| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 10,050,644 | 14,549,768 | +4,499,124 | 3.72 | 5.34 | +1.62 | buy |
| Siren, L.L.C. | 0 | 3,958,646 | +3,958,646 | 0.00 | 0.61 | +0.61 | buy |
| BANK OF AMERICA CORP /DE/ | 1,605,581 | 4,259,995 | +2,654,414 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 2,500,000 | +2,500,000 | 0.00 | 3.39 | +3.39 | buy |
| STATE STREET CORP | 4,652,185 | 6,919,255 | +2,267,070 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 8,960,434 | 10,938,509 | +1,978,075 | 0.00 | 0.00 | +0.00 | buy |
| MAK CAPITAL ONE LLC | 2,958,527 | 4,724,043 | +1,765,516 | 2.00 | 4.33 | +2.33 | buy |
| Point72 Asset Management, L.P. | 371,190 | 1,871,795 | +1,500,605 | 0.00 | 0.02 | +0.02 | buy |
| Nuveen, LLC | 2,915,324 | 4,246,330 | +1,331,006 | 0.00 | 0.01 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 1,319,913 | +1,319,913 | 0.00 | 0.14 | +0.14 | buy |
| UBS Group AG | 377,104 | 1,245,941 | +868,837 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 2,381,479 | 3,114,314 | +732,835 | 0.02 | 0.02 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 0 | 625,097 | +625,097 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,299,256 | 3,886,909 | +587,653 | 0.03 | 0.04 | +0.01 | buy |
| Palo Alto Investors LP | 2,384,192 | 2,948,090 | +563,898 | 1.67 | 2.50 | +0.83 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 496,461 | +496,461 | 0.00 | 0.32 | +0.32 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,902,896 | 3,377,823 | +474,927 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 462,068 | +462,068 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 10,222,470 | 10,635,648 | +413,178 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 403,657 | +403,657 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 1,768,745 | 2,152,880 | +384,135 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 230,244 | 580,244 | +350,000 | 0.15 | 0.46 | +0.31 | buy |
| MARSHALL WACE, LLP | 520,998 | 861,475 | +340,477 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 275,294 | 600,135 | +324,841 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 792,000 | 1,086,902 | +294,902 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 639,902 | 912,323 | +272,421 | 0.07 | 0.11 | +0.04 | buy |
| JPMORGAN CHASE & CO | 53,729 | 323,894 | +270,165 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 236,000 | +236,000 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 718,680 | 924,078 | +205,398 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 0 | 200,000 | +200,000 | 0.00 | 0.45 | +0.45 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 61,572 | 255,371 | +193,799 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 174,141 | +174,141 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 154,840 | +154,840 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 58,259 | 203,236 | +144,977 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 332,038 | 471,391 | +139,353 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 130,647 | +130,647 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 573,748 | 698,739 | +124,991 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 398,077 | 521,379 | +123,302 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 109,222 | +109,222 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 64,069 | 166,164 | +102,095 | 0.01 | 0.02 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 14,757 | 115,527 | +100,770 | 0.00 | 0.00 | +0.00 | buy |
| SCS Capital Management LLC | 0 | 99,000 | +99,000 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 92,707 | +92,707 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 601,202 | 674,013 | +72,811 | 0.29 | 0.39 | +0.10 | buy |
| Legal & General Group Plc | 9,307 | 80,046 | +70,739 | 0.00 | 0.00 | +0.00 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 0 | 70,152 | +70,152 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 67,956 | +67,956 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 62,073 | +62,073 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 141,644 | 203,269 | +61,625 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 59,100 | +59,100 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 55,500 | +55,500 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 54,484 | +54,484 | 0.00 | 0.02 | +0.02 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 53,867 | +53,867 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 49,746 | +49,746 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 31,585 | 79,173 | +47,588 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,057,060 | 1,102,445 | +45,385 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 40,753 | +40,753 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 53,008 | 90,959 | +37,951 | 0.01 | 0.02 | +0.01 | buy |
| FIFTH THIRD BANCORP | 0 | 35,398 | +35,398 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 39,059 | 72,444 | +33,385 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 361,677 | 395,019 | +33,342 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 126,463 | 159,670 | +33,207 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 32,753 | +32,753 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 31,694 | +31,694 | 0.00 | 0.01 | +0.01 | buy |
| AXQ CAPITAL, LP | 29,108 | 58,185 | +29,077 | 0.03 | 0.04 | +0.01 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 28,739 | +28,739 | 0.00 | 0.02 | +0.02 | buy |
| Virtu Financial LLC | 0 | 28,450 | +28,450 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 683,016 | 711,380 | +28,364 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 26,300 | +26,300 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 25,552 | +25,552 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 17,600 | 40,800 | +23,200 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 25 | 23,225 | +23,200 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 24,004 | 45,923 | +21,919 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 31,335 | 53,242 | +21,907 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 0 | 21,646 | +21,646 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 36,084 | 57,683 | +21,599 | 0.01 | 0.02 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 54,763 | 76,257 | +21,494 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 20,180 | +20,180 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 17,678 | +17,678 | 0.00 | 0.02 | +0.02 | buy |
| Pictet Asset Management Holding SA | 0 | 16,701 | +16,701 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 15,099 | +15,099 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 14,938 | +14,938 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 14,511 | +14,511 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 14,205 | +14,205 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 182,982 | 195,764 | +12,782 | 0.00 | 0.01 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 11,897 | +11,897 | 0.00 | 0.06 | +0.06 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 10,016 | 21,512 | +11,496 | 0.00 | 0.01 | +0.00 | buy |
| XPONANCE, INC. | 0 | 11,206 | +11,206 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 0 | 10,921 | +10,921 | 0.00 | 0.01 | +0.01 | buy |
| Merit Financial Group, LLC | 0 | 10,745 | +10,745 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,966 | 12,677 | +10,711 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 10,232 | +10,232 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 12,000 | 22,200 | +10,200 | 0.00 | 0.01 | +0.00 | buy |
| Shay Capital LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| CWM, LLC | 30,297 | 39,652 | +9,355 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 42,774 | 51,421 | +8,647 | 0.08 | 0.08 | -0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 10,386 | 18,714 | +8,328 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 28,105 | 36,028 | +7,923 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 23,640 | 30,817 | +7,177 | 0.00 | 0.00 | +0.00 | buy |