| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 6,194,925 | 9,192,447 | +2,997,522 | 0.00 | 0.00 | -0.00 | buy |
| ARMISTICE CAPITAL, LLC | 4,592,000 | 7,024,000 | +2,432,000 | 0.80 | 0.74 | -0.06 | buy |
| BAKER BROS. ADVISORS LP | 584,757 | 2,499,338 | +1,914,581 | 0.02 | 0.05 | +0.03 | buy |
| Rosalind Advisors, Inc. | 2,138,475 | 3,986,509 | +1,848,034 | 4.64 | 5.72 | +1.08 | buy |
| Opaleye Management Inc. | 0 | 1,800,000 | +1,800,000 | 0.00 | 0.62 | +0.62 | buy |
| STATE STREET CORP | 3,516,651 | 5,133,859 | +1,617,208 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 409,779 | 1,686,575 | +1,276,796 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,484,003 | 2,721,178 | +1,237,175 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 66,065 | 934,565 | +868,500 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 416,985 | 889,975 | +472,990 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 244,103 | 666,874 | +422,771 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,717,557 | 2,074,145 | +356,588 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 221,323 | 569,195 | +347,872 | 0.04 | 0.06 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 343,678 | 632,632 | +288,954 | 0.31 | 0.35 | +0.03 | buy |
| Diametric Capital, LP | 0 | 265,539 | +265,539 | 0.00 | 0.11 | +0.11 | buy |
| Virtus Investment Advisers, LLC | 28,374 | 283,630 | +255,256 | 0.04 | 0.25 | +0.21 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 243,950 | +243,950 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 2,050,000 | 2,289,625 | +239,625 | 0.03 | 0.02 | -0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 235,207 | +235,207 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 118,473 | 307,500 | +189,027 | 0.01 | 0.01 | +0.00 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 298,958 | 477,455 | +178,497 | 0.23 | 0.25 | +0.01 | buy |
| XTX Topco Ltd | 395,834 | 561,791 | +165,957 | 0.04 | 0.03 | -0.01 | buy |
| FMR LLC | 473,657 | 626,298 | +152,641 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 1,476,028 | 1,628,488 | +152,460 | 0.01 | 0.01 | -0.00 | buy |
| Janney Montgomery Scott LLC | 0 | 152,439 | +152,439 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 91,760 | 238,429 | +146,669 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 515,786 | 651,495 | +135,709 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 12,261 | 120,235 | +107,974 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 10,112 | 82,263 | +72,151 | 0.00 | 0.01 | +0.01 | buy |
| Palo Alto Investors LP | 246,093 | 309,685 | +63,592 | 0.20 | 0.16 | -0.04 | buy |
| UBS Group AG | 543,689 | 604,480 | +60,791 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 6,576,306 | 6,635,793 | +59,487 | 0.35 | 0.22 | -0.13 | buy |
| Jain Global LLC | 0 | 55,238 | +55,238 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 206,096 | 258,933 | +52,837 | 0.00 | 0.00 | -0.00 | buy |
| Knott David M Jr | 104,000 | 155,000 | +51,000 | 0.33 | 0.31 | -0.02 | buy |
| WELLS FARGO & COMPANY/MN | 30,086 | 80,687 | +50,601 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 67,270 | 117,090 | +49,820 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 196,501 | 243,950 | +47,449 | 0.00 | 0.00 | -0.00 | buy |
| Stonepine Capital Management, LLC | 3,302,300 | 3,349,627 | +47,327 | 15.39 | 9.74 | -5.65 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 42,803 | +42,803 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 1,261 | 36,639 | +35,378 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 13,324 | 47,588 | +34,264 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 0 | 32,245 | +32,245 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 26,622 | +26,622 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 32,958 | 59,249 | +26,291 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 62,804 | 87,668 | +24,864 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 161,707 | 184,944 | +23,237 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 51,158 | 72,383 | +21,225 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 104,049 | 125,077 | +21,028 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 39,390 | 59,466 | +20,076 | 0.00 | 0.00 | -0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 19,499 | +19,499 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 46,827 | 65,565 | +18,738 | 0.00 | 0.00 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 18,466 | +18,466 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 29,520 | 46,874 | +17,354 | 0.00 | 0.00 | +0.00 | buy |
| Regal Investment Advisors LLC | 0 | 14,071 | +14,071 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 14,454 | 27,757 | +13,303 | 0.00 | 0.00 | +0.00 | buy |
| Merit Financial Group, LLC | 0 | 12,382 | +12,382 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 12,326 | +12,326 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 11,954 | +11,954 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 71,973 | 83,678 | +11,705 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 0 | 10,457 | +10,457 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 9,054 | +9,054 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 39,007 | 47,568 | +8,561 | 0.00 | 0.00 | -0.00 | buy |
| Glass Jacobson Investment Advisors llc | 0 | 6,896 | +6,896 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 15,303 | 21,943 | +6,640 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 28,778 | 35,387 | +6,609 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 71,100 | 75,800 | +4,700 | 0.02 | 0.01 | -0.01 | buy |
| Aries Wealth Management | 26,249 | 30,833 | +4,584 | 0.03 | 0.02 | -0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 11,531 | 16,083 | +4,552 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,016 | 22,254 | +4,238 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 90,300 | 93,408 | +3,108 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 42,392 | 44,581 | +2,189 | 0.00 | 0.00 | -0.00 | buy |
| NewEdge Wealth, LLC | 25,885 | 27,826 | +1,941 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 1,907 | +1,907 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 5,887 | 7,739 | +1,852 | 0.00 | 0.00 | -0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 1,851 | +1,851 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 1,573 | +1,573 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 205 | 1,359 | +1,154 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 709 | +709 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 701 | +701 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 578 | +578 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 852 | 1,280 | +428 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 477 | 777 | +300 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 259 | +259 | 0.00 | 0.00 | +0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 212 | +212 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 416 | 596 | +180 | 0.00 | 0.00 | +0.00 | buy |
| Bare Financial Services, Inc | 0 | 129 | +129 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 114 | +114 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 12 | 87 | +75 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 43,346 | 43,412 | +66 | 0.00 | 0.00 | -0.00 | buy |
| JPL Wealth Management, LLC | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,483 | 5,483 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nantahala Capital Management, LLC | 3,584,820 | 3,584,820 | 0 | 1.19 | 0.83 | -0.36 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 68,541 | 68,541 | 0 | 0.01 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 41 | 41 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Inspire Investing, LLC | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Retirement Partners, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ikarian Capital, LLC | 213,865 | 213,865 | 0 | 0.16 | 0.13 | -0.03 | hold |