| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 6,194,925 | 9,192,447 | +2,997,522 | 0.00 | 0.00 | -0.00 | buy |
| ARMISTICE CAPITAL, LLC | 4,592,000 | 7,024,000 | +2,432,000 | 0.80 | 0.74 | -0.06 | buy |
| RTW INVESTMENTS, LP | 6,576,306 | 6,635,793 | +59,487 | 0.35 | 0.22 | -0.13 | buy |
| Deep Track Capital, LP | 5,740,850 | 5,740,850 | 0 | 0.63 | 0.32 | -0.30 | hold |
| STATE STREET CORP | 3,516,651 | 5,133,859 | +1,617,208 | 0.00 | 0.00 | -0.00 | buy |
| Rosalind Advisors, Inc. | 2,138,475 | 3,986,509 | +1,848,034 | 4.64 | 5.72 | +1.08 | buy |
| Nantahala Capital Management, LLC | 3,584,820 | 3,584,820 | 0 | 1.19 | 0.83 | -0.36 | hold |
| Stonepine Capital Management, LLC | 3,302,300 | 3,349,627 | +47,327 | 15.39 | 9.74 | -5.65 | buy |
| Foresite Capital Management VI LLC | 3,146,631 | 3,146,631 | 0 | 3.62 | 1.87 | -1.75 | hold |
| GOLDMAN SACHS GROUP INC | 1,484,003 | 2,721,178 | +1,237,175 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 584,757 | 2,499,338 | +1,914,581 | 0.02 | 0.05 | +0.03 | buy |
| Alyeska Investment Group, L.P. | 2,050,000 | 2,289,625 | +239,625 | 0.03 | 0.02 | -0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,411,965 | 2,078,003 | -333,962 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,717,557 | 2,074,145 | +356,588 | 0.00 | 0.00 | -0.00 | buy |
| AIGH Capital Management LLC | 2,000,000 | 1,927,000 | -73,000 | 2.17 | 0.67 | -1.50 | sell |
| Opaleye Management Inc. | 0 | 1,800,000 | +1,800,000 | 0.00 | 0.62 | +0.62 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 409,779 | 1,686,575 | +1,276,796 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 1,476,028 | 1,628,488 | +152,460 | 0.01 | 0.01 | -0.00 | buy |
| ACORN CAPITAL ADVISORS, LLC | 1,469,153 | 1,469,153 | 0 | 2.21 | 1.53 | -0.68 | hold |
| FRANKLIN RESOURCES INC | 1,105,885 | 1,105,021 | -864 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 66,065 | 934,565 | +868,500 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 416,985 | 889,975 | +472,990 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 2,247,273 | 715,822 | -1,531,451 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 244,103 | 666,874 | +422,771 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 515,786 | 651,495 | +135,709 | 0.00 | 0.00 | -0.00 | buy |
| J. Goldman & Co LP | 1,680,752 | 650,074 | -1,030,678 | 0.41 | 0.09 | -0.32 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 343,678 | 632,632 | +288,954 | 0.31 | 0.35 | +0.03 | buy |
| FMR LLC | 473,657 | 626,298 | +152,641 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 543,689 | 604,480 | +60,791 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 221,323 | 569,195 | +347,872 | 0.04 | 0.06 | +0.02 | buy |
| XTX Topco Ltd | 395,834 | 561,791 | +165,957 | 0.04 | 0.03 | -0.01 | buy |
| Jefferies Financial Group Inc. | 556,016 | 496,529 | -59,487 | 0.04 | 0.02 | -0.02 | sell |
| TORRAY INVESTMENT PARTNERS LLC | 298,958 | 477,455 | +178,497 | 0.23 | 0.25 | +0.01 | buy |
| TORONTO DOMINION BANK | 460,413 | 460,413 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Exome Asset Management LLC | 636,700 | 429,041 | -207,659 | 1.99 | 1.01 | -0.97 | sell |
| CITADEL ADVISORS LLC | 2,308,669 | 317,327 | -1,991,342 | 0.01 | 0.00 | -0.01 | sell |
| Palo Alto Investors LP | 246,093 | 309,685 | +63,592 | 0.20 | 0.16 | -0.04 | buy |
| Jump Financial, LLC | 118,473 | 307,500 | +189,027 | 0.01 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 28,374 | 283,630 | +255,256 | 0.04 | 0.25 | +0.21 | buy |
| Diametric Capital, LP | 0 | 265,539 | +265,539 | 0.00 | 0.11 | +0.11 | buy |
| Nuveen, LLC | 206,096 | 258,933 | +52,837 | 0.00 | 0.00 | -0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 243,950 | +243,950 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 196,501 | 243,950 | +47,449 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 91,760 | 238,429 | +146,669 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 235,207 | +235,207 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 213,865 | 213,865 | 0 | 0.16 | 0.13 | -0.03 | hold |
| RAYMOND JAMES FINANCIAL INC | 199,003 | 198,837 | -166 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 161,707 | 184,944 | +23,237 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 215,004 | 172,266 | -42,738 | 0.00 | 0.00 | -0.00 | sell |
