| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 0 | 3,000,000 | +3,000,000 | 0.00 | 0.39 | +0.39 | buy |
| Casdin Capital, LLC | 0 | 1,600,000 | +1,600,000 | 0.00 | 0.77 | +0.77 | buy |
| AMERIPRISE FINANCIAL INC | 6,287,151 | 7,592,807 | +1,305,656 | 0.01 | 0.01 | -0.00 | buy |
| JPMORGAN CHASE & CO | 26,716 | 575,490 | +548,774 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,712,652 | 2,183,572 | +470,920 | 0.29 | 0.29 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 419,128 | +419,128 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 342,475 | 737,132 | +394,657 | 0.00 | 0.00 | +0.00 | buy |
| Portolan Capital Management, LLC | 379,197 | 736,713 | +357,516 | 0.16 | 0.25 | +0.09 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 308,696 | +308,696 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 300,000 | +300,000 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 3,249,895 | 3,488,308 | +238,413 | 0.04 | 0.04 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 209,826 | +209,826 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,448,585 | 1,650,141 | +201,556 | 0.00 | 0.00 | -0.00 | buy |
| ROYCE & ASSOCIATES LP | 0 | 156,036 | +156,036 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,967 | 149,336 | +118,369 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 97,772 | 208,891 | +111,119 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 105,400 | +105,400 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 4,184 | 101,937 | +97,753 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,050,590 | 1,134,170 | +83,580 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 983,174 | 1,066,248 | +83,074 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 56,006 | 139,046 | +83,040 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 82,175 | +82,175 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 306,568 | 383,503 | +76,935 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 5,319,508 | 5,389,885 | +70,377 | 0.00 | 0.00 | -0.00 | buy |
| ARK Investment Management LLC | 7,879,087 | 7,944,112 | +65,025 | 0.42 | 0.39 | -0.02 | buy |
| PFM Health Sciences, LP | 805,817 | 870,097 | +64,280 | 0.65 | 0.58 | -0.07 | buy |
| Aquatic Capital Management LLC | 0 | 64,269 | +64,269 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 3,391 | 62,686 | +59,295 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 32,476 | 90,711 | +58,235 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 267,674 | 323,374 | +55,700 | 0.15 | 0.16 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 60,033 | 111,306 | +51,273 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 354,918 | 405,800 | +50,882 | 0.00 | 0.00 | -0.00 | buy |
| Janney Montgomery Scott LLC | 30,000 | 75,000 | +45,000 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 38,722 | +38,722 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 308,680 | 343,520 | +34,840 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 34,434 | +34,434 | 0.00 | 0.01 | +0.01 | buy |
| Cerity Partners LLC | 0 | 34,100 | +34,100 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 30,200 | +30,200 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,265 | 31,126 | +29,861 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 25,643 | +25,643 | 0.00 | 0.04 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.01 | +0.01 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 23,533 | +23,533 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,572 | 27,698 | +23,126 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 39,875 | 62,745 | +22,870 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 20,929 | +20,929 | 0.00 | 0.05 | +0.05 | buy |
| Tower Research Capital LLC (TRC) | 777 | 18,128 | +17,351 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 14,635 | +14,635 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 224,563 | 237,315 | +12,752 | 0.00 | 0.00 | -0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 11,700 | +11,700 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 11,495 | +11,495 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 18,658 | 28,002 | +9,344 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 10,240 | 17,422 | +7,182 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,471 | 18,568 | +4,097 | 0.01 | 0.01 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 3,600 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| Opal Wealth Advisors, LLC | 0 | 3,500 | +3,500 | 0.00 | 0.01 | +0.01 | buy |
| Quantbot Technologies LP | 0 | 2,239 | +2,239 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 56,834 | 58,972 | +2,138 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 1,977 | +1,977 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 122,951 | 124,641 | +1,690 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 11,600 | 12,800 | +1,200 | 0.00 | 0.00 | -0.00 | buy |
| Scientech Research LLC | 12,402 | 13,575 | +1,173 | 0.06 | 0.07 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 4,315 | 5,458 | +1,143 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 47 | 1,099 | +1,052 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 0 | 701 | +701 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 114,001 | 114,683 | +682 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 172 | 596 | +424 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,744 | 1,982 | +238 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 13,456 | 13,634 | +178 | 0.00 | 0.00 | -0.00 | buy |
| HUNTINGTON NATIONAL BANK | 0 | 144 | +144 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 85 | +85 | 0.00 | 0.00 | +0.00 | buy |
| TWIN PEAKS WEALTH ADVISORS, LLC | 0 | 72 | +72 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 53 | +53 | 0.00 | 0.00 | +0.00 | buy |
| Western Wealth Management, LLC | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 165 | 172 | +7 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 77 | 80 | +3 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,235 | 4,235 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HOWLAND CAPITAL MANAGEMENT LLC | 547,115 | 547,115 | 0 | 0.17 | 0.14 | -0.03 | hold |
| ALLIANCEBERNSTEIN L.P. | 28,700 | 28,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bruce & Co., Inc. | 233,000 | 233,000 | 0 | 0.58 | 0.42 | -0.15 | hold |
| Ancora Advisors LLC | 690 | 690 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Wellington Shields & Co., LLC | 292,489 | 292,489 | 0 | 0.57 | 0.47 | -0.10 | hold |
| Lightspeed Management Company, L.L.C. | 8,160,734 | 8,160,734 | 0 | 4.65 | 5.26 | +0.61 | hold |
| Sound Income Strategies, LLC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Williams Jones Wealth Management, LLC. | 134,072 | 134,072 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Blue Water Life Science Advisors, LP | 1,676,300 | 1,676,300 | 0 | 8.37 | 8.56 | +0.19 | hold |
| Physician Wealth Advisors, Inc. | 437 | 437 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 3,900 | 3,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AIGH Capital Management LLC | 2,900,000 | 2,900,000 | 0 | 6.82 | 3.78 | -3.04 | hold |
| Police & Firemen's Retirement System of New Jersey | 12,974 | 12,974 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Merck & Co., Inc. | 14,044,943 | 14,044,943 | 0 | 40.47 | 25.60 | -14.86 | hold |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 493,798 | 493,798 | 0 | 0.02 | 0.02 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,800 | 15,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 289 | 289 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERKINS CAPITAL MANAGEMENT INC | 239,000 | 239,000 | 0 | 1.51 | 1.43 | -0.08 | hold |
| Arax Advisory Partners | 9 | 0 | -9 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 15,768 | 15,748 | -20 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 187 | 162 | -25 | 0.00 | 0.00 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 36 | 0 | -36 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 57 | 0 | -57 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 100 | 31 | -69 | 0.00 | 0.00 | -0.00 | sell |