| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 211,400 | 915,000 | +703,600 | 0.54 | 0.62 | +0.08 | buy |
| Alyeska Investment Group, L.P. | 0 | 700,000 | +700,000 | 0.00 | 0.01 | +0.01 | buy |
| Nantahala Capital Management, LLC | 0 | 400,000 | +400,000 | 0.00 | 0.12 | +0.12 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 248,952 | 531,539 | +282,587 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 87,487 | 358,999 | +271,512 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 212,203 | +212,203 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 1,160,931 | 1,365,705 | +204,774 | 0.00 | 0.00 | -0.00 | buy |
| Sio Capital Management, LLC | 0 | 133,412 | +133,412 | 0.00 | 0.15 | +0.15 | buy |
| Soleus Capital Management, L.P. | 1,540,634 | 1,661,297 | +120,663 | 1.60 | 0.44 | -1.16 | buy |
| Bank of New York Mellon Corp | 0 | 68,224 | +68,224 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11,159 | 70,810 | +59,651 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 46,232 | 100,389 | +54,157 | 0.02 | 0.01 | -0.01 | buy |
| OMERS ADMINISTRATION Corp | 0 | 38,500 | +38,500 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 36,401 | +36,401 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 34,500 | +34,500 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 674 | 28,793 | +28,119 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 27,689 | +27,689 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 13,200 | 39,484 | +26,284 | 0.00 | 0.00 | -0.00 | buy |
| Alpine Global Management, LLC | 0 | 24,058 | +24,058 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 0 | 22,620 | +22,620 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 13,880 | +13,880 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 44,924 | 57,188 | +12,264 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 0 | 12,260 | +12,260 | 0.00 | 0.00 | +0.00 | buy |
| Apollon Wealth Management, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 289 | 7,050 | +6,761 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 53,383 | 57,164 | +3,781 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 0 | 2,808 | +2,808 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 72,265 | 74,814 | +2,549 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 2,489 | +2,489 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 43,653 | 46,094 | +2,441 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 92 | 2,092 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 1,841 | +1,841 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 17,303 | 18,697 | +1,394 | 0.00 | 0.00 | -0.00 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 0 | 900 | +900 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 879 | +879 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 416 | +416 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,529,115 | 1,529,115 | 0 | 0.33 | 0.09 | -0.24 | hold |
| BVF INC/IL | 1,685,219 | 1,685,219 | 0 | 0.55 | 0.14 | -0.41 | hold |
| TANG CAPITAL MANAGEMENT LLC | 541,514 | 541,514 | 0 | 0.67 | 0.16 | -0.50 | hold |
| Vivo Capital, LLC | 1,538,461 | 1,538,461 | 0 | 1.43 | 0.42 | -1.00 | hold |
| Aries Wealth Management | 13,081 | 13,081 | 0 | 0.05 | 0.01 | -0.04 | hold |
| Global Retirement Partners, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PSI Advisors, LLC | 27 | 27 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Wealth, LLC | 25,885 | 25,885 | 0 | 0.01 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 16 | 16 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 2,949 | 2,949 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIRST MANHATTAN CO. LLC. | 61 | 0 | -61 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 25,274 | 25,064 | -210 | 0.05 | 0.01 | -0.03 | sell |
| MACQUARIE GROUP LTD | 1,089 | 0 | -1,089 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,345 | 0 | -1,345 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,573 | 0 | -1,573 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 12,082 | 10,085 | -1,997 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 7,004 | 0 | -7,004 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 39,808 | 30,400 | -9,408 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 10,103 | 0 | -10,103 | 0.00 | 0.00 | -0.00 | sell |
| Cannon Global Investment Management, LLC | 11,100 | 0 | -11,100 | 0.35 | 0.00 | -0.35 | sell |
| AMERICAN CENTURY COMPANIES INC | 14,229 | 0 | -14,229 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 14,752 | 0 | -14,752 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 15,741 | 0 | -15,741 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 18,824 | 0 | -18,824 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 19,394 | 0 | -19,394 | 0.02 | 0.00 | -0.02 | sell |
| BARCLAYS PLC | 31,061 | 8,614 | -22,447 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 24,102 | 0 | -24,102 | 0.03 | 0.00 | -0.03 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 24,980 | 0 | -24,980 | 0.08 | 0.00 | -0.08 | sell |
| CIBC WORLD MARKETS CORP | 25,000 | 0 | -25,000 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 25,065 | 0 | -25,065 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 30,496 | 0 | -30,496 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 31,723 | 0 | -31,723 | 0.00 | 0.00 | -0.00 | sell |
| Marathon Trading Investment Management LLC | 33,700 | 0 | -33,700 | 0.16 | 0.00 | -0.16 | sell |
| HRT FINANCIAL LP | 65,206 | 0 | -65,206 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 77,220 | 5,528 | -71,692 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 74,200 | 0 | -74,200 | 0.34 | 0.00 | -0.34 | sell |
| Qube Research & Technologies Ltd | 80,626 | 0 | -80,626 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 173,736 | 50,659 | -123,077 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 130,141 | 0 | -130,141 | 0.03 | 0.00 | -0.03 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 233,283 | 89,870 | -143,413 | 0.00 | 0.00 | -0.00 | sell |
| Checkpoint Capital L.P. | 168,739 | 0 | -168,739 | 1.33 | 0.00 | -1.33 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 207,095 | 0 | -207,095 | 1.59 | 0.00 | -1.59 | sell |
| MILLENNIUM MANAGEMENT LLC | 625,942 | 20,784 | -605,158 | 0.01 | 0.00 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,350,000 | 0 | -1,350,000 | 0.03 | 0.00 | -0.03 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,538,461 | 0 | -1,538,461 | 0.32 | 0.00 | -0.32 | sell |
| VIKING GLOBAL INVESTORS LP | 2,456,292 | 0 | -2,456,292 | 0.11 | 0.00 | -0.11 | sell |