| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Merck & Co., Inc. | 14,044,943 | 14,044,943 | 0 | 40.16 | 40.47 | +0.31 | hold |
| T. Rowe Price Investment Management, Inc. | 2,883,576 | 10,780,290 | +7,896,714 | 0.01 | 0.05 | +0.04 | buy |
| Lightspeed Management Company, L.L.C. | 8,160,734 | 8,160,734 | 0 | 16.53 | 4.65 | -11.87 | hold |
| ARK Investment Management LLC | 7,910,191 | 7,879,087 | -31,104 | 0.31 | 0.42 | +0.11 | sell |
| AMERIPRISE FINANCIAL INC | 299,025 | 6,287,151 | +5,988,126 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 5,644,799 | 5,319,508 | -325,291 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 3,006,410 | 3,253,797 | +247,387 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 2,387,947 | 3,249,895 | +861,948 | 0.02 | 0.04 | +0.02 | buy |
| AIGH Capital Management LLC | 3,892,101 | 2,900,000 | -992,101 | 8.89 | 6.82 | -2.06 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,935,078 | 1,712,652 | -222,426 | 0.28 | 0.29 | +0.01 | sell |
| Blue Water Life Science Advisors, LP | 1,676,300 | 1,676,300 | 0 | 9.97 | 8.37 | -1.60 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 101,146 | 1,448,585 | +1,347,439 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,333,541 | 1,297,807 | -35,734 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 926,347 | 1,050,590 | +124,243 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 973,655 | 983,174 | +9,519 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 805,817 | +805,817 | 0.00 | 0.65 | +0.65 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 0 | 624,363 | +624,363 | 0.00 | 0.35 | +0.35 | buy |
| HOWLAND CAPITAL MANAGEMENT LLC | 330,673 | 547,115 | +216,442 | 0.08 | 0.17 | +0.08 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 590,996 | 518,441 | -72,555 | 0.00 | 0.00 | +0.00 | sell |
| Nikko Asset Management Americas, Inc. | 590,996 | 518,441 | -72,555 | 0.04 | 0.05 | +0.01 | sell |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 493,798 | 493,798 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Portolan Capital Management, LLC | 0 | 379,197 | +379,197 | 0.00 | 0.16 | +0.16 | buy |
| FIRST MANHATTAN CO. LLC. | 0 | 373,822 | +373,822 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 393,784 | 354,918 | -38,866 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 573,981 | 342,475 | -231,506 | 0.00 | 0.00 | -0.00 | sell |
| Wellington Shields Capital Management, LLC | 292,135 | 340,000 | +47,865 | 0.29 | 0.39 | +0.11 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 229,435 | 339,343 | +109,908 | 1.04 | 1.77 | +0.73 | buy |
| Nuveen, LLC | 308,680 | 308,680 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS Group AG | 295,564 | 306,568 | +11,004 | 0.00 | 0.00 | +0.00 | buy |
| Wellington Shields & Co., LLC | 292,489 | 292,489 | 0 | 0.50 | 0.57 | +0.08 | hold |
| TD ASSET MANAGEMENT INC | 54,584 | 271,876 | +217,292 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 185,036 | 267,674 | +82,638 | 0.08 | 0.15 | +0.07 | buy |
| PERKINS CAPITAL MANAGEMENT INC | 252,500 | 239,000 | -13,500 | 1.45 | 1.51 | +0.06 | sell |
| Bruce & Co., Inc. | 253,000 | 233,000 | -20,000 | 0.51 | 0.58 | +0.06 | sell |
| MORGAN STANLEY | 342,055 | 224,563 | -117,492 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 171,166 | +171,166 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 158,142 | 158,170 | +28 | 0.00 | 0.00 | +0.00 | buy |
| D.A. DAVIDSON & CO. | 0 | 145,507 | +145,507 | 0.00 | 0.01 | +0.01 | buy |
| Williams Jones Wealth Management, LLC. | 134,072 | 134,072 | 0 | 0.01 | 0.01 | +0.00 | hold |
| LPL Financial LLC | 134,092 | 132,343 | -1,749 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 125,312 | 122,951 | -2,361 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 114,803 | 119,951 | +5,148 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 112,010 | 114,001 | +1,991 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 108,951 | 108,951 | 0 | 0.03 | 0.03 | +0.00 | hold |
| HRT FINANCIAL LP | 0 | 97,772 | +97,772 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 453,043 | 92,994 | -360,049 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 92,162 | +92,162 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 154,377 | 79,310 | -75,067 | 0.00 | 0.00 | -0.00 | sell |
