| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 5,426,306 | 6,576,306 | +1,150,000 | 0.59 | 0.51 | -0.08 | buy |
| Deep Track Capital, LP | 0 | 5,740,850 | +5,740,850 | 0.00 | 1.01 | +1.01 | buy |
| BlackRock, Inc. | 3,717,182 | 4,752,842 | +1,035,660 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,479,011 | 4,152,706 | +673,695 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,058,776 | 3,925,126 | +2,866,350 | 0.05 | 0.14 | +0.09 | buy |
| ARMISTICE CAPITAL, LLC | 2,096,000 | 3,536,000 | +1,440,000 | 0.58 | 0.67 | +0.09 | buy |
| STATE STREET CORP | 2,228,640 | 3,219,295 | +990,655 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 4,146,762 | 3,195,726 | -951,036 | 0.07 | 0.05 | -0.03 | sell |
| Foresite Capital Management VI LLC | 2,615,120 | 3,135,120 | +520,000 | 8.92 | 7.32 | -1.60 | buy |
| Stonepine Capital Management, LLC | 2,670,032 | 2,732,079 | +62,047 | 19.17 | 16.68 | -2.48 | buy |
| CITADEL ADVISORS LLC | 184,840 | 2,353,465 | +2,168,625 | 0.00 | 0.01 | +0.01 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.08 | +0.08 | buy |
| MORGAN STANLEY | 1,579,486 | 1,871,562 | +292,076 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 1,929,563 | 1,788,475 | -141,088 | 6.02 | 5.03 | -0.99 | sell |
| Logos Global Management LP | 4,050,000 | 1,700,000 | -2,350,000 | 3.53 | 0.87 | -2.66 | sell |
| GOLDMAN SACHS GROUP INC | 247,413 | 1,495,424 | +1,248,011 | 0.00 | 0.00 | +0.00 | buy |
| ACORN CAPITAL ADVISORS, LLC | 779,498 | 1,469,153 | +689,655 | 3.49 | 3.84 | +0.35 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,244,581 | 1,392,822 | +148,241 | 0.00 | 0.00 | -0.00 | buy |
| Vivo Capital, LLC | 2,644,985 | 1,106,524 | -1,538,461 | 1.88 | 0.55 | -1.33 | sell |
| TANG CAPITAL MANAGEMENT LLC | 789,810 | 1,069,810 | +280,000 | 0.27 | 0.41 | +0.14 | buy |
| Point72 Asset Management, L.P. | 3,879,364 | 995,026 | -2,884,338 | 0.07 | 0.01 | -0.06 | sell |
| J. Goldman & Co LP | 413,872 | 947,303 | +533,431 | 0.14 | 0.28 | +0.15 | buy |
| FRANKLIN RESOURCES INC | 0 | 926,011 | +926,011 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 590,184 | 557,016 | -33,168 | 0.05 | 0.04 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,159,598 | 555,129 | -604,469 | 0.01 | 0.00 | -0.00 | sell |
| UBS Group AG | 284,402 | 501,471 | +217,069 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 424,252 | 476,892 | +52,640 | 0.01 | 0.01 | -0.00 | buy |
| Nantahala Capital Management, LLC | 1,292,903 | 462,140 | -830,763 | 0.71 | 0.21 | -0.49 | sell |
| TORONTO DOMINION BANK | 460,413 | 460,413 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Exome Asset Management LLC | 0 | 401,743 | +401,743 | 0.00 | 1.53 | +1.53 | buy |
| TWO SIGMA ADVISERS, LP | 87,092 | 398,992 | +311,900 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 320,256 | 398,546 | +78,290 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 377,291 | 393,097 | +15,806 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 11,367 | 390,325 | +378,958 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2,015 | 364,436 | +362,421 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 14,298 | 364,283 | +349,985 | 0.00 | 0.06 | +0.06 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 78,307 | 343,678 | +265,371 | 0.16 | 0.55 | +0.39 | buy |
| D. E. Shaw & Co., Inc. | 362,597 | 338,853 | -23,744 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 320,806 | +320,806 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 149,782 | 316,862 | +167,080 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 144,355 | 275,913 | +131,558 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 309,780 | 266,812 | -42,968 | 0.38 | 0.32 | -0.06 | sell |
| Qube Research & Technologies Ltd | 0 | 254,900 | +254,900 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 226,243 | 244,067 | +17,824 | 0.01 | 0.01 | -0.00 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 0 | 216,387 | +216,387 | 0.00 | 0.24 | +0.24 | buy |
| Ikarian Capital, LLC | 0 | 213,865 | +213,865 | 0.00 | 0.21 | +0.21 | buy |
