| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 8,703,268 | 8,449,208 | -254,060 | 5.02 | 4.55 | -0.47 | sell |
| FMR LLC | 9,372,822 | 8,299,720 | -1,073,102 | 0.00 | 0.00 | -0.00 | sell |
| BVF INC/IL | 7,000,000 | 7,000,000 | 0 | 1.38 | 0.96 | -0.42 | hold |
| Redmile Group, LLC | 5,503,190 | 6,427,462 | +924,272 | 1.45 | 1.90 | +0.46 | buy |
| Point72 Asset Management, L.P. | 5,156,400 | 5,989,017 | +832,617 | 0.11 | 0.09 | -0.01 | buy |
| Bellevue Group AG | 2,182,290 | 5,157,290 | +2,975,000 | 0.24 | 0.41 | +0.17 | buy |
| VANGUARD GROUP INC | 3,747,655 | 4,556,640 | +808,985 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 2,000,609 | 4,071,677 | +2,071,068 | 0.13 | 0.19 | +0.06 | buy |
| Logos Global Management LP | 3,050,000 | 3,300,000 | +250,000 | 2.30 | 1.86 | -0.44 | buy |
| GMT CAPITAL CORP | 2,645,524 | 2,939,945 | +294,421 | 0.75 | 0.53 | -0.21 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,319,975 | 2,840,145 | -1,479,830 | 0.06 | 0.03 | -0.03 | sell |
| Candriam S.C.A. | 0 | 2,053,459 | +2,053,459 | 0.00 | 0.06 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,429,486 | 1,812,366 | +382,880 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,198,123 | 1,773,585 | +575,462 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 315,612 | 1,693,665 | +1,378,053 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 959,648 | 1,686,372 | +726,724 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 0 | 1,257,985 | +1,257,985 | 0.00 | 1.91 | +1.91 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,323,704 | 1,094,472 | -229,232 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 773,914 | 1,064,801 | +290,887 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 899,513 | 1,008,414 | +108,901 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 774,698 | 914,648 | +139,950 | 0.11 | 0.10 | -0.02 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 957,993 | 912,151 | -45,842 | 0.02 | 0.01 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 0 | 900,000 | +900,000 | 0.00 | 0.42 | +0.42 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 883,448 | +883,448 | 0.00 | 0.21 | +0.21 | buy |
| DIMENSIONAL FUND ADVISORS LP | 333,913 | 822,605 | +488,692 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 761,600 | 814,221 | +52,621 | 0.04 | 0.03 | -0.01 | buy |
| CITIGROUP INC | 12,879 | 669,158 | +656,279 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0 | 639,573 | +639,573 | 0.00 | 0.03 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 562,966 | 596,191 | +33,225 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 671,200 | 584,200 | -87,000 | 0.01 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | 583,913 | 0 | 0.07 | 0.05 | -0.03 | hold |
| NORTHERN TRUST CORP | 555,566 | 555,295 | -271 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 155,883 | 495,690 | +339,807 | 0.00 | 0.00 | +0.00 | buy |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | 482,550 | 0 | 0.30 | 0.16 | -0.14 | hold |
| Alyeska Investment Group, L.P. | 0 | 450,000 | +450,000 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 14,806 | 447,700 | +432,894 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 500,000 | 400,600 | -99,400 | 0.39 | 0.21 | -0.19 | sell |
| Octagon Capital Advisors LP | 2,050,000 | 400,000 | -1,650,000 | 1.79 | 0.32 | -1.46 | sell |
| Ikarian Capital, LLC | 1,405,000 | 380,000 | -1,025,000 | 2.74 | 0.58 | -2.16 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,278,188 | 347,212 | -930,976 | 0.01 | 0.00 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,501 | 339,278 | +187,777 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 346,687 | 326,845 | -19,842 | 0.30 | 0.22 | -0.09 | sell |
| TWO SIGMA INVESTMENTS, LP | 373,448 | 326,404 | -47,044 | 0.01 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 313,093 | +313,093 | 0.00 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 11,378 | 279,463 | +268,085 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 258,314 | 258,314 | 0 | 0.00 | 0.01 | +0.01 | hold |
