| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 15,695,226 | 11,081,163 | -4,614,063 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 7,962,368 | 7,899,008 | -63,360 | 0.00 | 0.00 | +0.00 | sell |
| BVF INC/IL | 7,000,000 | 7,000,000 | 0 | 0.60 | 0.87 | +0.27 | hold |
| Redmile Group, LLC | 6,300,644 | 6,300,644 | 0 | 1.61 | 1.87 | +0.26 | hold |
| VANGUARD GROUP INC | 5,366,039 | 5,835,112 | +469,073 | 0.00 | 0.00 | +0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 5,249,069 | 5,249,069 | 0 | 1.58 | 1.06 | -0.51 | hold |
| Bellevue Group AG | 5,157,290 | 5,157,290 | 0 | 0.27 | 0.33 | +0.05 | hold |
| MORGAN STANLEY | 832,540 | 3,029,848 | +2,197,308 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,514,134 | 2,822,823 | +308,689 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 1,053,709 | 2,638,275 | +1,584,566 | 0.01 | 0.04 | +0.02 | buy |
| Opaleye Management Inc. | 0 | 2,600,000 | +2,600,000 | 0.00 | 1.12 | +1.12 | buy |
| Candriam S.C.A. | 2,534,230 | 2,534,230 | 0 | 0.04 | 0.04 | +0.01 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 2,284,773 | 2,436,944 | +152,171 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,630,649 | 2,406,432 | +775,783 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 2,166,178 | 2,192,354 | +26,176 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 2,810,000 | 2,112,455 | -697,545 | 1.22 | 0.94 | -0.28 | sell |
| STATE STREET CORP | 1,980,984 | 2,050,308 | +69,324 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,764,387 | 1,794,387 | +30,000 | 1.11 | 1.30 | +0.19 | buy |
| DEUTSCHE BANK AG\ | 511,448 | 1,504,349 | +992,901 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,297,260 | +1,297,260 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 1,452,795 | 1,294,302 | -158,493 | 0.00 | 0.00 | +0.00 | sell |
| J. Goldman & Co LP | 0 | 1,107,001 | +1,107,001 | 0.00 | 0.13 | +0.13 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 1,078,961 | 1,066,932 | -12,029 | 0.03 | 0.03 | +0.01 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 987,513 | 980,285 | -7,228 | 0.00 | 0.00 | +0.00 | sell |
| SIRIOS CAPITAL MANAGEMENT L P | 989,577 | 970,200 | -19,377 | 0.34 | 0.39 | +0.04 | sell |
| Rhenman & Partners Asset Management AB | 460,000 | 823,000 | +363,000 | 0.14 | 0.28 | +0.14 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 728,389 | 790,250 | +61,861 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 743,224 | 787,708 | +44,484 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 889,863 | 766,955 | -122,908 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 777,900 | 753,579 | -24,321 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 255,918 | 682,558 | +426,640 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 855,573 | 640,460 | -215,113 | 0.05 | 0.04 | -0.01 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | 583,913 | 0 | 0.03 | 0.03 | +0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 332,031 | 574,123 | +242,092 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 424,720 | 572,644 | +147,924 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 469,209 | 532,363 | +63,154 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 508,103 | 484,775 | -23,328 | 0.00 | 0.00 | +0.00 | sell |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | 482,550 | 0 | 0.13 | 0.17 | +0.05 | hold |
| Hennion & Walsh Asset Management, Inc. | 484,633 | 475,929 | -8,704 | 0.05 | 0.05 | +0.01 | sell |
| WELLS FARGO & COMPANY/MN | 376,974 | 409,477 | +32,503 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 404,194 | 405,953 | +1,759 | 0.11 | 0.14 | +0.02 | buy |
| Susquehanna Portfolio Strategies, LLC | 207,715 | 353,744 | +146,029 | 0.01 | 0.02 | +0.01 | buy |
| UBS Group AG | 325,122 | 346,139 | +21,017 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 301,048 | 308,188 | +7,140 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 206,798 | 302,861 | +96,063 | 0.03 | 0.05 | +0.02 | buy |
| ROYAL BANK OF CANADA | 245,199 | 285,848 | +40,649 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 201,160 | 279,134 | +77,974 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 61,691 | 243,755 | +182,064 | 0.00 | 0.01 | +0.01 | buy |
