| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 1,410,000 | 2,333,333 | +923,333 | 0.21 | 0.39 | +0.18 | buy |
| Nantahala Capital Management, LLC | 1,235,000 | 1,862,250 | +627,250 | 0.68 | 1.15 | +0.47 | buy |
| BVF INC/IL | 1,632,845 | 2,075,545 | +442,700 | 0.78 | 0.98 | +0.20 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 662,968 | 1,000,000 | +337,032 | 0.10 | 0.16 | +0.06 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 60,808 | 186,308 | +125,500 | 0.64 | 2.40 | +1.76 | buy |
| PERCEPTIVE ADVISORS LLC | 139,667 | 219,813 | +80,146 | 0.04 | 0.06 | +0.02 | buy |
| HighVista Strategies LLC | 58,622 | 122,610 | +63,988 | 0.24 | 0.52 | +0.27 | buy |
| MOODY ALDRICH PARTNERS LLC | 159,324 | 125,582 | -33,742 | 0.43 | 0.42 | -0.01 | sell |
| Aberdeen Group plc | 171,679 | 122,169 | -49,510 | 0.00 | 0.00 | -0.00 | sell |
| RTW INVESTMENTS, LP | 856,962 | 175,000 | -681,962 | 0.13 | 0.03 | -0.10 | sell |