| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 11,081,163 | 10,222,470 | -858,693 | 0.00 | 0.00 | +0.00 | sell |
| Redmile Group, LLC | 6,300,644 | 10,050,644 | +3,750,000 | 1.87 | 3.72 | +1.85 | buy |
| BVF INC/IL | 7,000,000 | 9,128,080 | +2,128,080 | 0.87 | 1.54 | +0.68 | buy |
| BlackRock, Inc. | 7,899,008 | 8,960,434 | +1,061,426 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 5,835,112 | 7,753,387 | +1,918,275 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,500,000 | 5,500,000 | +4,000,000 | 0.01 | 0.04 | +0.03 | buy |
| Bain Capital Life Sciences Investors, LLC | 5,249,069 | 5,249,069 | 0 | 1.06 | 2.02 | +0.96 | hold |
| Bellevue Group AG | 5,157,290 | 5,157,290 | 0 | 0.33 | 0.49 | +0.16 | hold |
| STATE STREET CORP | 2,050,308 | 4,652,185 | +2,601,877 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 2,192,354 | 4,348,782 | +2,156,428 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 2,638,275 | 4,000,074 | +1,361,799 | 0.04 | 0.08 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,297,260 | 3,299,256 | +2,001,996 | 0.01 | 0.03 | +0.02 | buy |
| Longaeva Partners L.P. | 0 | 3,100,000 | +3,100,000 | 0.00 | 1.85 | +1.85 | buy |
| MAK CAPITAL ONE LLC | 0 | 2,958,527 | +2,958,527 | 0.00 | 2.00 | +2.00 | buy |
| Nuveen, LLC | 682,558 | 2,915,324 | +2,232,766 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,436,944 | 2,902,896 | +465,952 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 3,029,848 | 2,856,143 | -173,705 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 2,822,823 | 2,836,857 | +14,034 | 0.01 | 0.01 | +0.00 | buy |
| Opaleye Management Inc. | 2,600,000 | 2,600,000 | 0 | 1.12 | 1.72 | +0.60 | hold |
| Palo Alto Investors LP | 0 | 2,384,192 | +2,384,192 | 0.00 | 1.67 | +1.67 | buy |
| Qube Research & Technologies Ltd | 572,644 | 2,381,479 | +1,808,835 | 0.00 | 0.02 | +0.01 | buy |
| TFG Asset Management GP Ltd | 2,112,455 | 2,032,455 | -80,000 | 0.94 | 2.15 | +1.22 | sell |
| GOLDMAN SACHS GROUP INC | 2,406,432 | 1,768,745 | -637,687 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,294,302 | 1,605,581 | +311,279 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,794,387 | 1,316,212 | -478,175 | 1.30 | 1.38 | +0.08 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 790,250 | 1,057,060 | +266,810 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 1,046,221 | +1,046,221 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 1,107,001 | 993,795 | -113,206 | 0.13 | 0.19 | +0.07 | sell |
| Invesco Ltd. | 201,945 | 972,449 | +770,504 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 980,285 | 903,439 | -76,846 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 532,363 | 861,245 | +328,882 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 753,579 | 802,600 | +49,021 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 787,708 | 792,000 | +4,292 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 574,123 | 776,307 | +202,184 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 766,955 | 718,680 | -48,275 | 0.00 | 0.00 | +0.00 | sell |
| SIRIOS CAPITAL MANAGEMENT L P | 970,200 | 710,256 | -259,944 | 0.39 | 0.44 | +0.06 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 22,589 | 683,879 | +661,290 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 18,220 | 683,016 | +664,796 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 1,066,932 | 642,038 | -424,894 | 0.03 | 0.03 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 640,460 | 639,902 | -558 | 0.04 | 0.07 | +0.02 | sell |
| Parkman Healthcare Partners LLC | 405,953 | 601,202 | +195,249 | 0.14 | 0.29 | +0.15 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583,913 | 583,913 | 0 | 0.03 | 0.04 | +0.01 | hold |
| WELLS FARGO & COMPANY/MN | 409,477 | 573,748 | +164,271 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,504,349 | 560,744 | -943,605 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 475,929 | 534,986 | +59,057 | 0.05 | 0.09 | +0.04 | buy |
| Schonfeld Strategic Advisors LLC | 212,219 | 522,846 | +310,627 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 520,998 | +520,998 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 219,494 | 513,836 | +294,342 | 0.00 | 0.00 | +0.00 | buy |
