| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 0 | 143,600 | +143,600 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,270 | 162,312 | +140,042 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 83,114 | +83,114 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 1,347,369 | 1,425,634 | +78,265 | 1.10 | 1.29 | +0.18 | buy |
| ExodusPoint Capital Management, LP | 0 | 51,379 | +51,379 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 30,075 | 73,908 | +43,833 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 59,887 | 83,587 | +23,700 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 219,915 | 232,128 | +12,213 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 42,544 | 54,661 | +12,117 | 0.00 | 0.00 | +0.00 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 8 | 9,158 | +9,150 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 12,461 | 17,570 | +5,109 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 3,094 | +3,094 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 2,367 | +2,367 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 230,000 | 232,249 | +2,249 | 1.36 | 1.06 | -0.30 | buy |
| DIMENSIONAL FUND ADVISORS LP | 38,155 | 39,423 | +1,268 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 562 | 1,292 | +730 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 4,725 | 5,435 | +710 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 44,669 | 44,924 | +255 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 166 | +166 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,538,461 | 1,538,461 | 0 | 0.28 | 0.23 | -0.04 | hold |
| VANGUARD GROUP INC | 1,150,253 | 1,150,253 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ORBIMED ADVISORS LLC | 1,529,115 | 1,529,115 | 0 | 0.27 | 0.25 | -0.02 | hold |
| BVF INC/IL | 1,685,219 | 1,685,219 | 0 | 0.37 | 0.34 | -0.03 | hold |
| CORNERCAP INVESTMENT COUNSEL INC | 25,274 | 25,274 | 0 | 0.04 | 0.03 | -0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 2,456,292 | 2,456,292 | 0 | 0.08 | 0.07 | -0.01 | hold |
| RHUMBLINE ADVISERS | 674 | 674 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,300,000 | 1,300,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| SECTORAL ASSET MANAGEMENT INC | 203,327 | 203,327 | 0 | 0.32 | 0.71 | +0.39 | hold |
| Vontobel Holding Ltd. | 203,327 | 203,327 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Opaleye Management Inc. | 211,400 | 211,400 | 0 | 0.56 | 0.46 | -0.10 | hold |
| Vivo Capital, LLC | 1,538,461 | 1,538,461 | 0 | 1.37 | 1.03 | -0.34 | hold |
| Aries Wealth Management | 13,081 | 13,081 | 0 | 0.04 | 0.04 | -0.00 | hold |
| Global Retirement Partners, LLC | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PSI Advisors, LLC | 27 | 27 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Wealth, LLC | 25,885 | 25,885 | 0 | 0.01 | 0.01 | -0.00 | hold |
| FMR LLC | 1,386 | 1,386 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIRST MANHATTAN CO. LLC. | 81 | 81 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 16 | 16 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 10,103 | 10,103 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 2,949 | 2,949 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 159,541 | 159,541 | 0 | 0.03 | 0.02 | -0.01 | hold |
| GROUP ONE TRADING LLC | 113 | 92 | -21 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,121 | 0 | -1,121 | 0.00 | 0.00 | -0.00 | sell |
| Dorsey Wright & Associates | 2,272 | 0 | -2,272 | 0.01 | 0.00 | -0.01 | sell |
| BARCLAYS PLC | 4,847 | 1,061 | -3,786 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 22,758 | 11,499 | -11,259 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 13,696 | 0 | -13,696 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 46,365 | 31,365 | -15,000 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 37,077 | 21,799 | -15,278 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 15,374 | 0 | -15,374 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 20,648 | 0 | -20,648 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 45,195 | 22,612 | -22,583 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 155,904 | 61,803 | -94,101 | 0.02 | 0.02 | -0.01 | sell |
| TANG CAPITAL MANAGEMENT LLC | 891,514 | 741,514 | -150,000 | 1.02 | 0.56 | -0.47 | sell |
| CITADEL ADVISORS LLC | 893,785 | 576,231 | -317,554 | 0.01 | 0.00 | -0.00 | sell |