| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 3,945,927 | +3,945,927 | 0.00 | 0.05 | +0.05 | buy |
| AIGH Capital Management LLC | 0 | 2,665,043 | +2,665,043 | 0.00 | 5.19 | +5.19 | buy |
| Rosalind Advisors, Inc. | 0 | 900,000 | +900,000 | 0.00 | 2.51 | +2.51 | buy |
| MORGAN STANLEY | 0 | 811,990 | +811,990 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 793,641 | +793,641 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 0 | 723,806 | +723,806 | 0.00 | 0.03 | +0.03 | buy |
| BVF INC/IL | 1,685,219 | 2,100,468 | +415,249 | 0.15 | 0.37 | +0.22 | buy |
| VANGUARD GROUP INC | 1,928,698 | 2,311,514 | +382,816 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 341,669 | +341,669 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 322,806 | +322,806 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 424,264 | 741,684 | +317,420 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 59,657 | 270,819 | +211,162 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 209,889 | +209,889 | 0.00 | 0.95 | +0.95 | buy |
| BlackRock, Inc. | 2,234,699 | 2,441,511 | +206,812 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 430,669 | 608,524 | +177,855 | 0.03 | 0.08 | +0.05 | buy |
| GOLDMAN SACHS GROUP INC | 95,731 | 224,529 | +128,798 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 77,165 | +77,165 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 74,904 | +74,904 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 63,423 | +63,423 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 63,411 | +63,411 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 890,599 | 948,790 | +58,191 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 54,960 | +54,960 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 286,607 | 339,264 | +52,657 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 37,818 | +37,818 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 36,180 | +36,180 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 30,966 | +30,966 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 0 | 25,656 | +25,656 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 14,444 | 36,515 | +22,071 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 3,733,333 | 3,752,583 | +19,250 | 0.94 | 1.36 | +0.42 | buy |
| Squarepoint Ops LLC | 0 | 17,865 | +17,865 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 17,545 | +17,545 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 42,517 | 60,017 | +17,500 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 16,601 | +16,601 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 14,315 | +14,315 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 13,334 | +13,334 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 11,741 | +11,741 | 0.00 | 0.02 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 11,402 | +11,402 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 10,925 | +10,925 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 27,277 | 37,629 | +10,352 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 103,601 | 113,601 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 78,921 | 88,424 | +9,503 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 30,339 | 39,593 | +9,254 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,049 | 22,234 | +8,185 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 14,559 | 20,571 | +6,012 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 55,708 | 61,445 | +5,737 | 0.00 | 0.00 | +0.00 | buy |
| Aries Wealth Management | 21,415 | 26,415 | +5,000 | 0.02 | 0.04 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 31,310 | 35,126 | +3,816 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 27,984 | 31,051 | +3,067 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 12,399 | 14,680 | +2,281 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,299 | 4,997 | +1,698 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 23,239 | 24,138 | +899 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 65 | 367 | +302 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 733 | 932 | +199 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,261 | 15,390 | +129 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 451 | 506 | +55 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Wealth, LLC | 25,885 | 25,912 | +27 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| EVERMAY WEALTH MANAGEMENT LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 26 | 29 | +3 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 2,862,448 | 2,862,448 | 0 | 0.16 | 0.31 | +0.15 | hold |
| Ameritas Investment Partners, Inc. | 2,489 | 2,489 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,915 | 2,915 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 13,880 | 13,880 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 270,000 | 270,000 | 0 | 0.06 | 0.09 | +0.03 | hold |
| IFP Advisors, Inc | 41 | 41 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vivo Capital, LLC | 1,538,461 | 1,538,461 | 0 | 0.38 | 0.89 | +0.51 | hold |
| Global Retirement Partners, LLC | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 16 | 16 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 14 | 14 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,200 | 5,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearstead Advisors, LLC | 416 | 416 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 879 | 879 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 5,949 | 5,949 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EARNED WEALTH ADVISORS, LLC | 124 | 0 | -124 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 4,822 | 4,587 | -235 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 20,742 | 19,286 | -1,456 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 2,648 | 0 | -2,648 | 0.00 | 0.00 | -0.00 | sell |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 2,691 | 0 | -2,691 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 2,946 | 0 | -2,946 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 13,704 | 8,310 | -5,394 | 0.00 | 0.00 | +0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 11,810 | 0 | -11,810 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 100,545 | 81,458 | -19,087 | 0.00 | 0.00 | +0.00 | sell |
| Apollon Wealth Management, LLC | 20,457 | 0 | -20,457 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 37,443 | 13,597 | -23,846 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 45,761 | 0 | -45,761 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 53,100 | 0 | -53,100 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 72,061 | 0 | -72,061 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 216,126 | 139,281 | -76,845 | 0.01 | 0.01 | -0.00 | sell |
| DAFNA Capital Management LLC | 127,700 | 0 | -127,700 | 0.09 | 0.00 | -0.09 | sell |
| Sio Capital Management, LLC | 133,412 | 0 | -133,412 | 0.18 | 0.00 | -0.18 | sell |
| Affinity Asset Advisors, LLC | 400,000 | 0 | -400,000 | 0.19 | 0.00 | -0.19 | sell |
| Stonepine Capital Management, LLC | 1,310,287 | 870,000 | -440,287 | 2.48 | 3.63 | +1.15 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 616,770 | 63,050 | -553,720 | 0.04 | 0.01 | -0.03 | sell |
| Soleus Capital Management, L.P. | 2,827,963 | 2,184,026 | -643,937 | 0.70 | 0.85 | +0.15 | sell |
| ARMISTICE CAPITAL, LLC | 1,364,000 | 0 | -1,364,000 | 0.11 | 0.00 | -0.11 | sell |
| Alyeska Investment Group, L.P. | 1,859,954 | 0 | -1,859,954 | 0.03 | 0.00 | -0.03 | sell |