| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,349,975 | 4,999,975 | +2,650,000 | 0.01 | 0.05 | +0.03 | buy |
| Bain Capital Life Sciences Investors, LLC | 5,701,926 | 8,061,719 | +2,359,793 | 1.50 | 3.51 | +2.00 | buy |
| Redmile Group, LLC | 3,503,190 | 5,503,190 | +2,000,000 | 0.39 | 0.89 | +0.50 | buy |
| Woodline Partners LP | 1,464,365 | 2,000,000 | +535,635 | 0.04 | 0.10 | +0.06 | buy |
| GMT CAPITAL CORP | 2,810,471 | 3,020,474 | +210,003 | 0.25 | 0.52 | +0.27 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 549,246 | 692,928 | +143,682 | 0.03 | 0.23 | 0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 976,987 | 1,075,730 | +98,743 | 0.06 | 0.11 | +0.05 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 399,716 | 417,429 | +17,713 | 0.35 | 0.58 | +0.23 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 165,100 | 179,500 | +14,400 | 0.01 | 0.02 | 0.00 | buy |
| Atom Investors LP | 14,607 | 15,615 | +1,008 | 0.01 | 0.01 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 777,199 | 777,968 | +769 | 0.00 | 0.00 | +0.00 | buy |
| Forefront Analytics, LLC | 31,680 | 31,280 | -400 | 0.04 | 0.07 | +0.03 | sell |
| Board of Trustees of The Leland Stanford Junior University | 494,169 | 482,550 | -11,619 | 0.09 | 0.14 | +0.05 | sell |
| SECTORAL ASSET MANAGEMENT INC | 898,785 | 650,911 | -247,874 | 0.41 | 1.27 | +0.86 | sell |
| Logos Global Management LP | 5,300,000 | 4,950,000 | -350,000 | 1.78 | 2.50 | +0.71 | sell |