| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Merck & Co., Inc. | 14,044,943 | 14,044,943 | 0 | 40.47 | 25.60 | -14.86 | hold |
| Lightspeed Management Company, L.L.C. | 8,160,734 | 8,160,734 | 0 | 4.65 | 5.26 | +0.61 | hold |
| ARK Investment Management LLC | 7,879,087 | 7,944,112 | +65,025 | 0.42 | 0.39 | -0.02 | buy |
| AMERIPRISE FINANCIAL INC | 6,287,151 | 7,592,807 | +1,305,656 | 0.01 | 0.01 | -0.00 | buy |
| BlackRock, Inc. | 5,319,508 | 5,389,885 | +70,377 | 0.00 | 0.00 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 10,780,290 | 4,758,091 | -6,022,199 | 0.05 | 0.02 | -0.03 | sell |
| Aberdeen Group plc | 3,249,895 | 3,488,308 | +238,413 | 0.04 | 0.04 | -0.00 | buy |
| Deep Track Capital, LP | 0 | 3,000,000 | +3,000,000 | 0.00 | 0.39 | +0.39 | buy |
| AIGH Capital Management LLC | 2,900,000 | 2,900,000 | 0 | 6.82 | 3.78 | -3.04 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,712,652 | 2,183,572 | +470,920 | 0.29 | 0.29 | +0.01 | buy |
| Blue Water Life Science Advisors, LP | 1,676,300 | 1,676,300 | 0 | 8.37 | 8.56 | +0.19 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,448,585 | 1,650,141 | +201,556 | 0.00 | 0.00 | -0.00 | buy |
| Casdin Capital, LLC | 0 | 1,600,000 | +1,600,000 | 0.00 | 0.77 | +0.77 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,297,807 | 1,297,655 | -152 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 1,050,590 | 1,134,170 | +83,580 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 983,174 | 1,066,248 | +83,074 | 0.00 | 0.00 | -0.00 | buy |
| PFM Health Sciences, LP | 805,817 | 870,097 | +64,280 | 0.65 | 0.58 | -0.07 | buy |
| GOLDMAN SACHS GROUP INC | 342,475 | 737,132 | +394,657 | 0.00 | 0.00 | +0.00 | buy |
| Portolan Capital Management, LLC | 379,197 | 736,713 | +357,516 | 0.16 | 0.25 | +0.09 | buy |
| JPMORGAN CHASE & CO | 26,716 | 575,490 | +548,774 | 0.00 | 0.00 | +0.00 | buy |
| HOWLAND CAPITAL MANAGEMENT LLC | 547,115 | 547,115 | 0 | 0.17 | 0.14 | -0.03 | hold |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 493,798 | 493,798 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Sumitomo Mitsui Trust Group, Inc. | 518,441 | 484,270 | -34,171 | 0.00 | 0.00 | -0.00 | sell |
| Nikko Asset Management Americas, Inc. | 518,441 | 484,270 | -34,171 | 0.05 | 0.04 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 0 | 419,128 | +419,128 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 354,918 | 405,800 | +50,882 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 306,568 | 383,503 | +76,935 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 308,680 | 343,520 | +34,840 | 0.00 | 0.00 | -0.00 | buy |
| Wellington Shields Capital Management, LLC | 340,000 | 339,733 | -267 | 0.39 | 0.32 | -0.07 | sell |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 267,674 | 323,374 | +55,700 | 0.15 | 0.16 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 308,696 | +308,696 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 300,000 | +300,000 | 0.00 | 0.00 | +0.00 | buy |
| Wellington Shields & Co., LLC | 292,489 | 292,489 | 0 | 0.57 | 0.47 | -0.10 | hold |
| PERKINS CAPITAL MANAGEMENT INC | 239,000 | 239,000 | 0 | 1.51 | 1.43 | -0.08 | hold |
| MORGAN STANLEY | 224,563 | 237,315 | +12,752 | 0.00 | 0.00 | -0.00 | buy |
| Bruce & Co., Inc. | 233,000 | 233,000 | 0 | 0.58 | 0.42 | -0.15 | hold |
| FIRST MANHATTAN CO. LLC. | 373,822 | 230,600 | -143,222 | 0.01 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 209,826 | +209,826 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 97,772 | 208,891 | +111,119 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 0 | 156,036 | +156,036 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,967 | 149,336 | +118,369 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 158,170 | 144,626 | -13,544 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 56,006 | 139,046 | +83,040 | 0.00 | 0.00 | +0.00 | buy |
| Williams Jones Wealth Management, LLC. | 134,072 | 134,072 | 0 | 0.01 | 0.01 | -0.00 | hold |
