| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Merck & Co., Inc. | 14,044,943 | 14,044,943 | 0 | 25.60 | 35.75 | +10.15 | hold |
| ARK Investment Management LLC | 7,944,112 | 8,271,339 | +327,227 | 0.39 | 0.72 | +0.33 | buy |
| BlackRock, Inc. | 5,389,885 | 7,082,491 | +1,692,606 | 0.00 | 0.00 | +0.00 | buy |
| Lightspeed Management Company, L.L.C. | 8,160,734 | 6,101,850 | -2,058,884 | 5.26 | 3.40 | -1.86 | sell |
| AMERIPRISE FINANCIAL INC | 7,592,807 | 6,086,315 | -1,506,492 | 0.01 | 0.02 | +0.01 | sell |
| Deep Track Capital, LP | 3,000,000 | 4,000,000 | +1,000,000 | 0.39 | 0.79 | +0.40 | buy |
| Aberdeen Group plc | 3,488,308 | 3,747,290 | +258,982 | 0.04 | 0.07 | +0.03 | buy |
| Casdin Capital, LLC | 1,600,000 | 2,550,000 | +950,000 | 0.77 | 1.71 | +0.94 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 2,183,572 | 2,364,282 | +180,710 | 0.29 | 0.56 | +0.27 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,297,655 | 1,822,445 | +524,790 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 111,306 | 1,820,541 | +1,709,235 | 0.00 | 0.00 | +0.00 | buy |
| AIGH Capital Management LLC | 2,900,000 | 1,715,000 | -1,185,000 | 3.78 | 2.08 | -1.70 | sell |
| Blue Water Life Science Advisors, LP | 1,676,300 | 1,676,300 | 0 | 8.56 | 14.15 | +5.59 | hold |
| DIMENSIONAL FUND ADVISORS LP | 1,066,248 | 1,496,983 | +430,735 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,134,170 | 1,487,077 | +352,907 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 237,315 | 1,270,946 | +1,033,631 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 737,132 | 931,031 | +193,899 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 208,891 | 930,816 | +721,925 | 0.00 | 0.02 | +0.02 | buy |
| Nuveen, LLC | 343,520 | 753,004 | +409,484 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 738,241 | +738,241 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 405,800 | 632,803 | +227,003 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 600,216 | +600,216 | 0.00 | 0.05 | +0.05 | buy |
| HOWLAND CAPITAL MANAGEMENT LLC | 547,115 | 555,641 | +8,526 | 0.14 | 0.27 | +0.13 | buy |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 493,798 | 493,798 | 0 | 0.02 | 0.03 | +0.01 | hold |
| MILLENNIUM MANAGEMENT LLC | 419,128 | 450,160 | +31,032 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 484,270 | 417,488 | -66,782 | 0.00 | 0.00 | +0.00 | sell |
| Nikko Asset Management Americas, Inc. | 484,270 | 417,488 | -66,782 | 0.04 | 0.07 | +0.03 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 13,634 | 364,764 | +351,130 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 323,374 | 351,741 | +28,367 | 0.16 | 0.30 | +0.14 | buy |
| Wellington Shields Capital Management, LLC | 339,733 | 339,733 | 0 | 0.32 | 0.58 | +0.25 | hold |
| Wellington Shields & Co., LLC | 292,489 | 292,489 | 0 | 0.47 | 0.88 | +0.40 | hold |
| GILDER GAGNON HOWE & CO LLC | 0 | 278,490 | +278,490 | 0.00 | 0.04 | +0.04 | buy |
| TUDOR INVESTMENT CORP ET AL | 209,826 | 274,321 | +64,495 | 0.01 | 0.02 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 0 | 247,783 | +247,783 | 0.00 | 0.57 | +0.57 | buy |
| PERKINS CAPITAL MANAGEMENT INC | 239,000 | 239,000 | 0 | 1.43 | 2.41 | +0.98 | hold |
| Bruce & Co., Inc. | 233,000 | 233,000 | 0 | 0.42 | 0.84 | +0.42 | hold |
| FIRST MANHATTAN CO. LLC. | 230,600 | 230,600 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Sixth Street Partners Management Company, L.P. | 0 | 209,320 | +209,320 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 144,626 | 209,320 | +64,694 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 124,641 | 189,065 | +64,424 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 165,579 | +165,579 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 383,503 | 164,761 | -218,742 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,650,141 | 158,838 | -1,491,303 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 144,998 | +144,998 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 105,400 | 136,500 | +31,100 | 0.00 | 0.00 | +0.00 | buy |
| Williams Jones Wealth Management, LLC. | 134,072 | 134,072 | 0 | 0.01 | 0.02 | +0.01 | hold |
