| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 10,050,644 | 14,549,768 | +4,499,124 | 3.72 | 5.34 | +1.62 | buy |
| BlackRock, Inc. | 8,960,434 | 10,938,509 | +1,978,075 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 10,222,470 | 10,635,648 | +413,178 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 9,128,080 | 8,698,173 | -429,907 | 1.54 | 1.54 | -0.01 | sell |
| STATE STREET CORP | 4,652,185 | 6,919,255 | +2,267,070 | 0.00 | 0.00 | +0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 5,249,069 | 5,212,674 | -36,395 | 2.02 | 2.60 | +0.59 | sell |
| Bellevue Group AG | 5,157,290 | 5,157,290 | 0 | 0.49 | 0.68 | +0.19 | hold |
| MAK CAPITAL ONE LLC | 2,958,527 | 4,724,043 | +1,765,516 | 2.00 | 4.33 | +2.33 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,500,000 | 4,300,000 | -1,200,000 | 0.04 | 0.04 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 1,605,581 | 4,259,995 | +2,654,414 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 2,915,324 | 4,246,330 | +1,331,006 | 0.00 | 0.01 | +0.00 | buy |
| Siren, L.L.C. | 0 | 3,958,646 | +3,958,646 | 0.00 | 0.61 | +0.61 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,299,256 | 3,886,909 | +587,653 | 0.03 | 0.04 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 4,348,782 | 3,449,121 | -899,661 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,902,896 | 3,377,823 | +474,927 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 2,381,479 | 3,114,314 | +732,835 | 0.02 | 0.02 | +0.01 | buy |
| Palo Alto Investors LP | 2,384,192 | 2,948,090 | +563,898 | 1.67 | 2.50 | +0.83 | buy |
| MORGAN STANLEY | 2,856,143 | 2,735,970 | -120,173 | 0.00 | 0.00 | +0.00 | sell |
| GREAT POINT PARTNERS LLC | 0 | 2,500,000 | +2,500,000 | 0.00 | 3.39 | +3.39 | buy |
| Woodline Partners LP | 4,000,074 | 2,337,137 | -1,662,937 | 0.08 | 0.05 | -0.03 | sell |
| Opaleye Management Inc. | 2,600,000 | 2,331,761 | -268,239 | 1.72 | 1.70 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 1,768,745 | 2,152,880 | +384,135 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 371,190 | 1,871,795 | +1,500,605 | 0.00 | 0.02 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 1,319,913 | +1,319,913 | 0.00 | 0.14 | +0.14 | buy |
| TFG Asset Management GP Ltd | 2,032,455 | 1,292,455 | -740,000 | 2.15 | 1.41 | -0.74 | sell |
| UBS Group AG | 377,104 | 1,245,941 | +868,837 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,836,857 | 1,238,678 | -1,598,179 | 0.01 | 0.01 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,057,060 | 1,102,445 | +45,385 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 792,000 | 1,086,902 | +294,902 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 718,680 | 924,078 | +205,398 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 639,902 | 912,323 | +272,421 | 0.07 | 0.11 | +0.04 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 903,439 | 903,368 | -71 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 520,998 | 861,475 | +340,477 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 776,307 | 777,253 | +946 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 972,449 | 763,005 | -209,444 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 861,245 | 758,232 | -103,013 | 0.01 | 0.01 | -0.00 | sell |
| Russell Investments Group, Ltd. | 683,016 | 711,380 | +28,364 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,046,221 | 702,799 | -343,422 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 573,748 | 698,739 | +124,991 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 601,202 | 674,013 | +72,811 | 0.29 | 0.39 | +0.10 | buy |
| Ensign Peak Advisors, Inc | 0 | 625,097 | +625,097 | 0.00 | 0.01 | +0.01 | buy |
| Longaeva Partners L.P. | 3,100,000 | 620,401 | -2,479,599 | 1.85 | 0.17 | -1.69 | sell |
| CITADEL ADVISORS LLC | 275,294 | 600,135 | +324,841 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | 583,913 | 0 | 0.04 | 0.04 | +0.00 | hold |
| Ikarian Capital, LLC | 230,244 | 580,244 | +350,000 | 0.15 | 0.46 | +0.31 | buy |
| SIRIOS CAPITAL MANAGEMENT L P | 710,256 | 575,063 | -135,193 | 0.44 | 0.39 | -0.06 | sell |
