| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 2,998,522 | 5,203,993 | +2,205,471 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,290,591 | 3,137,061 | +1,846,470 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 1,264,455 | +1,264,455 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 514,176 | 1,365,598 | +851,422 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 635,571 | +635,571 | 0.00 | 0.00 | +0.00 | buy |
| Blue Water Life Science Advisors, LP | 1,175,400 | 1,676,300 | +500,900 | 4.09 | 8.70 | +4.62 | buy |
| STATE STREET CORP | 195,263 | 687,584 | +492,321 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 34,172 | 437,369 | +403,197 | 0.00 | 0.03 | +0.03 | buy |
| AMERIPRISE FINANCIAL INC | 25,932 | 329,865 | +303,933 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 97,039 | 399,989 | +302,950 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 871,512 | 1,090,727 | +219,215 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 1,287 | 184,240 | +182,953 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 635,029 | 784,864 | +149,835 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,943 | 159,142 | +136,199 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 119,814 | +119,814 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 118,925 | +118,925 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 116,162 | +116,162 | 0.00 | 0.12 | +0.12 | buy |
| RHUMBLINE ADVISERS | 3,709 | 79,268 | +75,559 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 71,700 | +71,700 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 78,341 | 149,878 | +71,537 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 69,923 | +69,923 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 68,679 | +68,679 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 559,957 | 626,459 | +66,502 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 1,704,784 | 1,759,497 | +54,713 | 0.01 | 0.02 | +0.01 | buy |
| BARCLAYS PLC | 85,991 | 140,378 | +54,387 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 49,373 | +49,373 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 604,290 | 653,383 | +49,093 | 0.05 | 0.10 | +0.05 | buy |
| Mach-1 Financial Group, LLC | 0 | 48,822 | +48,822 | 0.00 | 0.09 | +0.09 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 38,459 | +38,459 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 55,583 | 92,841 | +37,258 | 0.02 | 0.05 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 0 | 32,867 | +32,867 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 30,471 | +30,471 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 29,491 | +29,491 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 28,700 | +28,700 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 21,412 | 47,944 | +26,532 | 0.03 | 0.01 | -0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 26,317 | +26,317 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 25,200 | +25,200 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 13,869 | 37,102 | +23,233 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 67,377 | 89,669 | +22,292 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 201,002 | 222,011 | +21,009 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 18,757 | +18,757 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 16,386 | +16,386 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 85,000 | 101,146 | +16,146 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 15,800 | +15,800 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 39,106 | 54,553 | +15,447 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 14,036 | +14,036 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 13,581 | +13,581 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 11,472 | +11,472 | 0.00 | 0.00 | +0.00 | buy |
| Alpha Wealth Funds, LLC | 0 | 10,034 | +10,034 | 0.00 | 0.06 | +0.06 | buy |
| STIFEL FINANCIAL CORP | 40,000 | 50,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,274 | 6,451 | +5,177 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 5,120 | +5,120 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 4,572 | +4,572 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 3,129 | +3,129 | 0.00 | 0.00 | +0.00 | buy |
| HOWLAND CAPITAL MANAGEMENT LLC | 282,808 | 285,308 | +2,500 | 0.04 | 0.08 | +0.03 | buy |
| AMALGAMATED BANK | 0 | 1,713 | +1,713 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 590 | 2,200 | +1,610 | 0.00 | 0.01 | +0.01 | buy |
| Sterling Capital Management LLC | 0 | 1,354 | +1,354 | 0.00 | 0.00 | +0.00 | buy |
| GPS Wealth Strategies Group, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,953 | 3,412 | +459 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 437 | +437 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 211 | +211 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 165 | +165 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 158 | +158 | 0.00 | 0.00 | +0.00 | buy |
| Rise Advisors, LLC | 0 | 142 | +142 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 65 | +65 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,704 | 17,740 | +36 | 0.01 | 0.01 | +0.01 | buy |
| Bruce & Co., Inc. | 253,000 | 253,000 | 0 | 0.28 | 0.54 | +0.25 | hold |
| Daiwa Securities Group Inc. | 400 | 400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Wellington Shields Capital Management, LLC | 426,331 | 426,331 | 0 | 0.27 | 0.47 | +0.20 | hold |
| Wellington Shields & Co., LLC | 292,489 | 292,489 | 0 | 0.32 | 0.54 | +0.22 | hold |
| Focus Partners Wealth | 13,527 | 13,527 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 16,522 | 16,522 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Lightspeed Management Company, L.L.C. | 8,160,734 | 8,160,734 | 0 | 20.99 | 22.42 | +1.43 | hold |
| IEQ CAPITAL, LLC | 22,000 | 22,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Williams Jones Wealth Management, LLC. | 134,072 | 134,072 | 0 | 0.01 | 0.01 | +0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 1,809 | 1,809 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Merck & Co., Inc. | 14,044,943 | 14,044,943 | 0 | 30.01 | 42.73 | +12.73 | hold |
| RAYMOND JAMES FINANCIAL INC | 10,600 | 10,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 493,798 | 493,798 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Larson Financial Group LLC | 1,912 | 1,869 | -43 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL SECURITIES, INC. | 195 | 134 | -61 | 0.00 | 0.00 | -0.00 | sell |
| ORG Partners LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 1,000 | 900 | -100 | 0.00 | 0.00 | +0.00 | sell |
| SBI Securities Co., Ltd. | 209 | 66 | -143 | 0.00 | 0.00 | -0.00 | sell |
| Berbice Capital Management LLC | 200 | 0 | -200 | 0.01 | 0.00 | -0.01 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,030 | 1,827 | -203 | 0.00 | 0.00 | +0.00 | sell |
| Asset Dedication, LLC | 400 | 0 | -400 | 0.00 | 0.00 | -0.00 | sell |
| PERKINS CAPITAL MANAGEMENT INC | 257,307 | 252,500 | -4,807 | 0.95 | 1.67 | +0.71 | sell |
| GROUP ONE TRADING LLC | 6,093 | 1,211 | -4,882 | 0.00 | 0.00 | -0.00 | sell |
| Green Alpha Advisors, LLC | 37,283 | 31,839 | -5,444 | 0.14 | 0.20 | +0.06 | sell |
| Russell Investments Group, Ltd. | 15,432 | 8,480 | -6,952 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 154,147 | 146,617 | -7,530 | 0.01 | 0.03 | +0.02 | sell |
| LPL Financial LLC | 147,915 | 139,390 | -8,525 | 0.00 | 0.00 | +0.00 | sell |
| Prime Capital Investment Advisors, LLC | 11,468 | 0 | -11,468 | 0.00 | 0.00 | -0.00 | sell |
| WEXFORD CAPITAL LP | 16,316 | 0 | -16,316 | 0.01 | 0.00 | -0.01 | sell |
| PRUDENTIAL FINANCIAL INC | 18,350 | 0 | -18,350 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 18,444 | 0 | -18,444 | 0.08 | 0.00 | -0.08 | sell |
| FRANKLIN RESOURCES INC | 18,490 | 0 | -18,490 | 0.00 | 0.00 | -0.00 | sell |
| SIH Partners, LLLP | 19,966 | 0 | -19,966 | 0.01 | 0.00 | -0.01 | sell |