| LPL Financial LLC | 132,012 | 132,602 | +590 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 130,294 | +130,294 | 0.00 | 0.02 | +0.02 | buy |
| Russell Investments Group, Ltd. | 101,937 | 123,271 | +21,334 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 61,292 | 121,299 | +60,007 | 0.01 | 0.03 | +0.02 | buy |
| Engineers Gate Manager LP | 0 | 115,842 | +115,842 | 0.00 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 58,972 | 105,225 | +46,253 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 75,000 | 105,001 | +30,001 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 114,683 | 100,094 | -14,589 | 0.00 | 0.00 | +0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 99,542 | +99,542 | 0.00 | 0.02 | +0.02 | buy |
| Kercheville Advisors, LLC | 0 | 93,800 | +93,800 | 0.00 | 0.38 | +0.38 | buy |
| CITIGROUP INC | 7,324 | 92,708 | +85,384 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,099 | 87,068 | +85,969 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 149,336 | 86,982 | -62,354 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 63,111 | 86,321 | +23,210 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 0 | 85,504 | +85,504 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 62,745 | 83,368 | +20,623 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,714 | 75,266 | +72,552 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 28,700 | 73,700 | +45,000 | 0.00 | 0.00 | +0.00 | buy |
| Green Alpha Advisors, LLC | 66,409 | 67,467 | +1,058 | 0.42 | 0.61 | +0.19 | buy |
| WELLS FARGO & COMPANY/MN | 28,975 | 66,775 | +37,800 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 34,899 | 66,188 | +31,289 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 78,742 | 63,947 | -14,795 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 16,035 | 59,143 | +43,108 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 90,711 | 57,258 | -33,453 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 51,577 | 53,437 | +1,860 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 139,046 | 52,033 | -87,013 | 0.00 | 0.00 | -0.00 | sell |
| UDINE WEALTH MANAGEMENT, INC. | 0 | 50,030 | +50,030 | 0.00 | 1.19 | +1.19 | buy |
| Cerity Partners LLC | 34,100 | 49,264 | +15,164 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 49,256 | +49,256 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 48,989 | +48,989 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 31,126 | 47,022 | +15,896 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 82,175 | 43,244 | -38,931 | 0.03 | 0.04 | +0.00 | sell |
| JPMORGAN CHASE & CO | 575,490 | 42,569 | -532,921 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 40,842 | +40,842 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 40,763 | +40,763 | 0.00 | 0.05 | +0.05 | buy |
| MetLife Investment Management, LLC | 28,002 | 39,769 | +11,767 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 38,449 | 39,015 | +566 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 38,394 | +38,394 | 0.00 | 0.11 | +0.11 | buy |
| AlpInvest Partners B.V. | 0 | 37,703 | +37,703 | 0.00 | 0.84 | +0.84 | buy |
| WINTON GROUP Ltd | 0 | 37,013 | +37,013 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 27,698 | 36,419 | +8,721 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 0 | 30,420 | +30,420 | 0.00 | 0.02 | +0.02 | buy |
| IEQ CAPITAL, LLC | 0 | 27,327 | +27,327 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 26,730 | +26,730 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 26,502 | +26,502 | 0.00 | 0.01 | +0.01 | buy |
| CAPTRUST FINANCIAL ADVISORS | 23,533 | 25,591 | +2,058 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 23,808 | +23,808 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,800 | 23,800 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 23,700 | +23,700 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 11,700 | 23,400 | +11,700 | 0.00 | 0.00 | +0.00 | buy |
| Alamea Verwaltungs GmbH | 0 | 23,275 | +23,275 | 0.00 | 0.25 | +0.25 | buy |
| Police & Firemen's Retirement System of New Jersey | 12,974 | 20,010 | +7,036 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 77 | 19,610 | +19,533 | 0.00 | 0.04 | +0.04 | buy |
| Arizona State Retirement System | 14,635 | 18,766 | +4,131 | 0.00 | 0.00 | +0.00 | buy |