| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 8,561,949 | 14,224,383 | +5,662,434 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 7,647,714 | 8,486,187 | +838,473 | 0.00 | 0.00 | -0.00 | buy |
| BVF INC/IL | 7,000,000 | 7,000,000 | 0 | 1.21 | 1.22 | +0.00 | hold |
| Redmile Group, LLC | 6,427,462 | 6,300,644 | -126,818 | 2.24 | 2.25 | +0.01 | sell |
| Point72 Asset Management, L.P. | 5,326,998 | 5,626,796 | +299,798 | 0.11 | 0.08 | -0.03 | buy |
| VANGUARD GROUP INC | 4,970,293 | 5,546,918 | +576,625 | 0.00 | 0.00 | -0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 8,449,748 | 5,249,069 | -3,200,679 | 5.20 | 3.17 | -2.04 | sell |
| Bellevue Group AG | 5,157,290 | 5,157,290 | 0 | 0.49 | 0.51 | +0.01 | hold |
| STATE STREET CORP | 3,841,879 | 4,510,714 | +668,835 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 3,430,160 | 2,690,787 | -739,373 | 0.17 | 0.09 | -0.08 | sell |
| Logos Global Management LP | 2,600,000 | 2,550,000 | -50,000 | 1.72 | 1.53 | -0.19 | sell |
| Candriam S.C.A. | 2,192,799 | 2,534,230 | +341,431 | 0.07 | 0.07 | +0.00 | buy |
| Sio Capital Management, LLC | 1,433,155 | 2,367,007 | +933,852 | 3.80 | 3.42 | -0.38 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,143,635 | 2,171,478 | +27,843 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 1,706,182 | 1,511,517 | -194,665 | 0.00 | 0.00 | -0.00 | sell |
| TFG Asset Management GP Ltd | 784,355 | 1,400,000 | +615,645 | 1.48 | 2.32 | +0.84 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,129,042 | 1,360,076 | +231,034 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,904,378 | 1,317,011 | -587,367 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 1,243,039 | +1,243,039 | 0.00 | 1.18 | +1.18 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,034,652 | 1,104,385 | +69,733 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,450,895 | 1,091,834 | -359,061 | 0.19 | 0.12 | -0.07 | sell |
| NORTHERN TRUST CORP | 790,065 | 1,029,750 | +239,685 | 0.00 | 0.00 | -0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 659,254 | 1,029,680 | +370,426 | 0.04 | 0.06 | +0.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 1,017,928 | +1,017,928 | 0.00 | 0.10 | +0.10 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,160,886 | 1,016,566 | -144,320 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 158,773 | 926,642 | +767,869 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 774,860 | 774,860 | 0 | 0.24 | 0.17 | -0.07 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 732,216 | 743,795 | +11,579 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 328,698 | 656,332 | +327,634 | 0.02 | 0.03 | +0.01 | buy |
| MORGAN STANLEY | 1,235,485 | 644,677 | -590,808 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | 583,913 | 0 | 0.05 | 0.06 | +0.01 | hold |
| Rhenman & Partners Asset Management AB | 560,000 | 542,500 | -17,500 | 0.27 | 0.29 | +0.02 | sell |
| DEUTSCHE BANK AG\ | 508,055 | 536,503 | +28,448 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 401,400 | 493,700 | +92,300 | 0.00 | 0.00 | +0.00 | buy |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | 482,550 | 0 | 0.24 | 0.21 | -0.03 | hold |
| Qube Research & Technologies Ltd | 429,559 | 461,372 | +31,813 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 259,404 | 429,584 | +170,180 | 0.07 | 0.10 | +0.03 | buy |
| Parkman Healthcare Partners LLC | 328,613 | 330,849 | +2,236 | 0.25 | 0.23 | -0.02 | buy |
| UBS Group AG | 219,127 | 328,721 | +109,594 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 320,574 | 318,884 | -1,690 | 0.05 | 0.04 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 263,360 | 268,166 | +4,806 | 0.00 | 0.00 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 258,314 | 258,314 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 218,214 | 235,755 | +17,541 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 224,320 | 230,546 | +6,226 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 176,825 | 218,369 | +41,544 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 177,765 | 206,991 | +29,226 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 144,214 | 178,511 | +34,297 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 172,226 | 172,226 | 0 | 0.29 | 0.36 | +0.07 | hold |
