| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,500,000 | 5,500,000 | +4,000,000 | 0.01 | 0.04 | +0.03 | buy |
| Redmile Group, LLC | 6,300,644 | 10,050,644 | +3,750,000 | 1.87 | 3.72 | +1.85 | buy |
| BVF INC/IL | 7,000,000 | 9,128,080 | +2,128,080 | 0.87 | 1.54 | +0.68 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 22,589 | 683,879 | +661,290 | 0.00 | 0.01 | +0.01 | buy |
| Cinctive Capital Management LP | 65,466 | 358,986 | +293,520 | 0.01 | 0.10 | +0.09 | buy |
| SummitTX Capital, L.P. | 241,991 | 438,497 | +196,506 | 0.03 | 0.07 | +0.04 | buy |
| Parkman Healthcare Partners LLC | 405,953 | 601,202 | +195,249 | 0.14 | 0.29 | +0.15 | buy |
| Hennion & Walsh Asset Management, Inc. | 475,929 | 534,986 | +59,057 | 0.05 | 0.09 | +0.04 | buy |
| Quarry LP | 110,000 | 75,000 | +35,000 | 0.09 | 0.06 | 0.00 | sell |
| DnB Asset Management AS | 84,523 | 118,324 | +33,801 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 19,971 | 42,774 | +22,803 | 0.02 | 0.08 | +0.06 | buy |
| Virtus Investment Advisers, LLC | 41,987 | 53,527 | +11,540 | 0.04 | 0.07 | +0.04 | buy |
| Susquehanna Portfolio Strategies, LLC | 353,744 | 356,619 | +2,875 | 0.02 | 0.03 | +0.01 | buy |
| AXQ CAPITAL, LP | 27,867 | 29,108 | +1,241 | 0.03 | 0.03 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 35,261 | 36,084 | +823 | 0.01 | 0.01 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,364 | 2,843 | +479 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 640,460 | 639,902 | -558 | 0.04 | 0.07 | +0.02 | sell |
| Forefront Analytics, LLC | 27,027 | 13,226 | -13,801 | 0.08 | 0.06 | -0.02 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 980,285 | 903,439 | -76,846 | 0.00 | 0.00 | +0.00 | sell |
| TFG Asset Management GP Ltd | 2,112,455 | 2,032,455 | -80,000 | 0.86 | 2.15 | +1.29 | sell |
| J. Safra Sarasin Holding AG | 223,221 | 117,768 | -105,453 | 0.01 | 0.01 | -0.00 | sell |
| J. Goldman & Co LP | 1,107,001 | 993,795 | -113,206 | 0.08 | 0.13 | +0.05 | sell |
| SIRIOS CAPITAL MANAGEMENT L P | 970,200 | 710,256 | -259,944 | 0.39 | 0.44 | +0.06 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 1,794,387 | 1,316,212 | -478,175 | 1.15 | 1.28 | +0.12 | sell |