| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| AMERIPRISE FINANCIAL INC | 926,642 | 3,985,295 | +3,058,653 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 2,550,000 | 4,000,000 | +1,450,000 | 1.53 | 1.37 | -0.16 | buy |
| TFG Asset Management GP Ltd | 1,400,000 | 2,650,000 | +1,250,000 | 2.32 | 1.64 | -0.68 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 1,038,724 | +1,038,724 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 2,367,007 | 3,397,786 | +1,030,779 | 3.42 | 1.99 | -1.43 | buy |
| SIRIOS CAPITAL MANAGEMENT L P | 0 | 768,686 | +768,686 | 0.00 | 0.26 | +0.26 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 493,700 | 1,162,437 | +668,737 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,243,039 | 1,764,387 | +521,348 | 1.18 | 0.84 | -0.34 | buy |
| Qube Research & Technologies Ltd | 461,372 | 737,268 | +275,896 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 318,884 | 466,819 | +147,935 | 0.04 | 0.02 | -0.02 | buy |
| Walleye Capital LLC | 656,332 | 802,913 | +146,581 | 0.03 | 0.02 | -0.01 | buy |
| SYON CAPITAL LLC | 0 | 144,485 | +144,485 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 62,841 | 199,225 | +136,384 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 235,755 | 347,892 | +112,137 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 83,437 | 183,287 | +99,850 | 0.00 | 0.00 | +0.00 | buy |
| J. Safra Sarasin Holding AG | 155,744 | 254,538 | +98,794 | 0.01 | 0.01 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 96,752 | +96,752 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 268,166 | 356,480 | +88,314 | 0.00 | 0.00 | -0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 80,000 | +80,000 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 78,100 | +78,100 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 57,153 | 132,997 | +75,844 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,171,478 | 2,245,010 | +73,532 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 65,918 | +65,918 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 47,300 | 111,201 | +63,901 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 62,074 | +62,074 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 61,276 | +61,276 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 31,881 | 91,409 | +59,528 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 230,546 | 288,698 | +58,152 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 644,677 | 701,356 | +56,679 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 0 | 53,271 | +53,271 | 0.00 | 0.05 | +0.05 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 155,645 | 203,990 | +48,345 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 429,584 | 477,567 | +47,983 | 0.10 | 0.04 | -0.06 | buy |
| AQR CAPITAL MANAGEMENT LLC | 33,153 | 73,790 | +40,637 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 8,486,187 | 8,526,506 | +40,319 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 36,399 | +36,399 | 0.00 | 0.02 | +0.02 | buy |
| SG Americas Securities, LLC | 30,968 | 63,161 | +32,193 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 49,062 | 78,857 | +29,795 | 0.00 | 0.00 | -0.00 | buy |
| DnB Asset Management AS | 47,665 | 74,379 | +26,714 | 0.00 | 0.00 | -0.00 | buy |
| Alpine Global Management, LLC | 0 | 25,145 | +25,145 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 35,151 | 58,130 | +22,979 | 0.02 | 0.01 | -0.01 | buy |
| CIBC WORLD MARKETS CORP | 0 | 21,667 | +21,667 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 45,726 | 67,265 | +21,539 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,883 | 34,026 | +21,143 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 20,600 | +20,600 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 330,849 | 351,436 | +20,587 | 0.23 | 0.08 | -0.15 | buy |
| Lido Advisors, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 178,511 | 198,194 | +19,683 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 155,676 | 175,303 | +19,627 | 0.00 | 0.00 | -0.00 | buy |
| Quantinno Capital Management LP | 0 | 17,770 | +17,770 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 17,732 | +17,732 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 14,117 | +14,117 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 69,248 | 81,636 | +12,388 | 0.00 | 0.00 | -0.00 | buy |
| Forefront Analytics, LLC | 16,433 | 28,591 | +12,158 | 0.04 | 0.06 | +0.02 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 11,760 | +11,760 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 11,425 | +11,425 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 10,947 | +10,947 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 30,799 | 36,935 | +6,136 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 5,994 | +5,994 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 31,000 | 35,162 | +4,162 | 0.04 | 0.02 | -0.02 | buy |
| CWM, LLC | 1,602 | 5,668 | +4,066 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,016,566 | 1,020,417 | +3,851 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 11,857 | 15,607 | +3,750 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 23,183 | 25,607 | +2,424 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 183 | 1,891 | +1,708 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 24,892 | 26,104 | +1,212 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 2,290 | 3,370 | +1,080 | 0.00 | 0.00 | -0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 1,029,680 | 1,030,683 | +1,003 | 0.06 | 0.02 | -0.03 | buy |
| DEUTSCHE BANK AG\ | 536,503 | 537,294 | +791 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,238 | 2,729 | +491 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,068 | 11,467 | +399 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 75 | 420 | +345 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 140 | +140 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 10 | 74 | +64 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,552 | 3,567 | +15 | 0.00 | 0.00 | -0.00 | buy |
| SBI Securities Co., Ltd. | 11 | 25 | +14 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | 583,913 | 0 | 0.06 | 0.02 | -0.03 | hold |
| CANADA LIFE ASSURANCE Co | 14,935 | 14,935 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 9,689 | 9,689 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 7,000,000 | 7,000,000 | 0 | 1.22 | 0.55 | -0.67 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 66,375 | 66,375 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 111,300 | 111,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 34,500 | 34,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 670 | 670 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | 482,550 | 0 | 0.21 | 0.08 | -0.13 | hold |
| Redmile Group, LLC | 6,300,644 | 6,300,644 | 0 | 2.25 | 1.15 | -1.10 | hold |
| Daiwa Securities Group Inc. | 352 | 352 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Candriam S.C.A. | 2,534,230 | 2,534,230 | 0 | 0.07 | 0.03 | -0.04 | hold |
| Swiss National Bank | 135,000 | 135,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Coastal Bridge Advisors, LLC | 17,000 | 17,000 | 0 | 0.02 | 0.00 | -0.02 | hold |
| Bellevue Group AG | 5,157,290 | 5,157,290 | 0 | 0.51 | 0.22 | -0.29 | hold |
| Harbor Advisors LLC | 10,000 | 10,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 5,249,069 | 5,249,069 | 0 | 3.17 | 1.50 | -1.67 | hold |
| KLP KAPITALFORVALTNING AS | 19,100 | 19,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cinctive Capital Management LP | 135,466 | 135,466 | 0 | 0.04 | 0.02 | -0.02 | hold |
| HighMark Wealth Management LLC | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allegheny Financial Group | 25,200 | 25,200 | 0 | 0.03 | 0.01 | -0.02 | hold |
| Farther Finance Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Wealth Management Group, LLC | 654 | 654 | 0 | 0.00 | 0.00 | -0.00 | hold |