| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Aberdeen Group plc | 297,889 | 1,704,784 | +1,406,895 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 70,010 | 696,286 | +626,276 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 604,290 | +604,290 | 0.00 | 0.05 | +0.05 | buy |
| ARK Investment Management LLC | 6,775,435 | 7,188,197 | +412,762 | 0.33 | 0.25 | -0.07 | buy |
| MORGAN STANLEY | 249,748 | 559,957 | +310,209 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 410,083 | 635,029 | +224,946 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 177,094 | +177,094 | 0.00 | 0.00 | +0.00 | buy |
| AIGH Capital Management LLC | 3,799,064 | 3,968,948 | +169,884 | 8.27 | 7.23 | -1.04 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 37,666 | 154,147 | +116,481 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 920,868 | 1,033,954 | +113,086 | 0.01 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 91,684 | 202,490 | +110,806 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 182,720 | 284,426 | +101,706 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 22,155 | 122,959 | +100,804 | 0.00 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 14,360 | 114,531 | +100,171 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 873,097 | 949,768 | +76,671 | 0.01 | 0.01 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 86,334 | 144,667 | +58,333 | 0.04 | 0.05 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 58,083 | +58,083 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 33,469 | 82,666 | +49,197 | 0.02 | 0.01 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 47,046 | +47,046 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 44,939 | +44,939 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 43,777 | +43,777 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 2,955,170 | 2,998,522 | +43,352 | 0.00 | 0.00 | -0.00 | buy |
| Blue Water Life Science Advisors, LP | 1,132,900 | 1,175,400 | +42,500 | 5.80 | 4.09 | -1.71 | buy |
| EntryPoint Capital, LLC | 47,513 | 83,628 | +36,115 | 0.12 | 0.13 | +0.02 | buy |
| Dynamic Technology Lab Private Ltd | 43,685 | 76,729 | +33,044 | 0.04 | 0.04 | -0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 25,168 | 55,583 | +30,415 | 0.02 | 0.02 | +0.01 | buy |
| Quantessence Capital LLC | 0 | 28,495 | +28,495 | 0.00 | 0.03 | +0.03 | buy |
| LMR Partners LLP | 0 | 24,232 | +24,232 | 0.00 | 0.00 | +0.00 | buy |
| Massar Capital Management, LP | 0 | 23,973 | +23,973 | 0.00 | 0.10 | +0.10 | buy |
| Brevan Howard Capital Management LP | 0 | 21,924 | +21,924 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 21,412 | +21,412 | 0.00 | 0.03 | +0.03 | buy |
| HOWLAND CAPITAL MANAGEMENT LLC | 262,608 | 282,808 | +20,200 | 0.07 | 0.04 | -0.02 | buy |
| SIH Partners, LLLP | 0 | 19,966 | +19,966 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 0 | 18,490 | +18,490 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 18,444 | +18,444 | 0.00 | 0.08 | +0.08 | buy |
| AMERICAN CENTURY COMPANIES INC | 50,321 | 67,377 | +17,056 | 0.00 | 0.00 | -0.00 | buy |
| WEXFORD CAPITAL LP | 0 | 16,316 | +16,316 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 498,093 | 514,176 | +16,083 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 25,000 | 40,000 | +15,000 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 23,054 | 34,172 | +11,118 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 40,372 | 50,527 | +10,155 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 89,005 | 97,039 | +8,034 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 17,346 | 24,920 | +7,574 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 143,915 | 147,915 | +4,000 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 2,281 | 6,093 | +3,812 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 398,521 | 402,276 | +3,755 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,980 | 17,704 | +2,724 | 0.01 | 0.01 | -0.00 | buy |
| ROYAL BANK OF CANADA | 75,946 | 78,341 | +2,395 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 0 | 1,912 | +1,912 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 202 | 2,030 | +1,828 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 14,557 | 15,432 | +875 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,354 | 2,953 | +599 | 0.00 | 0.00 | -0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,483 | 1,809 | +326 | 0.00 | 0.00 | -0.00 | buy |
| Asset Dedication, LLC | 200 | 400 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Berbice Capital Management LLC | 0 | 200 | +200 | 0.00 | 0.01 | +0.01 | buy |
| SBI Securities Co., Ltd. | 78 | 209 | +131 | 0.00 | 0.00 | +0.00 | buy |
| ORG Partners LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,941 | 22,943 | +2 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 3,709 | 3,709 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 18,350 | 18,350 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 195 | 195 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bruce & Co., Inc. | 253,000 | 253,000 | 0 | 0.47 | 0.28 | -0.18 | hold |
| Wellington Shields & Co., LLC | 292,489 | 292,489 | 0 | 0.52 | 0.32 | -0.20 | hold |
| Focus Partners Wealth | 13,527 | 13,527 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 16,522 | 16,522 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Lightspeed Management Company, L.L.C. | 8,160,734 | 8,160,734 | 0 | 16.63 | 20.99 | +4.35 | hold |
| IEQ CAPITAL, LLC | 22,000 | 22,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Williams Jones Wealth Management, LLC. | 134,072 | 134,072 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Merck & Co., Inc. | 14,044,943 | 14,044,943 | 0 | 31.46 | 30.01 | -1.45 | hold |
| US BANCORP \DE\ | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 493,798 | 493,798 | 0 | 0.01 | 0.01 | -0.00 | hold |
| PERKINS CAPITAL MANAGEMENT INC | 257,307 | 257,307 | 0 | 1.32 | 0.95 | -0.37 | hold |
| Jefferies Financial Group Inc. | 39,600 | 39,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Caitong International Asset Management Co., Ltd | 688 | 590 | -98 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 157 | 0 | -157 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 257 | 0 | -257 | 0.00 | 0.00 | -0.00 | sell |
| Prime Capital Investment Advisors, LLC | 11,772 | 11,468 | -304 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 14,190 | 13,869 | -321 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 11,100 | 10,600 | -500 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 531 | 0 | -531 | 0.00 | 0.00 | -0.00 | sell |
| Ancora Advisors LLC | 800 | 0 | -800 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 1,226 | 0 | -1,226 | 0.00 | 0.00 | -0.00 | sell |
| Green Alpha Advisors, LLC | 38,982 | 37,283 | -1,699 | 0.18 | 0.14 | -0.04 | sell |
| HSBC HOLDINGS PLC | 40,918 | 39,106 | -1,812 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 198,363 | 195,263 | -3,100 | 0.00 | 0.00 | -0.00 | sell |
| Wellington Shields Capital Management, LLC | 431,181 | 426,331 | -4,850 | 0.44 | 0.27 | -0.17 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 4,880 | 0 | -4,880 | 0.01 | 0.00 | -0.01 | sell |
| OMERS ADMINISTRATION Corp | 81,400 | 75,200 | -6,200 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 34,407 | 25,932 | -8,475 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 95,000 | 85,000 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Pathstone Holdings, LLC | 10,215 | 0 | -10,215 | 0.00 | 0.00 | -0.00 | sell |
| Olympiad Research LP | 10,284 | 0 | -10,284 | 0.06 | 0.00 | -0.06 | sell |
| Alpine Global Management, LLC | 10,412 | 0 | -10,412 | 0.02 | 0.00 | -0.02 | sell |
| SG Americas Securities, LLC | 10,829 | 0 | -10,829 | 0.00 | 0.00 | -0.00 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 11,482 | 0 | -11,482 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 212,527 | 201,002 | -11,525 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 11,848 | 0 | -11,848 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 12,560 | 0 | -12,560 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 12,708 | 0 | -12,708 | 0.00 | 0.00 | -0.00 | sell |