| SummitTX Capital, L.P. | 0 | 241,991 | +241,991 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 211,195 | 236,736 | +25,541 | 0.00 | 0.00 | +0.00 | buy |
| J. Safra Sarasin Holding AG | 381,441 | 223,221 | -158,220 | 0.02 | 0.01 | -0.00 | sell |
| JANE STREET GROUP, LLC | 145,869 | 219,494 | +73,625 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 266,050 | 212,219 | -53,831 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 150,414 | 201,945 | +51,531 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 167,500 | +167,500 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 266,812 | 151,250 | -115,562 | 0.00 | 0.00 | -0.00 | sell |
| IEQ CAPITAL, LLC | 135,797 | 150,322 | +14,525 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 177,628 | 147,930 | -29,698 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 0 | 147,840 | +147,840 | 0.00 | 0.02 | +0.02 | buy |
| OSAIC HOLDINGS, INC. | 80,375 | 147,375 | +67,000 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 140,740 | 140,740 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 97,800 | 137,800 | +40,000 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 134,035 | 132,673 | -1,362 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 137,536 | 132,603 | -4,933 | 0.00 | 0.00 | +0.00 | sell |
| PARK AVENUE SECURITIES LLC | 113,068 | 113,068 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quarry LP | 43,133 | 110,000 | +66,867 | 0.02 | 0.08 | +0.06 | buy |
| Brevan Howard Capital Management LP | 53,283 | 94,554 | +41,271 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 90,049 | +90,049 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 84,582 | +84,582 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 99,574 | 84,523 | -15,051 | 0.00 | 0.00 | -0.00 | sell |
| Cinctive Capital Management LP | 135,466 | 65,466 | -70,000 | 0.02 | 0.01 | -0.01 | sell |
| ALPS ADVISORS INC | 59,201 | 47,879 | -11,322 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 52,819 | 46,886 | -5,933 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 46,848 | 46,848 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 52,405 | 44,979 | -7,426 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 59,022 | 44,632 | -14,390 | 0.00 | 0.00 | -0.00 | sell |
| Allegheny Financial Group | 42,900 | 42,900 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Virtus Investment Advisers, LLC | 34,698 | 41,987 | +7,289 | 0.03 | 0.04 | +0.01 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 35,000 | 40,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 35,565 | +35,565 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 22,036 | 35,261 | +13,225 | 0.00 | 0.01 | +0.00 | buy |
| Lido Advisors, LLC | 35,000 | 34,952 | -48 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 34,479 | 34,479 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 25,607 | 32,357 | +6,750 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 30,453 | +30,453 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 20,587 | 28,105 | +7,518 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 27,867 | +27,867 | 0.00 | 0.03 | +0.03 | buy |
| Forefront Analytics, LLC | 27,575 | 27,027 | -548 | 0.03 | 0.08 | +0.05 | sell |
| Forefront Wealth Partners, LLC | 0 | 27,027 | +27,027 | 0.00 | 0.02 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 52,699 | 26,676 | -26,023 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 29,855 | 25,721 | -4,134 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 0 | 23,800 | +23,800 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 17,734 | 23,488 | +5,754 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 22,771 | +22,771 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 22,589 | +22,589 | 0.00 | 0.00 | +0.00 | buy |
| MATAURO, LLC | 11,084 | 20,572 | +9,488 | 0.00 | 0.01 | +0.00 | buy |
| ProShare Advisors LLC | 23,732 | 20,288 | -3,444 | 0.00 | 0.00 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 19,971 | +19,971 | 0.00 | 0.02 | +0.02 | buy |