| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| J. Goldman & Co LP | 177,237 | 2,454,519 | +2,277,282 | 0.04 | 0.32 | +0.28 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 2,136,000 | +2,136,000 | 0.00 | 0.34 | +0.34 | buy |
| STATE STREET CORP | 812,150 | 2,251,424 | +1,439,274 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 2,100,468 | 3,404,425 | +1,303,957 | 0.52 | 0.50 | -0.01 | buy |
| Foresite Capital Management VI LLC | 0 | 1,276,520 | +1,276,520 | 0.00 | 2.98 | +2.98 | buy |
| Logos Global Management LP | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.55 | +0.55 | buy |
| Polar Capital Holdings Plc | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 2,430,110 | 3,423,617 | +993,507 | 0.00 | 0.00 | -0.00 | buy |
| Stonepine Capital Management, LLC | 613,000 | 1,360,386 | +747,386 | 3.60 | 5.56 | +1.96 | buy |
| GOLDMAN SACHS GROUP INC | 756,402 | 1,450,680 | +694,278 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 2,298,541 | 2,954,735 | +656,194 | 1.15 | 0.87 | -0.28 | buy |
| Exome Asset Management LLC | 0 | 599,900 | +599,900 | 0.00 | 2.05 | +2.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 102,544 | 587,021 | +484,477 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 208,105 | 674,596 | +466,491 | 0.01 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 11,357 | 351,569 | +340,212 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 50,633 | 379,581 | +328,948 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 95,655 | 393,390 | +297,735 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 282,228 | +282,228 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 960,264 | 1,199,259 | +238,995 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 63,349 | 294,961 | +231,612 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 2,534,008 | 2,758,914 | +224,906 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 203,504 | 401,250 | +197,746 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 188,162 | +188,162 | 0.00 | 0.03 | +0.03 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 180,400 | +180,400 | 0.00 | 0.07 | +0.07 | buy |
| FMR LLC | 9,552 | 185,689 | +176,137 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 163,307 | +163,307 | 0.00 | 0.18 | +0.18 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 154,917 | +154,917 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 42,148 | 193,643 | +151,495 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 132,444 | +132,444 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 131,770 | +131,770 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 270,520 | 397,755 | +127,235 | 0.03 | 0.03 | -0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 104,850 | +104,850 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 98,600 | +98,600 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 87,107 | +87,107 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 13,880 | 90,410 | +76,530 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 27,224 | 90,203 | +62,979 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 58,521 | +58,521 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71,257 | 129,047 | +57,790 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 53,403 | +53,403 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 47,217 | 92,117 | +44,900 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 117,784 | 143,361 | +25,577 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 25,428 | +25,428 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 21,708 | +21,708 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 338,700 | 356,286 | +17,586 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 87,899 | 105,404 | +17,505 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 16,361 | +16,361 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 15,841 | +15,841 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 37,184 | 52,063 | +14,879 | 0.00 | 0.00 | -0.00 | buy |
| Nebula Research & Development LLC | 0 | 12,689 | +12,689 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 11,700 | +11,700 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 49,959 | 59,553 | +9,594 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 20,579 | 28,026 | +7,447 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 20,481 | 27,833 | +7,352 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23,254 | 29,945 | +6,691 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 162,064 | 168,326 | +6,262 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 4,245,476 | 4,251,616 | +6,140 | 0.39 | 0.25 | -0.14 | buy |
| CITIGROUP INC | 27,605 | 33,366 | +5,761 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 18,052 | 22,655 | +4,603 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 22,025 | 26,145 | +4,120 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 2,497 | +2,497 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,578 | 12,758 | +2,180 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,748 | 16,188 | +1,440 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,489 | 3,889 | +1,400 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 506 | 1,618 | +1,112 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,317 | 2,908 | +591 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 47 | 628 | +581 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 408 | +408 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,216 | 4,617 | +401 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 41,661 | 41,968 | +307 | 0.00 | 0.00 | -0.00 | buy |
| Clearstead Advisors, LLC | 416 | 609 | +193 | 0.00 | 0.00 | -0.00 | buy |
| SBI Securities Co., Ltd. | 2 | 100 | +98 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 37 | +37 | 0.00 | 0.00 | +0.00 | buy |
| EVERMAY WEALTH MANAGEMENT LLC | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,915 | 2,915 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 270,000 | 270,000 | 0 | 0.09 | 0.06 | -0.03 | hold |
| Vivo Capital, LLC | 1,538,461 | 1,538,461 | 0 | 1.23 | 0.65 | -0.58 | hold |
| Global Retirement Partners, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Soleus Capital Management, L.P. | 935,909 | 935,909 | 0 | 0.44 | 0.27 | -0.17 | hold |
| NewEdge Wealth, LLC | 25,885 | 25,885 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Accent Capital Management, LLC | 52 | 52 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 9,273 | 9,273 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACORN CAPITAL ADVISORS, LLC | 779,498 | 779,498 | 0 | 3.13 | 2.12 | -1.02 | hold |
| US BANCORP \DE\ | 23 | 23 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,200 | 5,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,339 | 1,339 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 5,949 | 5,949 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Grove Bank & Trust | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 462 | 450 | -12 | 0.00 | 0.00 | -0.00 | sell |
| True Wealth Design, LLC | 23 | 0 | -23 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 41 | 0 | -41 | 0.00 | 0.00 | +0.00 | sell |
| SIGNATUREFD, LLC | 45 | 0 | -45 | 0.00 | 0.00 | -0.00 | sell |
| Physician Wealth Advisors, Inc. | 95 | 0 | -95 | 0.00 | 0.00 | -0.00 | sell |
| SUMMIT SECURITIES GROUP LLC | 106 | 0 | -106 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 980 | 814 | -166 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 546 | 164 | -382 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 13,260 | 12,684 | -576 | 0.00 | 0.00 | -0.00 | sell |
| COLDSTREAM CAPITAL MANAGEMENT INC | 615 | 0 | -615 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,257 | 367 | -890 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 3,131 | 1,501 | -1,630 | 0.00 | 0.00 | -0.00 | sell |