| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,262,328 | 15,695,226 | +2,432,898 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 8,526,506 | 7,962,368 | -564,138 | 0.00 | 0.00 | +0.00 | sell |
| BVF INC/IL | 7,000,000 | 7,000,000 | 0 | 0.55 | 0.60 | +0.05 | hold |
| Redmile Group, LLC | 6,300,644 | 6,300,644 | 0 | 1.15 | 1.61 | +0.46 | hold |
| VANGUARD GROUP INC | 5,379,659 | 5,366,039 | -13,620 | 0.00 | 0.00 | +0.00 | sell |
| Bain Capital Life Sciences Investors, LLC | 5,249,069 | 5,249,069 | 0 | 1.50 | 1.58 | +0.08 | hold |
| Bellevue Group AG | 5,157,290 | 5,157,290 | 0 | 0.22 | 0.27 | +0.05 | hold |
| Sio Capital Management, LLC | 3,397,786 | 4,095,764 | +697,978 | 1.99 | 3.94 | +1.96 | buy |
| TFG Asset Management GP Ltd | 2,650,000 | 2,810,000 | +160,000 | 1.64 | 1.22 | -0.42 | buy |
| Candriam S.C.A. | 2,534,230 | 2,534,230 | 0 | 0.03 | 0.04 | +0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 175,303 | 2,514,134 | +2,338,831 | 0.00 | 0.01 | +0.01 | buy |
| Logos Global Management LP | 4,000,000 | 2,410,000 | -1,590,000 | 1.37 | 0.77 | -0.60 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,245,010 | 2,284,773 | +39,763 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 3,985,295 | 2,166,178 | -1,819,117 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 2,039,826 | 1,980,984 | -58,842 | 0.00 | 0.00 | +0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 1,764,387 | 1,764,387 | 0 | 0.84 | 1.11 | +0.27 | hold |
| GOLDMAN SACHS GROUP INC | 841,582 | 1,630,649 | +789,067 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,038,724 | 1,452,795 | +414,071 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 1,030,683 | 1,078,961 | +48,278 | 0.02 | 0.03 | +0.00 | buy |
| Woodline Partners LP | 2,114,696 | 1,053,709 | -1,060,987 | 0.03 | 0.01 | -0.01 | sell |
| SIRIOS CAPITAL MANAGEMENT L P | 768,686 | 989,577 | +220,891 | 0.26 | 0.34 | +0.08 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,020,417 | 987,513 | -32,904 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 986,879 | 889,863 | -97,016 | 0.00 | 0.00 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 874,726 | 855,573 | -19,153 | 0.04 | 0.05 | +0.01 | sell |
| MORGAN STANLEY | 701,356 | 832,540 | +131,184 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 802,913 | 794,639 | -8,274 | 0.02 | 0.02 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,162,437 | 777,900 | -384,537 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 1,025,925 | 743,224 | -282,701 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 725,752 | 728,389 | +2,637 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | 583,913 | 0 | 0.02 | 0.03 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 537,294 | 511,448 | -25,846 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 524,741 | 508,103 | -16,638 | 0.00 | 0.00 | +0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 466,819 | 492,698 | +25,879 | 0.02 | 0.03 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 477,567 | 484,633 | +7,066 | 0.04 | 0.05 | +0.01 | buy |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | 482,550 | 0 | 0.08 | 0.13 | +0.05 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 203,990 | 469,209 | +265,219 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 460,000 | 460,000 | 0 | 0.10 | 0.14 | +0.04 | hold |
| Qube Research & Technologies Ltd | 737,268 | 424,720 | -312,548 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 351,436 | 404,194 | +52,758 | 0.08 | 0.11 | +0.03 | buy |
| J. Safra Sarasin Holding AG | 254,538 | 381,441 | +126,903 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 347,892 | 376,974 | +29,082 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 73,790 | 332,031 | +258,241 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 267,348 | 325,122 | +57,774 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 288,698 | 301,048 | +12,350 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 199,225 | 266,812 | +67,587 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 111,201 | 266,050 | +154,849 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 258,314 | 258,314 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nuveen, LLC | 347,032 | 255,918 | -91,114 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 0 | 245,199 | +245,199 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 198,194 | 211,195 | +13,001 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 207,715 | +207,715 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Europe (London) LLP | 43,722 | 206,798 | +163,076 | 0.01 | 0.03 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 201,160 | +201,160 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 165,132 | 177,628 | +12,496 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 91,409 | 150,414 | +59,005 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 145,869 | +145,869 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 111,300 | 140,740 | +29,440 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 136,400 | 137,536 | +1,136 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 80,000 | 135,797 | +55,797 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 135,466 | 135,466 | 0 | 0.02 | 0.02 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 134,562 | 134,035 | -527 | 0.00 | 0.00 | +0.00 | sell |
| PARK AVENUE SECURITIES LLC | 83,068 | 113,068 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 74,379 | 99,574 | +25,195 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 97,800 | +97,800 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 78,857 | 93,500 | +14,643 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 80,375 | +80,375 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 77,100 | +77,100 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 183,287 | 61,691 | -121,596 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 82,626 | 59,201 | -23,425 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 37,411 | 59,022 | +21,611 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 62,074 | 53,283 | -8,791 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 1,431,965 | 52,819 | -1,379,146 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 67,265 | 52,699 | -14,566 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 57,263 | 52,405 | -4,858 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 46,848 | 46,848 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quarry LP | 21,000 | 43,133 | +22,133 | 0.01 | 0.02 | +0.01 | buy |
| Allegheny Financial Group | 25,200 | 42,900 | +17,700 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 74,664 | 37,796 | -36,868 | 0.00 | 0.00 | -0.00 | sell |
| Lido Advisors, LLC | 20,000 | 35,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 36,399 | 34,698 | -1,701 | 0.02 | 0.03 | +0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 34,479 | 34,479 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Virtu Financial LLC | 0 | 30,597 | +30,597 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 29,989 | +29,989 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 36,935 | 29,855 | -7,080 | 0.00 | 0.00 | -0.00 | sell |
| Forefront Analytics, LLC | 28,591 | 27,575 | -1,016 | 0.06 | 0.03 | -0.03 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 27,455 | 27,455 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 25,607 | 25,607 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ProShare Advisors LLC | 25,948 | 23,732 | -2,216 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 21,381 | 22,036 | +655 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 20,587 | 20,587 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quadrature Capital Ltd | 17,732 | 20,515 | +2,783 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 20,196 | +20,196 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 5,668 | 17,734 | +12,066 | 0.00 | 0.00 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 17,000 | 17,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15,607 | 15,607 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 26,104 | 15,558 | -10,546 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 13,401 | +13,401 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 12,284 | +12,284 | 0.00 | 0.00 | +0.00 | buy |
| 49 WEALTH MANAGEMENT, LLC | 0 | 12,083 | +12,083 | 0.00 | 0.00 | +0.00 | buy |