| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MAK CAPITAL ONE LLC | 4,724,043 | 5,862,180 | +1,138,137 | 3.86 | 4.69 | +0.83 | buy |
| GREAT POINT PARTNERS LLC | 2,500,000 | 3,500,000 | +1,000,000 | 3.18 | 3.78 | +0.59 | buy |
| DAFNA Capital Management LLC | 117,812 | 297,812 | +180,000 | 0.15 | 0.32 | +0.18 | buy |
| China Universal Asset Management Co., Ltd. | 57,683 | 62,076 | +4,393 | 0.02 | 0.02 | -0.00 | buy |
| Balefire, LLC | 15,000 | 15,011 | +11 | 0.02 | 0.01 | -0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 21,512 | 20,813 | -699 | 0.01 | 0.01 | +0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 509,689 | 507,050 | -2,639 | 0.10 | 0.08 | -0.01 | sell |
| SIRIOS CAPITAL MANAGEMENT L P | 575,063 | 569,276 | -5,787 | 0.39 | 0.40 | +0.01 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 17,678 | 10,920 | -6,758 | 0.02 | 0.01 | -0.01 | sell |
| DRW Securities, LLC | 54,484 | 39,443 | -15,041 | 0.00 | 0.01 | +0.00 | sell |
| TFG Asset Management GP Ltd | 1,292,455 | 1,242,455 | -50,000 | 1.39 | 1.12 | -0.27 | sell |
| J. Goldman & Co LP | 170,817 | 116,046 | -54,771 | 0.03 | 0.02 | -0.01 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 462,068 | 250,025 | -212,043 | 0.01 | 0.01 | -0.00 | sell |
| Opaleye Management Inc. | 2,331,761 | 1,714,451 | -617,310 | 1.70 | 0.89 | -0.81 | sell |
| Bain Capital Life Sciences Investors, LLC | 5,212,674 | 4,437,731 | -774,943 | 2.60 | 1.51 | -1.10 | sell |
| Bellevue Group AG | 5,157,290 | 4,100,016 | -1,057,274 | 0.68 | 0.49 | -0.19 | sell |
| Redmile Group, LLC | 14,549,768 | 11,869,877 | -2,679,891 | 5.34 | 4.55 | -0.79 | sell |