| PRUDENTIAL FINANCIAL INC | 161,280 | 171,680 | +10,400 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 70,006 | 168,787 | +98,781 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 159,586 | 159,019 | -567 | 0.00 | 0.00 | -0.00 | sell |
| J. Safra Sarasin Holding AG | 0 | 155,744 | +155,744 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 72,655 | 155,676 | +83,021 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 944,996 | 155,645 | -789,351 | 0.02 | 0.00 | -0.02 | sell |
| Point72 Europe (London) LLP | 159,953 | 155,573 | -4,380 | 0.08 | 0.05 | -0.03 | sell |
| Exome Asset Management LLC | 0 | 144,830 | +144,830 | 0.00 | 0.56 | +0.56 | buy |
| RHUMBLINE ADVISERS | 135,998 | 141,852 | +5,854 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 140,917 | 137,183 | -3,734 | 0.00 | 0.00 | -0.00 | sell |
| Cinctive Capital Management LP | 186,828 | 135,466 | -51,362 | 0.06 | 0.04 | -0.03 | sell |
| Swiss National Bank | 0 | 135,000 | +135,000 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 133,648 | 133,648 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 163,025 | 119,725 | -43,300 | 0.02 | 0.01 | -0.01 | sell |
| PARK AVENUE SECURITIES LLC | 118,068 | 118,068 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 127,360 | 111,300 | -16,060 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 66,864 | 92,371 | +25,507 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 74,344 | 86,194 | +11,850 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 13,870 | 85,535 | +71,665 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 83,437 | +83,437 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 62,625 | 80,475 | +17,850 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 25,955 | 69,248 | +43,293 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,994 | 66,375 | +59,381 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 55,212 | 64,967 | +9,755 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 59,310 | 63,402 | +4,092 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31,164 | 62,841 | +31,677 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 20,000 | 58,000 | +38,000 | 0.04 | 0.06 | +0.02 | buy |
| Squarepoint Ops LLC | 106,591 | 57,153 | -49,438 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 49,406 | 49,324 | -82 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 49,062 | +49,062 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 51,138 | 48,547 | -2,591 | 0.00 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 46,804 | 47,665 | +861 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 636,391 | 47,300 | -589,091 | 0.03 | 0.00 | -0.03 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 26,013 | 45,726 | +19,713 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 43,363 | +43,363 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 35,447 | 42,273 | +6,826 | 0.01 | 0.01 | -0.00 | buy |
| MARSHALL WACE, LLP | 292,374 | 38,845 | -253,529 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 0 | 35,151 | +35,151 | 0.00 | 0.02 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 34,500 | +34,500 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 14,168 | 34,479 | +20,311 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 64,791 | 33,153 | -31,638 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 18,073 | 32,548 | +14,475 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 21,270 | 31,881 | +10,611 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 31,000 | +31,000 | 0.00 | 0.04 | +0.04 | buy |
| SG Americas Securities, LLC | 32,763 | 30,968 | -1,795 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 37,825 | 30,799 | -7,026 | 0.00 | 0.00 | -0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 43,031 | 30,134 | -12,897 | 0.06 | 0.05 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 25,830 | 29,433 | +3,603 | 0.01 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 30,030 | 28,589 | -1,441 | 0.00 | 0.00 | -0.00 | sell |
| Allegheny Financial Group | 25,200 | 25,200 | 0 | 0.04 | 0.03 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 5,591 | 24,892 | +19,301 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 18,900 | 23,183 | +4,283 | 0.00 | 0.00 | +0.00 | buy |