| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 4,251,616 | 5,426,306 | +1,174,690 | 0.25 | 0.59 | +0.34 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 4,205,968 | 4,146,762 | -59,206 | 0.04 | 0.07 | +0.03 | sell |
| Logos Global Management LP | 1,000,000 | 4,050,000 | +3,050,000 | 0.55 | 3.53 | +2.98 | buy |
| Point72 Asset Management, L.P. | 0 | 3,879,364 | +3,879,364 | 0.00 | 0.07 | +0.07 | buy |
| BlackRock, Inc. | 2,758,914 | 3,717,182 | +958,268 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,423,617 | 3,479,011 | +55,394 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 1,360,386 | 2,670,032 | +1,309,646 | 5.56 | 19.17 | +13.61 | buy |
| Vivo Capital, LLC | 1,538,461 | 2,644,985 | +1,106,524 | 0.65 | 1.88 | +1.23 | buy |
| Foresite Capital Management VI LLC | 1,276,520 | 2,615,120 | +1,338,600 | 2.98 | 8.92 | +5.94 | buy |
| STATE STREET CORP | 2,251,424 | 2,228,640 | -22,784 | 0.00 | 0.00 | +0.00 | sell |
| ARMISTICE CAPITAL, LLC | 2,136,000 | 2,096,000 | -40,000 | 0.34 | 0.58 | +0.24 | sell |
| Rosalind Advisors, Inc. | 2,043,563 | 1,929,563 | -114,000 | 4.10 | 6.02 | +1.92 | sell |
| MORGAN STANLEY | 1,119,756 | 1,579,486 | +459,730 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 2,954,735 | 1,292,903 | -1,661,832 | 0.87 | 0.71 | -0.16 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,199,259 | 1,244,581 | +45,322 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 53,387 | 1,159,598 | +1,106,211 | 0.00 | 0.01 | +0.01 | buy |
| Polar Capital Holdings Plc | 1,000,000 | 1,058,776 | +58,776 | 0.02 | 0.05 | +0.02 | buy |
| MARSHALL WACE, LLP | 268,333 | 1,055,389 | +787,056 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 1,042,757 | +1,042,757 | 0.00 | 1.33 | +1.33 | buy |
| Soleus Capital Management, L.P. | 935,909 | 935,909 | 0 | 0.27 | 0.44 | +0.17 | hold |
| ORBIMED ADVISORS LLC | 0 | 887,561 | +887,561 | 0.00 | 0.19 | +0.19 | buy |
| TANG CAPITAL MANAGEMENT LLC | 270,000 | 789,810 | +519,810 | 0.06 | 0.27 | +0.21 | buy |
| ACORN CAPITAL ADVISORS, LLC | 779,498 | 779,498 | 0 | 2.12 | 3.49 | +1.38 | hold |
| Jefferies Financial Group Inc. | 397,755 | 590,184 | +192,429 | 0.03 | 0.05 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22,655 | 578,032 | +555,377 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 0 | 460,413 | +460,413 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 587,021 | 424,252 | -162,769 | 0.00 | 0.01 | +0.00 | sell |
| J. Goldman & Co LP | 2,454,519 | 413,872 | -2,040,647 | 0.32 | 0.14 | -0.18 | sell |
| ROYAL BANK OF CANADA | 393,390 | 412,541 | +19,151 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 356,286 | 377,291 | +21,005 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 362,597 | +362,597 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 185,689 | 320,256 | +134,567 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 309,780 | +309,780 | 0.00 | 0.38 | +0.38 | buy |
| Woodline Partners LP | 0 | 307,554 | +307,554 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 401,250 | 284,402 | -116,848 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,450,680 | 247,413 | -1,203,267 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 132,444 | 226,243 | +93,799 | 0.00 | 0.01 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 199,266 | +199,266 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 129,047 | 197,686 | +68,639 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 191,538 | +191,538 | 0.00 | 0.02 | +0.02 | buy |
| CITADEL ADVISORS LLC | 0 | 184,840 | +184,840 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 379,581 | 181,196 | -198,385 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 193,643 | 168,375 | -25,268 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 168,326 | 155,009 | -13,317 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 52,063 | 150,469 | +98,406 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 294,961 | 149,782 | -145,179 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 351,569 | 144,355 | -207,214 | 0.00 | 0.00 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 150,414 | 143,446 | -6,968 | 0.87 | 1.31 | +0.44 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 143,361 | 143,393 | +32 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 141,832 | +141,832 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 105,404 | 114,319 | +8,915 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 104,850 | 91,852 | -12,998 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 92,117 | 87,092 | -5,025 | 0.00 | 0.00 | +0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 163,307 | 78,307 | -85,000 | 0.18 | 0.16 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 0 | 74,000 | +74,000 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 90,410 | 67,270 | -23,140 | 0.00 | 0.00 | +0.00 | sell |
| Atom Investors LP | 0 | 67,042 | +67,042 | 0.00 | 0.04 | +0.04 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 92,836 | 63,411 | -29,425 | 0.01 | 0.02 | +0.01 | sell |
| RHUMBLINE ADVISERS | 59,553 | 57,994 | -1,559 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 42,274 | 57,311 | +15,037 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,188 | 52,377 | +36,189 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 188,162 | 48,911 | -139,251 | 0.03 | 0.02 | -0.01 | sell |
| GROUP ONE TRADING LLC | 15,841 | 42,930 | +27,089 | 0.00 | 0.01 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 41,968 | 42,098 | +130 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 32,999 | 38,357 | +5,358 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 35,900 | +35,900 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 28,026 | 34,463 | +6,437 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 32,078 | +32,078 | 0.00 | 0.04 | +0.04 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | 29,087 | +29,087 | 0.00 | 0.38 | +0.38 | buy |
| Aries Wealth Management | 23,749 | 26,249 | +2,500 | 0.03 | 0.05 | +0.03 | buy |
| MetLife Investment Management, LLC | 26,145 | 26,145 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NewEdge Wealth, LLC | 25,885 | 25,885 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,945 | 25,556 | -4,389 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 21,834 | 21,297 | -537 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 2,497 | 20,704 | +18,207 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 27,833 | 19,800 | -8,033 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 21,708 | 19,778 | -1,930 | 0.00 | 0.01 | +0.00 | sell |
| Quadrature Capital Ltd | 0 | 16,659 | +16,659 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 16,110 | +16,110 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 154,917 | 14,298 | -140,619 | 0.02 | 0.00 | -0.01 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 13,431 | +13,431 | 0.00 | 0.02 | +0.02 | buy |
| Engineers Gate Manager LP | 87,107 | 12,858 | -74,249 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 9,273 | 12,611 | +3,338 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 12,684 | 11,367 | -1,317 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 4,054 | 8,550 | +4,496 | 0.00 | 0.00 | +0.00 | buy |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 5,949 | 5,949 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,200 | 5,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 2,908 | 4,867 | +1,959 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,617 | 4,617 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 1,618 | 4,578 | +2,960 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,889 | 3,889 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,915 | 2,917 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 2,253 | +2,253 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 33,366 | 2,015 | -31,351 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 628 | 1,437 | +809 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,339 | 1,339 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 1,501 | 557 | -944 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 0 | 442 | +442 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 450 | 426 | -24 | 0.00 | 0.00 | +0.00 | sell |
| Clearstead Advisors, LLC | 609 | 416 | -193 | 0.00 | 0.00 | +0.00 | sell |