| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 220,300 | 2,879,481 | +2,659,181 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 2,162,684 | +2,162,684 | 0.00 | 0.02 | +0.02 | buy |
| Avoro Capital Advisors LLC | 0 | 1,410,000 | +1,410,000 | 0.00 | 0.21 | +0.21 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 916,000 | +916,000 | 0.00 | 0.08 | +0.08 | buy |
| RTW INVESTMENTS, LP | 0 | 856,962 | +856,962 | 0.00 | 0.13 | +0.13 | buy |
| Caligan Partners LP | 881,533 | 1,635,023 | +753,490 | 1.47 | 1.73 | +0.26 | buy |
| UBS Group AG | 477,816 | 1,141,980 | +664,164 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 52,641 | 455,000 | +402,359 | 0.04 | 0.32 | +0.28 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 387,982 | +387,982 | 0.00 | 0.12 | +0.12 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 550,000 | 854,000 | +304,000 | 0.02 | 0.02 | +0.00 | buy |
| Logos Global Management LP | 0 | 300,000 | +300,000 | 0.00 | 0.23 | +0.23 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 0 | 295,933 | +295,933 | 0.00 | 1.58 | +1.58 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 439,312 | 731,586 | +292,274 | 0.01 | 0.02 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 1,051,054 | 1,340,840 | +289,786 | 1.37 | 1.17 | -0.20 | buy |
| Point72 Asset Management, L.P. | 627,502 | 916,142 | +288,640 | 0.02 | 0.02 | +0.01 | buy |
| BVF INC/IL | 1,355,257 | 1,632,845 | +277,588 | 0.83 | 0.78 | -0.05 | buy |
| TCG Crossover Management, LLC | 483,000 | 738,383 | +255,383 | 0.29 | 0.32 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 197,747 | 422,781 | +225,034 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 659,979 | 835,484 | +175,505 | 0.01 | 0.01 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 159,341 | +159,341 | 0.00 | 1.40 | +1.40 | buy |
| JPMORGAN CHASE & CO | 44,431 | 194,391 | +149,960 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 16,771 | 161,087 | +144,316 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 202,127 | 324,258 | +122,131 | 0.09 | 0.11 | +0.02 | buy |
| Qube Research & Technologies Ltd | 64,463 | 174,506 | +110,043 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 18,300 | 120,114 | +101,814 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 40,458 | 126,732 | +86,274 | 0.02 | 0.03 | +0.01 | buy |
| Aberdeen Group plc | 95,426 | 171,679 | +76,253 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 0 | 75,000 | +75,000 | 0.00 | 0.46 | +0.46 | buy |
| Quadrature Capital Ltd | 53,044 | 125,195 | +72,151 | 0.01 | 0.02 | +0.01 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 60,808 | +60,808 | 0.00 | 0.65 | +0.65 | buy |
| SEI INVESTMENTS CO | 0 | 56,854 | +56,854 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 51,408 | +51,408 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 48,105 | +48,105 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 46,553 | +46,553 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 40,821 | +40,821 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 40,854 | 81,285 | +40,431 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 289,571 | 327,082 | +37,511 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 35,096 | +35,096 | 0.00 | 0.04 | +0.04 | buy |
| EntryPoint Capital, LLC | 0 | 30,041 | +30,041 | 0.00 | 0.13 | +0.13 | buy |
| Aquatic Capital Management LLC | 0 | 29,712 | +29,712 | 0.00 | 0.01 | +0.01 | buy |
| MOODY ALDRICH PARTNERS LLC | 133,231 | 159,324 | +26,093 | 0.45 | 0.43 | -0.02 | buy |
| Boxer Capital Management, LLC | 275,000 | 300,000 | +25,000 | 1.09 | 0.59 | -0.51 | buy |