| Green Alpha Advisors, LLC | 28,391 | 68,517 | +40,126 | 0.18 | 0.50 | +0.32 | buy |
| WELLS FARGO & COMPANY/MN | 46,929 | 64,251 | +17,322 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 74,115 | 64,181 | -9,934 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 61,844 | 61,844 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 0 | 60,033 | +60,033 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 64,665 | 56,834 | -7,831 | 0.00 | 0.00 | +0.00 | sell |
| SEI INVESTMENTS CO | 0 | 56,006 | +56,006 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 51,804 | +51,804 | 0.00 | 0.00 | +0.00 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 0 | 50,705 | +50,705 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 44,678 | +44,678 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 40,213 | 39,875 | -338 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 82,709 | 39,412 | -43,297 | 0.03 | 0.01 | -0.02 | sell |
| Pathstone Holdings, LLC | 0 | 39,015 | +39,015 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 37,172 | 38,827 | +1,655 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 56,758 | 32,476 | -24,282 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 43,548 | 30,967 | -12,581 | 0.00 | 0.00 | -0.00 | sell |
| Janney Montgomery Scott LLC | 25,000 | 30,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 28,700 | 28,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 2,290 | 27,608 | +25,318 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 24,833 | 26,716 | +1,883 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 16,491 | 20,342 | +3,851 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 20,062 | +20,062 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 29,793 | 18,658 | -11,135 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,800 | 15,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Creative Planning | 12,558 | 15,768 | +3,210 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,450 | 15,745 | -1,705 | 0.00 | 0.00 | +0.00 | sell |
| AXQ CAPITAL, LP | 0 | 14,965 | +14,965 | 0.00 | 0.03 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 15,544 | 14,471 | -1,073 | 0.01 | 0.01 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 48,001 | 13,933 | -34,068 | 0.00 | 0.00 | -0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 0 | 13,578 | +13,578 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 13,527 | 13,527 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 14,796 | 13,456 | -1,340 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 11,733 | 13,081 | +1,348 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 12,974 | 12,974 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Scientech Research LLC | 0 | 12,402 | +12,402 | 0.00 | 0.06 | +0.06 | buy |
| Brooklyn Investment Group | 110,883 | 12,045 | -98,838 | 0.08 | 0.00 | -0.07 | sell |
| RAYMOND JAMES FINANCIAL INC | 11,600 | 11,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 6,076 | 10,923 | +4,847 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 10,483 | +10,483 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 51,441 | 10,474 | -40,967 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 0 | 10,240 | +10,240 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 5,007 | +5,007 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,572 | 4,572 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 3,428 | 4,315 | +887 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,120 | 4,235 | -885 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 4,153 | 4,184 | +31 | 0.00 | 0.00 | +0.00 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 0 | 3,900 | +3,900 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 1,944 | 3,423 | +1,479 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 2,354 | 3,391 | +1,037 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,132 | 3,087 | -45 | 0.00 | 0.00 | +0.00 | sell |
| Sterling Capital Management LLC | 3,460 | 2,887 | -573 | 0.00 | 0.00 | +0.00 | sell |
| Farther Finance Advisors, LLC | 10,069 | 2,489 | -7,580 | 0.00 | 0.00 | -0.00 | sell |