| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sio Capital Management, LLC | 1,433,155 | 2,367,007 | +933,852 | 3.36 | 3.42 | +0.05 | buy |
| TFG Asset Management GP Ltd | 784,355 | 1,400,000 | +615,645 | 1.31 | 1.83 | +0.53 | buy |
| Candriam S.C.A. | 2,053,459 | 2,534,230 | +480,771 | 0.06 | 0.07 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 259,404 | 429,584 | +170,180 | 0.07 | 0.10 | +0.03 | buy |
| Rafferty Asset Management, LLC | 176,825 | 218,369 | +41,544 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 20,000 | 58,000 | +38,000 | 0.04 | 0.06 | 0.00 | buy |
| ALPS ADVISORS INC | 74,344 | 86,194 | +11,850 | 0.00 | 0.00 | -0.00 | buy |
| OMERS ADMINISTRATION Corp | 24,400 | 12,900 | +11,500 | 0.00 | 0.00 | -0.00 | sell |
| Forefront Analytics, LLC | 10,483 | 16,433 | +5,950 | 0.03 | 0.04 | +0.01 | buy |
| E Fund Management Co., Ltd. | 11,361 | 15,447 | +4,086 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 328,613 | 330,849 | +2,236 | 0.25 | 0.23 | -0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 320,574 | 318,884 | +1,690 | 0.15 | 0.13 | 0.00 | sell |
| DnB Asset Management AS | 46,804 | 47,665 | +861 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 15,339 | 15,763 | +424 | 0.04 | 0.03 | -0.01 | buy |
| Corton Capital Inc. | 17,441 | 13,741 | -3,700 | 0.05 | 0.04 | -0.01 | sell |
| Point72 Europe (London) LLP | 159,953 | 155,573 | -4,380 | 0.06 | 0.05 | -0.01 | sell |
| SHERBROOKE PARK ADVISERS LLC | 43,031 | 30,134 | -12,897 | 0.06 | 0.05 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 560,000 | 542,500 | -17,500 | 0.27 | 0.29 | +0.02 | sell |
| Logos Global Management LP | 2,600,000 | 2,550,000 | -50,000 | 1.72 | 1.53 | -0.19 | sell |
| Cinctive Capital Management LP | 186,828 | 135,466 | -51,362 | 0.06 | 0.04 | -0.03 | sell |
| Redmile Group, LLC | 6,427,462 | 6,300,644 | -126,818 | 2.24 | 2.25 | +0.01 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,160,886 | 1,016,566 | -144,320 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,450,895 | 1,091,834 | -359,061 | 0.19 | 0.12 | -0.07 | sell |
| Woodline Partners LP | 3,430,160 | 2,690,787 | -739,373 | 0.17 | 0.09 | -0.08 | sell |
| Bain Capital Life Sciences Investors, LLC | 8,449,748 | 5,249,069 | -3,200,679 | 5.20 | 3.17 | -2.04 | sell |