| BANK OF AMERICA CORP /DE/ | 621,350 | 643,000 | +21,650 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 19,321 | +19,321 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 17,227 | +17,227 | 0.00 | 0.00 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 15,639 | +15,639 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 10,166 | +10,166 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 16,039 | 19,996 | +3,957 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 166,152 | 169,889 | +3,737 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 2,733 | 3,387 | +654 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 75 | +75 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 63 | +63 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 139,667 | 139,667 | 0 | 0.05 | 0.04 | -0.01 | hold |
| GREAT POINT PARTNERS LLC | 124,666 | 124,666 | 0 | 0.73 | 0.46 | -0.28 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 662,968 | 662,968 | 0 | 0.12 | 0.10 | -0.02 | hold |
| 683 Capital Management, LLC | 56,850 | 56,850 | 0 | 0.09 | 0.08 | -0.01 | hold |
| Nantahala Capital Management, LLC | 1,235,000 | 1,235,000 | 0 | 1.34 | 1.15 | -0.19 | hold |
| Parallel Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NAN FUNG TRINITY (HK) Ltd | 189,000 | 189,000 | 0 | 0.27 | 0.31 | +0.04 | hold |
| Key FInancial Inc | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Soleus Capital Management, L.P. | 441,978 | 441,978 | 0 | 0.34 | 0.27 | -0.07 | hold |
| Commodore Capital LP | 483,000 | 483,000 | 0 | 0.58 | 0.42 | -0.17 | hold |
| Activest Wealth Management | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFS Partners, LLC | 2,000 | 2,000 | 0 | 0.02 | 0.01 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 150,000 | 150,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 13,092 | 12,810 | -282 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 135,552 | 134,742 | -810 | 0.42 | 0.39 | -0.04 | sell |
| CITIGROUP INC | 1,143 | 0 | -1,143 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,471 | 0 | -1,471 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 32,204 | 30,556 | -1,648 | 0.00 | 0.00 | -0.00 | sell |
| Belvedere Trading LLC | 4,526 | 0 | -4,526 | 0.02 | 0.00 | -0.02 | sell |
| JENNISON ASSOCIATES LLC | 475,625 | 470,775 | -4,850 | 0.01 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 65,313 | 60,106 | -5,207 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 178,855 | 173,320 | -5,535 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 15,087 | 7,918 | -7,169 | 0.13 | 0.05 | -0.09 | sell |
| STATE STREET CORP | 79,254 | 71,654 | -7,600 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 19,600 | 11,800 | -7,800 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 8,737 | 0 | -8,737 | 0.00 | 0.00 | -0.00 | sell |
| Artia Global Partners LP | 41,570 | 28,970 | -12,600 | 0.12 | 0.10 | -0.02 | sell |
| ExodusPoint Capital Management, LP | 32,267 | 17,751 | -14,516 | 0.01 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 31,106 | 0 | -31,106 | 0.07 | 0.00 | -0.07 | sell |
| HighVista Strategies LLC | 95,631 | 58,622 | -37,009 | 0.45 | 0.24 | -0.21 | sell |
| Walleye Capital LLC | 41,693 | 0 | -41,693 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 217,974 | 172,149 | -45,825 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 49,400 | 0 | -49,400 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 51,194 | 0 | -51,194 | 0.07 | 0.00 | -0.07 | sell |
| Woodline Partners LP | 52,041 | 0 | -52,041 | 0.00 | 0.00 | -0.00 | sell |
| Sio Capital Management, LLC | 72,173 | 0 | -72,173 | 0.22 | 0.00 | -0.22 | sell |
| Velan Capital Investment Management LP | 263,642 | 185,122 | -78,520 | 2.79 | 1.73 | -1.05 | sell |
| FRED ALGER MANAGEMENT, LLC | 80,092 | 0 | -80,092 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 148,237 | 64,425 | -83,812 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 105,814 | 14,642 | -91,172 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 264,907 | 161,392 | -103,515 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 153,313 | 0 | -153,313 | 1.49 | 0.00 | -1.49 | sell |
| SummitTX Capital, L.P. | 195,873 | 0 | -195,873 | 0.11 | 0.00 | -0.11 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 210,994 | 0 | -210,994 | 0.01 | 0.00 | -0.01 | sell |
| Jain Global LLC | 217,292 | 0 | -217,292 | 0.04 | 0.00 | -0.04 | sell |