| BARCLAYS PLC | 168,375 | 201,845 | +33,470 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 199,266 | 199,344 | +78 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 181,196 | 188,653 | +7,457 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 174,384 | +174,384 | 0.00 | 0.05 | +0.05 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 143,393 | 161,165 | +17,772 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 191,538 | 154,768 | -36,770 | 0.02 | 0.01 | -0.01 | sell |
| Birchview Capital, LP | 0 | 150,000 | +150,000 | 0.00 | 0.68 | +0.68 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 155,009 | 145,512 | -9,497 | 0.00 | 0.00 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 143,446 | 143,446 | 0 | 1.31 | 0.75 | -0.56 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 197,686 | 143,318 | -54,368 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 48,911 | 131,121 | +82,210 | 0.02 | 0.03 | +0.00 | buy |
| Rafferty Asset Management, LLC | 91,852 | 129,333 | +37,481 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 125,000 | +125,000 | 0.00 | 0.06 | +0.06 | buy |
| Bank of New York Mellon Corp | 114,319 | 122,689 | +8,370 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 35,900 | 104,947 | +69,047 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 150,469 | 104,093 | -46,376 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 412,541 | 96,046 | -316,495 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 0 | 88,851 | +88,851 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 74,221 | +74,221 | 0.00 | 0.04 | +0.04 | buy |
| Caption Management, LLC | 0 | 70,405 | +70,405 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 68,541 | +68,541 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 67,270 | 67,270 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 34,463 | 62,597 | +28,134 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 57,994 | 60,504 | +2,510 | 0.00 | 0.00 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 57,137 | +57,137 | 0.00 | 0.07 | +0.07 | buy |
| AQR CAPITAL MANAGEMENT LLC | 57,311 | 49,002 | -8,309 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 19,778 | 47,665 | +27,887 | 0.01 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 38,357 | 45,570 | +7,213 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 43,378 | +43,378 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 42,469 | +42,469 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 42,251 | +42,251 | 0.00 | 0.01 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 42,098 | 39,772 | -2,326 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 39,107 | +39,107 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,556 | 32,351 | +6,795 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 30,930 | +30,930 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 26,145 | 28,929 | +2,784 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 27,682 | +27,682 | 0.00 | 0.06 | +0.06 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 578,032 | 27,236 | -550,796 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 0 | 27,000 | +27,000 | 0.00 | 0.03 | +0.03 | buy |
| Aries Wealth Management | 26,249 | 26,249 | 0 | 0.05 | 0.04 | -0.01 | hold |
| NewEdge Wealth, LLC | 25,885 | 25,885 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Brevan Howard Capital Management LP | 0 | 25,172 | +25,172 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 23,438 | +23,438 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 21,297 | 22,361 | +1,064 | 0.00 | 0.00 | -0.00 | buy |
| Entropy Technologies, LP | 0 | 20,793 | +20,793 | 0.00 | 0.01 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 16,110 | 20,476 | +4,366 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 19,800 | 19,224 | -576 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 42,930 | 17,887 | -25,043 | 0.01 | 0.00 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 52,377 | 16,410 | -35,967 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 0 | 15,021 | +15,021 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 12,611 | 12,611 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 11,989 | +11,989 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 11,000 | +11,000 | 0.00 | 0.00 | +0.00 | buy |