0.01 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 401,743 | 636,700 | +234,957 | 1.53 | 1.99 | +0.45 | buy |
| BAKER BROS. ADVISORS LP | 0 | 584,757 | +584,757 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 320,806 | 570,618 | +249,812 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 557,016 | 556,016 | -1,000 | 0.04 | 0.04 | +0.00 | sell |
| UBS Group AG | 501,471 | 543,689 | +42,218 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 393,097 | 515,786 | +122,689 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 398,546 | 473,657 | +75,111 | 0.00 | 0.00 | -0.00 | buy |
| TORONTO DOMINION BANK | 460,413 | 460,413 | 0 | 0.01 | 0.00 | -0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 316,862 | 416,985 | +100,123 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,195,726 | 409,779 | -2,785,947 | 0.05 | 0.00 | -0.04 | sell |
| XTX Topco Ltd | 131,121 | 395,834 | +264,713 | 0.03 | 0.04 | +0.01 | buy |
| CANTOR FITZGERALD, L. P. | 42,251 | 363,132 | +320,881 | 0.01 | 0.07 | +0.06 | buy |
| Y-Intercept (Hong Kong) Ltd | 364,283 | 345,571 | -18,712 | 0.06 | 0.03 | -0.03 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 343,678 | 343,678 | 0 | 0.55 | 0.31 | -0.24 | hold |
| ALGERT GLOBAL LLC | 11,000 | 305,246 | +294,246 | 0.00 | 0.02 | +0.02 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 216,387 | 298,958 | +82,571 | 0.24 | 0.23 | -0.01 | buy |
| Squarepoint Ops LLC | 275,913 | 270,553 | -5,360 | 0.00 | 0.00 | -0.00 | sell |
| Palo Alto Investors LP | 0 | 246,093 | +246,093 | 0.00 | 0.20 | +0.20 | buy |
| PANAGORA ASSET MANAGEMENT INC | 244,067 | 244,103 | +36 | 0.01 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 174,384 | 221,323 | +46,939 | 0.05 | 0.04 | -0.01 | buy |
| SG Americas Securities, LLC | 390,325 | 215,004 | -175,321 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 213,865 | 213,865 | 0 | 0.21 | 0.16 | -0.05 | hold |
| Nuveen, LLC | 188,653 | 206,096 | +17,443 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 199,344 | 199,003 | -341 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,165 | 196,501 | +35,336 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 104,947 | 183,976 | +79,029 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 122,689 | 161,707 | +39,018 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 145,512 | 151,240 | +5,728 | 0.00 | 0.00 | -0.00 | buy |
| Birchview Capital, LP | 150,000 | 150,000 | 0 | 0.68 | 0.45 | -0.23 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 74,221 | 144,719 | +70,498 | 0.04 | 0.06 | +0.02 | buy |
| Jump Financial, LLC | 0 | 118,473 | +118,473 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 114,891 | +114,891 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 96,046 | 110,729 | +14,683 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 129,333 | 109,123 | -20,210 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 104,093 | 104,049 | -44 | 0.00 | 0.00 | -0.00 | sell |
| Knott David M Jr | 0 | 104,000 | +104,000 | 0.00 | 0.33 | +0.33 | buy |
| Quarry LP | 27,000 | 100,000 | +73,000 | 0.03 | 0.11 | +0.07 | buy |
| Man Group plc | 0 | 96,833 | +96,833 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 143,318 | 91,760 | -51,558 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 201,845 | 90,300 | -111,545 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 0 | 74,285 | +74,285 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 60,504 | 71,973 | +11,469 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 71,100 | +71,100 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 68,541 | 68,541 | 0 | 0.01 | 0.01 | -0.01 | hold |
| ALLIANCEBERNSTEIN L.P. | 67,270 | 67,270 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Graham Capital Management, L.P. | 23,438 | 67,065 | +43,627 | 0.01 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 49,002 | 66,065 | +17,063 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 45,570 | 62,804 | +17,234 | 0.00 | 0.00 | -0.00 | buy |
| Quadrature Capital Ltd | 0 | 52,098 | +52,098 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 25,172 | 51,158 | +25,986 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 47,665 | 48,761 | +1,096 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 27,236 | 46,827 | +19,591 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 46,200 | +46,200 | 0.00 | 0.01 | +0.01 | buy |
| Cetera Investment Advisers | 43,378 | 43,346 | -32 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 30,930 | 42,880 | +11,950 | 0.01 | 0.01 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 42,469 | 42,392 | -77 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 0 | 39,390 | +39,390 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,351 | 39,007 | +6,656 | 0.00 | 0.00 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 57,137 | 39,004 | -18,133 | 0.07 | 0.03 | -0.03 | sell |
| STIFEL FINANCIAL CORP | 39,772 | 38,891 | -881 | 0.00 | 0.00 | -0.00 | sell |
| Dauntless Investment Group, LLC | 0 | 36,750 | +36,750 | 0.00 | 0.55 | +0.55 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | 36,170 | +36,170 | 0.00 | 0.28 | +0.28 | buy |
| MetLife Investment Management, LLC | 28,929 | 32,958 | +4,029 | 0.00 | 0.00 | -0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 12,500 | 32,600 | +20,100 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 62,597 | 30,086 | -32,511 | 0.00 | 0.00 | -0.00 | sell |
| MIZUHO SECURITIES USA LLC | 0 | 30,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 29,520 | +29,520 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 22,361 | 28,778 | +6,417 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 27,682 | 28,374 | +692 | 0.06 | 0.04 | -0.02 | buy |
| D. E. Shaw & Co., Inc. | 338,853 | 26,659 | -312,194 | 0.00 | 0.00 | -0.00 | sell |
| Aries Wealth Management | 26,249 | 26,249 | 0 | 0.04 | 0.03 | -0.01 | hold |
| NewEdge Wealth, LLC | 25,885 | 25,885 | 0 | 0.00 | 0.00 | -0.00 | hold |
| OSAIC HOLDINGS, INC. | 20,476 | 21,737 | +1,261 | 0.00 | 0.00 | -0.00 | buy |
| Scientech Research LLC | 0 | 19,423 | +19,423 | 0.00 | 0.09 | +0.09 | buy |
| Police & Firemen's Retirement System of New Jersey | 12,611 | 19,385 | +6,774 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,507 | 19,025 | +15,518 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,410 | 18,016 | +1,606 | 0.00 | 0.00 | -0.00 | buy |