| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,262,328 | 15,695,226 | +2,432,898 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 175,303 | 2,514,134 | +2,338,831 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 841,582 | 1,630,649 | +789,067 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 3,397,786 | 4,095,764 | +697,978 | 1.99 | 3.94 | +1.96 | buy |
| BANK OF AMERICA CORP /DE/ | 1,038,724 | 1,452,795 | +414,071 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 203,990 | 469,209 | +265,219 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 73,790 | 332,031 | +258,241 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 245,199 | +245,199 | 0.00 | 0.00 | +0.00 | buy |
| SIRIOS CAPITAL MANAGEMENT L P | 768,686 | 989,577 | +220,891 | 0.26 | 0.34 | +0.08 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 207,715 | +207,715 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 201,160 | +201,160 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 43,722 | 206,798 | +163,076 | 0.01 | 0.03 | +0.02 | buy |
| TFG Asset Management GP Ltd | 2,650,000 | 2,810,000 | +160,000 | 1.64 | 1.22 | -0.42 | buy |
| Schonfeld Strategic Advisors LLC | 111,201 | 266,050 | +154,849 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 145,869 | +145,869 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 701,356 | 832,540 | +131,184 | 0.00 | 0.00 | +0.00 | buy |
| J. Safra Sarasin Holding AG | 254,538 | 381,441 | +126,903 | 0.01 | 0.02 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 97,800 | +97,800 | 0.00 | 0.01 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 0 | 80,375 | +80,375 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 77,100 | +77,100 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 199,225 | 266,812 | +67,587 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 91,409 | 150,414 | +59,005 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 267,348 | 325,122 | +57,774 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 80,000 | 135,797 | +55,797 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 351,436 | 404,194 | +52,758 | 0.08 | 0.11 | +0.03 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 1,030,683 | 1,078,961 | +48,278 | 0.02 | 0.03 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,245,010 | 2,284,773 | +39,763 | 0.00 | 0.00 | +0.00 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 30,597 | +30,597 | 0.00 | 0.00 | +0.00 | buy |
| PARK AVENUE SECURITIES LLC | 83,068 | 113,068 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 29,989 | +29,989 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 111,300 | 140,740 | +29,440 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 347,892 | 376,974 | +29,082 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 466,819 | 492,698 | +25,879 | 0.02 | 0.03 | +0.01 | buy |
| DnB Asset Management AS | 74,379 | 99,574 | +25,195 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 21,000 | 43,133 | +22,133 | 0.01 | 0.02 | +0.01 | buy |
| MetLife Investment Management, LLC | 37,411 | 59,022 | +21,611 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 20,196 | +20,196 | 0.00 | 0.00 | +0.00 | buy |
| Allegheny Financial Group | 25,200 | 42,900 | +17,700 | 0.01 | 0.02 | +0.01 | buy |
| Lido Advisors, LLC | 20,000 | 35,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 78,857 | 93,500 | +14,643 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 13,401 | +13,401 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 198,194 | 211,195 | +13,001 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 165,132 | 177,628 | +12,496 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 288,698 | 301,048 | +12,350 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 12,284 | +12,284 | 0.00 | 0.00 | +0.00 | buy |
| 49 WEALTH MANAGEMENT, LLC | 0 | 12,083 | +12,083 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 5,668 | 17,734 | +12,066 | 0.00 | 0.00 | +0.00 | buy |
| MATAURO, LLC | 0 | 11,084 | +11,084 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 477,567 | 484,633 | +7,066 | 0.04 | 0.05 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 6,673 | +6,673 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,885 | 9,979 | +4,094 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 17,732 | 20,515 | +2,783 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 725,752 | 728,389 | +2,637 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 1,964 | +1,964 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 136,400 | 137,536 | +1,136 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 5,994 | 7,111 | +1,117 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 1,685 | 2,758 | +1,073 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,891 | 2,707 | +816 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,567 | 4,238 | +671 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 21,381 | 22,036 | +655 | 0.00 | 0.00 | +0.00 | buy |
| Prestige Wealth Management Group LLC | 0 | 185 | +185 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 74 | 252 | +178 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 108 | +108 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 25 | 30 | +5 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | 583,913 | 0 | 0.02 | 0.03 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 9,689 | 9,689 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 46,848 | 46,848 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 7,000,000 | 7,000,000 | 0 | 0.55 | 0.60 | +0.05 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 27,455 | 27,455 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | 482,550 | 0 | 0.08 | 0.13 | +0.05 | hold |
| Cambridge Investment Research Advisors, Inc. | 10,700 | 10,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Redmile Group, LLC | 6,300,644 | 6,300,644 | 0 | 1.15 | 1.61 | +0.46 | hold |
| Daiwa Securities Group Inc. | 352 | 352 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 1,764,387 | 1,764,387 | 0 | 0.84 | 1.11 | +0.27 | hold |
| Candriam S.C.A. | 2,534,230 | 2,534,230 | 0 | 0.03 | 0.04 | +0.00 | hold |
| Rhenman & Partners Asset Management AB | 460,000 | 460,000 | 0 | 0.10 | 0.14 | +0.04 | hold |
| Coastal Bridge Advisors, LLC | 17,000 | 17,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bellevue Group AG | 5,157,290 | 5,157,290 | 0 | 0.22 | 0.27 | +0.05 | hold |
| Harbor Advisors LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 5,249,069 | 5,249,069 | 0 | 1.50 | 1.58 | +0.08 | hold |
| Cinctive Capital Management LP | 135,466 | 135,466 | 0 | 0.02 | 0.02 | -0.00 | hold |
| HighMark Wealth Management LLC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 20,587 | 20,587 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 2,729 | 2,729 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 34,479 | 34,479 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 25,607 | 25,607 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 3,370 | 3,370 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15,607 | 15,607 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 258,314 | 258,314 | 0 | 0.00 | 0.00 | -0.00 | hold |
| True Wealth Design, LLC | 17 | 0 | -17 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 11,467 | 11,391 | -76 | 0.00 | 0.00 | -0.00 | sell |
| Parkside Financial Bank & Trust | 140 | 0 | -140 | 0.00 | 0.00 | -0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 420 | 165 | -255 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 438 | 0 | -438 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 134,562 | 134,035 | -527 | 0.00 | 0.00 | +0.00 | sell |
| Private Wealth Management Group, LLC | 654 | 0 | -654 | 0.00 | 0.00 | -0.00 | sell |