| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bellevue Group AG | 2,182,290 | 5,157,290 | +2,975,000 | 0.24 | 0.41 | +0.17 | buy |
| Woodline Partners LP | 2,000,609 | 4,071,677 | +2,071,068 | 0.13 | 0.19 | +0.06 | buy |
| Redmile Group, LLC | 5,503,190 | 6,427,462 | +924,272 | 1.45 | 1.90 | +0.46 | buy |
| GMT CAPITAL CORP | 2,645,524 | 2,939,945 | +294,421 | 0.75 | 0.53 | -0.21 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 773,914 | 1,064,801 | +290,887 | 0.00 | 0.00 | -0.00 | buy |
| Logos Global Management LP | 3,050,000 | 3,300,000 | +250,000 | 2.30 | 1.86 | -0.44 | buy |
| Cinctive Capital Management LP | 44,300 | 218,090 | +173,790 | 0.02 | 0.06 | +0.04 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 774,698 | 914,648 | +139,950 | 0.11 | 0.10 | -0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 33,570 | 163,025 | +129,455 | 0.01 | 0.02 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 177,500 | 85,000 | +92,500 | 0.03 | 0.01 | 0.00 | sell |
| Bayesian Capital Management, LP | 16,599 | 38,599 | +22,000 | 0.01 | 0.02 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 248,277 | 228,277 | +20,000 | 0.13 | 0.07 | 0.00 | sell |
| DnB Asset Management AS | 35,911 | 46,485 | +10,574 | 0.00 | 0.00 | -0.00 | buy |
| Allegheny Financial Group | 21,700 | 25,200 | +3,500 | 0.05 | 0.04 | -0.01 | buy |
| Forefront Analytics, LLC | 14,818 | 16,103 | +1,285 | 0.05 | 0.04 | -0.01 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 46,698 | 46,057 | -641 | 0.05 | 0.04 | -0.01 | sell |
| 49 WEALTH MANAGEMENT, LLC | 13,293 | 10,111 | -3,182 | 0.02 | 0.01 | -0.01 | sell |
| EntryPoint Capital, LLC | 13,618 | 5,518 | -8,100 | 0.09 | 0.04 | -0.05 | sell |
| Parkman Healthcare Partners LLC | 346,687 | 326,845 | -19,842 | 0.30 | 0.22 | -0.09 | sell |
| Susquehanna Portfolio Strategies, LLC | 141,562 | 37,660 | -103,902 | 0.02 | 0.01 | -0.02 | sell |
| Bain Capital Life Sciences Investors, LLC | 8,703,268 | 8,449,208 | -254,060 | 5.02 | 4.55 | -0.47 | sell |
| Ikarian Capital, LLC | 1,405,000 | 380,000 | -1,025,000 | 2.74 | 0.58 | -2.16 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,319,975 | 2,840,145 | -1,479,830 | 0.06 | 0.03 | -0.03 | sell |
| Octagon Capital Advisors LP | 2,050,000 | 400,000 | -1,650,000 | 1.79 | 0.32 | -1.46 | sell |