| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 10,635,648 | 19,518,496 | +8,882,848 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 10,938,509 | 13,539,744 | +2,601,235 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 14,549,768 | 11,869,877 | -2,679,891 | 5.34 | 4.55 | -0.79 | sell |
| STATE STREET CORP | 6,919,255 | 9,824,321 | +2,905,066 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 8,698,173 | 8,698,173 | 0 | 1.54 | 1.27 | -0.27 | hold |
| Woodline Partners LP | 2,337,137 | 6,925,067 | +4,587,930 | 0.05 | 0.12 | +0.07 | buy |
| MAK CAPITAL ONE LLC | 4,724,043 | 5,862,180 | +1,138,137 | 4.33 | 4.69 | +0.36 | buy |
| GOLDMAN SACHS GROUP INC | 2,152,880 | 5,825,579 | +3,672,699 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 3,958,646 | 4,458,646 | +500,000 | 0.61 | 0.52 | -0.09 | buy |
| Bain Capital Life Sciences Investors, LLC | 5,212,674 | 4,437,731 | -774,943 | 2.60 | 1.51 | -1.10 | sell |
| Bellevue Group AG | 5,157,290 | 4,100,016 | -1,057,274 | 0.68 | 0.49 | -0.19 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,377,823 | 4,037,193 | +659,370 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 3,544,354 | +3,544,354 | 0.00 | 1.23 | +1.23 | buy |
| AMERIPRISE FINANCIAL INC | 3,449,121 | 3,509,623 | +60,502 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,300,000 | 3,500,000 | -800,000 | 0.04 | 0.03 | -0.01 | sell |
| GREAT POINT PARTNERS LLC | 2,500,000 | 3,500,000 | +1,000,000 | 3.39 | 4.71 | +1.32 | buy |
| MORGAN STANLEY | 2,735,970 | 3,144,453 | +408,483 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 2,948,090 | 2,948,090 | 0 | 2.50 | 2.33 | -0.17 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 3,886,909 | 2,830,976 | -1,055,933 | 0.04 | 0.03 | -0.01 | sell |
| Nuveen, LLC | 4,246,330 | 2,765,080 | -1,481,250 | 0.01 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 3,114,314 | 2,749,961 | -364,353 | 0.02 | 0.02 | -0.01 | sell |
| Opaleye Management Inc. | 2,331,761 | 1,714,451 | -617,310 | 1.70 | 0.89 | -0.81 | sell |
| Logos Global Management LP | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.37 | +0.37 | buy |
| DIMENSIONAL FUND ADVISORS LP | 924,078 | 1,497,756 | +573,678 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,871,795 | 1,382,699 | -489,096 | 0.02 | 0.01 | -0.01 | sell |
| NORTHERN TRUST CORP | 1,086,902 | 1,352,046 | +265,144 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,257,799 | +1,257,799 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,102,445 | 1,257,799 | +155,354 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 1,292,455 | 1,242,455 | -50,000 | 1.41 | 1.15 | -0.25 | sell |
| Candriam S.C.A. | 0 | 1,195,142 | +1,195,142 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,238,678 | 1,184,931 | -53,747 | 0.01 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 903,368 | 1,037,366 | +133,998 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 323,894 | 1,004,308 | +680,414 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 698,739 | 978,055 | +279,316 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 967,926 | +967,926 | 0.00 | 0.02 | +0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 912,323 | 898,394 | -13,929 | 0.11 | 0.09 | -0.02 | sell |
| Ensign Peak Advisors, Inc | 625,097 | 800,516 | +175,419 | 0.01 | 0.01 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 737,935 | +737,935 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 1,319,913 | 734,585 | -585,328 | 0.14 | 0.08 | -0.06 | sell |
| Russell Investments Group, Ltd. | 711,380 | 704,371 | -7,009 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 777,253 | 691,812 | -85,441 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 674,013 | 641,029 | -32,984 | 0.39 | 0.38 | -0.01 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 758,232 | 629,127 | -129,105 | 0.01 | 0.00 | -0.00 | sell |
| UBS Group AG | 1,245,941 | 623,094 | -622,847 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 562,181 | 616,489 | +54,308 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 4,259,995 | 614,186 | -3,645,809 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 600,135 | 596,582 | -3,553 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | 583,913 | 0 | 0.04 | 0.03 | -0.00 | hold |
| SIRIOS CAPITAL MANAGEMENT L P | 575,063 | 569,276 | -5,787 | 0.39 | 0.40 | +0.01 | sell |
