| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nantahala Capital Management, LLC | 400,000 | 3,733,333 | +3,333,333 | 0.12 | 0.94 | +0.82 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 1,364,000 | +1,364,000 | 0.00 | 0.11 | +0.11 | buy |
| ORBIMED ADVISORS LLC | 1,529,115 | 2,862,448 | +1,333,333 | 0.09 | 0.16 | +0.07 | buy |
| Stonepine Capital Management, LLC | 0 | 1,310,287 | +1,310,287 | 0.00 | 2.48 | +2.48 | buy |
| Soleus Capital Management, L.P. | 1,661,297 | 2,827,963 | +1,166,666 | 0.44 | 0.70 | +0.27 | buy |
| Alyeska Investment Group, L.P. | 700,000 | 1,859,954 | +1,159,954 | 0.01 | 0.03 | +0.02 | buy |
| VANGUARD GROUP INC | 1,365,705 | 1,928,698 | +562,993 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 212,203 | 616,770 | +404,567 | 0.01 | 0.04 | +0.03 | buy |
| Affinity Asset Advisors, LLC | 0 | 400,000 | +400,000 | 0.00 | 0.19 | +0.19 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 531,539 | 890,599 | +359,060 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 100,389 | 430,669 | +330,280 | 0.01 | 0.03 | +0.02 | buy |
| NORTHERN TRUST CORP | 57,188 | 286,607 | +229,419 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 36,401 | 216,126 | +179,725 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 0 | 127,700 | +127,700 | 0.00 | 0.09 | +0.09 | buy |
| TWO SIGMA INVESTMENTS, LP | 10,085 | 100,545 | +90,460 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 72,061 | +72,061 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 358,999 | 424,264 | +65,265 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 53,100 | +53,100 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 8,614 | 55,708 | +47,094 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 50,659 | 95,731 | +45,072 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 42,517 | +42,517 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 37,443 | +37,443 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 70,810 | 103,601 | +32,791 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 31,310 | +31,310 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 5,528 | 27,984 | +22,456 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 15,261 | +15,261 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 14,559 | +14,559 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 14,444 | +14,444 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 14,049 | +14,049 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 13,704 | +13,704 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 18,697 | 30,339 | +11,642 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 68,224 | 78,921 | +10,697 | 0.00 | 0.00 | +0.00 | buy |
| Apollon Wealth Management, LLC | 10,000 | 20,457 | +10,457 | 0.00 | 0.00 | +0.00 | buy |
| Aries Wealth Management | 13,081 | 21,415 | +8,334 | 0.01 | 0.02 | +0.01 | buy |
| Corebridge Financial, Inc. | 13,668 | 20,742 | +7,074 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 3,299 | +3,299 | 0.00 | 0.00 | +0.00 | buy |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 2,949 | 5,949 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 2,648 | +2,648 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 57,164 | 59,657 | +2,493 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 2,808 | 4,822 | +2,014 | 0.00 | 0.00 | +0.00 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 900 | 2,691 | +1,791 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,841 | 2,915 | +1,074 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 2,092 | 2,946 | +854 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 733 | +733 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 22,620 | 23,239 | +619 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 451 | +451 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 12,260 | 12,399 | +139 | 0.00 | 0.00 | -0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 124 | +124 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 65 | +65 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,489 | 2,489 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 1,685,219 | 1,685,219 | 0 | 0.14 | 0.15 | +0.01 | hold |
| ALLIANCEBERNSTEIN L.P. | 13,880 | 13,880 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sio Capital Management, LLC | 133,412 | 133,412 | 0 | 0.15 | 0.18 | +0.03 | hold |
| Vivo Capital, LLC | 1,538,461 | 1,538,461 | 0 | 0.42 | 0.38 | -0.04 | hold |
| Global Retirement Partners, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Wealth, LLC | 25,885 | 25,885 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 16 | 16 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 416 | 416 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 879 | 879 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PSI Advisors, LLC | 27 | 0 | -27 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 46,094 | 45,761 | -333 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 28,793 | 27,277 | -1,516 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 7,050 | 0 | -7,050 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 25,064 | 11,810 | -13,254 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 20,784 | 0 | -20,784 | 0.00 | 0.00 | -0.00 | sell |
| Alpine Global Management, LLC | 24,058 | 0 | -24,058 | 0.01 | 0.00 | -0.01 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 27,689 | 0 | -27,689 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 34,500 | 5,200 | -29,300 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 30,400 | 0 | -30,400 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 38,500 | 0 | -38,500 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 39,484 | 0 | -39,484 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 74,814 | 0 | -74,814 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 89,870 | 0 | -89,870 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 541,514 | 270,000 | -271,514 | 0.16 | 0.06 | -0.11 | sell |
| Opaleye Management Inc. | 915,000 | 0 | -915,000 | 0.62 | 0.00 | -0.62 | sell |