| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 0 | 2,600,000 | +2,600,000 | 0.00 | 1.12 | +1.12 | buy |
| MORGAN STANLEY | 832,540 | 3,029,848 | +2,197,308 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,053,709 | 2,638,275 | +1,584,566 | 0.01 | 0.04 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,297,260 | +1,297,260 | 0.00 | 0.01 | +0.01 | buy |
| J. Goldman & Co LP | 0 | 1,107,001 | +1,107,001 | 0.00 | 0.13 | +0.13 | buy |
| DEUTSCHE BANK AG\ | 511,448 | 1,504,349 | +992,901 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,630,649 | 2,406,432 | +775,783 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 5,366,039 | 5,835,112 | +469,073 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 255,918 | 682,558 | +426,640 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 460,000 | 823,000 | +363,000 | 0.14 | 0.28 | +0.14 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,514,134 | 2,822,823 | +308,689 | 0.01 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 332,031 | 574,123 | +242,092 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 241,991 | +241,991 | 0.00 | 0.03 | +0.03 | buy |
| ExodusPoint Capital Management, LP | 61,691 | 243,755 | +182,064 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 167,500 | +167,500 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,284,773 | 2,436,944 | +152,171 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 424,720 | 572,644 | +147,924 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 147,840 | +147,840 | 0.00 | 0.02 | +0.02 | buy |
| Susquehanna Portfolio Strategies, LLC | 207,715 | 353,744 | +146,029 | 0.01 | 0.02 | +0.01 | buy |
| Point72 Europe (London) LLP | 206,798 | 302,861 | +96,063 | 0.03 | 0.05 | +0.02 | buy |
| Point72 Asset Management, L.P. | 0 | 90,049 | +90,049 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 84,582 | +84,582 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 201,160 | 279,134 | +77,974 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 145,869 | 219,494 | +73,625 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,980,984 | 2,050,308 | +69,324 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 80,375 | 147,375 | +67,000 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 43,133 | 110,000 | +66,867 | 0.02 | 0.08 | +0.06 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 469,209 | 532,363 | +63,154 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 728,389 | 790,250 | +61,861 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 150,414 | 201,945 | +51,531 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 743,224 | 787,708 | +44,484 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 53,283 | 94,554 | +41,271 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 245,199 | 285,848 | +40,649 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 97,800 | 137,800 | +40,000 | 0.01 | 0.01 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 35,565 | +35,565 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 376,974 | 409,477 | +32,503 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 30,453 | +30,453 | 0.00 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,764,387 | 1,794,387 | +30,000 | 1.11 | 1.30 | +0.19 | buy |
| AXQ CAPITAL, LP | 0 | 27,867 | +27,867 | 0.00 | 0.03 | +0.03 | buy |
| Forefront Wealth Partners, LLC | 0 | 27,027 | +27,027 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 2,166,178 | 2,192,354 | +26,176 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 211,195 | 236,736 | +25,541 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 23,800 | +23,800 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 22,771 | +22,771 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 22,589 | +22,589 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 325,122 | 346,139 | +21,017 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 19,971 | +19,971 | 0.00 | 0.02 | +0.02 | buy |
| Corient Private Wealth LLC | 0 | 19,665 | +19,665 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 18,220 | +18,220 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 17,205 | +17,205 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 15,451 | +15,451 | 0.00 | 0.00 | +0.00 | buy |
| Balefire, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.01 | +0.01 | buy |
| IEQ CAPITAL, LLC | 135,797 | 150,322 | +14,525 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 22,036 | 35,261 | +13,225 | 0.00 | 0.01 | +0.00 | buy |
| Savant Capital, LLC | 0 | 13,095 | +13,095 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 10,997 | +10,997 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,979 | 19,739 | +9,760 | 0.00 | 0.00 | +0.00 | buy |
| MATAURO, LLC | 11,084 | 20,572 | +9,488 | 0.00 | 0.01 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 20,587 | 28,105 | +7,518 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 34,698 | 41,987 | +7,289 | 0.03 | 0.04 | +0.01 | buy |
| Bank of New York Mellon Corp | 301,048 | 308,188 | +7,140 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 25,607 | 32,357 | +6,750 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 6,530 | +6,530 | 0.00 | 0.00 | +0.00 | buy |
| Geneos Wealth Management Inc. | 0 | 6,000 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 5,995 | +5,995 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 17,734 | 23,488 | +5,754 | 0.00 | 0.00 | +0.00 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 35,000 | 40,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 2,758 | 6,607 | +3,849 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 404,194 | 405,953 | +1,759 | 0.11 | 0.14 | +0.02 | buy |
| Optiver Holding B.V. | 0 | 1,304 | +1,304 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 12,284 | 13,244 | +960 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 355 | +355 | 0.00 | 0.00 | +0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 296 | +296 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 269 | +269 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 108 | 350 | +242 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 45 | 152 | +107 | 0.00 | 0.00 | +0.00 | buy |
| Sunbelt Securities, Inc. | 0 | 87 | +87 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 252 | 296 | +44 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 4,238 | 4,248 | +10 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | 583,913 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 9,689 | 9,689 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 46,848 | 46,848 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 7,000,000 | 7,000,000 | 0 | 0.60 | 0.87 | +0.27 | hold |
| PARK AVENUE SECURITIES LLC | 113,068 | 113,068 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 140,740 | 140,740 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 11,670 | 11,670 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | 482,550 | 0 | 0.13 | 0.17 | +0.05 | hold |
| Cambridge Investment Research Advisors, Inc. | 10,700 | 10,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Redmile Group, LLC | 6,300,644 | 6,300,644 | 0 | 1.61 | 1.87 | +0.26 | hold |
| Daiwa Securities Group Inc. | 352 | 352 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Candriam S.C.A. | 2,534,230 | 2,534,230 | 0 | 0.04 | 0.04 | +0.01 | hold |
| Coastal Bridge Advisors, LLC | 17,000 | 17,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bellevue Group AG | 5,157,290 | 5,157,290 | 0 | 0.27 | 0.33 | +0.05 | hold |
| Harbor Advisors LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 5,249,069 | 5,249,069 | 0 | 1.58 | 1.06 | -0.51 | hold |
| HighMark Wealth Management LLC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |