| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Logos Global Management LP | 2,550,000 | 4,000,000 | +1,450,000 | 1.53 | 1.37 | -0.16 | buy |
| TFG Asset Management GP Ltd | 1,400,000 | 2,650,000 | +1,250,000 | 1.83 | 1.17 | -0.67 | buy |
| Sio Capital Management, LLC | 2,367,007 | 3,397,786 | +1,030,779 | 3.42 | 1.95 | -1.46 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,243,039 | 1,764,387 | +521,348 | 1.15 | 0.78 | -0.37 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 318,884 | 466,819 | +147,935 | 0.13 | 0.08 | 0.00 | buy |
| J. Safra Sarasin Holding AG | 155,744 | 254,538 | +98,794 | 0.01 | 0.01 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 429,584 | 477,567 | +47,983 | 0.10 | 0.04 | -0.06 | buy |
| Quarry LP | 58,000 | 21,000 | +37,000 | 0.06 | 0.01 | 0.00 | sell |
| DnB Asset Management AS | 47,665 | 74,379 | +26,714 | 0.00 | 0.00 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 330,849 | 351,436 | +20,587 | 0.23 | 0.08 | -0.15 | buy |
| Forefront Analytics, LLC | 16,433 | 28,591 | +12,158 | 0.04 | 0.06 | +0.02 | buy |
| Shay Capital LLC | 31,000 | 35,162 | +4,162 | 0.02 | 0.01 | -0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,016,566 | 1,020,417 | +3,851 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,238 | 2,729 | +491 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 22,602 | 21,381 | -1,221 | 0.01 | 0.00 | -0.01 | sell |
| ALPS ADVISORS INC | 86,194 | 82,626 | -3,568 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 542,500 | 460,000 | -82,500 | 0.29 | 0.10 | -0.18 | sell |
| Point72 Europe (London) LLP | 155,573 | 43,722 | -111,851 | 0.05 | 0.01 | -0.04 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,091,834 | 874,726 | -217,108 | 0.12 | 0.04 | -0.08 | sell |
| Woodline Partners LP | 2,690,787 | 2,114,696 | -576,091 | 0.09 | 0.03 | -0.07 | sell |