| DEUTSCHE BANK AG\ | 560,744 | 562,181 | +1,437 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 802,600 | 544,300 | -258,300 | 0.01 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 398,077 | 521,379 | +123,302 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 534,986 | 509,689 | -25,297 | 0.09 | 0.10 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 496,461 | +496,461 | 0.00 | 0.32 | +0.32 | buy |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | 482,550 | 0 | 0.49 | 0.31 | -0.17 | hold |
| TWO SIGMA INVESTMENTS, LP | 332,038 | 471,391 | +139,353 | 0.00 | 0.00 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 462,068 | +462,068 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 445,074 | 428,720 | -16,354 | 0.00 | 0.00 | +0.00 | sell |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 642,038 | 416,698 | -225,340 | 0.03 | 0.03 | -0.01 | sell |
| Trexquant Investment LP | 0 | 403,657 | +403,657 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 361,677 | 395,019 | +33,342 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 356,619 | 360,319 | +3,700 | 0.03 | 0.03 | +0.00 | buy |
| JPMORGAN CHASE & CO | 53,729 | 323,894 | +270,165 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 358,986 | 268,640 | -90,346 | 0.10 | 0.10 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 61,572 | 255,371 | +193,799 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 236,000 | +236,000 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 141,644 | 203,269 | +61,625 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 58,259 | 203,236 | +144,977 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 0 | 200,000 | +200,000 | 0.00 | 0.45 | +0.45 | buy |
| IEQ CAPITAL, LLC | 182,982 | 195,764 | +12,782 | 0.00 | 0.01 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 174,141 | +174,141 | 0.00 | 0.01 | +0.01 | buy |
| J. Goldman & Co LP | 993,795 | 170,817 | -822,978 | 0.19 | 0.04 | -0.15 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 64,069 | 166,164 | +102,095 | 0.01 | 0.02 | +0.01 | buy |
| RHUMBLINE ADVISERS | 126,463 | 159,670 | +33,207 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 185,508 | 158,640 | -26,868 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 154,840 | +154,840 | 0.00 | 0.01 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 683,879 | 148,941 | -534,938 | 0.01 | 0.00 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 130,102 | 134,786 | +4,684 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 350,000 | 132,916 | -217,084 | 1.05 | 0.30 | -0.74 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 130,647 | +130,647 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 522,846 | 123,282 | -399,564 | 0.01 | 0.01 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 140,740 | 119,050 | -21,690 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 272,812 | 117,812 | -155,000 | 0.32 | 0.15 | -0.17 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 14,757 | 115,527 | +100,770 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 109,222 | +109,222 | 0.00 | 0.00 | +0.00 | buy |
| SCS Capital Management LLC | 0 | 99,000 | +99,000 | 0.00 | 0.01 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 137,800 | 97,800 | -40,000 | 0.01 | 0.01 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 92,707 | +92,707 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 53,008 | 90,959 | +37,951 | 0.01 | 0.02 | +0.01 | buy |
| J. Safra Sarasin Holding AG | 117,768 | 90,487 | -27,281 | 0.01 | 0.01 | -0.00 | sell |
| DnB Asset Management AS | 118,324 | 88,617 | -29,707 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 243,313 | 80,495 | -162,818 | 0.03 | 0.01 | -0.02 | sell |
| Legal & General Group Plc | 9,307 | 80,046 | +70,739 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 31,585 | 79,173 | +47,588 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 54,763 | 76,257 | +21,494 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 39,059 | 72,444 | +33,385 | 0.00 | 0.00 | +0.00 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 0 | 70,152 | +70,152 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 67,956 | +67,956 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 62,073 | +62,073 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 59,100 | +59,100 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 123,753 | 58,433 | -65,320 | 0.01 | 0.00 | -0.01 | sell |
| AXQ CAPITAL, LP | 29,108 | 58,185 | +29,077 | 0.03 | 0.04 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 36,084 | 57,683 | +21,599 | 0.01 | 0.02 | +0.01 | buy |