| Knott David M Jr | 104,000 | 155,000 | +51,000 | 0.33 | 0.31 | -0.02 | buy |
| Janney Montgomery Scott LLC | 0 | 152,439 | +152,439 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 363,132 | 140,000 | -223,132 | 0.07 | 0.01 | -0.06 | sell |
| Invesco Ltd. | 104,049 | 125,077 | +21,028 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 12,261 | 120,235 | +107,974 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 67,270 | 117,090 | +49,820 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 110,729 | 108,863 | -1,866 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 183,976 | 99,236 | -84,740 | 0.01 | 0.00 | -0.01 | sell |
| Rafferty Asset Management, LLC | 109,123 | 94,204 | -14,919 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 90,300 | 93,408 | +3,108 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 62,804 | 87,668 | +24,864 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 71,973 | 83,678 | +11,705 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 10,112 | 82,263 | +72,151 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 30,086 | 80,687 | +50,601 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 71,100 | 75,800 | +4,700 | 0.02 | 0.01 | -0.01 | buy |
| Brevan Howard Capital Management LP | 51,158 | 72,383 | +21,225 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 68,541 | 68,541 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Man Group plc | 96,833 | 67,597 | -29,236 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 46,827 | 65,565 | +18,738 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 39,390 | 59,466 | +20,076 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 32,958 | 59,249 | +26,291 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 55,238 | +55,238 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 151,240 | 51,700 | -99,540 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 305,246 | 51,300 | -253,946 | 0.02 | 0.00 | -0.02 | sell |
| TWO SIGMA INVESTMENTS, LP | 667,010 | 49,954 | -617,056 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 13,324 | 47,588 | +34,264 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 39,007 | 47,568 | +8,561 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 48,761 | 47,484 | -1,277 | 0.01 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 52,098 | 46,982 | -5,116 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 29,520 | 46,874 | +17,354 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 74,285 | 46,337 | -27,948 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 42,392 | 44,581 | +2,189 | 0.00 | 0.00 | -0.00 | buy |
| Cetera Investment Advisers | 43,346 | 43,412 | +66 | 0.00 | 0.00 | -0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 42,803 | +42,803 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 67,065 | 40,131 | -26,934 | 0.01 | 0.00 | -0.01 | sell |
| STIFEL FINANCIAL CORP | 38,891 | 38,353 | -538 | 0.00 | 0.00 | -0.00 | sell |
| Quantbot Technologies LP | 1,261 | 36,639 | +35,378 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 28,778 | 35,387 | +6,609 | 0.00 | 0.00 | -0.00 | buy |
| Diversified Trust Co | 0 | 32,245 | +32,245 | 0.00 | 0.00 | +0.00 | buy |
| Aries Wealth Management | 26,249 | 30,833 | +4,584 | 0.03 | 0.02 | -0.01 | buy |
| NewEdge Wealth, LLC | 25,885 | 27,826 | +1,941 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 14,454 | 27,757 | +13,303 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 26,622 | +26,622 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 46,200 | 24,200 | -22,000 | 0.01 | 0.00 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,016 | 22,254 | +4,238 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 15,303 | 21,943 | +6,640 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 144,719 | 19,673 | -125,046 | 0.06 | 0.01 | -0.05 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 19,499 | +19,499 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 19,385 | 19,385 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 0 | 18,466 | +18,466 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 11,531 | 16,083 | +4,552 | 0.00 | 0.00 | -0.00 | buy |