| Board of Trustees of The Leland Stanford Junior University | 482,550 | 482,550 | 0 | 0.17 | 0.49 | +0.32 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 484,775 | 445,074 | -39,701 | 0.00 | 0.00 | +0.00 | sell |
| SummitTX Capital, L.P. | 241,991 | 438,497 | +196,506 | 0.03 | 0.07 | +0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 398,077 | +398,077 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 346,139 | 377,104 | +30,965 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 90,049 | 371,190 | +281,141 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 308,188 | 361,677 | +53,489 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 65,466 | 358,986 | +293,520 | 0.01 | 0.10 | +0.09 | buy |
| Susquehanna Portfolio Strategies, LLC | 353,744 | 356,619 | +2,875 | 0.02 | 0.03 | +0.01 | buy |
| DIADEMA PARTNERS LP | 0 | 350,000 | +350,000 | 0.00 | 1.05 | +1.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 279,134 | 332,038 | +52,904 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 147,930 | 289,963 | +142,033 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 167,500 | 275,294 | +107,794 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 272,812 | +272,812 | 0.00 | 0.32 | +0.32 | buy |
| AMERICAN CENTURY COMPANIES INC | 236,736 | 251,158 | +14,422 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 147,840 | 243,313 | +95,473 | 0.02 | 0.03 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 230,244 | +230,244 | 0.00 | 0.15 | +0.15 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,250 | 185,508 | +34,258 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 150,322 | 182,982 | +32,660 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 147,375 | 147,375 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rafferty Asset Management, LLC | 0 | 141,644 | +141,644 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 140,740 | 140,740 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 137,800 | 137,800 | 0 | 0.01 | 0.01 | +0.01 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 132,673 | 130,102 | -2,571 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 132,603 | 126,463 | -6,140 | 0.00 | 0.00 | +0.00 | sell |
| Brevan Howard Capital Management LP | 94,554 | 123,753 | +29,199 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 122,858 | +122,858 | 0.00 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 0 | 119,491 | +119,491 | 0.00 | 0.03 | +0.03 | buy |
| DnB Asset Management AS | 84,523 | 118,324 | +33,801 | 0.00 | 0.00 | +0.00 | buy |
| J. Safra Sarasin Holding AG | 223,221 | 117,768 | -105,453 | 0.01 | 0.01 | -0.00 | sell |
| Persistent Asset Partners Ltd | 0 | 93,657 | +93,657 | 0.00 | 0.23 | +0.23 | buy |
| Quarry LP | 110,000 | 75,000 | -35,000 | 0.08 | 0.06 | -0.02 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 64,069 | +64,069 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 19,739 | 61,572 | +41,833 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 58,259 | +58,259 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 44,979 | 54,763 | +9,784 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 46,886 | 53,729 | +6,843 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 41,987 | 53,527 | +11,540 | 0.04 | 0.07 | +0.04 | buy |
| WINTON GROUP Ltd | 0 | 53,400 | +53,400 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 0 | 53,008 | +53,008 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 48,573 | +48,573 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 48,000 | +48,000 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 46,848 | 46,848 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allegheny Financial Group | 42,900 | 42,900 | 0 | 0.02 | 0.03 | +0.01 | hold |
| EntryPoint Capital, LLC | 19,971 | 42,774 | +22,803 | 0.02 | 0.08 | +0.06 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 26,676 | 42,524 | +15,848 | 0.00 | 0.00 | +0.00 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 44,632 | 39,059 | -5,573 | 0.00 | 0.00 | +0.00 | sell |
| Pale Fire Capital SE | 0 | 38,600 | +38,600 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 35,261 | 36,084 | +823 | 0.01 | 0.01 | +0.01 | buy |
| Lido Advisors, LLC | 34,952 | 34,952 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Landing Point Financial Group, LLC | 0 | 34,900 | +34,900 | 0.00 | 0.09 | +0.09 | buy |