| Schonfeld Strategic Advisors LLC | 123,282 | 533,567 | +410,285 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 471,391 | 512,796 | +41,405 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 509,689 | 507,050 | -2,639 | 0.10 | 0.08 | -0.01 | sell |
| Bank of New York Mellon Corp | 395,019 | 501,442 | +106,423 | 0.00 | 0.00 | +0.00 | buy |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | 482,550 | 0 | 0.31 | 0.52 | +0.20 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 544,300 | 459,000 | -85,300 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 580,244 | 430,244 | -150,000 | 0.46 | 0.40 | -0.06 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 425,332 | +425,332 | 0.00 | 0.06 | +0.06 | buy |
| Trexquant Investment LP | 403,657 | 409,667 | +6,010 | 0.02 | 0.01 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 521,379 | 406,795 | -114,584 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 360,319 | 395,230 | +34,911 | 0.03 | 0.04 | +0.01 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 416,698 | 394,600 | -22,098 | 0.03 | 0.02 | -0.00 | sell |
| Invesco Ltd. | 763,005 | 330,729 | -432,276 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 174,141 | 319,057 | +144,916 | 0.01 | 0.02 | +0.01 | buy |
| DAFNA Capital Management LLC | 117,812 | 297,812 | +180,000 | 0.15 | 0.32 | +0.18 | buy |
| Jump Financial, LLC | 0 | 297,800 | +297,800 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 49,746 | 286,375 | +236,629 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 702,799 | 265,284 | -437,515 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 462,068 | 250,025 | -212,043 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 236,000 | 244,600 | +8,600 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 30,817 | 235,990 | +205,173 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 268,640 | 215,748 | -52,892 | 0.10 | 0.05 | -0.05 | sell |
| MARSHALL WACE, LLP | 861,475 | 210,607 | -650,868 | 0.01 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 159,670 | 189,578 | +29,908 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 203,236 | 183,817 | -19,419 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 130,647 | 180,647 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 67,956 | 173,285 | +105,329 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 203,269 | 173,279 | -29,990 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 0 | 147,624 | +147,624 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 119,050 | 147,240 | +28,190 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,173 | 134,259 | +127,086 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 428,720 | 129,243 | -299,477 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 115,527 | 127,338 | +11,811 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 166,164 | 120,129 | -46,035 | 0.02 | 0.01 | -0.01 | sell |
| IEQ CAPITAL, LLC | 195,764 | 120,010 | -75,754 | 0.01 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 170,817 | 116,046 | -54,771 | 0.04 | 0.02 | -0.02 | sell |
| XTX Topco Ltd | 80,495 | 112,147 | +31,652 | 0.01 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 31,694 | 104,378 | +72,684 | 0.01 | 0.04 | +0.03 | buy |
| Quarry LP | 21,250 | 100,000 | +78,750 | 0.02 | 0.09 | +0.07 | buy |
| SCS Capital Management LLC | 99,000 | 99,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Legal & General Group Plc | 80,046 | 98,118 | +18,072 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 76,257 | 91,661 | +15,404 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 72,444 | 91,005 | +18,561 | 0.00 | 0.00 | +0.00 | buy |
| J. Safra Sarasin Holding AG | 90,487 | 90,487 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 53,867 | 88,518 | +34,651 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 79,173 | 87,909 | +8,736 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 90,959 | 87,509 | -3,450 | 0.02 | 0.01 | -0.00 | sell |
| DnB Asset Management AS | 88,617 | 73,147 | -15,470 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 54,866 | 69,468 | +14,602 | 0.08 | 0.09 | +0.01 | buy |
| Jain Global LLC | 0 | 64,719 | +64,719 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 57,683 | 62,076 | +4,393 | 0.02 | 0.02 | -0.00 | buy |