| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 8,299,720 | 8,561,949 | +262,229 | 0.00 | 0.00 | +0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 8,449,208 | 8,449,748 | +540 | 4.55 | 5.20 | +0.66 | buy |
| BVF INC/IL | 7,000,000 | 7,000,000 | 0 | 0.96 | 1.21 | +0.25 | hold |
| Redmile Group, LLC | 6,427,462 | 6,427,462 | 0 | 1.90 | 2.24 | +0.34 | hold |
| Point72 Asset Management, L.P. | 5,989,017 | 5,326,998 | -662,019 | 0.09 | 0.11 | +0.01 | sell |
| Bellevue Group AG | 5,157,290 | 5,157,290 | 0 | 0.41 | 0.49 | +0.08 | hold |
| VANGUARD GROUP INC | 4,556,640 | 4,970,293 | +413,653 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,773,585 | 3,841,879 | +2,068,294 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 4,071,677 | 3,430,160 | -641,517 | 0.19 | 0.17 | -0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,840,145 | 2,840,145 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Logos Global Management LP | 3,300,000 | 2,600,000 | -700,000 | 1.86 | 1.72 | -0.14 | sell |
| Candriam S.C.A. | 2,053,459 | 2,192,799 | +139,340 | 0.06 | 0.07 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,812,366 | 2,143,635 | +331,269 | 0.00 | 0.00 | +0.00 | buy |
| GMT CAPITAL CORP | 2,939,945 | 1,908,366 | -1,031,579 | 0.53 | 0.45 | -0.08 | sell |
| GOLDMAN SACHS GROUP INC | 596,191 | 1,904,378 | +1,308,187 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,686,372 | 1,706,182 | +19,810 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 914,648 | 1,450,895 | +536,247 | 0.10 | 0.19 | +0.09 | buy |
| Sio Capital Management, LLC | 0 | 1,433,155 | +1,433,155 | 0.00 | 3.80 | +3.80 | buy |
| MORGAN STANLEY | 1,008,414 | 1,235,485 | +227,071 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,064,801 | 1,160,886 | +96,085 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 822,605 | 1,129,042 | +306,437 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,094,472 | 1,034,652 | -59,820 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 912,151 | 944,996 | +32,845 | 0.01 | 0.02 | +0.00 | buy |
| NORTHERN TRUST CORP | 555,295 | 790,065 | +234,770 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 1,257,985 | 784,355 | -473,630 | 1.91 | 1.48 | -0.43 | sell |
| READYSTATE ASSET MANAGEMENT LP | 883,448 | 774,860 | -108,588 | 0.21 | 0.24 | +0.03 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 227,560 | 732,216 | +504,656 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 639,573 | 659,254 | +19,681 | 0.03 | 0.04 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 814,221 | 636,391 | -177,830 | 0.03 | 0.03 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | 583,913 | 0 | 0.05 | 0.05 | +0.00 | hold |
| Rhenman & Partners Asset Management AB | 900,000 | 560,000 | -340,000 | 0.42 | 0.27 | -0.15 | sell |
| DEUTSCHE BANK AG\ | 495,690 | 508,055 | +12,365 | 0.00 | 0.00 | +0.00 | buy |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | 482,550 | 0 | 0.16 | 0.24 | +0.08 | hold |
| Alyeska Investment Group, L.P. | 450,000 | 450,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Qube Research & Technologies Ltd | 447,700 | 429,559 | -18,141 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 584,200 | 401,400 | -182,800 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 400,000 | 400,000 | 0 | 0.32 | 0.38 | +0.06 | hold |
| Walleye Capital LLC | 0 | 328,698 | +328,698 | 0.00 | 0.02 | +0.02 | buy |
| Parkman Healthcare Partners LLC | 326,845 | 328,613 | +1,768 | 0.22 | 0.25 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 228,277 | 320,574 | +92,297 | 0.03 | 0.05 | +0.02 | buy |
| MARSHALL WACE, LLP | 1,693,665 | 292,374 | -1,401,291 | 0.01 | 0.00 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 193,419 | 263,360 | +69,941 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 192,612 | 259,404 | +66,792 | 0.05 | 0.07 | +0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 258,314 | 258,314 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 258,033 | 224,320 | -33,713 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 75,573 | 219,127 | +143,554 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 150,616 | 218,214 | +67,598 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 218,090 | 186,828 | -31,262 | 0.06 | 0.06 | +0.01 | sell |
