| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Merck & Co., Inc. | 14,044,943 | 14,044,943 | 0 | 42.73 | 40.16 | -2.58 | hold |
| Lightspeed Management Company, L.L.C. | 8,160,734 | 8,160,734 | 0 | 22.42 | 16.53 | -5.89 | hold |
| ARK Investment Management LLC | 7,107,923 | 7,910,191 | +802,268 | 0.34 | 0.31 | -0.03 | buy |
| BlackRock, Inc. | 5,203,993 | 5,644,799 | +440,806 | 0.00 | 0.00 | -0.00 | buy |
| AIGH Capital Management LLC | 3,723,958 | 3,892,101 | +168,143 | 11.46 | 8.89 | -2.58 | buy |
| VANGUARD GROUP INC | 3,137,061 | 3,006,410 | -130,651 | 0.00 | 0.00 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 1,264,455 | 2,883,576 | +1,619,121 | 0.01 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 1,759,497 | 2,387,947 | +628,450 | 0.02 | 0.02 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 653,383 | 1,935,078 | +1,281,695 | 0.10 | 0.28 | +0.18 | buy |
| Blue Water Life Science Advisors, LP | 1,676,300 | 1,676,300 | 0 | 8.70 | 9.97 | +1.27 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,365,598 | 1,333,541 | -32,057 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,090,727 | 1,210,754 | +120,027 | 0.01 | 0.01 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 784,864 | 973,655 | +188,791 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 687,584 | 926,347 | +238,763 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 640,420 | 590,996 | -49,424 | 0.00 | 0.00 | -0.00 | sell |
| Nikko Asset Management Americas, Inc. | 634,317 | 590,996 | -43,321 | 0.04 | 0.04 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 209,666 | 573,981 | +364,315 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 493,798 | 493,798 | 0 | 0.02 | 0.02 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 563,243 | 453,043 | -110,200 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 399,989 | 393,784 | -6,205 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 626,459 | 342,055 | -284,404 | 0.00 | 0.00 | -0.00 | sell |
| HOWLAND CAPITAL MANAGEMENT LLC | 285,308 | 330,673 | +45,365 | 0.08 | 0.08 | +0.01 | buy |
| Nuveen, LLC | 635,571 | 308,680 | -326,891 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 329,865 | 299,025 | -30,840 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 119,814 | 295,564 | +175,750 | 0.00 | 0.00 | +0.00 | buy |
| Wellington Shields & Co., LLC | 292,489 | 292,489 | 0 | 0.54 | 0.50 | -0.05 | hold |
| Wellington Shields Capital Management, LLC | 426,331 | 292,135 | -134,196 | 0.47 | 0.29 | -0.18 | sell |
| Bruce & Co., Inc. | 253,000 | 253,000 | 0 | 0.54 | 0.51 | -0.03 | hold |
| PERKINS CAPITAL MANAGEMENT INC | 252,500 | 252,500 | 0 | 1.67 | 1.45 | -0.21 | hold |
| ORACLE INVESTMENT MANAGEMENT INC | 0 | 229,435 | +229,435 | 0.00 | 1.04 | +1.04 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 92,841 | 185,036 | +92,195 | 0.05 | 0.08 | +0.03 | buy |
| JBF Capital, Inc. | 0 | 166,104 | +166,104 | 0.00 | 0.15 | +0.15 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 159,142 | 158,142 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 149,878 | 154,377 | +4,499 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 139,390 | 134,092 | -5,298 | 0.00 | 0.00 | -0.00 | sell |
| Williams Jones Wealth Management, LLC. | 134,072 | 134,072 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Bank of New York Mellon Corp | 118,925 | 125,312 | +6,387 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 140,378 | 114,803 | -25,575 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 89,669 | 112,010 | +22,341 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 110,883 | +110,883 | 0.00 | 0.08 | +0.08 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 146,617 | 108,951 | -37,666 | 0.03 | 0.03 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 101,146 | 101,146 | 0 | 0.00 | 0.00 | -0.00 | hold |
| XTX Topco Ltd | 0 | 82,709 | +82,709 | 0.00 | 0.03 | +0.03 | buy |
| RHUMBLINE ADVISERS | 79,268 | 74,115 | -5,153 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 69,923 | 64,665 | -5,258 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 47,944 | 61,844 | +13,900 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 56,893 | 56,758 | -135 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 0 | 54,584 | +54,584 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 54,553 | 51,441 | -3,112 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 50,000 | 48,001 | -1,999 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 38,459 | 46,929 | +8,470 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 124,114 | 46,193 | -77,921 | 0.06 | 0.03 | -0.03 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 63,796 | 43,548 | -20,248 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 37,102 | 40,213 | +3,111 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 32,867 | 37,172 | +4,305 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 30,471 | 29,793 | -678 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 28,700 | 28,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Green Alpha Advisors, LLC | 31,839 | 28,391 | -3,448 | 0.20 | 0.18 | -0.02 | sell |
| Janney Montgomery Scott LLC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 29,491 | 24,833 | -4,658 | 0.00 | 0.00 | -0.00 | sell |
| IEQ CAPITAL, LLC | 22,000 | 22,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Squarepoint Ops LLC | 0 | 18,886 | +18,886 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 18,043 | +18,043 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,757 | 17,450 | -1,307 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 16,522 | 16,522 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 26,317 | 16,491 | -9,826 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,800 | 15,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 17,740 | 15,544 | -2,196 | 0.01 | 0.01 | -0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 14,855 | +14,855 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,451 | 14,796 | +8,345 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 13,527 | 13,527 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FourThought Financial Partners, LLC | 0 | 13,145 | +13,145 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,472 | 12,974 | +1,502 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 0 | 12,558 | +12,558 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 13,581 | 11,733 | -1,848 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 10,600 | 11,600 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 10,069 | +10,069 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 6,076 | +6,076 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,120 | 5,120 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 4,572 | 4,572 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 8,480 | 4,153 | -4,327 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 1,354 | 3,460 | +2,106 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,412 | 3,428 | +16 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,129 | 3,132 | +3 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,418 | 2,598 | -3,820 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 211 | 2,354 | +2,143 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 184,240 | 2,290 | -181,950 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 1,211 | 2,142 | +931 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 2,200 | 1,944 | -256 | 0.01 | 0.01 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,809 | 1,908 | +99 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 1,713 | 1,713 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,827 | 1,265 | -562 | 0.00 | 0.00 | -0.00 | sell |
| GPS Wealth Strategies Group, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 0 | 700 | +700 | 0.00 | 0.00 | +0.00 | buy |
| Ancora Advisors LLC | 0 | 690 | +690 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 437 | 437 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Berbice Capital Management LLC | 0 | 320 | +320 | 0.00 | 0.02 | +0.02 | buy |
| EverSource Wealth Advisors, LLC | 165 | 165 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rise Advisors, LLC | 142 | 142 | 0 | 0.00 | 0.00 | -0.00 | hold |