| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 9,685,401 | 9,372,822 | -312,579 | 0.00 | 0.00 | +0.00 | sell |
| Bain Capital Life Sciences Investors, LLC | 8,061,719 | 8,703,268 | +641,549 | 3.51 | 5.02 | +1.51 | buy |
| BVF INC/IL | 7,000,000 | 7,000,000 | 0 | 0.80 | 1.38 | +0.58 | hold |
| Redmile Group, LLC | 5,503,190 | 5,503,190 | 0 | 0.89 | 1.45 | +0.55 | hold |
| Point72 Asset Management, L.P. | 0 | 5,156,400 | +5,156,400 | 0.00 | 0.11 | +0.11 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,999,975 | 4,319,975 | -680,000 | 0.05 | 0.06 | +0.01 | sell |
| VANGUARD GROUP INC | 1,908,326 | 3,747,655 | +1,839,329 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 4,950,000 | 3,050,000 | -1,900,000 | 2.50 | 2.30 | -0.20 | sell |
| GMT CAPITAL CORP | 3,020,474 | 2,645,524 | -374,950 | 0.52 | 0.75 | +0.23 | sell |
| Bellevue Group AG | 0 | 2,182,290 | +2,182,290 | 0.00 | 0.24 | +0.24 | buy |
| Octagon Capital Advisors LP | 2,050,000 | 2,050,000 | 0 | 1.49 | 1.79 | +0.30 | hold |
| Woodline Partners LP | 2,000,000 | 2,000,609 | +609 | 0.10 | 0.13 | +0.03 | buy |
| Pictet Asset Management Holding SA | 1,803,149 | 1,644,591 | -158,558 | 0.01 | 0.01 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 922,232 | 1,429,486 | +507,254 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 2,650,000 | 1,405,000 | -1,245,000 | 3.29 | 2.74 | -0.55 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,509 | 1,323,704 | +1,311,195 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 811,019 | 1,278,188 | +467,169 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 846,274 | 1,198,123 | +351,849 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.04 | +0.04 | buy |
| JPMORGAN CHASE & CO | 29,585 | 959,648 | +930,063 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 874,024 | 957,993 | +83,969 | 0.02 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 192,060 | 899,513 | +707,453 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 21,772 | 789,044 | +767,272 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,075,730 | 774,698 | -301,032 | 0.11 | 0.11 | +0.01 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 777,968 | 773,914 | -4,054 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 17,000 | 761,600 | +744,600 | 0.00 | 0.04 | +0.04 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 484,200 | 671,200 | +187,000 | 0.00 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 607,100 | 605,117 | -1,983 | 0.74 | 1.16 | +0.42 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | 583,913 | 0 | 0.05 | 0.07 | +0.02 | hold |
| GOLDMAN SACHS GROUP INC | 284,933 | 562,966 | +278,033 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 367,275 | 555,566 | +188,291 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 500,000 | +500,000 | 0.00 | 0.39 | +0.39 | buy |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | 482,550 | 0 | 0.14 | 0.30 | +0.16 | hold |
| D. E. Shaw & Co., Inc. | 0 | 379,254 | +379,254 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 707,815 | 375,276 | -332,539 | 0.11 | 0.07 | -0.03 | sell |
| TWO SIGMA INVESTMENTS, LP | 26,583 | 373,448 | +346,865 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 0 | 346,687 | +346,687 | 0.00 | 0.30 | +0.30 | buy |
| DIMENSIONAL FUND ADVISORS LP | 87,047 | 333,913 | +246,866 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 315,612 | +315,612 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 342,939 | 315,155 | -27,784 | 0.02 | 0.03 | +0.01 | sell |
| Soleus Capital Management, L.P. | 515,400 | 292,400 | -223,000 | 0.26 | 0.18 | -0.08 | sell |
| CITADEL ADVISORS LLC | 1,057,687 | 258,675 | -799,012 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 258,314 | 258,314 | 0 | 0.00 | 0.00 | -0.00 | hold |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 692,928 | 248,277 | -444,651 | 0.10 | 0.05 | -0.05 | sell |
| Jump Financial, LLC | 0 | 210,200 | +210,200 | 0.00 | 0.04 | +0.04 | buy |
| TWO SIGMA ADVISERS, LP | 84,800 | 194,400 | +109,600 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 123,668 | 181,051 | +57,383 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 134,277 | 180,616 | +46,339 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 179,500 | 177,500 | -2,000 | 0.02 | 0.03 | +0.01 | sell |