| BARCLAYS PLC | 56,976 | 177,765 | +120,789 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 176,825 | +176,825 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 147,485 | 172,226 | +24,741 | 0.19 | 0.29 | +0.10 | buy |
| BANK OF AMERICA CORP /DE/ | 65,560 | 167,160 | +101,600 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 39,340 | 161,280 | +121,940 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 234,592 | 159,953 | -74,639 | 0.10 | 0.08 | -0.02 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 157,136 | 159,586 | +2,450 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 158,773 | +158,773 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 151,463 | +151,463 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 115,662 | 144,214 | +28,552 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 326,404 | 140,917 | -185,487 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 126,659 | 135,998 | +9,339 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 133,648 | 133,648 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 146,450 | 127,360 | -19,090 | 0.00 | 0.00 | +0.00 | sell |
| PARK AVENUE SECURITIES LLC | 49,986 | 118,068 | +68,082 | 0.00 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 28,337 | 106,591 | +78,254 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 92,085 | 81,411 | -10,674 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 71,077 | 74,344 | +3,267 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 347,212 | 72,655 | -274,557 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 669,158 | 70,006 | -599,152 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 69,965 | 66,864 | -3,101 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 279,463 | 64,791 | -214,672 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 62,625 | 62,625 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 34,167 | 59,310 | +25,143 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 49,398 | 55,212 | +5,814 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 45,318 | 51,138 | +5,820 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 85,000 | 50,000 | -35,000 | 0.01 | 0.01 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 0 | 49,406 | +49,406 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 46,485 | 46,804 | +319 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 61,109 | 43,031 | -18,078 | 0.05 | 0.06 | +0.01 | sell |
| HSBC HOLDINGS PLC | 36,369 | 37,825 | +1,456 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 119,400 | 37,200 | -82,200 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 0 | 35,447 | +35,447 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 26,865 | 34,779 | +7,914 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 31,226 | 34,581 | +3,355 | 0.01 | 0.02 | +0.00 | buy |
| SG Americas Securities, LLC | 15,040 | 32,763 | +17,723 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 339,278 | 31,164 | -308,114 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 28,282 | 30,030 | +1,748 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 14,333 | 29,399 | +15,066 | 0.00 | 0.01 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 26,013 | +26,013 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 64,309 | 25,955 | -38,354 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 0 | 25,830 | +25,830 | 0.00 | 0.01 | +0.01 | buy |
| Allegheny Financial Group | 25,200 | 25,200 | 0 | 0.04 | 0.04 | +0.00 | hold |
| CORNERCAP INVESTMENT COUNSEL INC | 46,057 | 22,604 | -23,453 | 0.04 | 0.04 | +0.00 | sell |
| Bayesian Capital Management, LP | 38,599 | 22,099 | -16,500 | 0.02 | 0.02 | -0.01 | sell |
| Invesco Ltd. | 22,838 | 21,270 | -1,568 | 0.00 | 0.00 | +0.00 | sell |
| Quarry LP | 0 | 20,000 | +20,000 | 0.00 | 0.04 | +0.04 | buy |
| Virtu Financial LLC | 29,664 | 19,165 | -10,499 | 0.01 | 0.01 | -0.00 | sell |
| COMERICA BANK | 10,000 | 18,900 | +8,900 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 18,073 | +18,073 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 11,478 | 17,441 | +5,963 | 0.03 | 0.05 | +0.02 | buy |
| Coastal Bridge Advisors, LLC | 17,000 | 17,000 | 0 | 0.02 | 0.02 | +0.00 | hold |