| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 91,782 | 9,685,401 | +9,593,619 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 0 | 7,000,000 | +7,000,000 | 0.00 | 0.80 | +0.80 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,349,975 | 4,999,975 | +2,650,000 | 0.01 | 0.05 | +0.03 | buy |
| Ikarian Capital, LLC | 0 | 2,650,000 | +2,650,000 | 0.00 | 3.29 | +3.29 | buy |
| Bain Capital Life Sciences Investors, LLC | 5,701,926 | 8,061,719 | +2,359,793 | 1.50 | 3.51 | +2.00 | buy |
| Redmile Group, LLC | 3,503,190 | 5,503,190 | +2,000,000 | 0.39 | 0.89 | +0.50 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 707,815 | +707,815 | 0.00 | 0.11 | +0.11 | buy |
| MILLENNIUM MANAGEMENT LLC | 222,279 | 811,019 | +588,740 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,464,365 | 2,000,000 | +535,635 | 0.04 | 0.10 | +0.06 | buy |
| Walleye Capital LLC | 0 | 378,279 | +378,279 | 0.00 | 0.02 | +0.02 | buy |
| CITADEL ADVISORS LLC | 684,962 | 1,057,687 | +372,725 | 0.00 | 0.00 | +0.00 | buy |
| GMT CAPITAL CORP | 2,810,471 | 3,020,474 | +210,003 | 0.25 | 0.52 | +0.27 | buy |
| MORGAN STANLEY | 0 | 192,060 | +192,060 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 157,002 | +157,002 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 35,731 | 185,331 | +149,600 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 549,246 | 692,928 | +143,682 | 0.02 | 0.10 | +0.08 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 976,987 | 1,075,730 | +98,743 | 0.06 | 0.11 | +0.05 | buy |
| Lighthouse Investment Partners, LLC | 0 | 67,511 | +67,511 | 0.00 | 0.02 | +0.02 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 812,224 | 874,024 | +61,800 | 0.01 | 0.02 | +0.01 | buy |
| UBS Group AG | 0 | 49,586 | +49,586 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 48,614 | +48,614 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 879,617 | 922,232 | +42,615 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 245,658 | 284,933 | +39,275 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 309,710 | 342,939 | +33,229 | 0.01 | 0.02 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 58,522 | 87,047 | +28,525 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 399,716 | 417,429 | +17,713 | 0.35 | 0.58 | +0.23 | buy |
| Cubist Systematic Strategies, LLC | 0 | 17,144 | +17,144 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 19,262 | 36,406 | +17,144 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 16,432 | +16,432 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 831,544 | 846,274 | +14,730 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 165,100 | 179,500 | +14,400 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 1,894,409 | 1,908,326 | +13,917 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 12,509 | +12,509 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 12,012 | +12,012 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 11,857 | +11,857 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 0 | 10,719 | +10,719 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 10,107 | +10,107 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 24,169 | 33,864 | +9,695 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 361,237 | 367,275 | +6,038 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,109 | 7,054 | +5,945 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 952 | 6,753 | +5,801 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 7,783 | 11,924 | +4,141 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 18,491 | 21,772 | +3,281 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 22,212 | 25,335 | +3,123 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 14,607 | 15,615 | +1,008 | 0.01 | 0.01 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 777,199 | 777,968 | +769 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Middle East FZE | 0 | 614 | +614 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | 583,913 | 0 | 0.03 | 0.05 | +0.02 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,769 | 3,769 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CORNERCAP INVESTMENT COUNSEL INC | 46,698 | 46,698 | 0 | 0.02 | 0.03 | +0.01 | hold |
| ALLIANCEBERNSTEIN L.P. | 40,620 | 40,620 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cambridge Investment Research Advisors, Inc. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Coastal Bridge Advisors, LLC | 17,000 | 17,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Russell Investments Group, Ltd. | 988 | 988 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighMark Wealth Management LLC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Soleus Capital Management, L.P. | 515,400 | 515,400 | 0 | 0.12 | 0.26 | +0.14 | hold |
| Octagon Capital Advisors LP | 2,050,000 | 2,050,000 | 0 | 0.85 | 1.49 | +0.64 | hold |
| Allegheny Financial Group | 21,700 | 21,700 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Pictet Asset Management Holding SA | 1,803,149 | 1,803,149 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 123,668 | 123,668 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,021 | 20,021 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 258,314 | 258,314 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 44 | 0 | -44 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 986 | 898 | -88 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 22,778 | 22,687 | -91 | 0.00 | 0.00 | +0.00 | sell |
| Daiwa Securities Group Inc. | 131 | 0 | -131 | 0.00 | 0.00 | 0.00 | sell |
| RHUMBLINE ADVISERS | 59,710 | 59,320 | -390 | 0.00 | 0.00 | +0.00 | sell |
| Forefront Analytics, LLC | 31,680 | 31,280 | -400 | 0.04 | 0.07 | +0.03 | sell |
| AMALGAMATED BANK | 4,439 | 3,981 | -458 | 0.00 | 0.00 | +0.00 | sell |
| Red Tortoise LLC | 583 | 0 | -583 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 4,372 | 3,528 | -844 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 1,368 | 0 | -1,368 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 21,481 | 19,070 | -2,411 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,071 | 7,512 | -2,559 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 10,960 | 3,938 | -7,022 | 0.00 | 0.00 | -0.00 | sell |
| EWG Elevate Inc. | 10,000 | 0 | -10,000 | 0.01 | 0.00 | -0.01 | sell |
| JPMORGAN CHASE & CO | 39,619 | 29,585 | -10,034 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 37,100 | 26,583 | -10,517 | 0.00 | 0.00 | +0.00 | sell |
| Kestra Advisory Services, LLC | 21,000 | 10,000 | -11,000 | 0.00 | 0.00 | -0.00 | sell |
| Board of Trustees of The Leland Stanford Junior University | 494,169 | 482,550 | -11,619 | 0.09 | 0.14 | +0.05 | sell |
| ALGERT GLOBAL LLC | 41,660 | 27,880 | -13,780 | 0.00 | 0.01 | +0.00 | sell |
| NOMURA HOLDINGS INC | 16,650 | 0 | -16,650 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 19,000 | 0 | -19,000 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 154,277 | 134,277 | -20,000 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 121,390 | 88,091 | -33,299 | 0.00 | 0.00 | +0.00 | sell |
| Parallax Volatility Advisers, L.P. | 41,536 | 0 | -41,536 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 155,200 | 84,800 | -70,400 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 75,600 | 0 | -75,600 | 0.02 | 0.00 | -0.02 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 561,310 | 484,200 | -77,110 | 0.00 | 0.00 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 172,805 | 80,605 | -92,200 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 147,345 | 17,000 | -130,345 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 220,486 | 0 | -220,486 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 898,785 | 650,911 | -247,874 | 0.41 | 1.27 | +0.86 | sell |
| Vontobel Holding Ltd. | 898,785 | 650,911 | -247,874 | 0.02 | 0.02 | +0.01 | sell |
| Logos Global Management LP | 5,300,000 | 4,950,000 | -350,000 | 1.78 | 2.50 | +0.71 | sell |
| Velan Capital Investment Management LP | 459,746 | 0 | -459,746 | 0.89 | 0.00 | -0.89 | sell |
| FEDERATED HERMES, INC. | 485,047 | 0 | -485,047 | 0.00 | 0.00 | -0.00 | sell |