| TD ASSET MANAGEMENT INC | 0 | 176,200 | +176,200 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 169,570 | +169,570 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 157,002 | 155,883 | -1,119 | 0.00 | 0.00 | +0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 155,728 | +155,728 | 0.00 | 0.74 | +0.74 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 151,501 | +151,501 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 147,485 | +147,485 | 0.00 | 0.26 | +0.26 | buy |
| Susquehanna Portfolio Strategies, LLC | 141,562 | 141,562 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 88,091 | 141,037 | +52,946 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 132,425 | +132,425 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 67,511 | 122,784 | +55,273 | 0.02 | 0.04 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,021 | 93,806 | +73,785 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 49,586 | 91,046 | +41,460 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 59,320 | 81,978 | +22,658 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 33,864 | 78,420 | +44,556 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 75,886 | +75,886 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 185,331 | 74,900 | -110,431 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 6,753 | 63,295 | +56,542 | 0.00 | 0.01 | +0.01 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 46,698 | 46,698 | 0 | 0.03 | 0.05 | +0.02 | hold |
| Virtu Financial LLC | 48,614 | 45,730 | -2,884 | 0.02 | 0.03 | +0.01 | sell |
| Cinctive Capital Management LP | 0 | 44,300 | +44,300 | 0.00 | 0.02 | +0.02 | buy |
| HSBC HOLDINGS PLC | 36,406 | 44,018 | +7,612 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,620 | 40,620 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PDT Partners, LLC | 0 | 39,505 | +39,505 | 0.00 | 0.03 | +0.03 | buy |
| PRUDENTIAL FINANCIAL INC | 80,605 | 37,125 | -43,480 | 0.00 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 0 | 35,911 | +35,911 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 35,007 | +35,007 | 0.00 | 0.00 | +0.00 | buy |
| LINCOLN NATIONAL CORP | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 33,570 | +33,570 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 22,687 | 33,197 | +10,510 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 16,432 | 28,905 | +12,473 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 25,712 | +25,712 | 0.00 | 0.01 | +0.01 | buy |
| AXQ CAPITAL, LP | 0 | 25,700 | +25,700 | 0.00 | 0.04 | +0.04 | buy |
| SG Americas Securities, LLC | 25,335 | 21,704 | -3,631 | 0.00 | 0.00 | -0.00 | sell |
| Allegheny Financial Group | 21,700 | 21,700 | 0 | 0.03 | 0.05 | +0.02 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 19,070 | 21,507 | +2,437 | 0.00 | 0.00 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 17,000 | 17,000 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Bayesian Capital Management, LP | 0 | 16,599 | +16,599 | 0.00 | 0.01 | +0.01 | buy |
| Belvedere Trading LLC | 0 | 16,446 | +16,446 | 0.00 | 0.01 | +0.01 | buy |
| Forefront Analytics, LLC | 31,280 | 14,818 | -16,462 | 0.07 | 0.05 | -0.02 | sell |
| Qube Research & Technologies Ltd | 0 | 14,806 | +14,806 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 14,670 | +14,670 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 13,618 | +13,618 | 0.00 | 0.09 | +0.09 | buy |
| 49 WEALTH MANAGEMENT, LLC | 16,094 | 13,293 | -2,801 | 0.02 | 0.02 | +0.00 | sell |
| CITIGROUP INC | 7,054 | 12,879 | +5,825 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 12,102 | +12,102 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 898 | 11,947 | +11,049 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 11,378 | +11,378 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 10,000 | 10,700 | +700 | 0.00 | 0.00 | +0.00 | buy |
| Kestra Advisory Services, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 17,144 | 8,094 | -9,050 | 0.00 | 0.00 | -0.00 | sell |