| LPL Financial LLC | 132,343 | 132,012 | -331 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 122,951 | 124,641 | +1,690 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 114,001 | 114,683 | +682 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 60,033 | 111,306 | +51,273 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 271,876 | 105,678 | -166,198 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 0 | 105,400 | +105,400 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 4,184 | 101,937 | +97,753 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 32,476 | 90,711 | +58,235 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 82,175 | +82,175 | 0.00 | 0.03 | +0.03 | buy |
| ROYAL BANK OF CANADA | 79,310 | 78,742 | -568 | 0.00 | 0.00 | -0.00 | sell |
| Janney Montgomery Scott LLC | 30,000 | 75,000 | +45,000 | 0.00 | 0.00 | +0.00 | buy |
| Green Alpha Advisors, LLC | 68,517 | 66,409 | -2,108 | 0.50 | 0.42 | -0.08 | sell |
| Aquatic Capital Management LLC | 0 | 64,269 | +64,269 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 64,181 | 63,111 | -1,070 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 39,875 | 62,745 | +22,870 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,391 | 62,686 | +59,295 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 61,844 | 61,292 | -552 | 0.01 | 0.01 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 56,834 | 58,972 | +2,138 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 119,951 | 51,577 | -68,374 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 0 | 38,722 | +38,722 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 39,015 | 38,449 | -566 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 38,827 | 34,899 | -3,928 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 34,434 | +34,434 | 0.00 | 0.01 | +0.01 | buy |
| Cerity Partners LLC | 0 | 34,100 | +34,100 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,265 | 31,126 | +29,861 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 30,200 | +30,200 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 64,251 | 28,975 | -35,276 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 28,700 | 28,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 18,658 | 28,002 | +9,344 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,572 | 27,698 | +23,126 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 25,643 | +25,643 | 0.00 | 0.04 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.01 | +0.01 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 23,533 | +23,533 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 20,929 | +20,929 | 0.00 | 0.05 | +0.05 | buy |
| China Universal Asset Management Co., Ltd. | 14,471 | 18,568 | +4,097 | 0.01 | 0.01 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 777 | 18,128 | +17,351 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 44,678 | 17,731 | -26,947 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 10,240 | 17,422 | +7,182 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 20,062 | 17,344 | -2,718 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 39,412 | 16,035 | -23,377 | 0.01 | 0.00 | -0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,800 | 15,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Creative Planning | 15,768 | 15,748 | -20 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 92,994 | 15,200 | -77,794 | 0.00 | 0.00 | -0.00 | sell |
| Arizona State Retirement System | 0 | 14,635 | +14,635 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,745 | 14,179 | -1,566 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 13,456 | 13,634 | +178 | 0.00 | 0.00 | -0.00 | buy |
| Scientech Research LLC | 12,402 | 13,575 | +1,173 | 0.06 | 0.07 | +0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 13,578 | 13,372 | -206 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 12,974 | 12,974 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RAYMOND JAMES FINANCIAL INC | 11,600 | 12,800 | +1,200 | 0.00 | 0.00 | -0.00 | buy |
| AXQ CAPITAL, LP | 14,965 | 12,350 | -2,615 | 0.03 | 0.01 | -0.02 | sell |
| ProShare Advisors LLC | 13,081 | 11,950 | -1,131 | 0.00 | 0.00 | -0.00 | sell |
| KLP KAPITALFORVALTNING AS | 0 | 11,700 | +11,700 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 11,495 | +11,495 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 20,342 | 10,945 | -9,397 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 27,608 | 7,324 | -20,284 | 0.00 | 0.00 | -0.00 | sell |