| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 1,058,776 | 3,925,126 | +2,866,350 | 0.05 | 0.14 | +0.09 | buy |
| ARMISTICE CAPITAL, LLC | 2,096,000 | 3,536,000 | +1,440,000 | 0.27 | 0.32 | +0.05 | buy |
| RTW INVESTMENTS, LP | 5,426,306 | 6,576,306 | +1,150,000 | 0.59 | 0.51 | -0.08 | buy |
| ACORN CAPITAL ADVISORS, LLC | 779,498 | 1,469,153 | +689,655 | 3.49 | 3.84 | +0.35 | buy |
| J. Goldman & Co LP | 413,872 | 947,303 | +533,431 | 0.09 | 0.19 | +0.10 | buy |
| Foresite Capital Management VI LLC | 2,615,120 | 3,135,120 | +520,000 | 8.92 | 7.32 | -1.60 | buy |
| TANG CAPITAL MANAGEMENT LLC | 789,810 | 1,069,810 | +280,000 | 0.27 | 0.41 | +0.14 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 78,307 | 343,678 | +265,371 | 0.15 | 0.51 | +0.37 | buy |
| Stonepine Capital Management, LLC | 2,670,032 | 2,732,079 | +62,047 | 19.17 | 15.40 | -3.77 | buy |
| Rafferty Asset Management, LLC | 91,852 | 129,333 | +37,481 | 0.00 | 0.00 | +0.00 | buy |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 5,949 | 4,500 | -1,449 | 0.00 | 0.00 | -0.00 | sell |
| Polymer Capital Management (HK) LTD | 309,780 | 266,812 | -42,968 | 0.38 | 0.32 | -0.06 | sell |
| Rosalind Advisors, Inc. | 1,929,563 | 1,788,475 | -141,088 | 5.82 | 4.85 | -0.97 | sell |
| Nantahala Capital Management, LLC | 1,292,903 | 462,140 | -830,763 | 0.40 | 0.12 | -0.28 | sell |
| Vivo Capital, LLC | 2,644,985 | 1,106,524 | -1,538,461 | 1.88 | 0.55 | -1.33 | sell |
| Logos Global Management LP | 4,050,000 | 1,700,000 | -2,350,000 | 3.53 | 0.87 | -2.66 | sell |