| Bank of New York Mellon Corp | 180,616 | 258,033 | +77,417 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Europe (London) LLP | 0 | 234,592 | +234,592 | 0.00 | 0.10 | +0.10 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 248,277 | 228,277 | -20,000 | 0.05 | 0.03 | -0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 181,051 | 227,560 | +46,509 | 0.00 | 0.00 | -0.00 | buy |
| Cinctive Capital Management LP | 44,300 | 218,090 | +173,790 | 0.02 | 0.06 | +0.04 | buy |
| Ovata Capital Management Ltd | 0 | 200,000 | +200,000 | 0.00 | 0.53 | +0.53 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 169,570 | 193,419 | +23,849 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 192,612 | +192,612 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 33,570 | 163,025 | +129,455 | 0.01 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 93,806 | 157,136 | +63,330 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 28,905 | 150,616 | +121,711 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 150,000 | +150,000 | 0.00 | 0.10 | +0.10 | buy |
| Artia Global Partners LP | 147,485 | 147,485 | 0 | 0.26 | 0.19 | -0.07 | hold |
| ALLIANCEBERNSTEIN L.P. | 40,620 | 146,450 | +105,830 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 176,200 | 133,648 | -42,552 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 81,978 | 126,659 | +44,681 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 194,400 | 119,400 | -75,000 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 78,420 | 115,662 | +37,242 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 375,276 | 103,493 | -271,783 | 0.07 | 0.02 | -0.06 | sell |
| D. E. Shaw & Co., Inc. | 379,254 | 92,085 | -287,169 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 177,500 | 85,000 | -92,500 | 0.03 | 0.01 | -0.02 | sell |
| UBS Group AG | 91,046 | 75,573 | -15,473 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 0 | 71,077 | +71,077 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 132,425 | 69,965 | -62,460 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 75,886 | 65,560 | -10,326 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 64,309 | +64,309 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 62,625 | +62,625 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 61,109 | +61,109 | 0.00 | 0.05 | +0.05 | buy |
| BARCLAYS PLC | 74,900 | 56,976 | -17,924 | 0.00 | 0.00 | -0.00 | sell |
| PARK AVENUE SECURITIES LLC | 0 | 49,986 | +49,986 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 35,007 | 49,398 | +14,391 | 0.00 | 0.00 | -0.00 | buy |
| DnB Asset Management AS | 35,911 | 46,485 | +10,574 | 0.00 | 0.00 | -0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 46,698 | 46,057 | -641 | 0.05 | 0.04 | -0.01 | sell |
| Jump Financial, LLC | 210,200 | 42,953 | -167,247 | 0.04 | 0.00 | -0.04 | sell |
| PRUDENTIAL FINANCIAL INC | 37,125 | 39,340 | +2,215 | 0.00 | 0.00 | -0.00 | buy |
| Bayesian Capital Management, LP | 16,599 | 38,599 | +22,000 | 0.01 | 0.02 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 141,562 | 37,660 | -103,902 | 0.02 | 0.01 | -0.02 | sell |
| HSBC HOLDINGS PLC | 44,018 | 36,369 | -7,649 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 0 | 35,300 | +35,300 | 0.00 | 0.01 | +0.01 | buy |
| Maven Securities LTD | 0 | 34,707 | +34,707 | 0.00 | 0.03 | +0.03 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 11,947 | 34,668 | +22,721 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 25,712 | 31,226 | +5,514 | 0.01 | 0.01 | -0.00 | buy |
| Virtu Financial LLC | 45,730 | 29,664 | -16,066 | 0.03 | 0.01 | -0.01 | sell |
| Squarepoint Ops LLC | 0 | 28,337 | +28,337 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 21,507 | 28,282 | +6,775 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 0 | 26,865 | +26,865 | 0.00 | 0.00 | +0.00 | buy |
| Allegheny Financial Group | 21,700 | 25,200 | +3,500 | 0.05 | 0.04 | -0.01 | buy |
| OMERS ADMINISTRATION Corp | 0 | 24,400 | +24,400 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 22,997 | +22,997 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 789,044 | 22,838 | -766,206 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 0 | 21,996 | +21,996 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 18,000 | +18,000 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 17,782 | +17,782 | 0.00 | 0.02 | +0.02 | buy |
| Coastal Bridge Advisors, LLC | 17,000 | 17,000 | 0 | 0.03 | 0.02 | -0.01 | hold |