| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bellevue Group AG | 2,182,290 | 5,157,290 | +2,975,000 | 0.24 | 0.41 | +0.17 | buy |
| Woodline Partners LP | 2,000,609 | 4,071,677 | +2,071,068 | 0.13 | 0.19 | +0.06 | buy |
| Candriam S.C.A. | 0 | 2,053,459 | +2,053,459 | 0.00 | 0.06 | +0.06 | buy |
| MARSHALL WACE, LLP | 315,612 | 1,693,665 | +1,378,053 | 0.00 | 0.01 | +0.01 | buy |
| TFG Asset Management GP Ltd | 0 | 1,257,985 | +1,257,985 | 0.00 | 1.91 | +1.91 | buy |
| Redmile Group, LLC | 5,503,190 | 6,427,462 | +924,272 | 1.45 | 1.90 | +0.46 | buy |
| Rhenman & Partners Asset Management AB | 0 | 900,000 | +900,000 | 0.00 | 0.42 | +0.42 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 883,448 | +883,448 | 0.00 | 0.21 | +0.21 | buy |
| Point72 Asset Management, L.P. | 5,156,400 | 5,989,017 | +832,617 | 0.11 | 0.09 | -0.01 | buy |
| VANGUARD GROUP INC | 3,747,655 | 4,556,640 | +808,985 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 959,648 | 1,686,372 | +726,724 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 12,879 | 669,158 | +656,279 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0 | 639,573 | +639,573 | 0.00 | 0.03 | +0.03 | buy |
| STATE STREET CORP | 1,198,123 | 1,773,585 | +575,462 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 333,913 | 822,605 | +488,692 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 450,000 | +450,000 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 14,806 | 447,700 | +432,894 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,429,486 | 1,812,366 | +382,880 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 155,883 | 495,690 | +339,807 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 313,093 | +313,093 | 0.00 | 0.02 | +0.02 | buy |
| GMT CAPITAL CORP | 2,645,524 | 2,939,945 | +294,421 | 0.75 | 0.53 | -0.21 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 773,914 | 1,064,801 | +290,887 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 11,378 | 279,463 | +268,085 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 3,050,000 | 3,300,000 | +250,000 | 2.30 | 1.86 | -0.44 | buy |
| Point72 Europe (London) LLP | 0 | 234,592 | +234,592 | 0.00 | 0.10 | +0.10 | buy |
| Ovata Capital Management Ltd | 0 | 200,000 | +200,000 | 0.00 | 0.53 | +0.53 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 192,612 | +192,612 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,501 | 339,278 | +187,777 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 44,300 | 218,090 | +173,790 | 0.02 | 0.06 | +0.04 | buy |
| Monashee Investment Management LLC | 0 | 150,000 | +150,000 | 0.00 | 0.10 | +0.10 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 774,698 | 914,648 | +139,950 | 0.11 | 0.10 | -0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 33,570 | 163,025 | +129,455 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 28,905 | 150,616 | +121,711 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 899,513 | 1,008,414 | +108,901 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,620 | 146,450 | +105,830 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 180,616 | 258,033 | +77,417 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 0 | 71,077 | +71,077 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 64,309 | +64,309 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 93,806 | 157,136 | +63,330 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 62,625 | +62,625 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 61,109 | +61,109 | 0.00 | 0.05 | +0.05 | buy |
| Schonfeld Strategic Advisors LLC | 761,600 | 814,221 | +52,621 | 0.04 | 0.03 | -0.01 | buy |
| PARK AVENUE SECURITIES LLC | 0 | 49,986 | +49,986 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 181,051 | 227,560 | +46,509 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 81,978 | 126,659 | +44,681 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 78,420 | 115,662 | +37,242 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 35,300 | +35,300 | 0.00 | 0.01 | +0.01 | buy |
| Maven Securities LTD | 0 | 34,707 | +34,707 | 0.00 | 0.03 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 562,966 | 596,191 | +33,225 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 28,337 | +28,337 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 26,865 | +26,865 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 24,400 | +24,400 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 169,570 | 193,419 | +23,849 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 0 | 22,997 | +22,997 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 11,947 | 34,668 | +22,721 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 16,599 | 38,599 | +22,000 | 0.01 | 0.02 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 21,996 | +21,996 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 18,000 | +18,000 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 17,782 | +17,782 | 0.00 | 0.02 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 0 | 15,063 | +15,063 | 0.00 | 0.04 | +0.04 | buy |
| MetLife Investment Management, LLC | 35,007 | 49,398 | +14,391 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 11,857 | +11,857 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 11,478 | +11,478 | 0.00 | 0.03 | +0.03 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 11,440 | +11,440 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 35,911 | 46,485 | +10,574 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 10,345 | +10,345 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 10,038 | +10,038 | 0.00 | 0.00 | +0.00 | buy |
| Harbor Advisors LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Sandia Investment Management LP | 0 | 10,000 | +10,000 | 0.00 | 0.06 | +0.06 | buy |
| Tower Research Capital LLC (TRC) | 7,014 | 15,881 | +8,867 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 5,520 | 14,333 | +8,813 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 5,506 | 12,663 | +7,157 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 21,507 | 28,282 | +6,775 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 25,712 | 31,226 | +5,514 | 0.01 | 0.01 | -0.00 | buy |
| Russell Investments Group, Ltd. | 988 | 6,098 | +5,110 | 0.00 | 0.00 | +0.00 | buy |
| Allegheny Financial Group | 21,700 | 25,200 | +3,500 | 0.05 | 0.04 | -0.01 | buy |
| CWM, LLC | 17 | 2,508 | +2,491 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 37,125 | 39,340 | +2,215 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 1,283 | 2,882 | +1,599 | 0.00 | 0.00 | +0.00 | buy |
| Forefront Analytics, LLC | 14,818 | 16,103 | +1,285 | 0.05 | 0.04 | -0.01 | buy |
| CIBC Private Wealth Group LLC | 0 | 670 | +670 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 10,700 | 11,317 | +617 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 457 | +457 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 22 | 187 | +165 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 151 | +151 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | 583,913 | 0 | 0.07 | 0.05 | -0.03 | hold |
| Ameritas Investment Partners, Inc. | 6,718 | 6,718 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 7,000,000 | 7,000,000 | 0 | 1.38 | 0.96 | -0.42 | hold |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | 482,550 | 0 | 0.30 | 0.16 | -0.14 | hold |
| Coastal Bridge Advisors, LLC | 17,000 | 17,000 | 0 | 0.03 | 0.02 | -0.01 | hold |
| HighMark Wealth Management LLC | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Kestra Advisory Services, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Artia Global Partners LP | 147,485 | 147,485 | 0 | 0.26 | 0.19 | -0.07 | hold |
| Farther Finance Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Wealth Management Group, LLC | 654 | 654 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| COMERICA BANK | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 2,290 | 2,290 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 258,314 | 258,314 | 0 | 0.00 | 0.01 | +0.01 | hold |