| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,500,000 | 5,500,000 | +4,000,000 | 0.01 | 0.04 | +0.03 | buy |
| Redmile Group, LLC | 6,300,644 | 10,050,644 | +3,750,000 | 1.87 | 3.72 | +1.85 | buy |
| Longaeva Partners L.P. | 0 | 3,100,000 | +3,100,000 | 0.00 | 1.85 | +1.85 | buy |
| MAK CAPITAL ONE LLC | 0 | 2,958,527 | +2,958,527 | 0.00 | 2.00 | +2.00 | buy |
| STATE STREET CORP | 2,050,308 | 4,652,185 | +2,601,877 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 0 | 2,384,192 | +2,384,192 | 0.00 | 1.67 | +1.67 | buy |
| Nuveen, LLC | 682,558 | 2,915,324 | +2,232,766 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 2,192,354 | 4,348,782 | +2,156,428 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 7,000,000 | 9,128,080 | +2,128,080 | 0.87 | 1.54 | +0.68 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,297,260 | 3,299,256 | +2,001,996 | 0.01 | 0.03 | +0.02 | buy |
| VANGUARD GROUP INC | 5,835,112 | 7,753,387 | +1,918,275 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 572,644 | 2,381,479 | +1,808,835 | 0.00 | 0.02 | +0.01 | buy |
| Woodline Partners LP | 2,638,275 | 4,000,074 | +1,361,799 | 0.04 | 0.08 | +0.04 | buy |
| BlackRock, Inc. | 7,899,008 | 8,960,434 | +1,061,426 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 1,046,221 | +1,046,221 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 201,945 | 972,449 | +770,504 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 18,220 | 683,016 | +664,796 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 22,589 | 683,879 | +661,290 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 520,998 | +520,998 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,436,944 | 2,902,896 | +465,952 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 398,077 | +398,077 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 350,000 | +350,000 | 0.00 | 1.05 | +1.05 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 532,363 | 861,245 | +328,882 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,294,302 | 1,605,581 | +311,279 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 212,219 | 522,846 | +310,627 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 219,494 | 513,836 | +294,342 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 65,466 | 358,986 | +293,520 | 0.01 | 0.10 | +0.09 | buy |
| Point72 Asset Management, L.P. | 90,049 | 371,190 | +281,141 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 272,812 | +272,812 | 0.00 | 0.32 | +0.32 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 790,250 | 1,057,060 | +266,810 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 230,244 | +230,244 | 0.00 | 0.15 | +0.15 | buy |
| AQR CAPITAL MANAGEMENT LLC | 574,123 | 776,307 | +202,184 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 241,991 | 438,497 | +196,506 | 0.03 | 0.07 | +0.04 | buy |
| Parkman Healthcare Partners LLC | 405,953 | 601,202 | +195,249 | 0.14 | 0.29 | +0.15 | buy |
| WELLS FARGO & COMPANY/MN | 409,477 | 573,748 | +164,271 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 147,930 | 289,963 | +142,033 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 141,644 | +141,644 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 122,858 | +122,858 | 0.00 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 0 | 119,491 | +119,491 | 0.00 | 0.03 | +0.03 | buy |
| CITADEL ADVISORS LLC | 167,500 | 275,294 | +107,794 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 147,840 | 243,313 | +95,473 | 0.02 | 0.03 | +0.01 | buy |
| Persistent Asset Partners Ltd | 0 | 93,657 | +93,657 | 0.00 | 0.23 | +0.23 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 64,069 | +64,069 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 475,929 | 534,986 | +59,057 | 0.05 | 0.09 | +0.04 | buy |
| SEI INVESTMENTS CO | 0 | 58,259 | +58,259 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 308,188 | 361,677 | +53,489 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 53,400 | +53,400 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 0 | 53,008 | +53,008 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 279,134 | 332,038 | +52,904 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 753,579 | 802,600 | +49,021 | 0.00 | 0.01 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 48,573 | +48,573 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 48,000 | +48,000 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 19,739 | 61,572 | +41,833 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 0 | 38,600 | +38,600 | 0.00 | 0.02 | +0.02 | buy |
| Landing Point Financial Group, LLC | 0 | 34,900 | +34,900 | 0.00 | 0.09 | +0.09 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,250 | 185,508 | +34,258 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 84,523 | 118,324 | +33,801 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 150,322 | 182,982 | +32,660 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 31,585 | +31,585 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 31,335 | +31,335 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 346,139 | 377,104 | +30,965 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 94,554 | 123,753 | +29,199 | 0.00 | 0.01 | +0.01 | buy |
| EntryPoint Capital, LLC | 19,971 | 42,774 | +22,803 | 0.02 | 0.08 | +0.06 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 19,197 | +19,197 | 0.00 | 0.02 | +0.02 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 17,600 | +17,600 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 17,216 | +17,216 | 0.00 | 0.05 | +0.05 | buy |
| SG Americas Securities, LLC | 10,997 | 28,071 | +17,074 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 6,828 | 23,640 | +16,812 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 26,676 | 42,524 | +15,848 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 14,801 | +14,801 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 236,736 | 251,158 | +14,422 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,822,823 | 2,836,857 | +14,034 | 0.01 | 0.01 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 41,987 | 53,527 | +11,540 | 0.04 | 0.07 | +0.04 | buy |
| MOUNT VERNON ASSOCIATES INC /MD/ | 0 | 10,500 | +10,500 | 0.00 | 0.04 | +0.04 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 10,386 | +10,386 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 10,268 | +10,268 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 10,016 | +10,016 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 44,979 | 54,763 | +9,784 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 15,451 | 24,004 | +8,553 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 46,886 | 53,729 | +6,843 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 23,488 | 30,297 | +6,809 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 20,000 | 24,869 | +4,869 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 20,288 | 24,698 | +4,410 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 787,708 | 792,000 | +4,292 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,021 | 14,757 | +3,736 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 2,987 | +2,987 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 353,744 | 356,619 | +2,875 | 0.02 | 0.03 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 4,248 | 7,033 | +2,785 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 17,205 | 19,553 | +2,348 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 27,867 | 29,108 | +1,241 | 0.03 | 0.03 | +0.00 | buy |
| Legal & General Group Plc | 8,476 | 9,307 | +831 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 35,261 | 36,084 | +823 | 0.01 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 0 | 753 | +753 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,364 | 2,843 | +479 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 334 | +334 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 0 | 333 | +333 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 1 | 309 | +308 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 152 | 416 | +264 | 0.00 | 0.00 | +0.00 | buy |